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3_beta-hydroxysteroid_dehydrogenase_delta_5-4_isomerase
Euk-VirEptesipox_virus
3_beta-hydroxysteroid_dehydrogenase_delta_5-4_isomerase__YP_009408095__Eptesipox_virus__1329402
Identity
- Accession:
- YP_009408095 ↗
- Protein ID:
- 3_beta-hydroxysteroid_dehydrogenase_delta_5-4_isomerase
- Kingdom:
- euk
Quality
93.9
mean pLDDT
Taxonomy
Bamfordvirae›
Nucleocytoviricota›
Pokkesviricetes›
Chitovirales›
Poxviridae›
Vespertilionpoxvirus›
Eptesipox_virus
TaxID: 1329402
Cluster
View cluster (115 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 2-184_218-248
Domain cluster:
rep: 3-beta_hydroxysteroid_dehydrogenase_isomerase_family__YP_009342125__Lymphocystis_disease_virus_Sa__1898060__D2-175_211-244_309-317
Pfam (8)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01370.28 | Epimerase | 79.5 | 3.70e-22 | 84.6% | 65.4% |
| PF01073.26 best | 3Beta_HSD | 207.6 | 2.80e-61 | 84.6% | 64.6% |
| PF04321.24 | RmlD_sub_bind | 33.8 | 2.70e-08 | 82.7% | 47.4% |
| PF07993.19 | NAD_binding_4 | 48.4 | 1.00e-12 | 82.7% | 74.4% |
| PF16363.12 | GDP_Man_Dehyd | 34.6 | 2.20e-08 | 78.5% | 49.4% |
| PF13460.13 | NAD_binding_10 | 36.2 | 7.90e-09 | 74.8% | 71.2% |
| PF02719.22 | Polysacc_synt_2 | 42.3 | 7.50e-11 | 60.3% | 45.7% |
| PF01073.26 | 3Beta_HSD | 25.8 | 7.20e-06 | 15.4% | 12.1% |
D2
high
residues 190-216_253-315_332-348
Domain cluster:
rep: putative_3-beta-hydroxy-delta_5-C27_steroid_oxidoreductase-like_protein__YP_009259419__Short-finned_eel_ranavirus__638660__D190-214_258-320
CATH (32)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3sc6A02 | 3.90.25.10 | Alpha Beta › Alpha-Beta Complex › UDP-galactose 4-epimerase; domain 1 › UDP-galactose 4-epimerase, domain 1 | 0.70 | 49.0 | 5.50e-01 | 97.2% | 100.0% |
| 4wpgA02 | 3.90.25.10 | Alpha Beta › Alpha-Beta Complex › UDP-galactose 4-epimerase; domain 1 › UDP-galactose 4-epimerase, domain 1 | 0.69 | 48.0 | 5.43e-01 | 97.2% | 98.7% |
| 5cz2C00 | 3.30.420.10 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H | 0.62 | 42.0 | 3.77e-01 | 70.1% | 56.6% |
| 1bsvA02 | 3.90.25.10 | Alpha Beta › Alpha-Beta Complex › UDP-galactose 4-epimerase; domain 1 › UDP-galactose 4-epimerase, domain 1 | 0.61 | 47.0 | 5.00e-01 | 100.0% | 95.7% |
| 7bmfA01 | 3.90.1640.30 | Alpha Beta › Alpha-Beta Complex › inorganic pyrophosphatase (n-terminal core) › | 0.60 | 48.0 | 4.05e-01 | 86.0% | 93.5% |
| 3g1wA02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.60 | 43.0 | 3.94e-01 | 75.7% | 86.3% |
| 7x0hC01 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.59 | 43.0 | 4.05e-01 | 78.5% | 90.5% |
| 3e3mA02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.58 | 41.0 | 3.72e-01 | 72.0% | 89.0% |
| 3tb6B02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.58 | 40.0 | 3.69e-01 | 72.0% | 89.0% |
| 1mv8A03 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.58 | 42.0 | 3.42e-01 | 75.7% | 66.3% |
| 2h4aA02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.58 | 40.0 | 3.72e-01 | 72.0% | 87.9% |
| 2h3hB02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.58 | 42.0 | 3.71e-01 | 75.7% | 79.6% |
| 3rotA02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.57 | 42.0 | 3.94e-01 | 78.5% | 93.4% |
| 2fqxA02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.57 | 47.0 | 3.98e-01 | 90.7% | 91.4% |
| 6gt9A02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.57 | 42.0 | 3.64e-01 | 78.5% | 74.1% |
| 1efaA03 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.57 | 41.0 | 3.80e-01 | 75.7% | 88.8% |
| 4ry8C02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.57 | 41.0 | 3.58e-01 | 75.7% | 77.7% |
| 5x4kA01 | 3.90.1640.30 | Alpha Beta › Alpha-Beta Complex › inorganic pyrophosphatase (n-terminal core) › | 0.55 | 45.0 | 3.83e-01 | 91.6% | 75.1% |
| 7yosA01 | 3.90.1640.30 | Alpha Beta › Alpha-Beta Complex › inorganic pyrophosphatase (n-terminal core) › | 0.55 | 44.0 | 3.70e-01 | 88.8% | 92.7% |
| 4rsmA02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.54 | 41.0 | 3.68e-01 | 78.5% | 84.7% |
| 6bwlA02 | 3.90.25.10 | Alpha Beta › Alpha-Beta Complex › UDP-galactose 4-epimerase; domain 1 › UDP-galactose 4-epimerase, domain 1 | 0.54 | 47.0 | 4.76e-01 | 100.0% | 96.2% |
| 4rkrD02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.54 | 39.0 | 3.59e-01 | 75.7% | 91.7% |
| 5dteA02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.54 | 41.0 | 3.72e-01 | 83.2% | 85.0% |
| 5ix8A02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.53 | 40.0 | 3.53e-01 | 78.5% | 78.6% |
| 1m0wA04 | 3.40.50.1760 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Glutathione synthase, substrate-binding domain superfamily, eukaryotic | 0.53 | 38.0 | 3.65e-01 | 75.7% | 93.8% |
| 4n03A02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.53 | 44.0 | 3.78e-01 | 90.7% | 92.0% |
| 4rweA02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.53 | 41.0 | 3.64e-01 | 83.2% | 83.0% |
| 1xngA01 | 3.40.50.620 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HUPs | 0.53 | 41.0 | 3.18e-01 | 84.1% | 62.8% |
| 3thxB02 | 3.30.420.110 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › MutS, connector domain | 0.51 | 34.0 | 3.13e-01 | 74.8% | 48.0% |
| 2v4uA00 | 3.40.50.880 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Class I glutamine amidotransferase (GATase) domain | 0.51 | 42.0 | 3.19e-01 | 90.7% | 97.0% |
| 2rjoA02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.51 | 40.0 | 3.49e-01 | 86.0% | 98.8% |
| 3k32B00 | 3.40.50.620 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HUPs | 0.50 | 45.0 | 3.69e-01 | 99.1% | 95.4% |
ECOD (38)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| None | — | 0.93 | 73.0 | 4.91e-01 | 80.4% | 43.9% | |
| 4000799 | 2003.1.1.11 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 3Beta_HSD | 0.81 | 75.0 | 5.05e-01 | 100.0% | 43.6% |
| 5035901 | 2003.1.1.20 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Epimerase | 0.79 | 73.0 | 5.08e-01 | 100.0% | 45.8% |
| 3235085 | 2003.1.1.11 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 3Beta_HSD | 0.79 | 68.0 | 4.70e-01 | 93.5% | 46.9% |
| 5034323 | 2003.1.1.20 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Epimerase | 0.78 | 72.0 | 5.08e-01 | 100.0% | 49.7% |
| 3786213 | 2003.1.1.11 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 3Beta_HSD | 0.78 | 71.0 | 4.88e-01 | 99.1% | 46.0% |
| 4946279 | 2003.1.1.20 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Epimerase | 0.78 | 72.0 | 5.00e-01 | 100.0% | 46.7% |
| 3794271 | 2003.1.1.11 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 3Beta_HSD | 0.76 | 70.0 | 4.75e-01 | 100.0% | 45.5% |
| 4613677 | 2003.1.1.20 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Epimerase | 0.76 | 69.0 | 4.83e-01 | 99.1% | 46.4% |
| 4984215 | 2003.1.1.20 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Epimerase | 0.75 | 68.0 | 4.78e-01 | 100.0% | 46.5% |
| 3966071 | 2003.1.1.20 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Epimerase | 0.74 | 67.0 | 4.65e-01 | 100.0% | 43.8% |
| 3982773 | 2003.1.1.20 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Epimerase | 0.72 | 65.0 | 4.65e-01 | 100.0% | 48.4% |
| 1173110 | 2007.1.2.10 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Peripla_BP_3 | 0.59 | 42.0 | 4.02e-01 | 75.7% | 93.8% |
| 2896511 | 2007.1.2.11 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Peripla_BP_4 | 0.58 | 43.0 | 4.06e-01 | 78.5% | 93.9% |
| 4267061 | 2484.1.1.40 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RuvX | 0.57 | 41.0 | 3.87e-01 | 76.6% | 86.7% |
| 3518537 | 2007.1.2.10 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Peripla_BP_3 | 0.56 | 39.0 | 3.70e-01 | 72.0% | 96.9% |
| 4942220 | 7512.1.1.3 ↗ | a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › Glycos_transf_1 | 0.56 | 38.0 | 3.65e-01 | 71.0% | 86.2% |
| 3290835 | 2007.1.2.10 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Peripla_BP_3 | 0.56 | 41.0 | 3.64e-01 | 78.5% | 78.8% |
| 4536847 | 2005.1.1.23 ↗ | a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › tRNA_Me_trans | 0.55 | 41.0 | 3.28e-01 | 77.6% | 83.7% |
| 3988599 | 2007.1.2.10 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Peripla_BP_3 | 0.55 | 40.0 | 3.59e-01 | 75.7% | 84.7% |
| 3745227 | 2007.1.2.4 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › ANF_receptor | 0.55 | 38.0 | 3.22e-01 | 70.1% | 76.7% |
| 5003534 | 2006.1.2.1 ↗ | a/b three-layered sandwiches › HAD domain-like › HAD domain-related › DHH phosphoesterases › DHH | 0.55 | 43.0 | 3.37e-01 | 86.0% | 68.8% |
| 1891415 | 2006.1.2.1 ↗ | a/b three-layered sandwiches › HAD domain-like › HAD domain-related › DHH phosphoesterases › DHH | 0.55 | 46.0 | 3.81e-01 | 91.6% | 73.7% |
| 5066833 | 2006.1.2.1 ↗ | a/b three-layered sandwiches › HAD domain-like › HAD domain-related › DHH phosphoesterases › DHH | 0.55 | 46.0 | 3.54e-01 | 91.6% | 58.0% |
| 2712717 | 2006.1.2.1 ↗ | a/b three-layered sandwiches › HAD domain-like › HAD domain-related › DHH phosphoesterases › DHH | 0.55 | 44.0 | 3.70e-01 | 88.8% | 92.7% |
| 3947020 | 2007.1.2.10 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Peripla_BP_3 | 0.55 | 39.0 | 3.69e-01 | 75.7% | 89.6% |
| 3943963 | 2007.1.2.11 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Peripla_BP_4 | 0.55 | 40.0 | 3.67e-01 | 78.5% | 85.3% |
| 3589423 | 2007.1.2.10 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Peripla_BP_3 | 0.53 | 41.0 | 3.76e-01 | 84.1% | 89.0% |
| 3288388 | 2003.1.1.61 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › KR | 0.53 | 41.0 | 3.14e-01 | 84.1% | 83.1% |
| 2048146 | 2007.1.14.8 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Chelatase-like › CbiK | 0.53 | 37.0 | 3.40e-01 | 72.9% | 91.7% |
| 4061833 | 2005.1.1.18 ↗ | a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › NAD_synthase | 0.52 | 40.0 | 2.99e-01 | 84.1% | 70.5% |
| 4644409 | 2005.1.1.18 ↗ | a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › NAD_synthase | 0.51 | 38.0 | 2.94e-01 | 79.4% | 60.8% |
| 3789539 | 7510.1.1.1 ↗ | a/b three-layered sandwiches › Isocitrate/Isopropylmalate dehydrogenase-like › Isocitrate/Isopropylmalate dehydrogenase-like › Isocitrate/Isopropylmalate dehydrogenase-like › Iso_dh | 0.51 | 37.0 | 3.52e-01 | 78.5% | 63.1% |
| 3015462 | 7523.1.1.17 ↗ | a/b three-layered sandwiches › Periplasmic binding protein-like II › Periplasmic binding protein-like II › Periplasmic binding protein-like II › OpuAC | 0.51 | 37.0 | 4.08e-01 | 77.6% | 100.0% |
| 4854029 | 2006.1.2.1 ↗ | a/b three-layered sandwiches › HAD domain-like › HAD domain-related › DHH phosphoesterases › DHH | 0.51 | 41.0 | 3.42e-01 | 89.7% | 89.8% |
| 5078496 | 7512.1.1.0 ↗ | a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase | 0.51 | 30.0 | 2.84e-01 | 84.1% | 45.2% |
| 3988402 | 2007.1.2.10 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Peripla_BP_3 | 0.51 | 38.0 | 3.50e-01 | 78.5% | 91.4% |
| 4262428 | 2005.1.1.18 ↗ | a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › NAD_synthase | 0.51 | 40.0 | 2.90e-01 | 84.1% | 68.1% |