Back to structures

ATP-dependent_DNA_ligase

Euk-Vir

Melbournevirus

ATP-dependent_DNA_ligase__YP_009094561__Melbournevirus__1560514

Identity

Accession:
YP_009094561 ↗
Protein ID:
ATP-dependent_DNA_ligase
Kingdom:
euk

Quality

80.6 mean pLDDT

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 5-100
PDB
D2 high residues 333-415
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF14743.13 best DNA_ligase_OB_2 33.7 4.00e-08 84.3% 81.8%
D3 medium residues 126-163_284-331
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF01068.27 best DNA_ligase_A_M 29.8 6.40e-07 69.8% 23.0%
D4 medium residues 164-283
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF01068.27 best DNA_ligase_A_M 38.3 1.70e-09 96.7% 57.4%
CATH (20)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
6imjA01 3.30.470.30 Alpha Beta › 2-Layer Sandwich › D-amino Acid Aminotransferase; Chain A, domain 1 › DNA ligase/mRNA capping enzyme 0.89 82.0 6.82e-01 100.0% 60.6%
4d05A02 3.30.470.30 Alpha Beta › 2-Layer Sandwich › D-amino Acid Aminotransferase; Chain A, domain 1 › DNA ligase/mRNA capping enzyme 0.88 71.0 7.71e-01 99.2% 100.0%
2cfmA02 3.30.470.30 Alpha Beta › 2-Layer Sandwich › D-amino Acid Aminotransferase; Chain A, domain 1 › DNA ligase/mRNA capping enzyme 0.84 80.0 6.52e-01 100.0% 61.7%
6rarI01 3.30.470.30 Alpha Beta › 2-Layer Sandwich › D-amino Acid Aminotransferase; Chain A, domain 1 › DNA ligase/mRNA capping enzyme 0.81 77.0 6.37e-01 100.0% 62.6%
1vs0A02 3.30.470.30 Alpha Beta › 2-Layer Sandwich › D-amino Acid Aminotransferase; Chain A, domain 1 › DNA ligase/mRNA capping enzyme 0.81 71.0 7.42e-01 99.2% 100.0%
2hivA02 3.30.470.30 Alpha Beta › 2-Layer Sandwich › D-amino Acid Aminotransferase; Chain A, domain 1 › DNA ligase/mRNA capping enzyme 0.80 76.0 6.17e-01 100.0% 60.2%
6p0cA03 3.30.470.30 Alpha Beta › 2-Layer Sandwich › D-amino Acid Aminotransferase; Chain A, domain 1 › DNA ligase/mRNA capping enzyme 0.80 75.0 7.38e-01 99.2% 100.0%
3l2pA03 3.30.470.30 Alpha Beta › 2-Layer Sandwich › D-amino Acid Aminotransferase; Chain A, domain 1 › DNA ligase/mRNA capping enzyme 0.75 70.0 7.01e-01 98.3% 100.0%
3qwuA02 3.30.470.30 Alpha Beta › 2-Layer Sandwich › D-amino Acid Aminotransferase; Chain A, domain 1 › DNA ligase/mRNA capping enzyme 0.73 61.0 5.21e-01 100.0% 58.3%
2vugA03 3.30.470.30 Alpha Beta › 2-Layer Sandwich › D-amino Acid Aminotransferase; Chain A, domain 1 › DNA ligase/mRNA capping enzyme 0.73 59.0 6.38e-01 98.3% 100.0%
3vnnA00 3.30.470.30 Alpha Beta › 2-Layer Sandwich › D-amino Acid Aminotransferase; Chain A, domain 1 › DNA ligase/mRNA capping enzyme 0.70 63.0 6.27e-01 100.0% 91.9%
1xk5A01 3.30.470.30 Alpha Beta › 2-Layer Sandwich › D-amino Acid Aminotransferase; Chain A, domain 1 › DNA ligase/mRNA capping enzyme 0.69 58.0 4.81e-01 100.0% 53.8%
3oyyA02 2.40.50.140 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins 0.65 35.0 4.49e-01 99.2% 95.4%
6az1E02 2.40.50.740 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Ribosomal protein S4, central domain 0.61 28.0 3.90e-01 70.0% 98.0%
2rcnA01 2.40.50.140 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins 0.60 30.0 4.00e-01 74.2% 93.4%
2kdoA01 3.30.1250.10 Alpha Beta › 2-Layer Sandwich › Hypothetical 12.0 Kda Protein In Nam8-gar1 Intergenic Region; Chain: A; › Ribosome maturation protein SBDS, N-terminal domain 0.56 34.0 3.65e-01 97.5% 71.7%
3d0fA01 2.40.50.140 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins 0.53 32.0 3.85e-01 99.2% 98.6%
5w7zA01 3.10.150.10 Alpha Beta › Roll › DNA Polymerase III; Chain A, domain 2 › DNA Polymerase III, subunit A, domain 2 0.52 34.0 3.58e-01 100.0% 71.7%
2vhjA02 2.30.270.20 Mainly Beta › Roll › duf1285 protein fold › 0.51 27.0 3.63e-01 80.8% 100.0%
4csbA00 2.40.128.480 Mainly Beta › Beta Barrel › Lipocalin › Rhodococcus equi virulence-associated protein 0.51 40.0 4.18e-01 94.2% 90.3%
ECOD (68)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3606912 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.88 84.0 6.31e-01 100.0% 52.9%
3605538 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.85 81.0 6.05e-01 100.0% 58.5%
4966636 206.1.3.0 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp 0.85 80.0 6.47e-01 100.0% 60.0%
3602296 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.84 80.0 6.32e-01 100.0% 62.7%
3599023 206.1.3.0 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp 0.84 80.0 6.27e-01 100.0% 56.5%
5016269 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.84 80.0 5.53e-01 100.0% 40.3%
4098851 4095.1.1.2 alpha bundles › ATP-dependent DNA ligase DNA-binding domain › ATP-dependent DNA ligase DNA-binding domain › ATP-dependent DNA ligase DNA-binding domain › DNA_ligase_A_M+DNA_ligase_A_N 0.83 79.0 5.55e-01 100.0% 41.5%
4495705 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.83 79.0 6.22e-01 100.0% 64.0%
4473535 4095.1.1.2 alpha bundles › ATP-dependent DNA ligase DNA-binding domain › ATP-dependent DNA ligase DNA-binding domain › ATP-dependent DNA ligase DNA-binding domain › DNA_ligase_A_M+DNA_ligase_A_N 0.83 79.0 5.53e-01 100.0% 37.9%
4325132 4095.1.1.2 alpha bundles › ATP-dependent DNA ligase DNA-binding domain › ATP-dependent DNA ligase DNA-binding domain › ATP-dependent DNA ligase DNA-binding domain › DNA_ligase_A_M+DNA_ligase_A_N 0.83 79.0 5.54e-01 100.0% 39.4%
4937749 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.83 78.0 5.52e-01 100.0% 37.9%
5036153 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.83 79.0 6.52e-01 100.0% 62.1%
4960010 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.83 78.0 6.28e-01 100.0% 56.7%
4935888 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.83 78.0 5.49e-01 100.0% 37.0%
5042001 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.82 78.0 5.52e-01 100.0% 38.5%
3281941 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.82 78.0 6.46e-01 100.0% 63.1%
4045857 4095.1.1.2 alpha bundles › ATP-dependent DNA ligase DNA-binding domain › ATP-dependent DNA ligase DNA-binding domain › ATP-dependent DNA ligase DNA-binding domain › DNA_ligase_A_M+DNA_ligase_A_N 0.82 78.0 5.16e-01 100.0% 30.0%
3962528 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.82 78.0 6.41e-01 100.0% 61.0%
4977191 206.1.3.0 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp 0.82 78.0 6.24e-01 100.0% 57.7%
4982625 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.82 78.0 6.13e-01 100.0% 55.1%
4399570 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.82 78.0 6.13e-01 100.0% 56.4%
4947392 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.82 78.0 6.27e-01 100.0% 57.6%
4945406 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.82 77.0 6.25e-01 100.0% 59.0%
5039677 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.82 77.0 6.15e-01 100.0% 56.8%
4237088 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.82 74.0 6.03e-01 100.0% 56.5%
3968582 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.82 76.0 6.36e-01 100.0% 61.6%
5066075 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.81 77.0 6.39e-01 100.0% 63.6%
4951306 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.81 76.0 5.05e-01 100.0% 28.4%
5076593 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.81 77.0 6.47e-01 100.0% 63.2%
4600922 4095.1.1.0 alpha bundles › ATP-dependent DNA ligase DNA-binding domain › ATP-dependent DNA ligase DNA-binding domain › ATP-dependent DNA ligase DNA-binding domain 0.81 77.0 5.09e-01 100.0% 29.4%
3947455 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.81 77.0 6.18e-01 100.0% 60.5%
5083927 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.81 77.0 6.13e-01 100.0% 66.5%
3798407 206.1.3.0 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp 0.81 76.0 6.15e-01 100.0% 58.6%
2559783 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.81 77.0 6.30e-01 100.0% 60.7%
4213407 4095.1.1.2 alpha bundles › ATP-dependent DNA ligase DNA-binding domain › ATP-dependent DNA ligase DNA-binding domain › ATP-dependent DNA ligase DNA-binding domain › DNA_ligase_A_M+DNA_ligase_A_N 0.81 76.0 5.12e-01 100.0% 29.9%
4631711 4095.1.1.3 alpha bundles › ATP-dependent DNA ligase DNA-binding domain › ATP-dependent DNA ligase DNA-binding domain › ATP-dependent DNA ligase DNA-binding domain › DNA_ligase_A_M 0.81 77.0 5.18e-01 100.0% 31.2%
3315215 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.81 75.0 5.96e-01 100.0% 57.8%
4914243 206.1.3.116 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M, DNA_ligase_A_C 0.80 75.0 6.14e-01 99.2% 61.5%
4947307 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.80 75.0 5.30e-01 100.0% 37.0%
4302481 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.80 76.0 6.06e-01 100.0% 61.9%
4056196 4095.1.1.2 alpha bundles › ATP-dependent DNA ligase DNA-binding domain › ATP-dependent DNA ligase DNA-binding domain › ATP-dependent DNA ligase DNA-binding domain › DNA_ligase_A_M+DNA_ligase_A_N 0.80 75.0 4.95e-01 100.0% 28.2%
4683228 4095.1.1.2 alpha bundles › ATP-dependent DNA ligase DNA-binding domain › ATP-dependent DNA ligase DNA-binding domain › ATP-dependent DNA ligase DNA-binding domain › DNA_ligase_A_M+DNA_ligase_A_N 0.80 75.0 5.10e-01 100.0% 31.2%
3643093 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.79 75.0 5.84e-01 100.0% 60.4%
4666907 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.79 74.0 6.09e-01 100.0% 59.5%
3960632 206.1.3.0 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp 0.79 75.0 6.13e-01 100.0% 58.5%
4680450 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.78 75.0 5.97e-01 100.0% 62.8%
4995719 206.1.3.0 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp 0.78 66.0 5.72e-01 100.0% 61.1%
5031580 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.78 73.0 6.05e-01 100.0% 62.0%
3476026 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.77 72.0 5.45e-01 100.0% 58.9%
3378267 4095.1.1.2 alpha bundles › ATP-dependent DNA ligase DNA-binding domain › ATP-dependent DNA ligase DNA-binding domain › ATP-dependent DNA ligase DNA-binding domain › DNA_ligase_A_M+DNA_ligase_A_N 0.77 72.0 4.79e-01 100.0% 32.0%
3397951 4095.1.1.2 alpha bundles › ATP-dependent DNA ligase DNA-binding domain › ATP-dependent DNA ligase DNA-binding domain › ATP-dependent DNA ligase DNA-binding domain › DNA_ligase_A_M+DNA_ligase_A_N 0.77 72.0 4.68e-01 100.0% 27.2%
3253455 4095.1.1.2 alpha bundles › ATP-dependent DNA ligase DNA-binding domain › ATP-dependent DNA ligase DNA-binding domain › ATP-dependent DNA ligase DNA-binding domain › DNA_ligase_A_M+DNA_ligase_A_N 0.77 72.0 4.73e-01 100.0% 29.6%
3922871 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.76 72.0 5.65e-01 100.0% 56.1%
3513779 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.76 72.0 5.75e-01 100.0% 59.2%
3799247 206.1.3.0 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp 0.76 72.0 5.41e-01 100.0% 46.9%
3795817 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.76 71.0 5.37e-01 100.0% 46.0%
3434631 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.76 58.0 5.64e-01 79.2% 80.6%
3581071 4095.1.1.2 alpha bundles › ATP-dependent DNA ligase DNA-binding domain › ATP-dependent DNA ligase DNA-binding domain › ATP-dependent DNA ligase DNA-binding domain › DNA_ligase_A_M+DNA_ligase_A_N 0.75 71.0 4.72e-01 100.0% 28.7%
5017089 206.1.3.23 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › RNA_ligase 0.73 62.0 4.82e-01 100.0% 44.6%
4943522 206.1.3.23 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › RNA_ligase 0.71 61.0 4.89e-01 100.0% 49.1%
1837660 206.1.3.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DNA_ligase_A_M 0.70 63.0 6.27e-01 100.0% 91.9%
5077223 206.1.3.23 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › RNA_ligase 0.68 61.0 4.16e-01 100.0% 29.5%
4387556 3468.1.1.1 a+b two layers › HLTF protein HIRAN domain › HLTF protein HIRAN domain › HLTF protein HIRAN domain › HIRAN 0.65 41.0 4.48e-01 88.3% 76.8%
5024218 206.1.3.23 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › RNA_ligase 0.62 57.0 4.13e-01 100.0% 54.4%
4114715 2.1.1.0 beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.53 32.0 3.36e-01 85.8% 65.7%
3290774 2.1.1.0 beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.52 33.0 3.47e-01 83.3% 69.1%
4130134 3468.1.1.1 a+b two layers › HLTF protein HIRAN domain › HLTF protein HIRAN domain › HLTF protein HIRAN domain › HIRAN 0.50 44.0 4.26e-01 97.5% 84.3%
3635125 3468.1.1.1 a+b two layers › HLTF protein HIRAN domain › HLTF protein HIRAN domain › HLTF protein HIRAN domain › HIRAN 0.50 44.0 4.01e-01 98.3% 71.3%