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Alkaline_exonuclease
Euk-VirHuman_betaherpesvirus_6B
Alkaline_exonuclease__NP_050249__Human_betaherpesvirus_6B__32604
Identity
- Accession:
- NP_050249 ↗
- Protein ID:
- Alkaline_exonuclease
- Kingdom:
- euk
Quality
80.6
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Roseolovirus›
Human_betaherpesvirus_6B
TaxID: 32604
Cluster
View cluster (76 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 4-77_89-140
Domain cluster:
rep: GP98__YP_007417864__Caviid_betaherpesvirus_2__33706__D55-187
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01771.24 best | Viral_alk_exo | 95.1 | 5.70e-27 | 96.0% | 24.9% |
D2
medium
residues 206-232_355-395_437-483
Domain cluster:
rep: Exonuclease__YP_214099__Murid_betaherpesvirus_1__10366__D221-282_429-473_511-556
Pfam (3)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01771.24 best | Viral_alk_exo | 49.1 | 5.10e-13 | 39.1% | 8.2% |
| PF01771.24 | Viral_alk_exo | 23.8 | 2.50e-05 | 35.6% | 8.0% |
| PF01771.24 | Viral_alk_exo | 20.6 | 2.30e-04 | 24.3% | 5.9% |
D3
medium
residues 328-354_396-436
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01771.24 best | Viral_alk_exo | 33.9 | 2.00e-08 | 79.4% | 9.8% |
CATH (10)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3owcB00 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.65 | 50.0 | 3.78e-01 | 85.3% | 89.4% |
| 3igrA00 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.63 | 49.0 | 3.59e-01 | 83.8% | 57.9% |
| 1nslA00 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.63 | 48.0 | 3.61e-01 | 83.8% | 57.4% |
| 3fbuA00 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.62 | 46.0 | 3.53e-01 | 82.4% | 59.0% |
| 5jtfB00 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.61 | 47.0 | 3.54e-01 | 85.3% | 60.0% |
| 3g7nB00 | 3.40.50.1820 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain | 0.58 | 44.0 | 3.09e-01 | 85.3% | 44.0% |
| 4hu4A00 | 3.20.20.450 | Alpha Beta › Alpha-Beta Barrel › TIM Barrel › EAL domain | 0.56 | 45.0 | 3.17e-01 | 92.6% | 92.3% |
| 3m6nA01 | 3.90.226.10 | Alpha Beta › Alpha-Beta Complex › 2-enoyl-CoA Hydratase; Chain A, domain 1 › 2-enoyl-CoA Hydratase; Chain A, domain 1 | 0.56 | 41.0 | 2.98e-01 | 80.9% | 49.1% |
| 3vl9B00 | 2.60.120.180 | Mainly Beta › Sandwich › Jelly Rolls › Glycoside hydrolase family 11/12, catalytic domain | 0.54 | 44.0 | 3.21e-01 | 95.6% | 92.8% |
| 4a37A01 | 2.60.40.3120 | Mainly Beta › Sandwich › Immunoglobulin-like › | 0.53 | 41.0 | 3.55e-01 | 88.2% | 89.4% |
ECOD (8)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4939340 | 223.8.1.0 ↗ | a+b three layers › Profilin-like › LapD periplasmic domain › LapD periplasmic domain | 0.64 | 48.0 | 4.22e-01 | 100.0% | 53.4% |
| 3867103 | 3417.1.1.1 ↗ | a+b three layers › Surfactant protein C BRICHOS domain › Surfactant protein C BRICHOS domain › Surfactant protein C BRICHOS domain › BRICHOS | 0.59 | 41.0 | 3.56e-01 | 72.1% | 53.3% |
| 4217323 | 327.13.1.0 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › Ring-building motif I in type III secretion system › Ring-building motif I in type III secretion system | 0.57 | 40.0 | 4.20e-01 | 79.4% | 83.3% |
| 5037746 | 327.11.1.0 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Prokaryotic type KH domain (KH-domain type II) | 0.57 | 32.0 | 3.48e-01 | 72.1% | 65.0% |
| 5015924 | 2004.1.1.22 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Sigma54_activat | 0.54 | 38.0 | 2.54e-01 | 76.5% | 69.7% |
| 3969660 | 2.1.1.0 ↗ | beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein | 0.53 | 47.0 | 3.70e-01 | 100.0% | 47.6% |
| 3984842 | 11.1.5.49 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Common fold of diphtheria toxin/transcription factors/cytochrome f › bMG10 | 0.51 | 41.0 | 3.37e-01 | 100.0% | 88.7% |
| 2526309 | 7083.1.1.1 ↗ | beta sandwiches › C-terminal domain of viral protein A26 › C-terminal domain of viral protein A26 › C-terminal domain of viral protein A26 › PF31251 | 0.51 | 35.0 | 2.89e-01 | 75.0% | 64.3% |