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BML_coassembly_scaffold_108_prodigal-single.1__X__X__00126
Bact-VirBML_coassembly_scaffold_108_prodigal-single.1__X__X__00126
Identity
- Kingdom:
- phage
Quality
64.9
mean pLDDT
Cluster
Singleton — not in a non-trivial cluster
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 201-251
Domain cluster:
representative
CATH (19)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4ghjB00 | 1.10.260.40 | Mainly Alpha › Orthogonal Bundle › 434 Repressor (Amino-terminal Domain) › lambda repressor-like DNA-binding domains | 0.63 | 53.0 | 4.73e-01 | 100.0% | 67.1% |
| 1j09A04 | 1.10.8.70 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Glutamate-tRNA synthetase, class I, anticodon-binding domain 1 | 0.62 | 43.0 | 4.47e-01 | 100.0% | 81.2% |
| 3vkgA15 | 1.10.8.1220 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › | 0.61 | 53.0 | 4.36e-01 | 100.0% | 68.1% |
| 2gf4A00 | 1.20.1270.110 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Uncharacterised protein family UPF0058 | 0.59 | 53.0 | 4.38e-01 | 100.0% | 61.4% |
| 1mu5A02 | 1.10.8.50 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › | 0.59 | 46.0 | 4.16e-01 | 92.2% | 93.6% |
| 2a3vB01 | 1.10.150.130 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Tyrosine recombinase, N-terminal domain | 0.59 | 39.0 | 3.29e-01 | 70.6% | 40.4% |
| 2ovbA02 | 1.25.40.460 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.58 | 40.0 | 3.56e-01 | 100.0% | 48.1% |
| 3ccfA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.58 | 44.0 | 2.85e-01 | 84.3% | 39.1% |
| 7f0uA01 | 1.10.8.1190 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Papain-like viral protease, thumb domain | 0.57 | 47.0 | 4.01e-01 | 100.0% | 69.5% |
| 1tdzA02 | 1.10.8.50 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › | 0.57 | 48.0 | 3.63e-01 | 98.0% | 47.0% |
| 3ftdA02 | 1.10.8.100 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › rRNA adenine dimethylase, C-terminal domain | 0.56 | 48.0 | 4.49e-01 | 98.0% | 79.4% |
| 4mb7A02 | 1.10.8.50 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › | 0.56 | 47.0 | 3.51e-01 | 100.0% | 42.9% |
| 1w7cA03 | 3.10.450.40 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › | 0.56 | 48.0 | 3.70e-01 | 98.0% | 80.0% |
| 2jvwA01 | 1.10.720.30 | Mainly Alpha › Orthogonal Bundle › Transcription Termination Factor Rho, Rna-binding Domain; Chain A, Domain 1 › SAP domain | 0.55 | 45.0 | 4.37e-01 | 100.0% | 91.7% |
| 2eucA00 | 1.10.8.570 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Hypothetical protein YfmB | 0.55 | 45.0 | 3.70e-01 | 100.0% | 69.2% |
| 3dv9A02 | 1.10.150.240 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 | 0.55 | 39.0 | 3.60e-01 | 78.4% | 91.4% |
| 2gfhA02 | 1.20.120.710 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Haloacid dehalogenase hydrolase-like domain | 0.53 | 36.0 | 3.07e-01 | 76.5% | 41.9% |
| 2ahoB02 | 1.10.150.190 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Translation initiation factor 2; subunit 1; domain 2 | 0.52 | 43.0 | 3.71e-01 | 100.0% | 68.1% |
| 1xg7B01 | 1.10.1670.10 | Mainly Alpha › Orthogonal Bundle › Endonuclease Iii, domain 2 › Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal) | 0.51 | 40.0 | 3.46e-01 | 98.0% | 70.8% |
ECOD (12)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4010451 | 3788.1.1.15 ↗ | alpha bundles › Viral accessory protein x (Vpx) / viral protein r (Vpr) › Viral accessory protein x (Vpx) / viral protein r (Vpr) › Viral accessory protein x (Vpx) / viral protein r (Vpr) › PF27202 | 0.70 | 60.0 | 5.37e-01 | 100.0% | 69.3% |
| 3407017 | 130.1.1.2 ↗ | alpha arrays › LEM/SAP HeH motif-like › LEM/SAP HeH motif › LEM/SAP HeH motif › LEM | 0.65 | 39.0 | 4.14e-01 | 100.0% | 68.9% |
| 4026045 | 101.1.4.85 ↗ | alpha arrays › HTH › HTH › tetra-helical, lambda repressor-like › HTH_3, PF28877 | 0.64 | 54.0 | 5.18e-01 | 100.0% | 85.0% |
| 4380775 | 2003.1.1.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains | 0.61 | 49.0 | 3.40e-01 | 98.0% | 29.0% |
| 221869 | 235.1.1.16 ↗ | a+b complex topology › Lysozyme-like › Lysozyme-like › Lysozyme-like › Peptidase_U40 | 0.60 | 46.0 | 3.26e-01 | 100.0% | 25.6% |
| 3955223 | 144.1.1.1 ↗ | alpha arrays › PGBD-like › PGBD-like › PGBD-like › PG_binding_1 | 0.59 | 48.0 | 4.32e-01 | 100.0% | 96.2% |
| 4024393 | 6155.1.1.2 ↗ | alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter › PQ-loop | 0.58 | 34.0 | 2.95e-01 | 78.4% | 37.5% |
| 3615878 | 632.1.1.3 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain › Alpha-mann_mid | 0.56 | 49.0 | 4.04e-01 | 100.0% | 68.4% |
| 4117418 | 144.1.1.1 ↗ | alpha arrays › PGBD-like › PGBD-like › PGBD-like › PG_binding_1 | 0.54 | 42.0 | 4.13e-01 | 100.0% | 100.0% |
| 3346840 | 102.1.1.84 ↗ | alpha arrays › HhH/H2TH › SAM/DNA-glycosylase › SAM domain-like › Calmod_bind_M | 0.53 | 39.0 | 3.34e-01 | 80.4% | 77.6% |
| 3465242 | 2004.1.1.5 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ABC_tran | 0.52 | 44.0 | 3.02e-01 | 100.0% | 29.8% |
| 3727213 | 101.1.1.0 ↗ | alpha arrays › HTH › HTH › Three-helical HTH | 0.51 | 34.0 | 3.21e-01 | 70.6% | 72.3% |
D2
high
residues 280-388
D3
high
residues 400-468
Domain cluster:
representative
CATH (30)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4a18X01 | 3.10.20.10 | Alpha Beta › Roll › Ubiquitin-like (UB roll) › | 0.68 | 55.0 | 5.27e-01 | 100.0% | 77.2% |
| 3f2bA05 | 6.10.50.10 | Special › Helix non-globular › Insulin-like, subunit E › | 0.67 | 39.0 | 4.56e-01 | 97.1% | 83.3% |
| 3umcD02 | 1.10.150.240 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 | 0.67 | 54.0 | 5.17e-01 | 87.0% | 98.7% |
| 2no4A02 | 1.10.150.240 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 | 0.67 | 54.0 | 5.26e-01 | 87.0% | 100.0% |
| 2hfqA00 | 3.10.510.10 | Alpha Beta › Roll › NE1680-like fold › NE1680-like | 0.66 | 49.0 | 4.68e-01 | 95.7% | 67.1% |
| 2w43A02 | 1.10.150.240 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 | 0.62 | 48.0 | 5.18e-01 | 82.6% | 100.0% |
| 3n28A01 | 3.40.50.1000 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HAD superfamily/HAD-like | 0.62 | 43.0 | 3.32e-01 | 72.5% | 90.9% |
| 1zoyB01 | 3.10.20.30 | Alpha Beta › Roll › Ubiquitin-like (UB roll) › Beta-grasp domain | 0.61 | 51.0 | 4.50e-01 | 94.2% | 78.3% |
| 1u84A00 | 1.10.340.20 | Mainly Alpha › Orthogonal Bundle › Endonuclease III; domain 1 › Apc36109-like domain | 0.61 | 49.0 | 4.71e-01 | 91.3% | 87.7% |
| 3weeB02 | 3.30.420.40 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain | 0.61 | 50.0 | 4.13e-01 | 92.8% | 50.0% |
| 1pp0B00 | 3.40.198.10 | Alpha Beta › 3-Layer(aba) Sandwich › Delta-endotoxin CytB › Delta-endotoxin CytB-like | 0.60 | 48.0 | 3.52e-01 | 88.4% | 89.2% |
| 2zw2A00 | 3.30.1280.10 | Alpha Beta › 2-Layer Sandwich › Mth169; Chain: A , › Phosphoribosylformylglycinamidine synthase subunit PurS | 0.59 | 50.0 | 4.77e-01 | 100.0% | 97.6% |
| 2vqxA01 | 3.10.170.10 | Alpha Beta › Roll › Elastase; domain 1 › | 0.58 | 40.0 | 3.13e-01 | 72.5% | 55.5% |
| 5c6dA01 | 3.10.20.90 | Alpha Beta › Roll › Ubiquitin-like (UB roll) › Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 | 0.58 | 48.0 | 4.20e-01 | 94.2% | 76.6% |
| 4u7cB04 | 3.30.1490.100 | Alpha Beta › 2-Layer Sandwich › Dna Ligase; domain 1 › DNA polymerase, Y-family, little finger domain | 0.56 | 47.0 | 4.09e-01 | 97.1% | 59.6% |
| 7sqxA02 | 3.30.70.2150 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.56 | 46.0 | 4.23e-01 | 97.1% | 87.8% |
| 4ge6A00 | 3.90.190.10 | Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily | 0.56 | 43.0 | 2.87e-01 | 85.5% | 91.4% |
| 2blfB01 | 1.10.760.10 | Mainly Alpha › Orthogonal Bundle › Cytochrome Bc1 Complex; Chain D, domain 2 › Cytochrome c-like domain | 0.56 | 43.0 | 4.48e-01 | 84.1% | 92.1% |
| 1kf6B01 | 3.10.20.30 | Alpha Beta › Roll › Ubiquitin-like (UB roll) › Beta-grasp domain | 0.55 | 46.0 | 4.15e-01 | 100.0% | 80.8% |
| 3ddmA01 | 3.30.390.10 | Alpha Beta › 2-Layer Sandwich › Enolase-like; domain 1 › Enolase-like, N-terminal domain | 0.54 | 44.0 | 3.79e-01 | 98.6% | 87.2% |
| 2kjgA00 | 1.20.120.970 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › | 0.54 | 37.0 | 3.33e-01 | 72.5% | 92.9% |
| 4p04A01 | 2.60.40.3100 | Mainly Beta › Sandwich › Immunoglobulin-like › Arylsulphate sulphotransferase monomer, N-terminal domain | 0.54 | 39.0 | 3.48e-01 | 100.0% | 51.9% |
| 1vb3A01 | 3.90.1380.10 | Alpha Beta › Alpha-Beta Complex › threonine synthase, domain 1, chain A › Threonine synthase, N-terminal domain | 0.54 | 39.0 | 3.74e-01 | 78.3% | 82.7% |
| 4gm6A00 | 3.40.1190.20 | Alpha Beta › 3-Layer(aba) Sandwich › UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase › Ribokinase | 0.53 | 46.0 | 3.02e-01 | 98.6% | 85.9% |
| 7bv5D01 | 3.40.140.10 | Alpha Beta › 3-Layer(aba) Sandwich › Cytidine Deaminase; domain 2 › Cytidine Deaminase, domain 2 | 0.53 | 44.0 | 3.45e-01 | 95.7% | 41.7% |
| 1n26A02 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.53 | 36.0 | 3.57e-01 | 100.0% | 65.4% |
| 6p3xB01 | 3.40.140.10 | Alpha Beta › 3-Layer(aba) Sandwich › Cytidine Deaminase; domain 2 › Cytidine Deaminase, domain 2 | 0.53 | 43.0 | 3.27e-01 | 100.0% | 36.2% |
| 3lpaA00 | 3.40.50.200 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Peptidase S8/S53 domain | 0.53 | 45.0 | 2.91e-01 | 97.1% | 95.6% |
| 6p10B02 | 1.10.8.60 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › | 0.51 | 36.0 | 3.29e-01 | 72.5% | 61.5% |
| 2b3rA00 | 2.60.40.150 | Mainly Beta › Sandwich › Immunoglobulin-like › C2 domain | 0.50 | 40.0 | 3.41e-01 | 91.3% | 86.3% |
ECOD (46)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4128974 | 3115.1.1.1 ↗ | a+b two layers › GP2-like › RplX-like › RplX-like › Ribosomal_L18A | 0.73 | 58.0 | 5.52e-01 | 100.0% | 75.0% |
| 3644157 | 148.1.3.42 ↗ | alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain › RCF1-5-like_lid | 0.71 | 39.0 | 4.30e-01 | 91.3% | 67.3% |
| 5066354 | 148.1.3.0 ↗ | alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain | 0.69 | 38.0 | 4.21e-01 | 91.3% | 67.3% |
| 3517068 | 3115.1.1.6 ↗ | a+b two layers › GP2-like › RplX-like › RplX-like › DUF4494 | 0.67 | 53.0 | 5.46e-01 | 100.0% | 89.2% |
| 3519328 | 148.1.3.18 ↗ | alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain › TIP49_C | 0.67 | 40.0 | 3.57e-01 | 95.7% | 43.2% |
| 3266734 | 148.1.3.42 ↗ | alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain › RCF1-5-like_lid | 0.67 | 37.0 | 3.88e-01 | 92.8% | 58.5% |
| 5014348 | 148.1.3.42 ↗ | alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain › RCF1-5-like_lid | 0.65 | 37.0 | 3.95e-01 | 97.1% | 63.3% |
| 3610213 | 221.1.1.0 ↗ | a+b two layers › beta-Grasp › Ubiquitin-related › Ubiquitin-like | 0.65 | 56.0 | 4.55e-01 | 100.0% | 67.1% |
| 3997639 | 7563.1.1.0 ↗ | a/b three-layered sandwiches › MCP/YpsA-related › MCP/YpsA-related › MCP/YpsA-related | 0.64 | 46.0 | 2.97e-01 | 75.4% | 37.1% |
| 4994844 | 2006.1.1.18 ↗ | a/b three-layered sandwiches › HAD domain-like › HAD domain-related › HAD-like › HAD_2 | 0.64 | 58.0 | 4.04e-01 | 100.0% | 45.9% |
| 387703 | 636.1.1.1 ↗ | alpha arrays › SopE-like GEF domain › SopE-like GEF domain › SopE-like GEF domain › IpaB_EvcA | 0.62 | 47.0 | 3.46e-01 | 81.2% | 59.1% |
| 3235148 | 221.1.1.58 ↗ | a+b two layers › beta-Grasp › Ubiquitin-related › Ubiquitin-like › CRIM | 0.62 | 54.0 | 4.68e-01 | 100.0% | 81.8% |
| 3326759 | 284.1.3.1 ↗ | a+b two layers › FKBP-like › FKBP-like › WNK1 autoinhibitory domain › SNF5 | 0.62 | 51.0 | 4.98e-01 | 91.3% | 82.7% |
| 4022896 | 101.1.2.0 ↗ | alpha arrays › HTH › HTH › winged helix domain | 0.62 | 47.0 | 3.55e-01 | 84.1% | 57.9% |
| None | — | 0.61 | 48.0 | 2.93e-01 | 88.4% | 17.8% | |
| 4443054 | 3115.1.1.9 ↗ | a+b two layers › GP2-like › RplX-like › RplX-like › YjeJ | 0.60 | 49.0 | 4.21e-01 | 100.0% | 55.0% |
| 5036344 | 2006.1.1.1 ↗ | a/b three-layered sandwiches › HAD domain-like › HAD domain-related › HAD-like › Hydrolase | 0.59 | 48.0 | 3.41e-01 | 92.8% | 47.7% |
| 3508713 | 382.1.1.25 ↗ | few secondary structure elements › Snake toxin-like › Snake toxin-like › Snake toxin-like › YjeJ | 0.59 | 49.0 | 4.21e-01 | 100.0% | 55.8% |
| 3743149 | 244.1.1.11 ↗ | a+b two layers › FAD-linked reductases, C-terminal domain-like › FAD-linked reductases-C › FAD-linked reductases-C › SE | 0.59 | 48.0 | 4.31e-01 | 95.7% | 83.8% |
| 3299665 | 244.1.1.11 ↗ | a+b two layers › FAD-linked reductases, C-terminal domain-like › FAD-linked reductases-C › FAD-linked reductases-C › SE | 0.59 | 47.0 | 3.27e-01 | 94.2% | 32.4% |
| 3833162 | 244.1.1.11 ↗ | a+b two layers › FAD-linked reductases, C-terminal domain-like › FAD-linked reductases-C › FAD-linked reductases-C › SE | 0.58 | 47.0 | 2.93e-01 | 94.2% | 19.4% |
| 3276506 | 244.1.1.11 ↗ | a+b two layers › FAD-linked reductases, C-terminal domain-like › FAD-linked reductases-C › FAD-linked reductases-C › SE | 0.58 | 47.0 | 2.93e-01 | 94.2% | 18.9% |
| 3834027 | 244.1.1.0 ↗ | a+b two layers › FAD-linked reductases, C-terminal domain-like › FAD-linked reductases-C › FAD-linked reductases-C | 0.58 | 46.0 | 4.03e-01 | 89.9% | 77.3% |
| 3480610 | 284.1.3.0 ↗ | a+b two layers › FKBP-like › FKBP-like › WNK1 autoinhibitory domain | 0.58 | 48.0 | 4.79e-01 | 100.0% | 94.3% |
| 3539588 | 221.1.1.119 ↗ | a+b two layers › beta-Grasp › Ubiquitin-related › Ubiquitin-like › USP47_C | 0.58 | 48.0 | 4.34e-01 | 97.1% | 82.0% |
| 3302022 | 2484.1.1.67 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 | 0.57 | 43.0 | 3.96e-01 | 89.9% | 59.0% |
| 3268522 | 221.1.1.46 ↗ | a+b two layers › beta-Grasp › Ubiquitin-related › Ubiquitin-like › USP7_ICP0_bdg | 0.57 | 48.0 | 4.22e-01 | 100.0% | 72.7% |
| 4646832 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.56 | 50.0 | 3.53e-01 | 98.6% | 68.6% |
| 3929989 | 330.16.1.2 ↗ | a+b two layers › dsRBD-like › ODA16 N-terminal domain › ODA16 N-terminal domain › KAP | 0.56 | 45.0 | 4.31e-01 | 94.2% | 84.7% |
| 3593981 | 302.1.1.0 ↗ | a+b two layers › Reverse ferredoxin › Lesion bypass DNA polymerase (Y-family), little finger domain › Lesion bypass DNA polymerase (Y-family), little finger domain | 0.56 | 44.0 | 3.92e-01 | 97.1% | 59.0% |
| 3388281 | 3019.1.1.0 ↗ | beta sandwiches › gp11/flagellar cap protein FliD insertion domain › gp11/flagellar cap protein FliD insertion domain › gp11/flagellar cap protein FliD insertion domain | 0.56 | 47.0 | 3.65e-01 | 100.0% | 64.1% |
| 3790957 | 3562.1.1.21 ↗ | alpha bundles › Calcium release-activated calcium channel protein 1 › Calcium release-activated calcium channel protein 1 › Calcium release-activated calcium channel protein 1 › NRF | 0.55 | 45.0 | 3.42e-01 | 100.0% | 36.1% |
| 3280008 | 3115.1.1.2 ↗ | a+b two layers › GP2-like › RplX-like › RplX-like › DUF4288 | 0.55 | 48.0 | 4.47e-01 | 100.0% | 82.2% |
| 3916184 | 221.1.1.168 ↗ | a+b two layers › beta-Grasp › Ubiquitin-related › Ubiquitin-like › PI3K_rbd, PI3K_p85B | 0.55 | 46.0 | 3.10e-01 | 100.0% | 29.4% |
| None | — | 0.55 | 48.0 | 3.45e-01 | 98.6% | 70.0% | |
| 4620379 | 2003.1.1.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains | 0.55 | 41.0 | 3.14e-01 | 94.2% | 35.4% |
| 3839524 | 129.1.1.0 ↗ | alpha arrays › 6-phosphogluconate dehydrogenase C-terminal domain-like › 6-phosphogluconate dehydrogenase C-terminal domain-like › 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.54 | 41.0 | 3.13e-01 | 94.2% | 35.4% |
| 3457419 | 244.1.1.0 ↗ | a+b two layers › FAD-linked reductases, C-terminal domain-like › FAD-linked reductases-C › FAD-linked reductases-C | 0.54 | 45.0 | 3.98e-01 | 95.7% | 85.7% |
| 3992999 | 3105.1.1.4 ↗ | a+b three layers › thylakoid acid phosphatase domain-related › thylakoid acid phosphatase domain-related › thylakoid acid phosphatase domain-related › MOLO1 | 0.54 | 45.0 | 3.31e-01 | 92.8% | 82.1% |
| 3510027 | 2485.1.1.81 ↗ | a+b three layers › Thioredoxin-like › Thioredoxin-like › Thioredoxin-like › TraF | 0.53 | 44.0 | 2.76e-01 | 92.8% | 44.7% |
| 4159436 | 327.19.1.1 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › DNA mismatch repair protein MutL regulatory subdomain › DNA mismatch repair protein MutL regulatory subdomain › MutL_C | 0.53 | 38.0 | 3.37e-01 | 92.8% | 51.4% |
| 3702088 | 221.1.1.0 ↗ | a+b two layers › beta-Grasp › Ubiquitin-related › Ubiquitin-like | 0.53 | 43.0 | 3.91e-01 | 97.1% | 92.0% |
| 4043156 | 327.19.1.1 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › DNA mismatch repair protein MutL regulatory subdomain › DNA mismatch repair protein MutL regulatory subdomain › MutL_C | 0.52 | 36.0 | 3.41e-01 | 92.8% | 57.8% |
| 3312745 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.52 | 44.0 | 3.33e-01 | 92.8% | 72.5% |
| 4947650 | 223.2.1.0 ↗ | a+b three layers › Profilin-like › profilin-like › profilin-like | 0.52 | 35.0 | 3.06e-01 | 71.0% | 89.6% |
| 5010925 | 304.45.1.1 ↗ | a+b two layers › Alpha-beta plaits › 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK › 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK › HPPK | 0.51 | 42.0 | 3.31e-01 | 97.1% | 61.8% |
D4
high
residues 506-552
Domain cluster:
representative
CATH (40)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3tufA00 | 1.10.287.4300 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Stage III sporulation protein AH-like | 0.94 | 70.0 | 5.07e-01 | 78.7% | 32.2% |
| 1cmjA00 | 1.10.630.10 | Mainly Alpha › Orthogonal Bundle › Cytochrome p450 › Cytochrome P450 | 0.92 | 68.0 | 3.90e-01 | 78.7% | 9.3% |
| 1gwiA00 | 1.10.630.10 | Mainly Alpha › Orthogonal Bundle › Cytochrome p450 › Cytochrome P450 | 0.92 | 68.0 | 3.88e-01 | 78.7% | 9.2% |
| 4hojA02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.90 | 68.0 | 5.09e-01 | 78.7% | 35.9% |
| 8d8lN01 | 1.10.287.1480 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.90 | 60.0 | 4.80e-01 | 74.5% | 38.4% |
| 2qsbA00 | 1.20.1440.50 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › Ta0600-like | 0.88 | 63.0 | 5.01e-01 | 78.7% | 41.2% |
| 1f2eA02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.87 | 64.0 | 4.84e-01 | 78.7% | 34.9% |
| 1bd3A00 | 3.40.50.2020 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › | 0.86 | 64.0 | 3.99e-01 | 78.7% | 16.5% |
| 1x4tA01 | 1.10.287.660 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.86 | 63.0 | 5.86e-01 | 78.7% | 63.8% |
| 1lfkA00 | 1.10.630.10 | Mainly Alpha › Orthogonal Bundle › Cytochrome p450 › Cytochrome P450 | 0.84 | 63.0 | 3.68e-01 | 80.9% | 10.4% |
| 3nfqB02 | 1.20.930.10 | Mainly Alpha › Up-down Bundle › Transcription Elongation Factor S-II; Chain A › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0.84 | 64.0 | 4.76e-01 | 80.9% | 50.0% |
| 3mq1A01 | 1.20.58.970 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.84 | 62.0 | 4.89e-01 | 78.7% | 40.2% |
| 3behB01 | 1.20.120.540 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Voltage-gated potassium channels | 0.83 | 60.0 | 4.48e-01 | 78.7% | 31.6% |
| 3uumA00 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.82 | 67.0 | 4.91e-01 | 91.5% | 77.0% |
| 2efkA01 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.81 | 61.0 | 3.76e-01 | 80.9% | 15.3% |
| 4mh6A00 | 1.10.287.1700 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.81 | 60.0 | 4.06e-01 | 78.7% | 23.3% |
| 3d36B02 | 1.10.287.130 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domain | 0.81 | 60.0 | 5.45e-01 | 78.7% | 60.7% |
| 2xppA00 | 1.20.930.10 | Mainly Alpha › Up-down Bundle › Transcription Elongation Factor S-II; Chain A › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0.80 | 68.0 | 4.79e-01 | 93.6% | 70.1% |
| 2qyuA02 | 1.25.40.300 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Putative secreted effector protein | 0.78 | 65.0 | 4.28e-01 | 93.6% | 53.3% |
| 3n5lA03 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.78 | 56.0 | 5.26e-01 | 76.6% | 64.9% |
| 1yxrA01 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.76 | 60.0 | 5.27e-01 | 89.4% | 91.9% |
| 7ep1B01 | 1.25.10.10 | Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant | 0.76 | 64.0 | 4.03e-01 | 93.6% | 38.0% |
| 2pvqA02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.76 | 54.0 | 4.18e-01 | 76.6% | 34.0% |
| 1o67C00 | 2.40.33.20 | Mainly Beta › Beta Barrel › M1 Pyruvate Kinase; Domain 3 › PK beta-barrel domain-like | 0.75 | 56.0 | 3.64e-01 | 80.9% | 45.7% |
| 3bjdA01 | 1.10.1240.20 | Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › Lytic transglycosylase, superhelical linker domain | 0.75 | 54.0 | 4.46e-01 | 78.7% | 42.0% |
| 1hu3A00 | 1.25.40.180 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.75 | 63.0 | 4.08e-01 | 93.6% | 33.8% |
| 3h95A01 | 3.90.79.10 | Alpha Beta › Alpha-Beta Complex › Nucleoside Triphosphate Pyrophosphohydrolase › Nucleoside Triphosphate Pyrophosphohydrolase | 0.75 | 63.0 | 4.46e-01 | 91.5% | 94.7% |
| 3layF00 | 1.20.120.1490 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › | 0.74 | 55.0 | 4.64e-01 | 80.9% | 51.3% |
| 2vsoF01 | 1.25.40.180 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.74 | 58.0 | 3.71e-01 | 87.2% | 27.3% |
| 6ruiB04 | 3.90.1110.10 | Alpha Beta › Alpha-Beta Complex › Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; domain 3 › RNA polymerase Rpb2, domain 2 | 0.73 | 54.0 | 3.57e-01 | 78.7% | 96.7% |
| 3qxyA02 | 3.90.1420.10 | Alpha Beta › Alpha-Beta Complex › set domain protein methyltransferase, domain 2 › Rubisco LSMT, substrate-binding domain | 0.71 | 54.0 | 3.68e-01 | 83.0% | 25.1% |
| 2zxqA06 | 1.20.1270.70 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Designed single chain three-helix bundle | 0.71 | 50.0 | 4.55e-01 | 76.6% | 56.1% |
| 5yjlB01 | 3.30.460.30 | Alpha Beta › 2-Layer Sandwich › Beta Polymerase; domain 2 › Glutamyl-tRNA reductase, N-terminal domain | 0.68 | 59.0 | 4.11e-01 | 100.0% | 95.7% |
| 3itfA00 | 1.20.120.1490 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › | 0.68 | 49.0 | 3.77e-01 | 78.7% | 34.2% |
| 3axsA01 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.66 | 54.0 | 3.28e-01 | 93.6% | 93.2% |
| 1blwC00 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.66 | 56.0 | 4.10e-01 | 100.0% | 61.0% |
| 2pmsC00 | 6.10.140.920 | Special › Helix non-globular › Helix Hairpins › | 0.64 | 50.0 | 3.78e-01 | 85.1% | 45.9% |
| 2aaaA01 | 3.20.20.80 | Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Glycosidases | 0.63 | 47.0 | 2.76e-01 | 80.9% | 30.7% |
| 4hteA03 | 1.10.167.30 | Mainly Alpha › Orthogonal Bundle › Regulator of G-protein Signalling 4; domain 2 › | 0.60 | 42.0 | 3.65e-01 | 76.6% | 47.5% |
| 2qezA02 | 1.10.220.70 | Mainly Alpha › Orthogonal Bundle › Annexin V; domain 1 › lyase | 0.56 | 44.0 | 3.71e-01 | 89.4% | 50.6% |
ECOD (68)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4020944 | 2498.1.1.12 ↗ | mixed a+b and a/b › Zincin-like › "Metalloproteases (""zincins"") catalytic domain" › "Metalloproteases (""zincins"") catalytic domain" › Peptidase_M4,Peptidase_M4_C | 0.98 | 75.0 | 4.28e-01 | 80.9% | 10.0% |
| 4928483 | 101.1.3.36 ↗ | alpha arrays › HTH › HTH › tetra-helical, LuxR-like › HTH_23 | 0.96 | 72.0 | 5.38e-01 | 78.7% | 35.9% |
| 3438255 | 622.4.1.0 ↗ | alpha bundles › YvfG-like › Mite allergen Der p 5-related › Mite allergen Der p 5-related | 0.95 | 71.0 | 5.91e-01 | 78.7% | 50.7% |
| 4100012 | 327.13.1.5 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › Ring-building motif I in type III secretion system › Ring-building motif I in type III secretion system › SpoIIIAH | 0.91 | 68.0 | 4.90e-01 | 78.7% | 31.4% |
| 3251379 | 605.1.1.1 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA | 0.91 | 68.0 | 5.42e-01 | 78.7% | 43.5% |
| 3225544 | 4006.1.1.0 ↗ | alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain | 0.91 | 66.0 | 5.01e-01 | 78.7% | 36.0% |
| 4318541 | 4006.1.1.1 ↗ | alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF | 0.90 | 67.0 | 5.04e-01 | 78.7% | 35.2% |
| 3808540 | 376.1.6.9 ↗ | few secondary structure elements › RING/U-box-like › RING/U-box-like › IBR domain › PF26200 | 0.89 | 70.0 | 4.72e-01 | 83.0% | 33.3% |
| 3623615 | 109.4.1.222 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › DCB | 0.89 | 80.0 | 5.01e-01 | 95.7% | 52.4% |
| 3714594 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.89 | 69.0 | 4.66e-01 | 80.9% | 46.2% |
| 4023249 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.88 | 64.0 | 4.86e-01 | 76.6% | 37.0% |
| 4634395 | 4006.1.1.1 ↗ | alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF | 0.88 | 65.0 | 4.91e-01 | 78.7% | 35.2% |
| 4029016 | 109.4.1.1 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › 14-3-3 | 0.88 | 65.0 | 3.97e-01 | 78.7% | 14.2% |
| 4309794 | 192.6.1.0 ↗ | alpha bundles › Long alpha-hairpin › Epsilon subunit of F1F0-ATP synthase C-terminal domain › Epsilon subunit of F1F0-ATP synthase C-terminal domain | 0.88 | 65.0 | 6.94e-01 | 78.7% | 92.5% |
| 3314132 | 376.1.6.10 ↗ | few secondary structure elements › RING/U-box-like › RING/U-box-like › IBR domain › IBR, PF26200 | 0.88 | 68.0 | 4.62e-01 | 83.0% | 33.3% |
| 4293733 | 4006.1.1.1 ↗ | alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF | 0.87 | 67.0 | 5.00e-01 | 80.9% | 36.2% |
| 3684830 | 4006.1.1.1 ↗ | alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF | 0.87 | 67.0 | 5.08e-01 | 80.9% | 38.0% |
| 2028819 | 377.1.1.2 ↗ | few secondary structure elements › Glucocorticoid receptor-like › LIM domain-like › LIM domain-like › Ribosomal_S14 | 0.87 | 59.0 | 4.28e-01 | 74.5% | 28.7% |
| 4232718 | 4006.1.1.1 ↗ | alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF | 0.87 | 66.0 | 5.03e-01 | 80.9% | 38.0% |
| 4970733 | 4163.1.1.1 ↗ | alpha bundles › GINS helical bundle-like › GINS helical bundle-like › PSF1 N-terminal domain-like › Sld5 | 0.87 | 65.0 | 4.58e-01 | 80.9% | 49.6% |
| 5021503 | 109.4.1.207 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › HEAT_2 | 0.87 | 76.0 | 4.53e-01 | 95.7% | 27.8% |
| 3707093 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.86 | 76.0 | 4.86e-01 | 95.7% | 54.5% |
| 5055634 | 633.12.1.1 ↗ | alpha bundles › Bromodomain-like › Ta0600-like › Ta0600-like › UPF0147 | 0.86 | 61.0 | 5.02e-01 | 78.7% | 43.8% |
| 4435642 | 4006.1.1.1 ↗ | alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF | 0.86 | 62.0 | 4.77e-01 | 78.7% | 36.0% |
| 4416633 | 604.11.1.1 ↗ | alpha bundles › Spectrin repeat-like › XseB-like › XseB-like › Exonuc_VII_S | 0.86 | 64.0 | 5.85e-01 | 78.7% | 61.7% |
| 4129436 | 4006.1.1.1 ↗ | alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF | 0.86 | 66.0 | 4.92e-01 | 80.9% | 37.1% |
| 4221333 | 109.4.1.1283 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › HEAT, HEAT_PBS, HEAT_2 | 0.86 | 75.0 | 4.84e-01 | 95.7% | 27.7% |
| 4058363 | 611.3.1.8 ↗ | alpha bundles › N-cbl like › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Arm | 0.85 | 70.0 | 5.14e-01 | 87.2% | 83.6% |
| 3278856 | 4970.1.1.0 ↗ | alpha bundles › fingers domain in bacteriophage RB69-like DNA polymerase I › fingers domain in bacteriophage RB69-like DNA polymerase I › fingers domain in bacteriophage RB69-like DNA polymerase I | 0.85 | 62.0 | 6.14e-01 | 78.7% | 74.0% |
| 4387547 | 7013.1.1.1 ↗ | alpha bundles › Ribosome assembly factor Efg1-like › Ribosome assembly factor Efg1-like › Ribosome assembly factor Efg1-like › Efg1 | 0.85 | 62.0 | 4.03e-01 | 78.7% | 19.5% |
| 3880244 | 603.2.1.24 ↗ | alpha bundles › STAT-like › STAT › STAT › TBCA_PH | 0.84 | 65.0 | 4.44e-01 | 83.0% | 86.5% |
| 3257797 | 605.1.1.1 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA | 0.84 | 62.0 | 3.86e-01 | 78.7% | 15.7% |
| 3866264 | 109.4.1.2027 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_2, TPR_EMC2 | 0.84 | 69.0 | 4.70e-01 | 89.4% | 40.0% |
| 4166693 | 7013.1.1.1 ↗ | alpha bundles › Ribosome assembly factor Efg1-like › Ribosome assembly factor Efg1-like › Ribosome assembly factor Efg1-like › Efg1 | 0.84 | 61.0 | 4.02e-01 | 78.7% | 20.0% |
| 4300897 | 5094.1.1.1 ↗ | a+b duplicates or obligate multimers › OmpH-like › OmpH-like › OmpH-like › OmpH | 0.84 | 60.0 | 4.29e-01 | 76.6% | 27.7% |
| 3285485 | 191.1.1.64 ↗ | alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › DUF4254 | 0.84 | 62.0 | 4.21e-01 | 78.7% | 23.9% |
| 3867255 | 109.4.1.2 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Arm | 0.84 | 64.0 | 4.85e-01 | 80.9% | 89.0% |
| 4970557 | 604.12.1.0 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain | 0.83 | 66.0 | 5.77e-01 | 87.2% | 92.9% |
| 3592341 | 3877.1.1.0 ↗ | alpha bundles › Membrane protein insertase YidC-related › Membrane protein insertase YidC-related › Membrane protein insertase YidC | 0.83 | 60.0 | 3.71e-01 | 76.6% | 15.4% |
| 3729194 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.82 | 74.0 | 4.75e-01 | 100.0% | 28.6% |
| 3894562 | 611.3.1.0 ↗ | alpha bundles › N-cbl like › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0.81 | 72.0 | 5.34e-01 | 95.7% | 85.5% |
| 3520435 | 611.3.1.1 ↗ | alpha bundles › N-cbl like › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Med26 | 0.80 | 70.0 | 4.91e-01 | 95.7% | 69.3% |
| 3382096 | 611.3.1.1 ↗ | alpha bundles › N-cbl like › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Med26 | 0.80 | 69.0 | 4.40e-01 | 93.6% | 31.7% |
| 4932900 | 633.12.1.1 ↗ | alpha bundles › Bromodomain-like › Ta0600-like › Ta0600-like › UPF0147 | 0.80 | 68.0 | 5.52e-01 | 100.0% | 77.4% |
| 3933449 | 192.8.1.0 ↗ | alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain | 0.79 | 56.0 | 4.57e-01 | 76.6% | 40.0% |
| 3875308 | 611.3.1.1 ↗ | alpha bundles › N-cbl like › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Med26 | 0.79 | 68.0 | 4.41e-01 | 93.6% | 31.1% |
| 4682501 | 4006.1.1.1 ↗ | alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF | 0.79 | 59.0 | 4.60e-01 | 80.9% | 38.0% |
| 3223989 | 385.1.1.0 ↗ | few secondary structure elements › Cystine-knot cytokines › Cystine-knot cytokines › Cystine-knot cytokines | 0.79 | 59.0 | 4.09e-01 | 83.0% | 30.8% |
| 4549695 | 611.3.1.1 ↗ | alpha bundles › N-cbl like › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Med26 | 0.79 | 67.0 | 4.35e-01 | 93.6% | 29.0% |
| 3460697 | 109.4.1.901 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › HEAT_GCN1 | 0.79 | 67.0 | 4.01e-01 | 95.7% | 29.5% |
| 3712939 | 109.4.1.32 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › MIF4G | 0.78 | 64.0 | 3.77e-01 | 89.4% | 28.7% |
| 3638800 | 611.3.1.1 ↗ | alpha bundles › N-cbl like › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Med26 | 0.78 | 67.0 | 4.61e-01 | 93.6% | 38.7% |
| 4132373 | 3860.1.1.0 ↗ | alpha bundles › Myosin VI lever arm › Myosin VI lever arm › Myosin VI lever arm | 0.78 | 67.0 | 5.34e-01 | 95.7% | 54.4% |
| 4118454 | 611.3.1.1 ↗ | alpha bundles › N-cbl like › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Med26 | 0.78 | 66.0 | 4.15e-01 | 93.6% | 25.2% |
| 3997708 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.77 | 68.0 | 4.85e-01 | 100.0% | 60.0% |
| 3291034 | 3271.1.1.1 ↗ | alpha arrays › CdiA C-terminal nuclease domain › CdiA C-terminal nuclease domain › CdiA C-terminal nuclease domain › Ntox28 | 0.77 | 67.0 | 5.23e-01 | 95.7% | 93.7% |
| 3834362 | 3832.1.1.2 ↗ | alpha bundles › Tumor necrosis factor alpha-induced protein 8-like protein 2 › Tumor necrosis factor alpha-induced protein 8-like protein 2 › Tumor necrosis factor alpha-induced protein 8-like protein 2 › PF25968 | 0.77 | 57.0 | 3.17e-01 | 78.7% | 6.7% |
| 4124331 | 192.15.1.76 ↗ | alpha bundles › Long alpha-hairpin › Endosomal sorting complex assembly domains › Endosomal sorting complex assembly domains › CUPID | 0.77 | 57.0 | 4.34e-01 | 80.9% | 45.5% |
| 4940281 | 192.7.1.0 ↗ | alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm | 0.76 | 57.0 | 5.11e-01 | 80.9% | 61.5% |
| 4113259 | 2004.1.1.470 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD, UvrD-helicase, UvrD_C | 0.75 | 66.0 | 3.57e-01 | 100.0% | 5.7% |
| 5056432 | 607.1.1.0 ↗ | alpha arrays › Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain › Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain › Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain | 0.75 | 69.0 | 4.91e-01 | 100.0% | 83.2% |
| 3925907 | 109.4.1.15 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › VHS | 0.74 | 64.0 | 4.32e-01 | 95.7% | 27.3% |
| 4282858 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.74 | 65.0 | 3.45e-01 | 100.0% | 4.6% |
| 5074225 | 604.5.1.0 ↗ | alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) | 0.73 | 58.0 | 4.71e-01 | 87.2% | 90.0% |
| 3577145 | 4030.1.1.0 ↗ | alpha bundles › alpha-helical domain in subunits of heterodimeric actin filament capping protein Capz › alpha-helical domain in subunits of heterodimeric actin filament capping protein Capz › alpha-helical domain in subunits of heterodimeric actin filament capping protein Capz | 0.73 | 60.0 | 5.71e-01 | 91.5% | 100.0% |
| 4956583 | 633.12.1.1 ↗ | alpha bundles › Bromodomain-like › Ta0600-like › Ta0600-like › UPF0147 | 0.73 | 63.0 | 5.08e-01 | 100.0% | 77.7% |
| 3619200 | 192.15.1.76 ↗ | alpha bundles › Long alpha-hairpin › Endosomal sorting complex assembly domains › Endosomal sorting complex assembly domains › CUPID | 0.70 | 56.0 | 3.91e-01 | 89.4% | 44.5% |
| 3545485 | 110.1.1.0 ↗ | alpha arrays › DEATH domain › DEATH domain › DEATH domain | 0.67 | 51.0 | 3.97e-01 | 87.2% | 83.6% |
D5
medium
residues 1-57
D6
medium
residues 101-193
Domain cluster:
representative
CATH (15)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1xzpA02 | 1.20.120.430 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › tRNA modification GTPase MnmE domain 2 | 0.74 | 67.0 | 5.40e-01 | 96.8% | 74.7% |
| 4asvA00 | 1.20.5.420 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › Immunoglobulin FC, subunit C | 0.73 | 42.0 | 4.54e-01 | 92.5% | 67.1% |
| 3zdmB00 | 1.20.5.420 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › Immunoglobulin FC, subunit C | 0.72 | 38.0 | 4.92e-01 | 86.0% | 94.0% |
| 3veaA01 | 1.20.1270.380 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › MatP, N-terminal domain | 0.67 | 36.0 | 3.73e-01 | 94.6% | 53.9% |
| 3mfnB00 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.61 | 51.0 | 4.62e-01 | 92.5% | 92.1% |
| 1io1A01 | 1.20.1330.10 | Mainly Alpha › Up-down Bundle › f41 fragment of flagellin, N-terminal domain › f41 fragment of flagellin, N-terminal domain | 0.60 | 52.0 | 4.23e-01 | 93.5% | 65.1% |
| 3ayhA00 | 1.20.1250.40 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › RNA Polymerase II, Rpb4 subunit | 0.60 | 37.0 | 3.29e-01 | 92.5% | 43.3% |
| 5w0kA01 | 3.90.380.20 | Alpha Beta › Alpha-Beta Complex › Naphthalene 1,2-dioxygenase Alpha Subunit; Chain A, domain 1 › Herpesvirus glycoprotein H, domain D-II | 0.59 | 35.0 | 2.43e-01 | 82.8% | 16.9% |
| 1dtoA01 | 1.10.287.30 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › E2 (early) protein, N terminal domain, subdomain 1 | 0.57 | 40.0 | 3.97e-01 | 74.2% | 97.1% |
| 2jaeA03 | 1.20.1440.240 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › | 0.55 | 36.0 | 3.52e-01 | 92.5% | 60.4% |
| 2iiuA00 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.54 | 44.0 | 3.52e-01 | 94.6% | 98.1% |
| 3zgyA02 | 1.10.1040.10 | Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 | 0.53 | 38.0 | 3.45e-01 | 75.3% | 80.6% |
| 4me9B00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.52 | 43.0 | 3.50e-01 | 92.5% | 61.3% |
| 4mk6A00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.52 | 44.0 | 3.61e-01 | 97.8% | 56.9% |
| 1nh1A01 | 1.10.3290.20 | Mainly Alpha › Orthogonal Bundle › Fic-like fold › | 0.51 | 44.0 | 3.57e-01 | 100.0% | 74.0% |
ECOD (14)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3594084 | 604.5.1.0 ↗ | alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) | 0.62 | 47.0 | 4.03e-01 | 80.6% | 77.2% |
| 4977893 | 3651.1.1.1 ↗ | alpha bundles › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › IF-2B | 0.59 | 49.0 | 4.75e-01 | 91.4% | 84.8% |
| 5058526 | 3651.1.1.1 ↗ | alpha bundles › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › IF-2B | 0.59 | 48.0 | 4.67e-01 | 91.4% | 80.0% |
| 3206723 | 5001.1.1.121 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › TRAM_LAG1_CLN8 | 0.57 | 50.0 | 3.83e-01 | 100.0% | 80.9% |
| 4964270 | 3651.1.1.1 ↗ | alpha bundles › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › IF-2B | 0.57 | 46.0 | 4.59e-01 | 91.4% | 85.0% |
| 3289203 | 191.1.1.0 ↗ | alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain | 0.56 | 48.0 | 4.58e-01 | 95.7% | 95.5% |
| 4012358 | 310.2.1.0 ↗ | a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF | 0.55 | 50.0 | 4.29e-01 | 100.0% | 78.6% |
| 3820865 | 108.1.1.0 ↗ | alpha arrays › EF-hand › EF-hand-related › EF-hand | 0.55 | 47.0 | 4.47e-01 | 93.5% | 90.9% |
| 3905142 | 101.1.1.112 ↗ | alpha arrays › HTH › HTH › Three-helical HTH › MADF_DNA_bdg | 0.55 | 33.0 | 3.88e-01 | 88.2% | 98.2% |
| 3479759 | 101.1.1.0 ↗ | alpha arrays › HTH › HTH › Three-helical HTH | 0.54 | 36.0 | 3.97e-01 | 93.5% | 85.3% |
| 3709824 | 101.21.1.0 ↗ | alpha arrays › HTH › HTH domain in DNA topoisomerase IV alpha subunit › HTH domain in DNA topoisomerase IV alpha subunit | 0.52 | 35.0 | 4.00e-01 | 78.5% | 98.5% |
| 4014925 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.52 | 43.0 | 4.21e-01 | 100.0% | 82.9% |
| 5072615 | 601.7.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain | 0.51 | 39.0 | 3.67e-01 | 79.6% | 76.4% |
| 3173720 | 5076.1.1.1 ↗ | alpha complex topology › Mitochondrial ADP/ATP carrier-like › Mitochondrial ADP/ATP carrier › Mitochondrial ADP/ATP carrier › Mito_carr | 0.51 | 41.0 | 2.90e-01 | 88.2% | 80.0% |