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BRRF1

Euk-Vir

Phascolarctid_gammaherpesvirus_1

BRRF1__YP_010087490__Phascolarctid_gammaherpesvirus_1__2249313

Identity

Accession:
YP_010087490 ↗
Protein ID:
BRRF1
Kingdom:
euk

Quality

86.0 mean pLDDT

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 80-237
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF04793.18 best Herpes_BBRF1 26.3 5.20e-06 82.3% 18.9%
CATH (18)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1u89A00 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.66 47.0 5.04e-01 100.0% 83.5%
2btdA00 1.25.40.340 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › DhaL domain 0.65 57.0 5.21e-01 94.3% 98.1%
7cj3A01 1.20.1070.10 Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins 0.63 46.0 3.88e-01 73.4% 73.3%
3lmfA00 1.20.1270.360 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.63 43.0 5.07e-01 96.8% 100.0%
3msyA01 3.30.390.10 Alpha Beta › 2-Layer Sandwich › Enolase-like; domain 1 › Enolase-like, N-terminal domain 0.62 36.0 4.27e-01 82.9% 82.0%
2gscC00 1.20.1440.60 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 23S rRNA-intervening sequence 0.62 42.0 4.94e-01 97.5% 99.1%
4zvaA00 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.61 43.0 4.50e-01 72.2% 100.0%
2w31A00 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.59 42.0 4.37e-01 73.4% 100.0%
1or4B00 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.58 40.0 4.06e-01 70.3% 92.4%
3akjA02 1.10.1070.20 Mainly Alpha › Orthogonal Bundle › Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, Domain 5 › 0.58 38.0 3.49e-01 88.0% 51.2%
3bjsA01 3.30.390.10 Alpha Beta › 2-Layer Sandwich › Enolase-like; domain 1 › Enolase-like, N-terminal domain 0.57 35.0 4.00e-01 85.4% 82.1%
7rkxR01 1.20.1070.10 Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins 0.57 44.0 3.78e-01 82.3% 94.7%
3godB02 1.20.120.920 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › CRISPR-associated endonuclease Cas1, C-terminal domain 0.56 47.0 4.27e-01 89.2% 87.0%
1nafA02 1.20.58.160 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.54 30.0 3.94e-01 87.3% 100.0%
1o5hA00 1.20.120.680 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Formiminotetrahydrofolate cyclodeaminase monomer, up-and-down helical bundle 0.54 43.0 3.97e-01 100.0% 66.0%
7dl9A01 1.20.1250.20 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains 0.54 39.0 3.67e-01 100.0% 60.3%
3gi7A00 1.20.1270.180 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.51 32.0 3.95e-01 88.0% 96.1%
4lixA03 1.10.600.10 Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase 0.51 40.0 3.57e-01 82.9% 94.1%
ECOD (26)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
1923803 1120.1.1.1 alpha bundles › KSHV ORF49 protein › KSHV ORF49 protein › KSHV ORF49 protein › Herpes_BBRF1 0.86 78.0 6.20e-01 100.0% 52.1%
2426517 1120.1.1.1 alpha bundles › KSHV ORF49 protein › KSHV ORF49 protein › KSHV ORF49 protein › Herpes_BBRF1 0.86 76.0 6.23e-01 100.0% 54.3%
3943935 601.1.1.89 alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › FUSC 0.67 40.0 4.02e-01 100.0% 57.0%
3466334 174.1.1.0 few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain 0.66 47.0 5.15e-01 100.0% 87.7%
3815191 633.4.1.1 alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI 0.64 46.0 4.67e-01 74.7% 93.7%
3825046 174.1.1.0 few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain 0.62 47.0 4.93e-01 100.0% 85.5%
3508095 6155.1.1.4 alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter › MPC 0.61 31.0 3.65e-01 88.0% 68.2%
5026318 604.5.1.2 alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PhoU 0.59 41.0 3.88e-01 74.7% 60.0%
3259409 150.1.1.0 alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin 0.59 39.0 4.14e-01 100.0% 75.7%
4019140 5001.1.1.85 alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Fung_rhodopsin 0.57 45.0 3.93e-01 84.8% 94.8%
4014281 5001.1.1.0 alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like 0.57 46.0 3.86e-01 85.4% 95.2%
5006070 604.5.1.2 alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PhoU 0.57 41.0 3.81e-01 75.3% 60.0%
5055257 1075.1.2.1 alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › MacB transmembrane domain › FtsX 0.56 39.0 3.55e-01 70.3% 70.0%
2576189 7579.1.1.0 a/b three-layered sandwiches › alpha/beta-Hydrolases › alpha/beta-Hydrolases › alpha/beta-Hydrolases 0.56 41.0 3.51e-01 77.2% 77.8%
4959725 604.5.1.2 alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PhoU 0.56 39.0 3.65e-01 74.7% 57.0%
3584767 5050.1.1.0 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.56 40.0 3.50e-01 100.0% 49.4%
3782610 606.1.1.1 alpha complex topology › Nop N-terminal domain › Nop N-terminal domain › Nop N-terminal domain › Nop 0.53 43.0 4.09e-01 87.3% 84.2%
4017168 150.1.1.114 alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › PF30036 0.52 47.0 4.76e-01 100.0% 96.8%
4968659 604.5.1.2 alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PhoU 0.52 41.0 3.91e-01 82.9% 78.4%
3580924 5067.1.1.3 alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Patched 0.52 47.0 3.18e-01 100.0% 75.4%
4048107 5050.1.1.0 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.52 39.0 3.50e-01 100.0% 54.7%
3623413 5067.1.1.3 alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Patched 0.51 46.0 4.16e-01 100.0% 89.5%
3269005 3745.1.1.1 alpha bundles › Sodium/Calcium exchanger › Sodium/Calcium exchanger › Sodium/Calcium exchanger › Na_Ca_ex 0.51 46.0 3.59e-01 100.0% 62.3%
4936301 604.5.1.2 alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PhoU 0.51 40.0 3.72e-01 82.9% 79.5%
3789005 150.1.1.114 alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › PF30036 0.51 48.0 4.68e-01 100.0% 92.0%
3824606 633.4.1.1 alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI 0.51 47.0 4.56e-01 100.0% 92.0%
D2 medium residues 8-77_241-315
PDB
Domain cluster: representative
CATH (24)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
4k0dA00 1.20.120.1730 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.83 59.0 5.95e-01 71.7% 88.1%
2yevA03 1.20.120.80 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c oxidase, subunit III, four-helix bundle 0.83 58.0 5.34e-01 71.7% 72.8%
2d4uB00 1.20.120.30 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Aspartate receptor, ligand-binding domain 0.76 53.0 5.17e-01 71.0% 81.3%
3kyiA00 1.20.120.160 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain 0.76 50.0 5.31e-01 71.7% 75.8%
1f1mA00 1.20.120.240 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Lipoprotein, type 6 0.74 52.0 5.04e-01 71.7% 85.8%
1wn0A00 1.20.120.160 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain 0.74 48.0 5.05e-01 71.7% 72.5%
1orsC00 1.20.120.350 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Voltage-gated potassium channels. Chain C 0.73 53.0 5.51e-01 73.1% 97.0%
6a7hA01 1.20.140.180 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › 0.68 42.0 4.44e-01 87.6% 67.4%
3ajmB02 1.20.120.330 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 0.65 52.0 5.45e-01 99.3% 92.5%
2r17C00 1.25.40.660 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Vacuolar protein sorting-associated protein 35, helical subcomplex Vps35-C 0.65 51.0 4.03e-01 82.1% 51.3%
4u72A01 1.20.58.480 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.64 49.0 4.30e-01 81.4% 97.7%
1s2xA00 1.20.190.30 Mainly Alpha › Up-down Bundle › Delta-Endotoxin; domain 1 › CAG pathogenicity island protein, CagZ 0.62 43.0 4.04e-01 70.3% 95.0%
3n71A03 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.62 41.0 3.63e-01 78.6% 45.1%
4nqfA00 1.20.120.330 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 0.62 44.0 4.44e-01 73.1% 93.8%
1jogA00 1.20.120.330 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 0.61 43.0 4.46e-01 71.7% 100.0%
2q00B00 1.20.120.330 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 0.60 44.0 4.75e-01 75.9% 100.0%
1aluA00 1.20.1250.10 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › 0.60 42.0 4.12e-01 71.7% 96.2%
3fnbA01 1.20.1440.110 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › acylaminoacyl peptidase 0.58 41.0 4.46e-01 72.4% 93.9%
1h2uA01 1.25.40.180 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.56 49.0 4.10e-01 97.2% 80.5%
3thxB03 1.10.1420.10 Mainly Alpha › Orthogonal Bundle › MutS, DNA mismatch repair protein; Chain A, domain 3 › 0.55 49.0 4.58e-01 98.6% 78.8%
1ki1B01 1.20.900.10 Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain 0.54 38.0 3.45e-01 71.0% 71.9%
5fglA00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.54 45.0 4.02e-01 89.7% 92.5%
2ce7B03 1.20.58.760 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Peptidase M41 0.52 39.0 3.73e-01 78.6% 70.8%
3fnrA01 1.10.730.10 Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1 0.50 39.0 3.96e-01 81.4% 91.7%
ECOD (22)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4501305 601.4.1.3 alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains › 4HB_MCP_1 0.83 58.0 5.64e-01 71.7% 80.6%
3283506 601.4.1.0 alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains 0.80 55.0 6.44e-01 70.3% 99.0%
3974601 601.3.1.0 alpha bundles › Four-helical up-and-down bundle › Histidine-containing phosphotransfer domain, HPT domain › Histidine-containing phosphotransfer domain, HPT domain 0.79 53.0 6.01e-01 71.7% 89.1%
3962352 192.29.1.146 alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › DUF2231 0.78 55.0 5.43e-01 71.7% 96.1%
3389673 192.29.1.104 alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › DUF4149 0.72 51.0 5.21e-01 72.4% 95.7%
3486995 601.1.1.0 alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin 0.72 59.0 6.22e-01 95.9% 94.6%
4268045 5069.1.1.61 alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes › PF28674 0.72 51.0 5.20e-01 72.4% 95.7%
3215358 603.1.1.98 alpha bundles › STAT-like › t-snare proteins › t-snare proteins › SNARE, Syntaxin_2 0.69 48.0 4.32e-01 71.0% 87.0%
3166419 5069.1.1.91 alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes › PF27206 0.68 61.0 5.07e-01 98.6% 95.4%
3598985 601.1.1.0 alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin 0.66 61.0 5.81e-01 99.3% 88.5%
3257840 6155.1.1.2 alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter › PQ-loop 0.64 44.0 4.25e-01 70.3% 83.0%
4013731 601.1.1.12 alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › AflR 0.63 49.0 4.86e-01 80.7% 88.0%
4600241 3883.1.1.1 alpha bundles › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-OH_P_transf 0.61 49.0 4.50e-01 85.5% 78.8%
3838201 3883.1.1.1 alpha bundles › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-OH_P_transf 0.61 49.0 4.62e-01 84.8% 84.6%
3720598 109.4.1.356 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Fungal_trans 0.60 52.0 3.69e-01 93.8% 55.1%
3233652 109.4.1.911 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › COG6_C 0.60 49.0 3.39e-01 87.6% 32.2%
4027659 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.59 48.0 3.90e-01 88.3% 48.8%
3819023 109.2.1.0 alpha superhelices › Repetitive alpha hairpins › alpha/alpha toroid › alpha/alpha toroid 0.58 48.0 4.07e-01 90.3% 85.3%
3551590 109.4.1.1647 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PF28330 0.57 48.0 4.41e-01 91.7% 92.3%
3602790 603.1.1.0 alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.51 36.0 3.25e-01 71.7% 95.6%
4952823 1174.1.1.1 alpha complex topology › Potassium channel TMEM175 › Potassium channel TMEM175 › Potassium channel TMEM175 › TMEM175 0.50 42.0 3.83e-01 90.3% 90.8%
3699053 5059.1.1.3 alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › TPT 0.50 44.0 3.53e-01 97.2% 96.3%