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CAKLQF020000003.1__CAH1076396.1__SAMEA5780031_00770__00104
Bact-VirCAKLQF020000003.1__CAH1076396.1__SAMEA5780031_00770__00104
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 28-218
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF03547.24 best | Mem_trans | 63.0 | 2.70e-17 | 99.0% | 65.3% |
CATH (22)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4bwzA00 | 1.20.1530.20 | Mainly Alpha › Up-down Bundle › Na+/H+ antiporter like fold › | 0.74 | 69.0 | 5.42e-01 | 100.0% | 61.5% |
| 6z3yB01 | 1.20.1530.20 | Mainly Alpha › Up-down Bundle › Na+/H+ antiporter like fold › | 0.68 | 62.0 | 4.94e-01 | 100.0% | 74.5% |
| 7dswA01 | 1.20.1530.20 | Mainly Alpha › Up-down Bundle › Na+/H+ antiporter like fold › | 0.67 | 62.0 | 4.83e-01 | 100.0% | 74.8% |
| 8sbeA01 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.61 | 47.0 | 4.67e-01 | 91.1% | 78.1% |
| 7fciA01 | 1.20.1530.20 | Mainly Alpha › Up-down Bundle › Na+/H+ antiporter like fold › | 0.61 | 55.0 | 4.80e-01 | 100.0% | 66.6% |
| 8ex5A01 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.60 | 48.0 | 4.83e-01 | 90.1% | 82.7% |
| 3zuxA00 | 1.20.1530.20 | Mainly Alpha › Up-down Bundle › Na+/H+ antiporter like fold › | 0.60 | 53.0 | 4.60e-01 | 100.0% | 60.4% |
| 8sbeA02 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.60 | 50.0 | 5.05e-01 | 90.6% | 89.8% |
| 1pw4A02 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.60 | 48.0 | 4.68e-01 | 90.6% | 76.4% |
| 7d5qA01 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.58 | 46.0 | 4.76e-01 | 90.6% | 88.5% |
| 8ex5A02 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.58 | 49.0 | 4.70e-01 | 90.6% | 80.6% |
| 4a64A01 | 1.20.1310.10 | Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › Cullin Repeats | 0.57 | 29.0 | 3.39e-01 | 79.1% | 66.7% |
| 2cfqA01 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.57 | 44.0 | 4.30e-01 | 88.5% | 74.6% |
| 7dl9B02 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.55 | 47.0 | 4.65e-01 | 92.1% | 85.7% |
| 1rqgA04 | 1.10.730.10 | Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1 | 0.55 | 39.0 | 4.29e-01 | 77.0% | 90.1% |
| 6grjB01 | 1.20.1170.10 | Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; › | 0.53 | 38.0 | 3.20e-01 | 70.7% | 97.1% |
| 6v9zA02 | 1.20.1560.10 | Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain | 0.53 | 37.0 | 3.18e-01 | 71.2% | 95.7% |
| 4gc0A02 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.53 | 43.0 | 4.09e-01 | 92.1% | 72.1% |
| 4mk6A00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.51 | 37.0 | 3.80e-01 | 84.3% | 75.0% |
| 3lmfA00 | 1.20.1270.360 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.51 | 29.0 | 3.70e-01 | 74.9% | 97.2% |
| 7twaC00 | 1.20.910.10 | Mainly Alpha › Up-down Bundle › Heme Oxygenase; Chain A › Heme oxygenase-like | 0.51 | 36.0 | 3.44e-01 | 70.7% | 84.6% |
| 3kflA03 | 1.10.730.10 | Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1 | 0.51 | 39.0 | 4.07e-01 | 88.0% | 88.0% |
ECOD (77)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3282125 | 3236.1.1.3 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Mem_trans | 0.93 | 91.0 | 7.45e-01 | 100.0% | 62.9% |
| 4446859 | 3236.1.1.3 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Mem_trans | 0.91 | 87.0 | 7.17e-01 | 100.0% | 61.0% |
| 3947924 | 3236.1.1.3 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Mem_trans | 0.90 | 86.0 | 7.05e-01 | 100.0% | 63.3% |
| 4954099 | 3236.1.1.3 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Mem_trans | 0.88 | 81.0 | 6.85e-01 | 100.0% | 62.0% |
| 4955304 | 3236.1.1.3 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Mem_trans | 0.88 | 81.0 | 6.82e-01 | 100.0% | 61.7% |
| 4961414 | 3236.1.1.3 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Mem_trans | 0.88 | 82.0 | 6.87e-01 | 100.0% | 62.4% |
| 4960035 | 3236.1.1.3 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Mem_trans | 0.87 | 80.0 | 6.76e-01 | 100.0% | 61.9% |
| 4099056 | 3236.1.1.3 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Mem_trans | 0.87 | 79.0 | 6.70e-01 | 100.0% | 61.7% |
| 4948940 | 3236.1.1.3 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Mem_trans | 0.86 | 79.0 | 6.65e-01 | 100.0% | 61.3% |
| 3944997 | 3236.1.1.3 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Mem_trans | 0.86 | 81.0 | 6.79e-01 | 100.0% | 62.0% |
| 3402599 | 3236.1.1.3 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Mem_trans | 0.85 | 81.0 | 6.45e-01 | 100.0% | 64.0% |
| 5014172 | 3236.1.1.0 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) | 0.85 | 78.0 | 6.66e-01 | 100.0% | 63.8% |
| 3602365 | 3236.1.1.3 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Mem_trans | 0.83 | 78.0 | 6.54e-01 | 100.0% | 62.4% |
| 4944999 | 3236.1.1.0 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) | 0.83 | 77.0 | 6.44e-01 | 100.0% | 60.8% |
| 5038153 | 3236.1.1.3 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Mem_trans | 0.82 | 75.0 | 6.35e-01 | 100.0% | 61.7% |
| 4939520 | 3236.1.1.3 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Mem_trans | 0.82 | 74.0 | 6.34e-01 | 100.0% | 63.1% |
| 4993348 | 3236.1.1.3 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Mem_trans | 0.81 | 71.0 | 6.29e-01 | 98.4% | 66.4% |
| 5060832 | 3236.1.1.3 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Mem_trans | 0.81 | 74.0 | 6.31e-01 | 100.0% | 62.2% |
| 5067283 | 3236.1.1.0 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) | 0.80 | 71.0 | 6.07e-01 | 100.0% | 60.7% |
| 4963297 | 3236.1.1.12 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Cons_hypoth698 | 0.79 | 74.0 | 6.20e-01 | 100.0% | 78.7% |
| 3469622 | 3236.1.1.3 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Mem_trans | 0.78 | 74.0 | 5.95e-01 | 100.0% | 60.1% |
| 4019610 | 3236.1.1.3 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Mem_trans | 0.78 | 74.0 | 5.85e-01 | 100.0% | 59.2% |
| 4212802 | 3236.1.1.3 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Mem_trans | 0.76 | 72.0 | 6.00e-01 | 100.0% | 61.5% |
| 3207394 | 3236.1.1.1 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Na_H_Exchanger | 0.73 | 59.0 | 5.26e-01 | 84.8% | 80.0% |
| 3600046 | 3236.1.1.0 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) | 0.73 | 68.0 | 5.44e-01 | 100.0% | 58.9% |
| 4949710 | 3236.1.1.1 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Na_H_Exchanger | 0.72 | 67.0 | 5.21e-01 | 100.0% | 60.0% |
| 5022454 | 3236.1.1.3 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Mem_trans | 0.72 | 64.0 | 5.48e-01 | 100.0% | 61.7% |
| 4120355 | 3236.1.1.1 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Na_H_Exchanger | 0.71 | 65.0 | 5.11e-01 | 100.0% | 74.3% |
| 4338492 | 3236.1.1.1 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Na_H_Exchanger | 0.70 | 65.0 | 5.13e-01 | 100.0% | 62.1% |
| 3692849 | 3236.1.1.3 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Mem_trans | 0.70 | 65.0 | 5.10e-01 | 100.0% | 62.4% |
| 3973559 | 3236.1.1.0 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) | 0.68 | 59.0 | 5.12e-01 | 100.0% | 60.3% |
| 4979999 | 3236.1.1.1 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Na_H_Exchanger | 0.67 | 62.0 | 4.72e-01 | 100.0% | 74.5% |
| 4942453 | 3236.1.1.1 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Na_H_Exchanger | 0.66 | 60.0 | 4.76e-01 | 100.0% | 62.6% |
| 4177917 | 3236.1.1.1 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Na_H_Exchanger | 0.66 | 60.0 | 4.67e-01 | 100.0% | 68.9% |
| 4944890 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.63 | 52.0 | 5.12e-01 | 93.2% | 82.5% |
| 4995093 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.63 | 48.0 | 4.92e-01 | 90.1% | 83.9% |
| 4126386 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.62 | 49.0 | 4.77e-01 | 92.1% | 74.3% |
| 3713349 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.62 | 51.0 | 4.98e-01 | 90.1% | 79.0% |
| 5072028 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.62 | 53.0 | 5.08e-01 | 96.3% | 79.9% |
| 5027313 | 3236.1.1.1 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Na_H_Exchanger | 0.62 | 57.0 | 4.49e-01 | 100.0% | 75.1% |
| 5066060 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.62 | 49.0 | 4.93e-01 | 93.7% | 82.6% |
| 4938189 | 3236.1.1.1 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Na_H_Exchanger | 0.62 | 57.0 | 4.59e-01 | 100.0% | 61.9% |
| 3982394 | 5050.1.1.1 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Sugar_tr | 0.61 | 48.0 | 4.14e-01 | 81.2% | 85.4% |
| 5000956 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.61 | 48.0 | 4.91e-01 | 92.1% | 83.7% |
| 3284529 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.61 | 49.0 | 4.98e-01 | 90.6% | 85.3% |
| 5010388 | 5050.1.1.1 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Sugar_tr | 0.60 | 47.0 | 4.44e-01 | 90.6% | 66.8% |
| 3945908 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.60 | 47.0 | 4.60e-01 | 88.5% | 75.6% |
| 5083432 | 3236.1.1.1 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Na_H_Exchanger | 0.60 | 52.0 | 4.66e-01 | 93.2% | 97.4% |
| 3839074 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.60 | 46.0 | 4.71e-01 | 91.6% | 81.6% |
| 4976596 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.59 | 47.0 | 4.55e-01 | 90.6% | 74.8% |
| 3244457 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.59 | 45.0 | 4.65e-01 | 89.5% | 82.2% |
| 3279461 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.59 | 46.0 | 4.61e-01 | 93.7% | 80.0% |
| 4273256 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.58 | 48.0 | 4.53e-01 | 90.6% | 71.1% |
| 3957729 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.58 | 47.0 | 4.46e-01 | 90.6% | 71.7% |
| 3267402 | 5050.1.1.11 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › UNC-93 | 0.58 | 45.0 | 4.52e-01 | 92.7% | 78.5% |
| 3489229 | 5050.1.1.22 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1_like | 0.57 | 51.0 | 4.68e-01 | 97.9% | 94.5% |
| 3490726 | 5050.1.1.6 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › OATP | 0.57 | 48.0 | 4.56e-01 | 90.6% | 76.0% |
| 4971806 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.56 | 45.0 | 4.44e-01 | 88.0% | 78.5% |
| 4019402 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.56 | 43.0 | 4.09e-01 | 92.1% | 67.1% |
| 3226789 | 5001.1.1.62 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › YIF1 | 0.56 | 40.0 | 3.93e-01 | 72.3% | 91.2% |
| 3952681 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.56 | 43.0 | 4.02e-01 | 90.6% | 63.3% |
| 3262258 | 5050.1.1.4 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Nucleoside_tran | 0.56 | 41.0 | 4.31e-01 | 83.2% | 84.7% |
| 4983897 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.56 | 41.0 | 4.42e-01 | 84.8% | 91.3% |
| 3291081 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.55 | 44.0 | 4.38e-01 | 92.1% | 80.0% |
| 3391622 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.55 | 48.0 | 4.33e-01 | 93.7% | 86.9% |
| 3495706 | 5050.1.1.23 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › CLN3 | 0.55 | 41.0 | 4.16e-01 | 84.8% | 78.3% |
| 5057574 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.54 | 46.0 | 4.68e-01 | 91.1% | 92.4% |
| 4368936 | 3236.1.1.16 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Asp-Al_Ex | 0.53 | 49.0 | 3.89e-01 | 100.0% | 63.4% |
| 4989463 | 140.1.1.9 ↗ | alpha bundles › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon_3 | 0.53 | 40.0 | 3.92e-01 | 78.5% | 72.2% |
| 4348123 | 3236.1.1.16 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Asp-Al_Ex | 0.52 | 48.0 | 3.95e-01 | 100.0% | 82.3% |
| 4372584 | 3236.2.1.8 ↗ | alpha complex topology › Cation-proton antiporter › Sodium-dependent citrate symporter › Sodium-dependent citrate symporter › Asp-Al_Ex | 0.52 | 48.0 | 3.91e-01 | 100.0% | 60.5% |
| 4943622 | 7064.1.1.0 ↗ | alpha bundles › Transmembrane domain of VIT1 › Transmembrane domain of VIT1 › Transmembrane domain of VIT1 | 0.51 | 35.0 | 3.94e-01 | 92.7% | 90.3% |
| 5040245 | 140.1.1.9 ↗ | alpha bundles › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon_3 | 0.51 | 39.0 | 3.79e-01 | 86.9% | 70.7% |
| 4995421 | 3281.1.2.1 ↗ | alpha complex topology › Sodium/proton antiporter subunits-like › Sodium/proton antiporter subunits-like › NADH-quinone oxidoreductase subunit 8 (Nqo8)-related › NADHdh | 0.51 | 46.0 | 4.02e-01 | 100.0% | 85.4% |
| 4958586 | 1079.1.1.5 ↗ | alpha complex topology › Transmembrane reductase CcdA › Transmembrane reductase CcdA › Transmembrane reductase CcdA › DsbD_2 | 0.50 | 43.0 | 4.15e-01 | 94.8% | 92.4% |
| 3761479 | 1075.1.1.0 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › ABCG5/ABCG8 transmembrane domain | 0.50 | 40.0 | 2.86e-01 | 82.7% | 46.9% |
| None | — | 0.50 | 39.0 | 3.32e-01 | 79.6% | 82.0% |
D2
medium
residues 219-307
Domain cluster:
representative
CATH (30)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3zuxA00 | 1.20.1530.20 | Mainly Alpha › Up-down Bundle › Na+/H+ antiporter like fold › | 0.83 | 76.0 | 5.11e-01 | 100.0% | 32.1% |
| 3l9tA01 | 1.10.1240.70 | Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › | 0.71 | 40.0 | 4.20e-01 | 86.5% | 59.0% |
| 2lm9A00 | 1.20.58.970 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.66 | 55.0 | 5.38e-01 | 89.9% | 93.8% |
| 3u61D03 | 1.20.272.10 | Mainly Alpha › Up-down Bundle › Zinc Finger, Delta Prime; domain 3 › | 0.65 | 34.0 | 3.41e-01 | 77.5% | 47.3% |
| 7c1iA01 | 1.20.120.160 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain | 0.64 | 45.0 | 4.36e-01 | 73.0% | 100.0% |
| 3dzaA01 | 1.20.120.1940 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › YfdX protein domain | 0.64 | 43.0 | 3.96e-01 | 80.9% | 53.0% |
| 3rc3A05 | 1.20.58.1080 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.63 | 47.0 | 4.40e-01 | 96.6% | 62.8% |
| 2qw6D00 | 1.20.272.10 | Mainly Alpha › Up-down Bundle › Zinc Finger, Delta Prime; domain 3 › | 0.62 | 30.0 | 3.08e-01 | 71.9% | 45.3% |
| 2ggfA00 | 1.25.40.180 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.61 | 43.0 | 3.74e-01 | 86.5% | 47.4% |
| 3zojA00 | 1.20.1080.10 | Mainly Alpha › Up-down Bundle › Glycerol uptake facilitator protein › Glycerol uptake facilitator protein. | 0.61 | 53.0 | 3.82e-01 | 97.8% | 43.3% |
| 8igrI01 | 2.40.270.10 | Mainly Beta › Beta Barrel › Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; Domain 6 › DNA-directed RNA polymerase, subunit 2, domain 6 | 0.61 | 42.0 | 3.41e-01 | 73.0% | 85.2% |
| 4v1gA00 | 1.20.20.10 | Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C | 0.60 | 40.0 | 4.09e-01 | 85.4% | 70.6% |
| 1wfdA00 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.60 | 42.0 | 4.16e-01 | 85.4% | 69.9% |
| 2nr4A02 | 1.20.58.290 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Hypothetical membrane protein ta0354_69_121. | 0.58 | 37.0 | 4.26e-01 | 93.3% | 100.0% |
| 1t72A01 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.57 | 48.0 | 4.43e-01 | 93.3% | 80.3% |
| 2qgaB01 | 1.10.275.10 | Mainly Alpha › Orthogonal Bundle › Fumarase C; Chain B, domain 1 › Fumarase/aspartase (N-terminal domain) | 0.57 | 41.0 | 3.79e-01 | 74.2% | 75.4% |
| 3g0oA02 | 1.10.1040.10 | Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 | 0.57 | 39.0 | 3.52e-01 | 98.9% | 50.4% |
| 2gslF00 | 1.10.1520.10 | Mainly Alpha › Orthogonal Bundle › Ribonuclease iii, N-terminal Endonuclease Domain; Chain A › Ribonuclease III domain | 0.57 | 43.0 | 3.89e-01 | 83.1% | 68.5% |
| 1c9bA02 | 1.10.472.10 | Mainly Alpha › Orthogonal Bundle › Cyclin A; domain 1 › Cyclin-like | 0.57 | 36.0 | 3.45e-01 | 87.6% | 53.8% |
| 4it4A02 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.56 | 42.0 | 4.25e-01 | 88.8% | 80.2% |
| 2kjgA00 | 1.20.120.970 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › | 0.56 | 40.0 | 3.89e-01 | 94.4% | 67.7% |
| 4adnA01 | 1.20.1280.250 | Mainly Alpha › Up-down Bundle › Monooxygenase › | 0.56 | 39.0 | 4.02e-01 | 96.6% | 77.6% |
| 2d2sA02 | 1.20.58.1220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Exo84p, C-terminal helical domain | 0.56 | 44.0 | 4.31e-01 | 94.4% | 79.2% |
| 3v53E00 | 1.20.1390.10 | Mainly Alpha › Up-down Bundle › PWI domain › PWI domain | 0.55 | 35.0 | 3.43e-01 | 98.9% | 55.9% |
| 1u61A00 | 1.10.1520.10 | Mainly Alpha › Orthogonal Bundle › Ribonuclease iii, N-terminal Endonuclease Domain; Chain A › Ribonuclease III domain | 0.55 | 42.0 | 3.82e-01 | 84.3% | 73.2% |
| 1ymgA00 | 1.20.1080.10 | Mainly Alpha › Up-down Bundle › Glycerol uptake facilitator protein › Glycerol uptake facilitator protein. | 0.55 | 49.0 | 3.61e-01 | 98.9% | 72.1% |
| 3e3vA03 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.53 | 31.0 | 3.67e-01 | 85.4% | 89.3% |
| 2cwoA01 | 1.20.58.1200 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › RNA silencing suppressor P21, N-terminal domain | 0.52 | 39.0 | 4.18e-01 | 92.1% | 97.3% |
| 3s64A00 | 1.10.225.10 | Mainly Alpha › Orthogonal Bundle › NK-Lysin › Saposin-like | 0.51 | 36.0 | 3.75e-01 | 94.4% | 82.7% |
| 3bniB00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.50 | 43.0 | 3.57e-01 | 100.0% | 87.1% |
ECOD (25)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4961414 | 3236.1.1.3 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Mem_trans | 0.89 | 83.0 | 5.57e-01 | 98.9% | 30.2% |
| 4977137 | 3236.1.1.0 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) | 0.81 | 73.0 | 5.10e-01 | 100.0% | 33.5% |
| 4963036 | 3236.1.1.3 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Mem_trans | 0.80 | 73.0 | 4.89e-01 | 100.0% | 31.6% |
| 3207394 | 3236.1.1.1 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Na_H_Exchanger | 0.75 | 67.0 | 4.75e-01 | 100.0% | 37.4% |
| 4193980 | 1002.1.1.1 ↗ | alpha complex topology › Fluoride ion channel › Fluoride ion channel › Fluoride ion channel › CRCB | 0.67 | 58.0 | 5.07e-01 | 97.8% | 63.7% |
| 3297362 | 5067.1.1.13 ↗ | alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › ALMT | 0.66 | 57.0 | 4.73e-01 | 98.9% | 55.8% |
| 3699262 | 1002.1.1.1 ↗ | alpha complex topology › Fluoride ion channel › Fluoride ion channel › Fluoride ion channel › CRCB | 0.64 | 55.0 | 4.90e-01 | 100.0% | 66.7% |
| 3471023 | 164.1.1.15 ↗ | alpha bundles › Chorismate mutase II › Chorismate mutase II › Chorismate mutase II › PPPI_inhib | 0.64 | 45.0 | 3.70e-01 | 73.0% | 59.4% |
| 3171901 | 181.1.1.1 ↗ | alpha bundles › Domain of the SRP/SRP receptor G proteins-like › Domain of the SRP/SRP receptor G-proteins › Domain of the SRP/SRP receptor G-proteins › SRP54_N | 0.63 | 42.0 | 4.18e-01 | 94.4% | 65.3% |
| 3164037 | 3405.1.1.6 ↗ | alpha duplicates or obligate multimers › FkpA dimerization domain-like › FkpA dimerization domain-like › FkpA dimerization domain-like › PF29764 | 0.61 | 43.0 | 3.79e-01 | 100.0% | 48.1% |
| 3680798 | 109.4.1.1269 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR, E_motif | 0.61 | 33.0 | 3.26e-01 | 85.4% | 45.0% |
| 3842317 | 213.1.1.1 ↗ | a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_1 | 0.60 | 42.0 | 3.22e-01 | 73.0% | 51.6% |
| 3356616 | 632.22.1.67 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats › DUF842 | 0.60 | 43.0 | 4.15e-01 | 74.2% | 66.0% |
| 5045750 | 1075.5.1.0 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter | 0.60 | 51.0 | 4.06e-01 | 98.9% | 77.5% |
| 3938097 | 621.1.1.0 ↗ | alpha bundles › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain | 0.60 | 50.0 | 4.65e-01 | 97.8% | 73.0% |
| 4974147 | 601.47.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › Cucumopine synthase helical bundle domain › Cucumopine synthase helical bundle domain › Cucumopine_C | 0.59 | 53.0 | 4.38e-01 | 100.0% | 55.6% |
| 3979656 | 5065.1.1.3 ↗ | alpha bundles › Type II ABC importer transmembrane domain fold › Type II ABC importer transmembrane domain fold › Type II ABC importer transmembrane domain fold › BPD_transp_2 | 0.58 | 51.0 | 3.57e-01 | 97.8% | 65.8% |
| 5072045 | 604.10.1.0 ↗ | alpha bundles › Spectrin repeat-like › Enzyme IIa from lactose specific PTS, IIa-lac › Enzyme IIa from lactose specific PTS, IIa-lac | 0.58 | 49.0 | 4.68e-01 | 93.3% | 79.0% |
| 4946740 | 1075.5.1.0 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter | 0.58 | 48.0 | 3.82e-01 | 97.8% | 76.1% |
| 4033699 | 621.1.1.10 ↗ | alpha bundles › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › DUF4118 | 0.56 | 49.0 | 4.40e-01 | 98.9% | 73.6% |
| 3725615 | 604.12.1.0 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain | 0.56 | 44.0 | 4.56e-01 | 95.5% | 93.8% |
| 4992024 | 5069.1.3.0 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Fumarate reductase respiratory complex transmembrane subunits | 0.54 | 47.0 | 4.34e-01 | 98.9% | 81.7% |
| 3412630 | 101.1.10.7 ↗ | alpha arrays › HTH › HTH › Cyclin-like › Cyclin_C | 0.54 | 38.0 | 3.36e-01 | 97.8% | 49.6% |
| 3718891 | 5050.1.1.1 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Sugar_tr | 0.52 | 44.0 | 3.80e-01 | 100.0% | 69.0% |
| 3817662 | 102.1.1.2 ↗ | alpha arrays › HhH/H2TH › SAM/DNA-glycosylase › SAM domain-like › HRDC | 0.50 | 36.0 | 3.60e-01 | 100.0% | 71.6% |