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CAKLQF020000004.1__CAH1076707.1__SAMEA5780031_00936__00030

Bact-Vir

CAKLQF020000004.1__CAH1076707.1__SAMEA5780031_00936__00030

Identity

Kingdom:
phage

Quality

85.0 mean pLDDT

Cluster

Singleton — not in a non-trivial cluster

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 11-163
PDB
Domain cluster: representative
CATH (34)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2dq0A01 1.10.287.40 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain 0.78 38.0 4.48e-01 100.0% 66.4%
4lwsA00 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.73 32.0 3.95e-01 100.0% 64.0%
2gl2B00 1.10.287.1700 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.71 42.0 4.94e-01 100.0% 82.6%
1zvuA03 1.10.268.10 Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3 0.71 34.0 3.61e-01 92.8% 51.4%
6ircA01 1.20.1230.10 Mainly Alpha › Up-down Bundle › Phospholipase C Beta; Chain: A › Phospholipase C beta, distal C-terminal domain 0.70 35.0 3.18e-01 96.1% 35.5%
1sg2A00 3.30.910.20 Alpha Beta › 2-Layer Sandwich › Protein Binding, DinI Protein; Chain A › Skp domain 0.70 38.0 3.94e-01 87.6% 56.7%
1lvfB00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.69 32.0 3.82e-01 98.0% 63.5%
2v0xA01 1.10.287.3160 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.68 37.0 3.63e-01 100.0% 47.6%
1qdbA02 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.68 35.0 3.70e-01 100.0% 52.4%
2rd0B00 1.10.287.1490 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.68 42.0 4.42e-01 100.0% 68.3%
6p73A02 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.68 35.0 3.65e-01 100.0% 52.4%
5j1hA01 1.20.58.1060 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.68 38.0 3.56e-01 100.0% 45.1%
3pe0A01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.67 32.0 3.86e-01 93.5% 67.3%
4egwA02 1.20.58.340 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Magnesium transport protein CorA, transmembrane region 0.67 34.0 3.82e-01 95.4% 62.2%
3teqB00 1.10.287.3550 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.67 36.0 4.38e-01 100.0% 80.2%
6h2dS01 1.20.1170.10 Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; › 0.66 41.0 3.60e-01 100.0% 43.5%
2yinA03 1.20.58.740 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › DOCK DHR2 domain, lobe C 0.65 30.0 3.27e-01 93.5% 50.0%
3syvA01 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.65 38.0 3.21e-01 100.0% 35.5%
6iknD01 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.65 36.0 2.95e-01 100.0% 30.3%
1s9uA00 1.10.3480.10 Mainly Alpha › Orthogonal Bundle › TorD-like › TorD-like 0.65 26.0 2.41e-01 90.8% 26.9%
1kt1A03 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.64 26.0 2.63e-01 88.2% 34.2%
4g6dB02 6.10.140.1800 Special › Helix non-globular › Helix Hairpins › 0.61 33.0 4.48e-01 85.6% 100.0%
3vbbE01 1.10.287.40 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain 0.60 36.0 4.07e-01 95.4% 76.5%
2id6A02 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.60 30.0 3.02e-01 83.0% 45.5%
3g67A00 1.10.287.950 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Methyl-accepting chemotaxis protein 0.59 39.0 3.49e-01 100.0% 48.8%
3r6nB01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.58 35.0 3.04e-01 100.0% 39.7%
3ajwA00 1.10.287.1700 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.58 36.0 3.86e-01 100.0% 70.9%
2b5uA02 1.10.287.620 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix Hairpins 0.58 41.0 4.05e-01 100.0% 68.9%
5mawD00 1.20.1330.10 Mainly Alpha › Up-down Bundle › f41 fragment of flagellin, N-terminal domain › f41 fragment of flagellin, N-terminal domain 0.56 34.0 2.84e-01 100.0% 34.6%
4dxwA02 1.10.287.70 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.56 34.0 3.93e-01 84.3% 82.1%
7m2wE01 1.20.120.1900 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Gamma-tubulin complex, C-terminal domain 0.53 39.0 3.06e-01 75.2% 98.4%
1qu7A00 1.10.287.950 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Methyl-accepting chemotaxis protein 0.53 40.0 3.43e-01 100.0% 52.0%
1gvnA00 1.10.8.130 Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › 0.53 22.0 2.94e-01 79.7% 69.0%
1rp3G02 1.20.140.160 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › PhyR, sigma-like (SL) domain 0.51 28.0 2.93e-01 96.1% 55.6%
ECOD (37)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4379341 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.76 41.0 3.90e-01 100.0% 45.6%
3297061 632.1.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain 0.72 34.0 3.91e-01 96.1% 59.1%
3923558 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.72 38.0 3.61e-01 100.0% 42.2%
3482286 192.8.1.0 alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain 0.71 39.0 3.56e-01 100.0% 40.5%
3812652 3922.1.1.0 alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 0.70 39.0 3.56e-01 100.0% 41.5%
3735933 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.70 35.0 3.65e-01 97.4% 50.3%
4982498 2004.1.1.0 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.70 39.0 2.54e-01 100.0% 13.3%
4642325 5086.1.1.84 alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › HH_MFP_RND 0.70 39.0 4.19e-01 100.0% 63.1%
4022048 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.69 40.0 3.84e-01 100.0% 50.3%
4583258 2004.1.1.198 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_23 0.67 39.0 2.80e-01 100.0% 20.5%
3589446 2004.1.1.301 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_27 0.64 38.0 2.63e-01 90.2% 19.2%
3295653 4268.2.1.0 alpha duplicates or obligate multimers › EspA/CesA-like › EspA chaperone CesA › EspA chaperone CesA 0.64 31.0 3.51e-01 96.1% 57.5%
4321938 3755.4.1.0 alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain 0.64 40.0 3.93e-01 100.0% 58.8%
3415933 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.62 42.0 4.23e-01 100.0% 68.0%
5010596 5086.1.1.0 alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins 0.62 40.0 3.53e-01 100.0% 45.9%
4982005 2004.1.1.0 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.61 38.0 2.68e-01 90.2% 21.4%
3215140 3939.1.1.190 alpha duplicates or obligate multimers › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain › KIF21A_4th 0.61 36.0 3.51e-01 100.0% 52.7%
3598168 3755.1.1.0 alpha bundles › YscO-like › Putative type III secretion protein YscO-related › Putative type III secretion protein YscO-related 0.60 39.0 3.84e-01 100.0% 61.2%
3237824 632.22.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats 0.59 36.0 3.71e-01 100.0% 62.7%
3398185 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.59 36.0 3.56e-01 100.0% 56.2%
3968997 5086.1.1.0 alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins 0.57 39.0 4.26e-01 100.0% 82.3%
4027056 603.1.1.0 alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.57 32.0 3.36e-01 100.0% 59.3%
4177363 5086.1.1.0 alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins 0.56 39.0 4.07e-01 100.0% 75.2%
4024992 603.1.1.0 alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.56 39.0 4.04e-01 100.0% 74.5%
4683246 632.22.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats 0.56 39.0 3.69e-01 100.0% 60.0%
3739544 2004.1.1.433 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N, AAA_23 0.56 40.0 2.60e-01 91.5% 16.4%
3180887 174.1.1.9 few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › DUF1746 0.55 44.0 4.74e-01 98.0% 98.5%
4516566 3755.4.1.0 alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain 0.55 36.0 3.38e-01 100.0% 53.2%
3174956 3755.3.1.481 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › PF30554 0.54 41.0 3.67e-01 100.0% 57.1%
5054862 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.54 40.0 3.97e-01 100.0% 72.5%
4479045 192.2.1.0 alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin 0.54 38.0 3.34e-01 100.0% 50.0%
3965698 2004.1.1.87 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N 0.54 40.0 2.60e-01 100.0% 18.6%
3671258 632.22.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats 0.53 38.0 4.14e-01 100.0% 87.7%
5036205 2004.1.1.348 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SbcC_Walker_B 0.53 39.0 2.49e-01 76.5% 73.5%
3165834 3291.1.1.0 alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related 0.51 36.0 3.02e-01 100.0% 42.3%
3715936 5086.1.1.0 alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins 0.51 40.0 3.81e-01 100.0% 71.4%
3973285 3755.1.1.28 alpha bundles › YscO-like › Putative type III secretion protein YscO-related › Putative type III secretion protein YscO-related › PF25876 0.50 36.0 3.87e-01 100.0% 85.2%
D2 high residues 192-296
PDB
Domain cluster: representative
CATH (33)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1h7cA00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.71 50.0 5.05e-01 71.4% 82.5%
3r2kA00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.71 55.0 4.78e-01 100.0% 55.2%
1jgcA00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.70 55.0 4.72e-01 100.0% 53.8%
1vjxA00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.68 57.0 5.08e-01 99.0% 63.8%
2ib0A01 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.67 51.0 4.67e-01 100.0% 62.2%
1lb3A00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.66 54.0 4.58e-01 100.0% 54.5%
1b5lA00 1.20.1250.10 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › 0.65 47.0 4.16e-01 100.0% 52.0%
5u1aL00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.65 52.0 4.41e-01 100.0% 53.6%
2e9xA01 1.20.58.1030 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.65 45.0 4.22e-01 71.4% 67.2%
1yuzB01 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.64 50.0 4.55e-01 81.9% 71.7%
2d4uB00 1.20.120.30 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Aspartate receptor, ligand-binding domain 0.64 45.0 3.94e-01 72.4% 91.6%
3e6sA00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.63 51.0 4.37e-01 100.0% 56.0%
3cazB00 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.63 49.0 3.87e-01 81.9% 78.6%
5ffdA00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.62 48.0 4.37e-01 99.0% 62.0%
2qf9A01 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.62 57.0 4.97e-01 100.0% 67.9%
4mt4A00 1.20.1600.10 Mainly Alpha › Up-down Bundle › Outer membrane efflux proteins (OEP) › Outer membrane efflux proteins (OEP) 0.62 58.0 3.68e-01 100.0% 54.4%
3fseB02 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.61 51.0 4.51e-01 100.0% 63.2%
1oahA02 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.61 56.0 5.03e-01 98.1% 79.6%
7zxkC01 1.20.1250.10 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › 0.60 46.0 4.09e-01 81.0% 58.0%
5azsC01 1.20.1600.10 Mainly Alpha › Up-down Bundle › Outer membrane efflux proteins (OEP) › Outer membrane efflux proteins (OEP) 0.60 55.0 3.77e-01 100.0% 67.0%
7wivA01 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.60 54.0 3.83e-01 99.0% 85.7%
1jkvA01 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.59 55.0 4.39e-01 100.0% 64.0%
7aalA01 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.59 47.0 3.59e-01 87.6% 78.9%
3rq9A00 1.10.287.2500 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.58 41.0 4.63e-01 95.2% 98.7%
7xxiA01 1.20.1070.10 Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins 0.58 50.0 3.72e-01 99.0% 40.0%
3r2qA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.57 39.0 3.89e-01 84.8% 66.4%
4gycA00 1.20.1070.10 Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins 0.56 48.0 3.84e-01 96.2% 95.5%
6bl6B01 1.20.1560.10 Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain 0.56 49.0 3.52e-01 99.0% 83.9%
4o6yB00 1.20.120.1770 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.55 50.0 3.99e-01 100.0% 82.5%
1o5hA00 1.20.120.680 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Formiminotetrahydrofolate cyclodeaminase monomer, up-and-down helical bundle 0.55 49.0 3.99e-01 99.0% 60.0%
3pivA00 1.20.1250.10 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › 0.55 51.0 4.41e-01 100.0% 87.8%
4ib4A01 1.20.1070.10 Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins 0.55 49.0 3.61e-01 99.0% 37.9%
1gzmA00 1.20.1070.10 Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins 0.54 49.0 3.44e-01 100.0% 34.5%
ECOD (48)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3375617 192.5.1.30 alpha bundles › Long alpha-hairpin › HR1 repeat › HR1 repeat › DUF641 0.80 58.0 6.56e-01 84.8% 98.8%
3498924 5086.1.1.0 alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins 0.79 55.0 4.91e-01 71.4% 74.3%
5029347 2004.1.1.87 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N 0.78 57.0 3.55e-01 78.1% 16.2%
3226256 3684.1.1.0 alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like 0.77 55.0 4.74e-01 73.3% 93.5%
3819179 632.7.1.62 alpha bundles › immunoglobulin/albumin-binding domain-like › Heat shock protein 70kD (HSP70), C-terminal subdomain › Heat shock protein 70kD (HSP70), C-terminal subdomain › DUF641 0.77 62.0 5.60e-01 100.0% 64.3%
3408094 603.1.1.0 alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.77 53.0 4.86e-01 71.4% 65.9%
3644115 603.1.1.177 alpha bundles › STAT-like › t-snare proteins › t-snare proteins › DUF641 0.73 57.0 5.36e-01 95.2% 67.7%
3814578 2004.1.1.0 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.67 49.0 5.15e-01 82.9% 83.2%
3735658 192.8.1.0 alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain 0.66 48.0 4.72e-01 83.8% 69.6%
3402340 4177.1.1.1 alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › FCH 0.66 51.0 3.72e-01 81.0% 78.5%
3289188 1075.4.1.0 alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold 0.66 60.0 4.14e-01 100.0% 80.9%
3782069 633.21.1.0 alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 0.65 50.0 4.63e-01 81.9% 91.9%
3172261 150.1.1.0 alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin 0.65 60.0 5.14e-01 100.0% 70.6%
5047544 3755.4.1.0 alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain 0.64 58.0 5.23e-01 100.0% 79.3%
3558580 1075.4.1.1 alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane 0.64 59.0 3.96e-01 99.0% 71.5%
3839248 1075.4.1.1 alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane 0.63 59.0 4.05e-01 99.0% 81.6%
5057498 5054.1.1.6 alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels › TrkH 0.63 54.0 4.58e-01 94.3% 85.7%
4376272 601.2.1.4 alpha bundles › Four-helical up-and-down bundle › Cytochromes › Cytochromes › Cytochrom_C_2 0.63 43.0 3.89e-01 89.5% 52.5%
3249312 1075.4.1.1 alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane 0.62 58.0 3.96e-01 99.0% 78.2%
3268700 632.1.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain 0.62 56.0 4.50e-01 96.2% 55.9%
4611277 1075.4.1.1 alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane 0.62 57.0 3.98e-01 99.0% 81.9%
3948656 601.4.1.2 alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains › NIT 0.62 44.0 3.88e-01 74.3% 83.9%
3255335 5001.1.1.0 alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like 0.62 57.0 4.52e-01 100.0% 96.1%
3671851 5086.1.1.47 alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › Auxin_canalis 0.61 47.0 4.38e-01 100.0% 63.7%
3615184 2004.1.1.87 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N 0.61 49.0 3.08e-01 95.2% 16.5%
4123284 5085.1.1.2 a+b duplicates or obligate multimers › Outer membrane efflux proteins (OEP) › Outer membrane efflux proteins (OEP) › Outer membrane efflux proteins (OEP) › PF27489, PF29296 0.61 57.0 3.70e-01 100.0% 60.7%
4601110 1075.4.1.1 alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane 0.61 55.0 3.87e-01 99.0% 81.9%
4325844 5085.1.1.2 a+b duplicates or obligate multimers › Outer membrane efflux proteins (OEP) › Outer membrane efflux proteins (OEP) › Outer membrane efflux proteins (OEP) › PF27489, PF29296 0.60 54.0 3.49e-01 96.2% 59.1%
4589836 5085.1.1.2 a+b duplicates or obligate multimers › Outer membrane efflux proteins (OEP) › Outer membrane efflux proteins (OEP) › Outer membrane efflux proteins (OEP) › PF27489, PF29296 0.60 55.0 3.52e-01 99.0% 59.8%
3894262 4177.1.1.1 alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › FCH 0.60 47.0 3.41e-01 84.8% 67.9%
3484443 1075.4.1.1 alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane 0.60 53.0 3.74e-01 100.0% 77.1%
3688960 3755.4.1.0 alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain 0.59 53.0 4.27e-01 99.0% 64.4%
4029042 3939.1.1.0 alpha duplicates or obligate multimers › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain 0.59 53.0 4.09e-01 96.2% 49.1%
3636681 4177.1.1.1 alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › FCH 0.59 47.0 3.38e-01 86.7% 66.8%
3719613 1189.1.1.0 alpha bundles › VSG (variant surface glycoprotein) N-terminal domain and haptoglobin-hemoglobin receptor › VSG (variant surface glycoprotein) N-terminal domain and haptoglobin-hemoglobin receptor › VSG (variant surface glycoprotein) N-terminal domain and haptoglobin-hemoglobin receptor 0.58 53.0 4.10e-01 100.0% 82.2%
3894479 5057.1.1.13 alpha bundles › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore › Strabismus 0.58 51.0 4.72e-01 100.0% 83.7%
3744662 604.5.1.8 alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › ArAE_2 0.58 51.0 3.99e-01 91.4% 71.0%
3163944 1075.4.1.1 alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane 0.58 51.0 3.68e-01 100.0% 86.6%
3941981 5050.1.1.0 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.57 52.0 4.21e-01 100.0% 81.0%
3284311 1075.4.1.1 alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane 0.57 51.0 3.53e-01 94.3% 43.1%
3430430 5050.1.1.2 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › PTR2 0.57 52.0 3.80e-01 100.0% 68.6%
3283114 601.33.1.1 alpha bundles › Four-helical up-and-down bundle › CHAD domain › CHAD domain › CHAD 0.56 52.0 3.72e-01 99.0% 72.3%
1883969 1075.4.1.1 alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane 0.56 49.0 3.45e-01 95.2% 44.0%
4943964 3922.1.1.355 alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › ABC_membrane 0.56 50.0 3.52e-01 99.0% 81.2%
3291650 1075.4.1.1 alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane 0.55 49.0 3.48e-01 99.0% 84.1%
3937355 5050.1.1.1 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Sugar_tr 0.54 49.0 3.87e-01 100.0% 76.7%
3244457 5050.1.1.0 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.52 46.0 3.90e-01 100.0% 84.3%
3935599 5050.1.1.0 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.52 47.0 3.83e-01 100.0% 76.5%
D3 medium residues 307-374_554-591
PDB
Domain cluster: representative
CATH (17)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
4ioeA00 1.10.287.850 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain 0.73 38.0 4.15e-01 96.2% 62.1%
2qvwA04 1.10.1520.10 Mainly Alpha › Orthogonal Bundle › Ribonuclease iii, N-terminal Endonuclease Domain; Chain A › Ribonuclease III domain 0.66 37.0 3.33e-01 99.1% 40.0%
4l8iB00 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.66 38.0 3.78e-01 100.0% 53.6%
3rq9A00 1.10.287.2500 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.63 31.0 3.55e-01 91.5% 61.5%
2oerA00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.63 54.0 4.53e-01 92.5% 63.7%
1qsdA00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.62 34.0 3.48e-01 92.5% 54.9%
2i0mA01 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.62 33.0 3.40e-01 96.2% 52.8%
1zvuA03 1.10.268.10 Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3 0.58 43.0 3.96e-01 90.6% 59.3%
4udsA00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.58 48.0 3.94e-01 89.6% 63.7%
3f1bA00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.57 47.0 3.97e-01 89.6% 58.5%
3vvaA00 1.20.1260.140 Mainly Alpha › Up-down Bundle › Ferritin › Alternative oxidase 0.55 43.0 3.18e-01 82.1% 79.7%
8ek4A01 1.20.120.20 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein 0.53 36.0 3.35e-01 97.2% 55.6%
1sumB01 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.53 34.0 3.46e-01 88.7% 62.6%
5hxgB00 1.10.4000.10 Mainly Alpha › Orthogonal Bundle › Flagellar transcriptional activator fold › Flagellar transcriptional activator FlhD 0.51 30.0 3.65e-01 84.9% 95.4%
3l8rA00 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.51 33.0 3.36e-01 93.4% 66.7%
1x04A00 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.50 35.0 2.81e-01 93.4% 38.0%
1hx8A02 1.20.58.150 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › ANTH domain 0.50 32.0 3.11e-01 87.7% 55.6%
ECOD (27)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3894567 603.2.1.0 alpha bundles › STAT-like › STAT › STAT 0.72 38.0 3.08e-01 96.2% 28.9%
3511563 192.29.1.143 alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › CCDC28 0.69 37.0 3.77e-01 97.2% 54.3%
4302914 2004.1.1.250 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Kinesin,Microtub_bd 0.67 36.0 2.25e-01 97.2% 10.3%
56928 191.1.1.0 alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain 0.67 53.0 5.18e-01 84.9% 100.0%
3279544 7516.1.1.2 a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Glycos_transf_2 0.66 36.0 2.57e-01 92.5% 19.0%
3285488 1075.1.1.1 alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › ABCG5/ABCG8 transmembrane domain › ABC2_membrane 0.63 54.0 4.30e-01 96.2% 73.5%
5044572 310.2.1.0 a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF 0.62 36.0 3.67e-01 100.0% 57.1%
3858695 2004.1.1.0 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.61 33.0 3.65e-01 89.6% 64.7%
5048961 1075.1.1.1 alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › ABCG5/ABCG8 transmembrane domain › ABC2_membrane 0.59 51.0 3.98e-01 98.1% 66.1%
3967098 191.1.1.0 alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain 0.59 47.0 4.19e-01 87.7% 80.0%
5039785 632.22.1.200 alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats › PF26119 0.58 37.0 3.92e-01 91.5% 72.3%
3279897 191.1.1.0 alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain 0.58 46.0 4.39e-01 88.7% 88.5%
3960902 191.1.1.0 alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain 0.58 45.0 4.63e-01 85.8% 98.1%
4373100 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.57 43.0 3.96e-01 90.6% 58.6%
4946213 4016.1.1.18 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_gyraseA_C 0.57 42.0 3.81e-01 87.7% 56.6%
4218225 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.57 43.0 3.84e-01 89.6% 54.8%
4043618 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.56 43.0 3.83e-01 90.6% 56.7%
3170063 180.1.1.1 alpha bundles › Acid phosphatase/Vanadium-dependent haloperoxidase › Acid phosphatase/Vanadium-dependent haloperoxidase › Acid phosphatase/Vanadium-dependent haloperoxidase › PAP2 0.56 35.0 2.90e-01 100.0% 35.3%
5083298 4016.1.1.0 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase 0.55 41.0 3.74e-01 90.6% 56.7%
3591396 3866.1.1.0 extended segments › Mitochondrial 54S ribosomal protein L25 › Mitochondrial 54S ribosomal protein L25 › Mitochondrial 54S ribosomal protein L25 0.54 35.0 3.71e-01 91.5% 74.7%
3629047 192.15.1.0 alpha bundles › Long alpha-hairpin › Endosomal sorting complex assembly domains › Endosomal sorting complex assembly domains 0.53 33.0 3.46e-01 94.3% 67.0%
3467691 150.5.1.76 alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like › DUF1110 0.52 35.0 3.82e-01 88.7% 85.9%
3201043 604.1.1.132 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › KAR9 0.52 35.0 3.21e-01 92.5% 50.7%
3477559 601.4.1.0 alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains 0.52 42.0 4.25e-01 93.4% 85.7%
3523336 174.1.1.12 few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › BCLP 0.51 40.0 3.42e-01 83.0% 72.4%
1392807 628.1.1.1 alpha bundles › Fatty acid responsive transcription factor FadR, C-terminal domain › Fatty acid responsive transcription factor FadR, C-terminal domain › Fatty acid responsive transcription factor FadR, C-terminal domain › FCD 0.50 42.0 3.91e-01 92.5% 100.0%
4397328 604.10.1.1 alpha bundles › Spectrin repeat-like › Enzyme IIa from lactose specific PTS, IIa-lac › Enzyme IIa from lactose specific PTS, IIa-lac › PTS_IIA 0.50 32.0 3.23e-01 92.5% 60.0%
D4 medium residues 375-455_668-704
PDB
Domain cluster: representative
CATH (9)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3wvoC02 1.10.132.100 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › 0.61 39.0 3.79e-01 95.8% 57.7%
2e9xB02 1.20.58.1020 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.58 31.0 3.25e-01 83.1% 55.0%
4uvmA00 1.20.1250.20 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains 0.56 45.0 2.99e-01 87.3% 37.2%
5b00A00 1.10.600.10 Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase 0.55 42.0 3.21e-01 79.7% 74.3%
8fbnB01 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.55 33.0 2.67e-01 100.0% 30.6%
2itbB00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.54 37.0 3.16e-01 70.3% 89.4%
3e7qA00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.53 33.0 2.73e-01 98.3% 34.1%
4ie5A02 1.20.58.1470 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › FTO C-terminal domain 0.53 33.0 3.21e-01 85.6% 55.2%
2d2sA01 1.20.58.1210 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Exo84p, N-terminal helical domain 0.53 33.0 3.39e-01 100.0% 63.8%
ECOD (11)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3483536 5059.1.1.0 alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter 0.61 47.0 4.68e-01 80.5% 95.8%
5001604 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.60 38.0 3.22e-01 100.0% 37.0%
3375617 192.5.1.30 alpha bundles › Long alpha-hairpin › HR1 repeat › HR1 repeat › DUF641 0.59 36.0 4.21e-01 91.5% 90.0%
4417777 547.1.1.1 alpha duplicates or obligate multimers › Glutamyl tRNA-reductase dimerization domain › Glutamyl tRNA-reductase dimerization domain › Glutamyl tRNA-reductase dimerization domain › GlutR_dimer 0.58 40.0 3.95e-01 96.6% 64.6%
3791183 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.58 27.0 2.72e-01 91.5% 40.8%
4971089 1075.1.2.0 alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › MacB transmembrane domain 0.55 37.0 3.37e-01 84.7% 49.7%
3247632 5050.1.1.0 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.54 43.0 3.77e-01 88.1% 98.4%
None 0.53 38.0 2.70e-01 76.3% 51.4%
5072346 5082.1.1.1 alpha bundles › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation_efflux 0.52 42.0 3.59e-01 89.0% 75.5%
3324034 1015.1.1.7 alpha complex topology › Insulin-induced gene (Insig) homologs › Insulin-induced gene (Insig) homologs › Insulin-induced gene (Insig) homologs › Yip1 0.51 43.0 3.91e-01 93.2% 84.8%
3417107 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.50 40.0 3.33e-01 86.4% 91.2%
D5 medium residues 592-667_705-731
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF06808.19 best DctM 40.1 3.00e-10 98.1% 17.7%
CATH (33)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2g7lA00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.70 62.0 4.93e-01 97.1% 68.2%
2xgcA02 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.69 62.0 5.76e-01 98.1% 96.9%
4g12A02 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.67 61.0 5.39e-01 100.0% 91.9%
2hh6A00 1.10.1900.10 Mainly Alpha › Orthogonal Bundle › c-terminal domain of poly(a) binding protein › c-terminal domain of poly(a) binding protein 0.67 33.0 3.24e-01 90.3% 42.3%
4huqS00 1.10.1760.20 Mainly Alpha › Orthogonal Bundle › Arp2/3 complex 21 kDa subunit ARPC3 › 0.65 57.0 4.98e-01 100.0% 68.3%
6cnzF00 1.20.59.10 Mainly Alpha › Up-down Bundle › Chorismate Mutase Domain, subunit A › Chorismate mutase 0.65 48.0 4.14e-01 76.7% 98.7%
7eqeB01 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.63 53.0 4.52e-01 91.3% 64.5%
4od4A01 1.10.357.140 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › UbiA prenyltransferase 0.62 52.0 4.55e-01 92.2% 82.7%
3zibC00 1.20.120.1620 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.62 51.0 5.31e-01 90.3% 100.0%
4wpeA00 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.60 43.0 3.17e-01 74.8% 77.8%
4b6iA00 1.20.120.1620 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.59 52.0 5.32e-01 97.1% 100.0%
1zvzA02 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.58 49.0 4.63e-01 92.2% 87.1%
2ccyA00 1.20.120.10 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c/b562 0.58 50.0 4.66e-01 93.2% 92.1%
7p5hB03 1.20.1440.230 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain 0.58 34.0 3.66e-01 81.6% 66.3%
4hfkB00 1.20.120.1620 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.57 48.0 4.93e-01 95.1% 98.0%
1sj7C00 1.20.1420.10 Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › Talin, central domain 0.56 48.0 4.09e-01 92.2% 70.5%
3ripA02 1.20.120.1900 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Gamma-tubulin complex, C-terminal domain 0.56 45.0 3.38e-01 89.3% 67.7%
1lm3B00 1.20.120.10 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c/b562 0.56 48.0 4.80e-01 94.2% 100.0%
1a7vA00 1.20.120.10 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c/b562 0.55 47.0 4.46e-01 93.2% 92.8%
3b9qA01 1.20.120.140 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › SRP54, nucleotide-binding domain 0.55 40.0 4.31e-01 86.4% 89.9%
1nlxA00 1.20.120.320 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Group V grass pollen allergen 0.55 43.0 4.31e-01 84.5% 93.3%
7oq4Z01 1.20.120.950 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Uncharacterised protein DUF5062 0.54 41.0 4.21e-01 81.6% 89.8%
7c1iA01 1.20.120.160 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain 0.54 43.0 4.40e-01 92.2% 88.0%
8a1gC01 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.54 44.0 3.60e-01 86.4% 83.4%
3c7jA02 1.20.120.530 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › GntR ligand-binding domain-like 0.54 43.0 3.93e-01 89.3% 91.8%
1dqeA00 1.10.238.20 Mainly Alpha › Orthogonal Bundle › Recoverin; domain 1 › Pheromone/general odorant binding protein domain 0.54 41.0 3.82e-01 83.5% 92.7%
1x8zB00 1.20.140.40 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Invertase/pectin methylesterase inhibitor family protein 0.54 40.0 3.59e-01 82.5% 55.1%
1vcsA00 1.20.58.400 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › t-snare proteins 0.53 37.0 3.72e-01 71.8% 92.2%
6xz3A01 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.53 44.0 4.29e-01 93.2% 97.4%
2hfiA00 1.20.120.440 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › YppE-like 0.52 44.0 4.15e-01 92.2% 97.6%
3t6gB00 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.52 44.0 4.04e-01 92.2% 96.3%
3zh9B03 1.20.272.10 Mainly Alpha › Up-down Bundle › Zinc Finger, Delta Prime; domain 3 › 0.51 41.0 3.87e-01 86.4% 98.4%
3m7gA02 1.10.8.1010 Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › 0.51 37.0 3.84e-01 82.5% 82.1%
ECOD (26)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
5007958 3355.1.1.4 alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › DctM 0.80 73.0 4.65e-01 98.1% 26.9%
5079242 5057.1.1.36 alpha bundles › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore › DctM 0.79 72.0 6.79e-01 97.1% 92.5%
3481410 3355.1.1.1 alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Na_sulph_symp 0.74 67.0 4.23e-01 100.0% 94.6%
3867881 3355.1.1.1 alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Na_sulph_symp 0.73 65.0 4.25e-01 100.0% 94.3%
3556322 3355.1.1.1 alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Na_sulph_symp 0.73 65.0 4.09e-01 100.0% 93.3%
3283065 191.1.1.1 alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › TetR_C_1 0.69 61.0 5.35e-01 96.1% 100.0%
5010597 5058.1.1.99 alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › DUF373 0.59 41.0 3.77e-01 72.8% 62.9%
3182665 632.7.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Heat shock protein 70kD (HSP70), C-terminal subdomain › Heat shock protein 70kD (HSP70), C-terminal subdomain 0.57 40.0 4.20e-01 75.7% 77.9%
3577574 601.1.2.0 alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) 0.57 43.0 3.56e-01 78.6% 68.3%
4057021 605.4.1.20 alpha duplicates or obligate multimers › ROP-like › ROP protein › ROP protein › DUF6092 0.57 39.0 4.17e-01 71.8% 81.1%
185784 3368.1.1.1 alpha bundles › Rap2b (SMA2266) › Rap2b (SMA2266) › Rap2b (SMA2266) › Tai4 0.57 48.0 4.93e-01 95.1% 98.0%
3833190 633.4.1.1 alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI 0.55 40.0 3.53e-01 82.5% 51.7%
5062170 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.55 34.0 3.30e-01 78.6% 52.5%
5014336 192.29.1.0 alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) 0.55 47.0 4.19e-01 93.2% 79.3%
3933378 5001.1.1.60 alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7TM_GPCR_Srx 0.55 46.0 3.48e-01 92.2% 90.8%
3835373 633.4.1.1 alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI 0.54 40.0 3.52e-01 82.5% 53.3%
3189990 3684.1.1.25 alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › DUF3433 0.53 44.0 3.75e-01 93.2% 91.4%
3735730 5001.1.1.131 alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › DUF7702 0.53 40.0 2.94e-01 79.6% 30.4%
3831865 633.4.1.1 alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI 0.53 40.0 3.73e-01 80.6% 68.5%
3475770 5069.1.1.38 alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes › Frag1 0.52 45.0 3.79e-01 94.2% 70.6%
3253210 633.6.1.2 alpha bundles › Bromodomain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA dehydrogenase C-terminal domain-like › ACOX 0.52 46.0 3.74e-01 98.1% 64.6%
3825200 181.1.1.0 alpha bundles › Domain of the SRP/SRP receptor G proteins-like › Domain of the SRP/SRP receptor G-proteins › Domain of the SRP/SRP receptor G-proteins 0.52 40.0 4.20e-01 87.4% 92.6%
3190257 605.1.1.0 alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase 0.52 37.0 3.30e-01 72.8% 55.2%
3934932 150.1.1.0 alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin 0.51 40.0 3.62e-01 83.5% 72.9%
3964156 138.1.1.0 alpha arrays › DNA polymerase III clamp loader subunits, C-terminal domain › DNA polymerase III clamp loader subunits, C-terminal domain › DNA polymerase III clamp loader subunits, C-terminal domain 0.51 39.0 3.87e-01 81.6% 95.5%
3693664 601.16.1.19 alpha bundles › Four-helical up-and-down bundle › FAT domain of focal adhesion kinase › FAT domain of focal adhesion kinase › DUF3433 0.51 43.0 3.63e-01 94.2% 88.3%