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CAKLQF020000005.1__CAH1078395.1__SAMEA5780031_01326__00168
Bact-VirCAKLQF020000005.1__CAH1078395.1__SAMEA5780031_01326__00168
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 57-214
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF13972.12 best | TetR | 111.7 | 3.70e-32 | 93.0% | 100.0% |
CATH (44)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3rh2A00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.94 | 89.0 | 7.93e-01 | 100.0% | 74.2% |
| 3nnrA00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.91 | 83.0 | 7.50e-01 | 100.0% | 74.3% |
| 3f0cA02 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.77 | 66.0 | 6.89e-01 | 91.8% | 99.3% |
| 4g12A02 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.76 | 64.0 | 6.58e-01 | 91.1% | 94.0% |
| 2w53B00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.76 | 67.0 | 6.55e-01 | 98.7% | 86.1% |
| 3dcfA02 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.75 | 59.0 | 6.21e-01 | 96.8% | 91.5% |
| 3lwjA00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.75 | 62.0 | 5.80e-01 | 90.5% | 71.5% |
| 4kwaB00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.75 | 63.0 | 5.90e-01 | 92.4% | 73.4% |
| 3vibA00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.74 | 62.0 | 5.77e-01 | 90.5% | 71.5% |
| 1ui6A00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.74 | 61.0 | 5.68e-01 | 100.0% | 70.8% |
| 5c4yA00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.74 | 60.0 | 6.42e-01 | 91.1% | 99.3% |
| 3himA00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.73 | 60.0 | 5.67e-01 | 94.3% | 72.6% |
| 5d18A00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.73 | 62.0 | 5.65e-01 | 91.1% | 69.8% |
| 1t33A02 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.70 | 61.0 | 6.14e-01 | 93.7% | 98.7% |
| 2iu5B00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.70 | 54.0 | 5.20e-01 | 91.8% | 71.8% |
| 4me9B00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.69 | 55.0 | 5.24e-01 | 94.3% | 72.0% |
| 2fx0A02 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.68 | 52.0 | 5.65e-01 | 91.8% | 95.5% |
| 3nrgA00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.68 | 59.0 | 5.29e-01 | 92.4% | 70.0% |
| 2pz9A00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.67 | 53.0 | 5.07e-01 | 93.7% | 73.2% |
| 2f07B00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.67 | 57.0 | 5.32e-01 | 91.8% | 92.3% |
| 4jykA02 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.67 | 56.0 | 5.88e-01 | 90.5% | 100.0% |
| 5fglA00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.65 | 55.0 | 5.09e-01 | 91.1% | 95.0% |
| 4mk6A00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.65 | 56.0 | 5.27e-01 | 91.8% | 88.3% |
| 2dg8D00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.64 | 48.0 | 4.65e-01 | 91.8% | 69.9% |
| 2genA00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.64 | 53.0 | 5.07e-01 | 92.4% | 75.5% |
| 2id6A02 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.64 | 55.0 | 5.56e-01 | 91.8% | 95.5% |
| 5x56B00 | 1.20.58.810 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Photosystem II Pbs27 | 0.64 | 34.0 | 4.08e-01 | 91.8% | 76.2% |
| 2qibB00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.64 | 58.0 | 5.29e-01 | 99.4% | 91.3% |
| 2d6yA00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.63 | 54.0 | 5.10e-01 | 91.8% | 96.2% |
| 3f1xA01 | 1.10.3130.10 | Mainly Alpha › Orthogonal Bundle › serine acetyltransferase, domain 1 › serine acetyltransferase, domain 1 | 0.62 | 51.0 | 5.27e-01 | 87.3% | 96.6% |
| 4gf0A02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.61 | 36.0 | 4.19e-01 | 70.3% | 80.5% |
| 2kmfA01 | 1.20.58.810 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Photosystem II Pbs27 | 0.61 | 32.0 | 3.85e-01 | 91.1% | 76.5% |
| 2dg7A00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.60 | 49.0 | 4.72e-01 | 89.2% | 92.5% |
| 3ppbA00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.59 | 51.0 | 4.85e-01 | 94.3% | 96.3% |
| 3qkxB00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.58 | 49.0 | 4.75e-01 | 91.8% | 97.2% |
| 3rauA00 | 1.25.40.280 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › alix/aip1 like domains | 0.57 | 44.0 | 3.37e-01 | 80.4% | 94.4% |
| 2gtvX00 | 1.20.59.10 | Mainly Alpha › Up-down Bundle › Chorismate Mutase Domain, subunit A › Chorismate mutase | 0.57 | 37.0 | 4.39e-01 | 75.9% | 99.0% |
| 2qr4A01 | 1.20.140.70 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Oligopeptidase f, N-terminal domain | 0.56 | 41.0 | 4.15e-01 | 91.1% | 76.9% |
| 7tj9A01 | 1.20.120.350 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Voltage-gated potassium channels. Chain C | 0.54 | 36.0 | 4.29e-01 | 83.5% | 100.0% |
| 6xpdA01 | 1.20.1510.10 | Mainly Alpha › Up-down Bundle › Alpha-lytic protease prodomain-like › Cation efflux protein transmembrane domain | 0.54 | 47.0 | 4.39e-01 | 95.6% | 83.2% |
| 3ajmB02 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.52 | 37.0 | 4.01e-01 | 79.7% | 85.7% |
| 4akgA11 | 1.20.920.20 | Mainly Alpha › Up-down Bundle › Histone Acetyltransferase; Chain A › | 0.51 | 36.0 | 3.01e-01 | 71.5% | 70.3% |
| 2e9xD01 | 1.20.58.1030 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.50 | 40.0 | 4.28e-01 | 91.8% | 97.1% |
| 3lk5A00 | 1.10.600.10 | Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase | 0.50 | 44.0 | 3.54e-01 | 98.1% | 49.2% |
ECOD (26)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 143173 | 191.1.1.9 ↗ | alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › TetR | 0.94 | 77.0 | 8.26e-01 | 86.1% | 96.4% |
| 1639086 | 191.1.1.9 ↗ | alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › TetR | 0.90 | 77.0 | 8.12e-01 | 94.3% | 97.9% |
| 3969254 | 191.1.1.9 ↗ | alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › TetR | 0.89 | 76.0 | 7.94e-01 | 94.3% | 96.6% |
| 3963880 | 191.1.1.9 ↗ | alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › TetR | 0.86 | 75.0 | 7.82e-01 | 94.3% | 99.3% |
| 1304876 | 191.1.1.41 ↗ | alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › EthR_C | 0.77 | 62.0 | 6.62e-01 | 90.5% | 96.4% |
| 3952549 | 191.1.1.41 ↗ | alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › EthR_C | 0.74 | 57.0 | 6.31e-01 | 82.9% | 100.0% |
| 3289317 | 191.1.1.41 ↗ | alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › EthR_C | 0.73 | 62.0 | 6.34e-01 | 91.1% | 93.3% |
| 4952332 | 191.1.1.0 ↗ | alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain | 0.73 | 57.0 | 6.19e-01 | 88.0% | 98.5% |
| 3959415 | 191.1.1.0 ↗ | alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain | 0.72 | 55.0 | 6.12e-01 | 83.5% | 100.0% |
| 3957242 | 191.1.1.41 ↗ | alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › EthR_C | 0.72 | 60.0 | 6.12e-01 | 91.1% | 92.7% |
| 3951929 | 191.1.1.10 ↗ | alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › TetR_C_6 | 0.72 | 56.0 | 6.07e-01 | 86.1% | 95.6% |
| 3962218 | 191.1.1.0 ↗ | alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain | 0.71 | 47.0 | 5.63e-01 | 70.9% | 100.0% |
| 4928534 | 191.1.1.63 ↗ | alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › TetR_N | 0.71 | 61.0 | 5.78e-01 | 91.1% | 98.9% |
| 5016502 | 191.1.1.14 ↗ | alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › TetR_C_10 | 0.64 | 50.0 | 5.37e-01 | 91.1% | 98.5% |
| 3503329 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.63 | 38.0 | 4.70e-01 | 92.4% | 98.9% |
| 3291268 | 191.1.1.0 ↗ | alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain | 0.63 | 47.0 | 5.23e-01 | 87.3% | 100.0% |
| 5000698 | 604.38.1.0 ↗ | alpha bundles › Spectrin repeat-like › Legionella effector SdeA 3-helical bundle › Legionella effector SdeA 3-helical bundle | 0.62 | 40.0 | 4.67e-01 | 100.0% | 95.2% |
| 4993050 | 192.2.1.0 ↗ | alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin | 0.62 | 27.0 | 2.47e-01 | 80.4% | 30.0% |
| 4031691 | 5067.1.1.1 ↗ | alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › ACR_tran | 0.54 | 38.0 | 3.43e-01 | 71.5% | 60.0% |
| 3899064 | 5001.1.1.1 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 | 0.53 | 41.0 | 3.36e-01 | 82.9% | 80.7% |
| 4960822 | 1075.5.1.8 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › Polysacc_synt_3 | 0.52 | 47.0 | 4.07e-01 | 100.0% | 87.8% |
| 3925622 | 603.1.1.97 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins › Syntaxin, SNARE | 0.52 | 48.0 | 4.15e-01 | 98.7% | 68.5% |
| 4112439 | 5045.1.1.1 ↗ | alpha bundles › F1F0 ATP synthase subunit A › F1F0 ATP synthase subunit A › F1F0 ATP synthase subunit A › ATP-synt_A | 0.52 | 44.0 | 3.97e-01 | 93.7% | 91.3% |
| 4133341 | 5069.1.1.0 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes | 0.52 | 38.0 | 4.26e-01 | 84.2% | 100.0% |
| 4606152 | 4163.1.1.1 ↗ | alpha bundles › GINS helical bundle-like › GINS helical bundle-like › PSF1 N-terminal domain-like › Sld5 | 0.51 | 44.0 | 4.31e-01 | 91.1% | 88.2% |
| 3225374 | 601.1.2.6 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › Talin_IBS2B | 0.51 | 38.0 | 4.24e-01 | 83.5% | 100.0% |