←Back to structures
CAKLQF020000013.1__CAH1086907.1__SAMEA5780031_02529__00065
Bact-VirCAKLQF020000013.1__CAH1086907.1__SAMEA5780031_02529__00065
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 320-390
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02652.21 best | Lactate_perm | 50.2 | 2.50e-13 | 100.0% | 13.0% |
ECOD (2)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3970050 | 3355.1.1.0 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter | 1.00 | 97.0 | 5.61e-01 | 100.0% | 14.9% |
| 4042805 | 213.1.1.0 ↗ | a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) | 0.50 | 35.0 | 2.82e-01 | 74.6% | 49.0% |
D2
medium
residues 1-81
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02652.21 best | Lactate_perm | 59.6 | 3.60e-16 | 80.2% | 12.4% |
CATH (26)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3aqlA02 | 1.10.3090.10 | Mainly Alpha › Orthogonal Bundle › cca-adding enzyme, domain 2 › cca-adding enzyme, domain 2 | 0.67 | 58.0 | 4.13e-01 | 97.5% | 69.4% |
| 2hytA00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.66 | 53.0 | 4.01e-01 | 86.4% | 69.9% |
| 4cc9B00 | 1.20.5.4730 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › | 0.65 | 43.0 | 4.03e-01 | 85.2% | 56.1% |
| 1rykA00 | 1.10.1470.10 | Mainly Alpha › Orthogonal Bundle › Protein Yjbj; Chain: A; › YjbJ | 0.65 | 37.0 | 3.92e-01 | 74.1% | 63.8% |
| 3bniB00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.64 | 51.0 | 4.06e-01 | 87.7% | 94.7% |
| 1exaA00 | 1.10.565.10 | Mainly Alpha › Orthogonal Bundle › Retinoid X Receptor › Retinoid X Receptor | 0.64 | 46.0 | 3.34e-01 | 76.5% | 86.0% |
| 6fhoA01 | 3.50.50.60 | Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain | 0.63 | 43.0 | 3.25e-01 | 70.4% | 36.0% |
| 2qdjA03 | 1.10.472.140 | Mainly Alpha › Orthogonal Bundle › Cyclin A; domain 1 › | 0.63 | 44.0 | 3.89e-01 | 71.6% | 58.6% |
| 2hjmA01 | 1.20.120.460 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › protein pf1176 like | 0.62 | 49.0 | 4.82e-01 | 85.2% | 81.4% |
| 4nleA03 | 1.10.40.30 | Mainly Alpha › Orthogonal Bundle › Ribonucleotide Reductase Protein R1; domain 1 › Fumarase/aspartase (C-terminal domain) | 0.62 | 44.0 | 4.58e-01 | 95.1% | 81.6% |
| 3qkxB00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.62 | 49.0 | 3.87e-01 | 87.7% | 96.1% |
| 4iv6B01 | 1.10.540.10 | Mainly Alpha › Orthogonal Bundle › Butyryl-Coa Dehydrogenase, subunit A; domain 1 › Acyl-CoA dehydrogenase/oxidase, N-terminal domain | 0.58 | 42.0 | 3.72e-01 | 75.3% | 99.1% |
| 3ddhA02 | 1.10.150.240 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 | 0.58 | 44.0 | 4.41e-01 | 95.1% | 84.0% |
| 3ousA00 | 1.10.287.70 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.57 | 40.0 | 4.03e-01 | 72.8% | 97.6% |
| 3lcnB00 | 1.10.340.40 | Mainly Alpha › Orthogonal Bundle › Endonuclease III; domain 1 › Nuclear abundant poly(A) RNA-bind protein 2, N-terminal domain | 0.57 | 40.0 | 3.80e-01 | 96.3% | 60.8% |
| 1sr2A00 | 1.20.120.160 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain | 0.57 | 49.0 | 4.40e-01 | 96.3% | 70.7% |
| 4yt2A02 | 1.20.120.1300 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Hmd, C-terminal helical subdomain | 0.57 | 44.0 | 4.06e-01 | 85.2% | 67.0% |
| 5cbgA00 | 1.10.287.70 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.57 | 40.0 | 3.78e-01 | 75.3% | 85.3% |
| 8ctsB01 | 1.10.287.70 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.55 | 37.0 | 3.67e-01 | 70.4% | 90.8% |
| 2b0jA02 | 1.20.120.1300 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Hmd, C-terminal helical subdomain | 0.55 | 42.0 | 4.11e-01 | 85.2% | 77.2% |
| 2gsvA00 | 6.10.140.40 | Special › Helix non-globular › Helix Hairpins › | 0.54 | 41.0 | 4.39e-01 | 92.6% | 98.5% |
| 3cqcB01 | 1.20.58.1380 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.53 | 38.0 | 3.70e-01 | 76.5% | 67.8% |
| 2nr4A02 | 1.20.58.290 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Hypothetical membrane protein ta0354_69_121. | 0.51 | 35.0 | 4.02e-01 | 82.7% | 100.0% |
| 6gy8A01 | 1.20.1170.10 | Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; › | 0.51 | 41.0 | 2.82e-01 | 92.6% | 93.7% |
| 3c8eA02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.50 | 41.0 | 3.36e-01 | 90.1% | 96.8% |
| 2y1vA04 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.50 | 43.0 | 3.37e-01 | 98.8% | 96.8% |
ECOD (32)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3970050 | 3355.1.1.0 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter | 1.00 | 90.0 | 5.30e-01 | 92.6% | 15.8% |
| 4331902 | 3355.1.1.14 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Lactate_perm | 1.00 | 87.0 | 5.12e-01 | 90.1% | 14.6% |
| 5048227 | 3355.1.1.14 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Lactate_perm | 0.97 | 73.0 | 4.37e-01 | 79.0% | 13.5% |
| 4980272 | 3355.1.1.0 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter | 0.95 | 71.0 | 4.14e-01 | 77.8% | 11.8% |
| 3965043 | 3355.1.1.14 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Lactate_perm | 0.92 | 71.0 | 4.28e-01 | 80.2% | 15.0% |
| 4466218 | 3355.1.1.8 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Na_H_antiporter | 0.83 | 61.0 | 3.79e-01 | 79.0% | 15.0% |
| 5079301 | 3355.1.1.4 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › DctM | 0.77 | 66.0 | 4.15e-01 | 92.6% | 53.7% |
| 4238771 | 3355.1.1.8 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Na_H_antiporter | 0.76 | 64.0 | 3.95e-01 | 96.3% | 16.5% |
| 4582471 | 3355.1.1.11 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › GntP_permease | 0.76 | 65.0 | 4.00e-01 | 92.6% | 51.3% |
| 3284303 | 3355.1.1.11 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › GntP_permease | 0.75 | 63.0 | 3.86e-01 | 90.1% | 16.9% |
| 3171139 | 7022.1.1.1 ↗ | alpha bundles › central core domain of D-alanyl transfer protein › central core domain of D-alanyl transfer protein › central core domain of D-alanyl transfer protein › MBOAT | 0.72 | 51.0 | 3.86e-01 | 74.1% | 77.3% |
| 3164286 | 3355.1.1.21 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Na_sulph_symp, CitMHS | 0.71 | 53.0 | 3.31e-01 | 88.9% | 14.4% |
| 4134287 | 131.2.1.2 ↗ | alpha complex topology › PDEase-like › Poly A polymerase C-terminal region-like › Poly A polymerase C-terminal region-like › PolyA_pol_arg_C,PolyA_pol_RNAbd | 0.67 | 58.0 | 4.13e-01 | 97.5% | 69.0% |
| 4954814 | 7516.1.1.2 ↗ | a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Glycos_transf_2 | 0.67 | 47.0 | 3.04e-01 | 72.8% | 34.9% |
| 4937529 | 103.9.1.0 ↗ | alpha arrays › RuvA-C › RanGAP2 N-terminal domain › RanGAP2 N-terminal domain | 0.66 | 51.0 | 4.73e-01 | 88.9% | 66.0% |
| 4480528 | 3355.1.1.2 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › CitMHS | 0.65 | 55.0 | 3.50e-01 | 100.0% | 39.2% |
| 3946006 | 5065.1.1.3 ↗ | alpha bundles › Type II ABC importer transmembrane domain fold › Type II ABC importer transmembrane domain fold › Type II ABC importer transmembrane domain fold › BPD_transp_2 | 0.64 | 49.0 | 3.57e-01 | 82.7% | 79.6% |
| 5002576 | 3625.1.1.0 ↗ | alpha bundles › CRISPR RNA silencing complex Cmr2 subunit second helical domain › CRISPR RNA silencing complex Cmr2 subunit second helical domain › CRISPR RNA silencing complex Cmr2 subunit second helical domain | 0.64 | 45.0 | 4.61e-01 | 80.2% | 75.0% |
| 3590175 | 5065.1.1.3 ↗ | alpha bundles › Type II ABC importer transmembrane domain fold › Type II ABC importer transmembrane domain fold › Type II ABC importer transmembrane domain fold › BPD_transp_2 | 0.64 | 55.0 | 3.83e-01 | 93.8% | 80.4% |
| 3218544 | 604.12.1.0 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain | 0.64 | 49.0 | 4.92e-01 | 92.6% | 81.2% |
| 3175796 | 148.1.3.56 ↗ | alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain › Arv1 | 0.63 | 56.0 | 4.42e-01 | 98.8% | 50.0% |
| 3242626 | 148.1.3.0 ↗ | alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain | 0.62 | 38.0 | 3.89e-01 | 87.7% | 62.5% |
| 3836801 | 5050.1.1.15 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Nodulin-like | 0.60 | 50.0 | 3.43e-01 | 93.8% | 80.7% |
| 3596071 | 198.1.1.0 ↗ | alpha arrays › Saposin-like › Saposin-like › Saposin-like | 0.60 | 46.0 | 4.35e-01 | 85.2% | 88.0% |
| 1792251 | 3616.1.1.2 ↗ | alpha bundles › ExoU toxin middle helical domain › ExoU toxin middle helical domain › ExoU toxin middle helical domain › VipD-like_C | 0.59 | 47.0 | 3.99e-01 | 90.1% | 87.0% |
| 2438944 | 129.1.1.8 ↗ | alpha arrays › 6-phosphogluconate dehydrogenase C-terminal domain-like › 6-phosphogluconate dehydrogenase C-terminal domain-like › 6-phosphogluconate dehydrogenase C-terminal domain-like › HMD | 0.59 | 44.0 | 3.59e-01 | 81.5% | 77.6% |
| 3972199 | 210.2.1.3 ↗ | a+b four layers › Ntn/PP2C › Protein serine/threonine phosphatase 2C, catalytic domain › Protein serine/threonine phosphatase 2C, catalytic domain › PP2C_2 | 0.58 | 49.0 | 3.41e-01 | 95.1% | 57.9% |
| 4466434 | 101.1.1.70 ↗ | alpha arrays › HTH › HTH › Three-helical HTH › SANT_DAMP1_like | 0.56 | 39.0 | 3.43e-01 | 72.8% | 73.3% |
| 4962441 | 5065.1.1.3 ↗ | alpha bundles › Type II ABC importer transmembrane domain fold › Type II ABC importer transmembrane domain fold › Type II ABC importer transmembrane domain fold › BPD_transp_2 | 0.56 | 49.0 | 3.40e-01 | 97.5% | 78.9% |
| 5056432 | 607.1.1.0 ↗ | alpha arrays › Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain › Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain › Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain | 0.55 | 43.0 | 3.73e-01 | 85.2% | 76.0% |
| 2420107 | 532.1.1.1 ↗ | alpha arrays › Type III secretion system domain-like › Antibiotic binding domain of TipA-like multidrug resistance regulators › Antibiotic binding domain of TipA-like multidrug resistance regulators › TipAS | 0.54 | 43.0 | 4.01e-01 | 95.1% | 67.6% |
| 4939538 | 4033.1.1.1 ↗ | alpha arrays › Acyl-CoA dehydrogenase N-terminal domain-like › Acyl-CoA dehydrogenase N-terminal domain-like › Acyl-CoA dehydrogenase N-terminal domain-like › Acyl-CoA_dh_N | 0.52 | 40.0 | 3.53e-01 | 98.8% | 55.2% |
D3
medium
residues 82-174_291-308
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02652.21 best | Lactate_perm | 169.8 | 1.50e-49 | 97.3% | 17.8% |
CATH (11)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2xubA05 | 6.10.140.1450 | Special › Helix non-globular › Helix Hairpins › | 0.67 | 32.0 | 3.50e-01 | 100.0% | 54.2% |
| 2fji102 | 1.10.357.70 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Exocyst complex component Sec6, C-terminal domain | 0.64 | 46.0 | 3.91e-01 | 76.6% | 73.7% |
| 6ynwH01 | 1.20.20.10 | Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C | 0.59 | 30.0 | 3.54e-01 | 80.2% | 71.6% |
| 1u84A00 | 1.10.340.20 | Mainly Alpha › Orthogonal Bundle › Endonuclease III; domain 1 › Apc36109-like domain | 0.59 | 34.0 | 3.93e-01 | 78.4% | 79.0% |
| 1oj6A00 | 1.10.490.10 | Mainly Alpha › Orthogonal Bundle › Globin-like › Globins | 0.57 | 41.0 | 3.76e-01 | 74.8% | 74.8% |
| 7szaA01 | 1.10.510.10 | Mainly Alpha › Orthogonal Bundle › Transferase(Phosphotransferase); domain 1 › Transferase(Phosphotransferase) domain 1 | 0.56 | 39.0 | 3.82e-01 | 73.0% | 92.0% |
| 4iu9B01 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.54 | 49.0 | 3.89e-01 | 100.0% | 95.1% |
| 4gzrB00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.54 | 29.0 | 3.31e-01 | 82.9% | 71.4% |
| 4ol9A02 | 1.10.1040.10 | Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 | 0.53 | 44.0 | 4.26e-01 | 93.7% | 79.5% |
| 3pvlA03 | 1.20.80.10 | Mainly Alpha › Up-down Bundle › Acyl-CoA Binding Protein › | 0.52 | 43.0 | 4.26e-01 | 90.1% | 84.7% |
| 2m6uA00 | 1.20.81.20 | Mainly Alpha › Up-down Bundle › Receptor-associated Protein › | 0.50 | 32.0 | 3.60e-01 | 99.1% | 85.4% |
ECOD (14)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4169832 | 3355.1.1.14 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Lactate_perm | 1.00 | 98.0 | 5.93e-01 | 100.0% | 41.5% |
| 4331902 | 3355.1.1.14 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Lactate_perm | 0.99 | 97.0 | 5.98e-01 | 100.0% | 44.2% |
| 3970050 | 3355.1.1.0 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter | 0.98 | 96.0 | 5.97e-01 | 100.0% | 33.9% |
| 4048966 | 3355.1.1.14 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Lactate_perm | 0.96 | 93.0 | 5.89e-01 | 100.0% | 47.8% |
| 3983640 | 3355.1.1.14 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Lactate_perm | 0.94 | 93.0 | 5.76e-01 | 100.0% | 42.3% |
| 3965043 | 3355.1.1.14 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Lactate_perm | 0.91 | 87.0 | 5.58e-01 | 100.0% | 37.9% |
| 4600042 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.69 | 49.0 | 3.91e-01 | 73.0% | 96.3% |
| 3341058 | 6155.1.1.6 ↗ | alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter › DUF2921 | 0.60 | 45.0 | 4.29e-01 | 80.2% | 94.8% |
| 5065168 | 1075.5.1.0 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter | 0.57 | 39.0 | 3.36e-01 | 71.2% | 79.5% |
| 3467691 | 150.5.1.76 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like › DUF1110 | 0.56 | 30.0 | 3.40e-01 | 83.8% | 65.9% |
| 4855020 | 1188.1.1.1 ↗ | alpha bundles › ZIP zinc transporter › ZIP zinc transporter › ZIP zinc transporter › Zip | 0.54 | 44.0 | 3.59e-01 | 87.4% | 88.3% |
| 4070320 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.52 | 30.0 | 2.76e-01 | 80.2% | 42.8% |
| 3215014 | 632.22.1.184 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats › SMC_N | 0.52 | 39.0 | 2.62e-01 | 82.9% | 95.6% |
| 3744084 | 563.1.1.1 ↗ | alpha bundles › ATPD N-terminal domain-like › N-terminal domain of the delta subunit of the F1F0-ATP synthase › N-terminal domain of the delta subunit of the F1F0-ATP synthase › OSCP | 0.51 | 32.0 | 2.78e-01 | 81.1% | 38.3% |
D4
medium
residues 175-269
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02652.21 best | Lactate_perm | 109.9 | 2.00e-31 | 100.0% | 18.0% |
CATH (39)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2k3qA00 | 1.10.274.70 | Mainly Alpha › Orthogonal Bundle › Enzyme I; Chain A, domain 2 › Spidroin, N-terminal domain | 0.69 | 48.0 | 4.46e-01 | 76.8% | 57.6% |
| 3wvoC02 | 1.10.132.100 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › | 0.66 | 48.0 | 4.33e-01 | 75.8% | 90.8% |
| 6lumD01 | 1.20.1300.10 | Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Fumarate reductase/succinate dehydrogenase, transmembrane subunit | 0.65 | 47.0 | 4.31e-01 | 75.8% | 71.2% |
| 2m6uA00 | 1.20.81.20 | Mainly Alpha › Up-down Bundle › Receptor-associated Protein › | 0.64 | 49.0 | 5.13e-01 | 82.1% | 97.6% |
| 2l10A00 | 1.20.1420.10 | Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › Talin, central domain | 0.64 | 51.0 | 4.36e-01 | 87.4% | 96.2% |
| 2k3nA00 | 1.10.274.60 | Mainly Alpha › Orthogonal Bundle › Enzyme I; Chain A, domain 2 › Spidroin, repetitive domain | 0.64 | 47.0 | 3.93e-01 | 97.9% | 45.6% |
| 7dfeA01 | 1.10.274.60 | Mainly Alpha › Orthogonal Bundle › Enzyme I; Chain A, domain 2 › Spidroin, repetitive domain | 0.63 | 46.0 | 4.27e-01 | 98.9% | 58.3% |
| 1dowA00 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.62 | 47.0 | 3.67e-01 | 80.0% | 39.5% |
| 2zy9A03 | 1.10.357.20 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › SLC41 divalent cation transporters, integral membrane domain | 0.62 | 54.0 | 4.53e-01 | 100.0% | 64.9% |
| 3cazB00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.62 | 51.0 | 4.03e-01 | 91.6% | 86.2% |
| 2okuA00 | 1.20.120.470 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Acyl-CoA dehydrogenase, C-terminal domain | 0.62 | 45.0 | 4.22e-01 | 77.9% | 66.4% |
| 1zymA02 | 1.10.274.10 | Mainly Alpha › Orthogonal Bundle › Enzyme I; Chain A, domain 2 › PtsI, HPr-binding domain | 0.62 | 53.0 | 4.87e-01 | 95.8% | 81.0% |
| 1ad6A00 | 1.10.472.10 | Mainly Alpha › Orthogonal Bundle › Cyclin A; domain 1 › Cyclin-like | 0.62 | 48.0 | 3.92e-01 | 85.3% | 51.4% |
| 4al0A00 | 1.20.120.550 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Membrane associated eicosanoid/glutathione metabolism-like domain | 0.61 | 46.0 | 4.03e-01 | 82.1% | 52.7% |
| 2b5uA02 | 1.10.287.620 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix Hairpins | 0.61 | 44.0 | 3.68e-01 | 74.7% | 88.2% |
| 6xz3A01 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.61 | 50.0 | 4.70e-01 | 90.5% | 82.9% |
| 3h36A00 | 1.10.10.400 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Polyribonucleotide nucleotidyltransferase, RNA-binding domain | 0.60 | 39.0 | 4.27e-01 | 74.7% | 80.8% |
| 1y4cA03 | 1.20.120.660 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › IL-4 antagonist (De novo design) like domain | 0.60 | 48.0 | 4.54e-01 | 93.7% | 72.6% |
| 1kxpD01 | 1.10.246.10 | Mainly Alpha › Orthogonal Bundle › Serum Albumin; Chain A, Domain 1 › | 0.60 | 46.0 | 4.82e-01 | 100.0% | 91.9% |
| 4w8pA02 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.60 | 49.0 | 4.46e-01 | 90.5% | 72.3% |
| 1b8dA00 | 1.10.490.20 | Mainly Alpha › Orthogonal Bundle › Globin-like › Phycocyanins | 0.60 | 49.0 | 4.15e-01 | 90.5% | 56.7% |
| 4p9tA01 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.59 | 48.0 | 4.46e-01 | 91.6% | 70.0% |
| 3i44A01 | 3.40.605.10 | Alpha Beta › 3-Layer(aba) Sandwich › Aldehyde Dehydrogenase; Chain A, domain 1 › Aldehyde Dehydrogenase; Chain A, domain 1 | 0.58 | 47.0 | 3.38e-01 | 88.4% | 76.5% |
| 1n5uA02 | 1.10.246.10 | Mainly Alpha › Orthogonal Bundle › Serum Albumin; Chain A, Domain 1 › | 0.58 | 45.0 | 4.58e-01 | 98.9% | 87.8% |
| 7dluA01 | 1.10.287.1260 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.58 | 46.0 | 4.51e-01 | 87.4% | 82.9% |
| 1rp3A01 | 1.10.1740.10 | Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › RNA polymerase sigma factor, region 2, helix turn helix motif | 0.57 | 46.0 | 4.83e-01 | 86.3% | 100.0% |
| 3kavA00 | 1.20.1270.360 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.56 | 41.0 | 4.01e-01 | 97.9% | 71.6% |
| 8hk0B03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.56 | 41.0 | 3.59e-01 | 75.8% | 85.5% |
| 3k3fA00 | 1.10.3430.10 | Mainly Alpha › Orthogonal Bundle › Ammonium transporter fold › Ammonium transporter AmtB like domains | 0.56 | 48.0 | 3.41e-01 | 100.0% | 66.3% |
| 1f45B00 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.55 | 41.0 | 3.68e-01 | 78.9% | 76.7% |
| 1zvzA02 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.55 | 44.0 | 4.14e-01 | 91.6% | 74.2% |
| 2o7gA00 | 1.10.1740.10 | Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › RNA polymerase sigma factor, region 2, helix turn helix motif | 0.54 | 43.0 | 4.43e-01 | 97.9% | 94.3% |
| 1h6gA02 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.54 | 43.0 | 4.02e-01 | 89.5% | 79.8% |
| 1t10A01 | 3.40.50.10490 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Glucose-6-phosphate isomerase like protein; domain 1 | 0.54 | 44.0 | 3.01e-01 | 91.6% | 75.9% |
| 6p73A02 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.53 | 40.0 | 3.58e-01 | 82.1% | 60.1% |
| 3n3uA00 | 1.10.3290.10 | Mainly Alpha › Orthogonal Bundle › Fic-like fold › Fido-like domain | 0.53 | 46.0 | 3.32e-01 | 100.0% | 88.7% |
| 2wb0X01 | 1.10.269.10 | Mainly Alpha › Orthogonal Bundle › Adenovirus Single-stranded Dna-binding Protein, domain 1 › Adenovirus DNA-binding, N-terminal domain | 0.52 | 38.0 | 3.60e-01 | 77.9% | 100.0% |
| 5figA00 | 1.20.1270.360 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.52 | 37.0 | 3.72e-01 | 97.9% | 72.0% |
| 4egwA02 | 1.20.58.340 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Magnesium transport protein CorA, transmembrane region | 0.51 | 37.0 | 3.46e-01 | 76.8% | 72.3% |
ECOD (44)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4331902 | 3355.1.1.14 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Lactate_perm | 0.96 | 93.0 | 5.59e-01 | 100.0% | 19.0% |
| 4048966 | 3355.1.1.14 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Lactate_perm | 0.95 | 91.0 | 5.60e-01 | 100.0% | 21.3% |
| 4964221 | 3355.1.1.14 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Lactate_perm | 0.93 | 89.0 | 5.37e-01 | 100.0% | 22.7% |
| 3711195 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.74 | 60.0 | 5.75e-01 | 87.4% | 95.5% |
| 3969505 | 142.1.1.0 ↗ | alpha complex topology › Sigma2 domain-like › Sigma2 domain of RNA polymerase sigma factors › Sigma2 domain of RNA polymerase sigma factors | 0.73 | 50.0 | 5.00e-01 | 77.9% | 69.5% |
| 4085257 | 547.1.1.4 ↗ | alpha duplicates or obligate multimers › Glutamyl tRNA-reductase dimerization domain › Glutamyl tRNA-reductase dimerization domain › Glutamyl tRNA-reductase dimerization domain › Shikimate_DH | 0.70 | 48.0 | 3.55e-01 | 70.5% | 31.1% |
| 3488922 | 109.3.1.181 ↗ | alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat › Serinc | 0.65 | 47.0 | 4.02e-01 | 76.8% | 50.3% |
| 4967612 | 3896.1.1.0 ↗ | alpha duplicates or obligate multimers › Intramembrane CDP-DAG synthetase-related › Intramembrane CDP-DAG synthetase-related › Intramembrane CDP-DAG synthetase | 0.64 | 58.0 | 4.61e-01 | 98.9% | 74.6% |
| 5029827 | 4070.1.1.0 ↗ | alpha arrays › FtsH protease domain-like › FtsH protease domain-like › FtsH protease domain-like | 0.63 | 51.0 | 4.03e-01 | 100.0% | 40.7% |
| 3413892 | 632.19.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Choline binding protein A › Choline binding protein A | 0.63 | 48.0 | 4.50e-01 | 82.1% | 65.0% |
| 4004623 | 192.5.1.15 ↗ | alpha bundles › Long alpha-hairpin › HR1 repeat › HR1 repeat › FxsA | 0.62 | 50.0 | 4.79e-01 | 88.4% | 77.3% |
| 3974030 | 1075.5.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › MatE | 0.61 | 55.0 | 4.10e-01 | 98.9% | 55.7% |
| 3181445 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.60 | 43.0 | 3.06e-01 | 76.8% | 27.9% |
| 4986380 | 1075.5.1.0 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter | 0.59 | 52.0 | 4.14e-01 | 100.0% | 55.5% |
| 5077194 | 191.1.1.0 ↗ | alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain | 0.59 | 51.0 | 4.78e-01 | 97.9% | 86.6% |
| 5050286 | 632.1.1.3 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain › Alpha-mann_mid | 0.59 | 43.0 | 4.23e-01 | 76.8% | 84.0% |
| 5078767 | 1076.1.1.1 ↗ | alpha bundles › Intramembrane protease Rce1-related › Intramembrane protease Rce1-related › Intramembrane protease Rce1-related › Rce1-like | 0.59 | 50.0 | 3.83e-01 | 94.7% | 81.3% |
| 3225374 | 601.1.2.6 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › Talin_IBS2B | 0.58 | 47.0 | 4.43e-01 | 90.5% | 70.8% |
| 5046308 | 1075.5.1.0 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter | 0.58 | 51.0 | 3.80e-01 | 100.0% | 43.1% |
| 4997741 | 1075.5.1.8 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › Polysacc_synt_3 | 0.58 | 52.0 | 4.14e-01 | 100.0% | 57.4% |
| 5061845 | 603.1.1.0 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins | 0.57 | 40.0 | 3.96e-01 | 76.8% | 69.0% |
| 5077996 | 1075.5.1.8 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › Polysacc_synt_3 | 0.57 | 50.0 | 3.58e-01 | 100.0% | 40.3% |
| 4952080 | 1075.5.1.0 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter | 0.56 | 49.0 | 3.91e-01 | 100.0% | 53.7% |
| 3279978 | 1075.5.1.0 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter | 0.55 | 48.0 | 3.97e-01 | 100.0% | 57.3% |
| 4953900 | 1075.5.1.2 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › MurJ | 0.55 | 49.0 | 3.53e-01 | 100.0% | 41.8% |
| 3953183 | 5073.1.2.0 ↗ | alpha bundles › Calcium ATPase transmembrane domain-related › Calcium ATPase transmembrane domain-related › Copper efflux ATPase transmembrane domain | 0.55 | 46.0 | 3.47e-01 | 93.7% | 85.2% |
| 4974047 | 1075.5.1.0 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter | 0.55 | 49.0 | 3.84e-01 | 100.0% | 56.5% |
| 5063887 | 1075.5.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › MatE | 0.55 | 48.0 | 3.75e-01 | 100.0% | 58.2% |
| 4972429 | 1075.5.1.0 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter | 0.55 | 48.0 | 3.57e-01 | 100.0% | 43.0% |
| 4988447 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.55 | 43.0 | 4.12e-01 | 86.3% | 88.7% |
| 4974860 | 1075.5.1.4 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › Polysacc_synt | 0.54 | 49.0 | 3.87e-01 | 100.0% | 57.9% |
| 3988973 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.54 | 45.0 | 4.20e-01 | 91.6% | 78.3% |
| 4973301 | 1075.5.1.4 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › Polysacc_synt | 0.54 | 48.0 | 3.78e-01 | 100.0% | 56.2% |
| 4955682 | 1075.5.1.4 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › Polysacc_synt | 0.54 | 47.0 | 3.84e-01 | 100.0% | 61.1% |
| 4950954 | 1075.5.1.0 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter | 0.54 | 47.0 | 3.76e-01 | 100.0% | 55.5% |
| 4438215 | 6056.1.1.2 ↗ | alpha arrays › SP1917-like › SP1917-like › SP1917-like › PrmC_N | 0.53 | 40.0 | 4.27e-01 | 78.9% | 100.0% |
| 5065782 | 1075.5.1.4 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › Polysacc_synt | 0.53 | 47.0 | 3.74e-01 | 100.0% | 57.0% |
| 5039267 | 1075.5.1.0 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter | 0.53 | 48.0 | 3.81e-01 | 100.0% | 60.5% |
| 3514002 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.52 | 39.0 | 3.51e-01 | 82.1% | 76.6% |
| 3593000 | 632.1.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain | 0.52 | 40.0 | 4.20e-01 | 87.4% | 96.5% |
| 4075540 | 4067.1.1.0 ↗ | alpha bundles › FdhE-like › FdhE-like › FdhE-like | 0.52 | 37.0 | 3.44e-01 | 75.8% | 60.0% |
| 4995712 | 142.1.1.0 ↗ | alpha complex topology › Sigma2 domain-like › Sigma2 domain of RNA polymerase sigma factors › Sigma2 domain of RNA polymerase sigma factors | 0.51 | 45.0 | 4.60e-01 | 100.0% | 100.0% |
| 4538265 | 1075.5.1.0 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter | 0.51 | 43.0 | 3.42e-01 | 96.8% | 62.4% |
| 5026840 | 109.3.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat | 0.50 | 39.0 | 3.29e-01 | 86.3% | 47.4% |
D5
medium
residues 425-553
Domain cluster:
rep: CAKLQF020000005.1__CAH1077933.1__SAMEA5780031_01166__00014__D348-474
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02652.21 best | Lactate_perm | 199.0 | 2.10e-58 | 93.0% | 22.8% |
CATH (26)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4akvA02 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.67 | 47.0 | 4.17e-01 | 72.9% | 90.5% |
| 6lumG01 | 1.20.1300.10 | Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Fumarate reductase/succinate dehydrogenase, transmembrane subunit | 0.65 | 46.0 | 4.94e-01 | 72.9% | 95.5% |
| 3dytA02 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.65 | 46.0 | 4.06e-01 | 72.9% | 90.5% |
| 3g9gA00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.64 | 45.0 | 3.65e-01 | 72.1% | 73.2% |
| 3s84A02 | 1.20.120.20 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein | 0.64 | 45.0 | 4.28e-01 | 73.6% | 84.7% |
| 8e9gJ01 | 1.20.120.1200 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ | 0.63 | 37.0 | 3.43e-01 | 76.0% | 45.5% |
| 8e9gK01 | 1.10.287.3510 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.62 | 39.0 | 4.52e-01 | 73.6% | 89.0% |
| 2mabA00 | 1.10.10.1350 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Spidroin domain, C-terminal domain | 0.61 | 36.0 | 3.93e-01 | 72.1% | 68.8% |
| 2jqqA00 | 1.20.58.1240 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.61 | 35.0 | 3.35e-01 | 75.2% | 46.1% |
| 3i2wA01 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.58 | 42.0 | 3.36e-01 | 75.2% | 81.4% |
| 3g7rA00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.57 | 49.0 | 4.33e-01 | 92.2% | 66.7% |
| 4bemJ00 | 1.20.120.610 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › lithium bound rotor ring of v- atpase | 0.56 | 41.0 | 3.74e-01 | 76.7% | 76.2% |
| 4an8A02 | 1.10.132.100 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › | 0.56 | 38.0 | 3.94e-01 | 72.9% | 73.0% |
| 4iu9B02 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.55 | 46.0 | 3.97e-01 | 89.9% | 67.5% |
| 6xkyA01 | 1.20.1330.10 | Mainly Alpha › Up-down Bundle › f41 fragment of flagellin, N-terminal domain › f41 fragment of flagellin, N-terminal domain | 0.54 | 43.0 | 3.80e-01 | 84.5% | 74.3% |
| 2j1oA00 | 1.10.600.10 | Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase | 0.53 | 43.0 | 3.50e-01 | 87.6% | 61.2% |
| 1jgcA00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.53 | 39.0 | 3.70e-01 | 77.5% | 88.1% |
| 1nfvA00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.53 | 39.0 | 3.63e-01 | 77.5% | 83.4% |
| 1ah7A00 | 1.10.575.10 | Mainly Alpha › Orthogonal Bundle › P1 Nuclease › P1 Nuclease | 0.52 | 46.0 | 3.77e-01 | 96.9% | 66.1% |
| 3on2A00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.52 | 46.0 | 4.06e-01 | 97.7% | 72.6% |
| 7uzqK01 | 1.10.3430.10 | Mainly Alpha › Orthogonal Bundle › Ammonium transporter fold › Ammonium transporter AmtB like domains | 0.52 | 46.0 | 3.34e-01 | 97.7% | 85.6% |
| 5bqnA02 | 1.20.1120.10 | Mainly Alpha › Up-down Bundle › "Clostridium botulinum neurotoxin B, ""coiled-coil"" domain" › "Clostridium botulinum neurotoxin b, ""coiled-coil"" domain" | 0.51 | 44.0 | 3.27e-01 | 97.7% | 78.9% |
| 4flbA00 | 1.25.40.90 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.51 | 38.0 | 3.87e-01 | 100.0% | 78.6% |
| 3fmsA02 | 1.20.120.530 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › GntR ligand-binding domain-like | 0.50 | 40.0 | 3.96e-01 | 85.3% | 92.9% |
| 4iu9B01 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.50 | 42.0 | 3.50e-01 | 89.1% | 63.4% |
| 3o6xA02 | 1.20.120.1560 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › | 0.50 | 35.0 | 3.41e-01 | 72.1% | 71.6% |
ECOD (63)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4331902 | 3355.1.1.14 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Lactate_perm | 0.98 | 92.0 | 5.88e-01 | 96.9% | 24.8% |
| 4990006 | 3355.1.1.14 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Lactate_perm | 0.96 | 93.0 | 6.00e-01 | 100.0% | 26.9% |
| 5061183 | 3355.1.1.14 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Lactate_perm | 0.96 | 89.0 | 5.85e-01 | 96.9% | 27.9% |
| 4959752 | 3355.1.1.14 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Lactate_perm | 0.95 | 88.0 | 5.63e-01 | 95.3% | 28.9% |
| 3965043 | 3355.1.1.14 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Lactate_perm | 0.94 | 86.0 | 5.70e-01 | 94.6% | 29.1% |
| 5048227 | 3355.1.1.14 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Lactate_perm | 0.94 | 88.0 | 5.72e-01 | 96.9% | 30.1% |
| 3163965 | 3355.1.1.14 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Lactate_perm | 0.93 | 89.0 | 5.72e-01 | 98.4% | 26.9% |
| 5083410 | 3355.1.1.0 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter | 0.92 | 84.0 | 5.73e-01 | 94.6% | 32.4% |
| 4964221 | 3355.1.1.14 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Lactate_perm | 0.90 | 85.0 | 5.37e-01 | 96.9% | 69.0% |
| 5064843 | 3355.1.1.2 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › CitMHS | 0.87 | 81.0 | 5.52e-01 | 99.2% | 33.2% |
| 4963256 | 3355.1.1.2 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › CitMHS | 0.84 | 77.0 | 5.14e-01 | 96.9% | 30.0% |
| 5062923 | 3355.1.1.1 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Na_sulph_symp | 0.83 | 77.0 | 5.37e-01 | 97.7% | 34.4% |
| 4949155 | 3355.1.1.2 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › CitMHS | 0.83 | 73.0 | 5.13e-01 | 94.6% | 32.7% |
| 4998532 | 3355.1.1.1 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Na_sulph_symp | 0.82 | 75.0 | 4.99e-01 | 96.1% | 95.2% |
| 4010800 | 3355.1.1.16 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › DcuC | 0.82 | 73.0 | 4.91e-01 | 94.6% | 28.7% |
| 5063799 | 3355.1.1.8 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Na_H_antiporter | 0.82 | 75.0 | 5.00e-01 | 99.2% | 27.9% |
| 3942409 | 3355.1.1.3 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › ABG_transport | 0.82 | 76.0 | 5.03e-01 | 100.0% | 31.1% |
| 5017419 | 3355.1.1.2 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › CitMHS | 0.81 | 74.0 | 5.09e-01 | 96.9% | 32.2% |
| 3963976 | 3355.1.1.8 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Na_H_antiporter | 0.81 | 69.0 | 4.66e-01 | 91.5% | 28.7% |
| None | — | 0.81 | 75.0 | 4.96e-01 | 100.0% | 30.0% | |
| 4032976 | 3355.1.1.3 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › ABG_transport | 0.81 | 75.0 | 4.93e-01 | 100.0% | 29.2% |
| 3278891 | 3355.1.1.5 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › SCFA_trans | 0.80 | 74.0 | 4.99e-01 | 100.0% | 29.5% |
| 3389849 | 3355.1.1.21 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Na_sulph_symp, CitMHS | 0.80 | 74.0 | 4.81e-01 | 99.2% | 25.2% |
| 3943055 | 3355.1.1.16 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › DcuC | 0.80 | 72.0 | 4.84e-01 | 96.9% | 72.7% |
| 4569735 | 3355.1.1.21 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Na_sulph_symp, CitMHS | 0.79 | 72.0 | 4.94e-01 | 96.9% | 99.5% |
| 5020409 | 3355.1.1.11 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › GntP_permease | 0.79 | 74.0 | 4.96e-01 | 100.0% | 76.9% |
| 3624834 | 3355.1.1.21 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Na_sulph_symp, CitMHS | 0.79 | 73.0 | 4.76e-01 | 100.0% | 25.7% |
| 1409928 | 3355.1.1.2 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › CitMHS | 0.78 | 70.0 | 4.75e-01 | 95.3% | 93.7% |
| 3245918 | 3355.1.1.1 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Na_sulph_symp | 0.78 | 73.0 | 4.78e-01 | 100.0% | 26.2% |
| 3245799 | 3355.1.1.1 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Na_sulph_symp | 0.78 | 73.0 | 4.83e-01 | 100.0% | 95.2% |
| 3867881 | 3355.1.1.1 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Na_sulph_symp | 0.78 | 72.0 | 4.86e-01 | 100.0% | 28.6% |
| 1545111 | 3355.1.1.3 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › ABG_transport | 0.78 | 72.0 | 4.73e-01 | 100.0% | 29.4% |
| 3562959 | 3355.1.1.21 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Na_sulph_symp, CitMHS | 0.77 | 71.0 | 4.68e-01 | 100.0% | 26.5% |
| 3481410 | 3355.1.1.1 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Na_sulph_symp | 0.77 | 71.0 | 4.67e-01 | 100.0% | 25.4% |
| 5004389 | 3355.1.1.11 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › GntP_permease | 0.77 | 72.0 | 4.91e-01 | 100.0% | 75.7% |
| 4972055 | 3355.1.1.0 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter | 0.77 | 72.0 | 4.99e-01 | 100.0% | 34.1% |
| 5033193 | 3355.1.1.41 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › DUF401 | 0.77 | 68.0 | 4.75e-01 | 96.9% | 30.6% |
| 3556322 | 3355.1.1.1 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › Na_sulph_symp | 0.77 | 71.0 | 4.58e-01 | 100.0% | 23.4% |
| 4982691 | 3355.1.1.41 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › DUF401 | 0.76 | 68.0 | 4.79e-01 | 96.1% | 32.6% |
| 4950983 | 3355.1.1.11 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › GntP_permease | 0.76 | 72.0 | 4.91e-01 | 100.0% | 76.1% |
| 4994403 | 109.3.1.480 ↗ | alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat › Na_H_antiporter | 0.76 | 67.0 | 6.41e-01 | 94.6% | 86.2% |
| 4031025 | 3355.1.1.2 ↗ | alpha complex topology › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › dicarboxylate/sodium symporter › CitMHS | 0.75 | 67.0 | 4.57e-01 | 96.9% | 77.8% |
| 5059534 | 1075.1.1.0 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › ABCG5/ABCG8 transmembrane domain | 0.72 | 62.0 | 5.12e-01 | 93.0% | 76.5% |
| 4823728 | 109.3.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat | 0.66 | 39.0 | 4.33e-01 | 79.1% | 72.1% |
| 3464571 | 106.1.1.0 ↗ | alpha arrays › Globin-like › Globin-like › Globin-like | 0.62 | 44.0 | 3.60e-01 | 72.1% | 48.3% |
| 3517735 | 4177.1.1.2 ↗ | alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › BAR | 0.61 | 45.0 | 3.85e-01 | 75.2% | 86.5% |
| 3459964 | 191.1.1.0 ↗ | alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain | 0.61 | 48.0 | 4.33e-01 | 83.7% | 87.4% |
| 5025472 | 1075.5.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › MatE | 0.58 | 45.0 | 3.88e-01 | 82.9% | 68.6% |
| 4405286 | 604.39.1.12 ↗ | alpha bundles › Spectrin repeat-like › S-component of energy-coupling factor (ECF) transporters › S-component of energy-coupling factor (ECF) transporters › VTT_dom | 0.57 | 49.0 | 4.28e-01 | 95.3% | 86.3% |
| 3277417 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.57 | 47.0 | 3.59e-01 | 87.6% | 88.3% |
| 4998866 | 1075.1.2.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › MacB transmembrane domain › FtsX | 0.56 | 40.0 | 3.53e-01 | 74.4% | 95.0% |
| 3192242 | 604.39.1.0 ↗ | alpha bundles › Spectrin repeat-like › S-component of energy-coupling factor (ECF) transporters › S-component of energy-coupling factor (ECF) transporters | 0.56 | 49.0 | 4.54e-01 | 97.7% | 89.4% |
| 5001603 | 198.1.1.0 ↗ | alpha arrays › Saposin-like › Saposin-like › Saposin-like | 0.55 | 38.0 | 4.33e-01 | 76.0% | 98.9% |
| 3779631 | 4177.1.1.0 ↗ | alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like | 0.55 | 39.0 | 3.44e-01 | 74.4% | 73.5% |
| 3753760 | 5082.1.1.0 ↗ | alpha bundles › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like | 0.54 | 47.0 | 3.99e-01 | 96.9% | 88.2% |
| 3058105 | 1175.1.1.1 ↗ | alpha complex topology › Apolipoprotein N-acyltransferase transmembrane domain › Apolipoprotein N-acyltransferase transmembrane domain › Apolipoprotein N-acyltransferase transmembrane domain › LNT_N | 0.54 | 45.0 | 3.80e-01 | 92.2% | 58.0% |
| 3873866 | 633.23.1.34 ↗ | alpha bundles › Bromodomain-like › Claudin › Claudin › CD20 | 0.54 | 38.0 | 3.38e-01 | 77.5% | 51.1% |
| 3616343 | 601.1.1.97 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › DNA_repr_REX1B | 0.53 | 41.0 | 4.13e-01 | 84.5% | 96.3% |
| 5002530 | 1079.1.1.11 ↗ | alpha complex topology › Transmembrane reductase CcdA › Transmembrane reductase CcdA › Transmembrane reductase CcdA › NicO | 0.53 | 42.0 | 3.68e-01 | 87.6% | 73.2% |
| 5052922 | 601.4.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains | 0.52 | 42.0 | 4.31e-01 | 87.6% | 99.2% |
| 3706598 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.52 | 43.0 | 3.68e-01 | 89.9% | 70.2% |
| 3500286 | 601.1.3.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › A middle domain of Talin 1 | 0.51 | 44.0 | 3.80e-01 | 95.3% | 72.4% |
| 3711200 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.51 | 45.0 | 3.16e-01 | 100.0% | 75.0% |