Back to structures

CAKLQF020000014.1__CAH1087254.1__SAMEA5780031_02648__00069

Bact-Vir

CAKLQF020000014.1__CAH1087254.1__SAMEA5780031_02648__00069

Identity

Kingdom:
phage

Quality

88.3 mean pLDDT

Cluster

Singleton — not in a non-trivial cluster

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 303-424
PDB
Domain cluster: representative
CATH (38)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1wn0A00 1.20.120.160 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain 0.73 40.0 3.89e-01 80.3% 48.9%
4dwlA00 1.20.1440.60 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 23S rRNA-intervening sequence 0.65 51.0 5.36e-01 100.0% 92.6%
2rldA00 1.20.1440.60 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 23S rRNA-intervening sequence 0.65 55.0 5.67e-01 100.0% 96.5%
1yo7A00 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.62 54.0 5.52e-01 100.0% 95.8%
4f0cA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.62 47.0 4.53e-01 79.5% 73.9%
3i9wA00 1.20.58.920 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.62 58.0 4.39e-01 100.0% 50.0%
4nn1A00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.62 47.0 3.98e-01 80.3% 81.0%
1qkrB00 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.60 48.0 4.26e-01 99.2% 58.3%
7ldgA00 1.25.10.10 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant 0.60 45.0 3.73e-01 79.5% 47.7%
4mdcD02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.60 45.0 4.54e-01 79.5% 84.6%
3himA00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.59 46.0 3.99e-01 82.8% 83.2%
1i5pA02 1.20.190.10 Mainly Alpha › Up-down Bundle › Delta-Endotoxin; domain 1 › Pesticidal crystal protein, N-terminal domain 0.59 50.0 4.06e-01 93.4% 85.0%
3ggyA00 1.20.1260.60 Mainly Alpha › Up-down Bundle › Ferritin › Vacuolar protein sorting-associated protein Ist1 0.58 53.0 4.61e-01 100.0% 71.0%
3dcfA02 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.58 40.0 3.79e-01 76.2% 59.9%
1qoyA00 1.20.1170.10 Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; › 0.58 52.0 3.92e-01 100.0% 74.3%
4cqiA00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.58 46.0 4.93e-01 88.5% 95.3%
3thxB03 1.10.1420.10 Mainly Alpha › Orthogonal Bundle › MutS, DNA mismatch repair protein; Chain A, domain 3 › 0.58 46.0 4.01e-01 84.4% 65.8%
2xqyA01 3.30.500.50 Alpha Beta › 2-Layer Sandwich › Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1 › 0.58 51.0 4.57e-01 99.2% 94.9%
3sl9B00 1.25.10.10 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant 0.58 44.0 4.02e-01 82.8% 60.0%
3hlzA02 1.20.120.1090 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.58 34.0 3.43e-01 99.2% 55.0%
1sumB01 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.58 40.0 4.25e-01 86.1% 81.3%
4j8sA00 1.25.40.840 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › CCR4-NOT transcription complex subunit 1 TTP binding domain 0.58 50.0 4.38e-01 94.3% 72.8%
1li5A02 1.20.120.640 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 0.58 35.0 4.03e-01 70.5% 83.9%
1cnt200 1.20.1250.10 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › 0.56 39.0 3.89e-01 100.0% 68.5%
4nt1A00 1.10.3520.10 Mainly Alpha › Orthogonal Bundle › Glycolipid transfer protein, GLTP › Glycolipid transfer protein 0.55 48.0 4.17e-01 100.0% 85.5%
1ed1A00 1.10.150.90 Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Immunodeficiency lentiviruses, gag gene matrix protein p17 0.54 36.0 3.78e-01 100.0% 72.8%
1z9hA03 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.54 41.0 3.82e-01 79.5% 87.4%
2zxqA06 1.20.1270.70 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Designed single chain three-helix bundle 0.54 30.0 3.73e-01 80.3% 97.0%
4akvA02 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.54 39.0 3.38e-01 76.2% 89.5%
3au4A01 1.25.40.530 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › MyTH4 domain 0.54 48.0 4.11e-01 99.2% 74.5%
3fseB02 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.53 42.0 4.02e-01 100.0% 71.5%
2rekA00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.53 41.0 3.71e-01 83.6% 79.1%
7ccmB01 1.10.437.10 Mainly Alpha › Orthogonal Bundle › Apoptosis Regulator Bcl-x › Blc2-like 0.52 42.0 4.07e-01 89.3% 87.4%
2vvyA01 1.10.437.20 Mainly Alpha › Orthogonal Bundle › Apoptosis Regulator Bcl-x › dsDNA poxvirus 0.52 42.0 4.14e-01 89.3% 82.1%
4fm3A00 1.20.1270.390 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.52 32.0 3.51e-01 82.8% 76.8%
6z74C02 1.20.120.530 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › GntR ligand-binding domain-like 0.52 33.0 3.07e-01 80.3% 49.1%
4nqiD00 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.51 39.0 3.16e-01 80.3% 77.6%
1jwnA00 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.51 44.0 4.25e-01 99.2% 98.6%
ECOD (45)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
5038873 603.1.1.0 alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.72 48.0 5.49e-01 89.3% 92.2%
3691841 601.1.1.0 alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin 0.71 64.0 5.50e-01 100.0% 91.3%
4054419 604.12.1.78 alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › FUSC 0.70 51.0 4.62e-01 100.0% 55.8%
3614644 604.12.1.0 alpha bundles › Spectrin repeat-like › MIT domain › MIT domain 0.70 54.0 5.67e-01 99.2% 89.1%
3176648 603.1.1.6 alpha bundles › STAT-like › t-snare proteins › t-snare proteins › Syntaxin_2 0.69 51.0 4.37e-01 78.7% 85.5%
3808989 603.1.1.0 alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.68 51.0 5.60e-01 79.5% 99.0%
4972684 150.3.1.0 alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › 4-helical cytokines › 4-helical cytokine 0.67 52.0 5.50e-01 100.0% 91.8%
3525986 148.1.3.0 alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain 0.63 47.0 4.93e-01 94.3% 87.3%
3959899 1153.1.1.0 alpha superhelices › Helical domain in conserved hypothetical protein Rv3899c › Helical domain in conserved hypothetical protein Rv3899c › Helical domain in conserved hypothetical protein Rv3899c 0.62 47.0 4.34e-01 100.0% 61.9%
3540972 174.1.1.34 few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › FAM70 0.62 56.0 5.25e-01 100.0% 84.7%
3962643 101.1.1.5 alpha arrays › HTH › HTH › Three-helical HTH › TetR_N 0.61 41.0 3.80e-01 76.2% 52.5%
4651060 633.22.1.0 alpha bundles › Bromodomain-like › Vitamin K epoxide reductase (VKOR) › Vitamin K epoxide reductase (VKOR) 0.61 53.0 4.84e-01 100.0% 70.9%
3621307 601.54.1.0 alpha bundles › Four-helical up-and-down bundle › low CO2-inducible protein LCI1 › low CO2-inducible protein LCI1 0.61 55.0 4.99e-01 100.0% 92.7%
3735904 601.4.1.51 alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains › PigN 0.61 54.0 4.78e-01 100.0% 67.4%
3793454 150.1.1.0 alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin 0.61 55.0 4.87e-01 100.0% 87.4%
3591733 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.60 44.0 4.20e-01 91.8% 65.7%
5005724 3755.3.1.637 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › DUF7121 0.60 45.0 3.64e-01 91.8% 40.9%
3758651 633.23.1.34 alpha bundles › Bromodomain-like › Claudin › Claudin › CD20 0.59 53.0 4.64e-01 100.0% 88.9%
3282706 174.1.1.0 few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain 0.59 49.0 4.86e-01 100.0% 85.4%
3428358 633.4.1.1 alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI 0.59 53.0 4.66e-01 100.0% 80.4%
3514684 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.58 43.0 4.48e-01 88.5% 81.7%
4015041 150.1.1.0 alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin 0.58 50.0 4.45e-01 100.0% 65.0%
3625427 174.1.1.0 few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain 0.57 47.0 4.83e-01 100.0% 93.0%
3437255 611.7.1.1 alpha bundles › N-cbl like › Mixed lineage kinase domain-like (MLKL) N-terminal domain › Mixed lineage kinase domain-like (MLKL) N-terminal domain › MLKL_N 0.56 36.0 3.69e-01 77.9% 64.2%
4525539 5069.1.1.88 alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes › Bombinin 0.56 47.0 4.75e-01 100.0% 90.0%
3696846 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.56 44.0 3.11e-01 85.2% 37.9%
3816774 601.1.1.0 alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin 0.56 46.0 4.24e-01 99.2% 68.4%
3728798 601.1.1.0 alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin 0.55 45.0 3.99e-01 86.9% 70.3%
4108162 140.1.1.4 alpha bundles › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › tRNA-synt_1e,DALR_2 0.55 40.0 3.73e-01 92.6% 60.0%
3486940 601.1.2.0 alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) 0.54 49.0 3.98e-01 100.0% 91.7%
4999571 4156.1.1.1 alpha arrays › Sec63 N-terminal subdomain-like › Sec63 N-terminal subdomain-like › Sec63 N-terminal subdomain-like › Sec63 0.53 45.0 4.41e-01 91.8% 85.2%
3218640 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.53 41.0 4.03e-01 87.7% 76.9%
3284685 1174.1.1.2 alpha complex topology › Potassium channel TMEM175 › Potassium channel TMEM175 › Potassium channel TMEM175 › LtrA 0.52 45.0 3.88e-01 100.0% 59.5%
4223629 140.1.1.0 alpha bundles › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 0.52 42.0 3.48e-01 86.1% 48.2%
3727071 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.52 47.0 3.25e-01 100.0% 43.5%
1157195 5000.3.1.3 alpha arrays › Toxins' membrane translocation domains › Bcl-2 inhibitors of programmed cell death › Bcl-2 inhibitors of programmed cell death › Poxv_Bcl-2-like 0.52 42.0 4.08e-01 89.3% 99.3%
5022783 603.1.1.0 alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.52 44.0 3.95e-01 95.1% 83.3%
3657174 5069.1.1.7 alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes › Cytochrom_B561 0.52 46.0 4.19e-01 100.0% 72.1%
3200410 5050.1.1.50 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › DUF1275 0.52 47.0 3.98e-01 100.0% 91.0%
4348932 5069.1.3.1 alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Fumarate reductase respiratory complex transmembrane subunits › Sdh_cyt 0.51 36.0 3.69e-01 73.0% 85.8%
3511563 192.29.1.143 alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › CCDC28 0.51 39.0 4.18e-01 80.3% 98.1%
None 0.51 36.0 3.15e-01 82.0% 48.1%
3165845 5059.1.1.1 alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › EamA 0.51 45.0 3.46e-01 99.2% 93.0%
3289490 109.4.1.777 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.50 44.0 3.11e-01 100.0% 30.7%
1148165 3859.1.1.1 alpha arrays › uncharacterized protein BT_1490 C-terminal domain › uncharacterized protein BT_1490 C-terminal domain › uncharacterized protein BT_1490 C-terminal domain › DUF3806 0.50 35.0 3.47e-01 72.1% 78.9%
D2 medium residues 31-167_258-298_430-450
PDB
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF01384.26 best PHO4 57.7 1.50e-15 44.2% 23.2%
PF01384.26 PHO4 45.2 9.50e-12 32.2% 18.8%
CATH (12)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
8sbeA02 1.20.1250.20 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains 0.60 38.0 3.92e-01 98.5% 66.3%
7qoaA01 1.10.4160.10 Mainly Alpha › Orthogonal Bundle › Hydantoin permease › Hydantoin permease 0.58 47.0 3.78e-01 84.9% 61.5%
4oydB00 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.56 32.0 4.16e-01 81.9% 95.7%
1sumB01 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.56 28.0 3.70e-01 79.4% 86.9%
4rm7A03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.55 28.0 3.28e-01 83.9% 66.9%
4p9fA02 1.20.120.530 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › GntR ligand-binding domain-like 0.55 30.0 3.42e-01 99.0% 68.8%
2kbbA00 1.20.1420.10 Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › Talin, central domain 0.52 37.0 3.97e-01 74.9% 82.8%
3ihuA02 1.20.120.530 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › GntR ligand-binding domain-like 0.51 31.0 3.64e-01 83.9% 84.2%
1eq1A00 1.20.120.20 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein 0.51 36.0 3.93e-01 77.4% 85.5%
3vnxA00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.51 36.0 3.67e-01 78.9% 72.3%
5u1aL00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.51 34.0 3.67e-01 75.9% 79.5%
1ileA03 1.10.730.10 Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1 0.50 34.0 3.54e-01 74.4% 70.7%
ECOD (34)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3285707 5051.1.1.28 alpha complex topology › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › PHO4 0.93 74.0 5.81e-01 81.9% 65.7%
3482492 5025.1.1.4 extended segments › PetL subunit of the cytochrome b6f complex › PetL subunit of the cytochrome b6f complex › PetL subunit of the cytochrome b6f complex › PHO4 0.88 72.0 7.13e-01 83.4% 99.0%
3479678 5025.1.1.0 extended segments › PetL subunit of the cytochrome b6f complex › PetL subunit of the cytochrome b6f complex › PetL subunit of the cytochrome b6f complex 0.88 71.0 7.09e-01 83.4% 99.0%
3744749 1075.5.1.1 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › MatE 0.62 44.0 4.05e-01 97.0% 56.9%
3692241 5050.1.1.0 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.61 41.0 3.97e-01 98.0% 58.7%
3194749 5050.1.1.0 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.61 41.0 3.91e-01 98.5% 57.0%
3686303 5050.1.1.0 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.59 39.0 3.66e-01 98.5% 53.9%
3722487 5050.1.1.0 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.58 41.0 3.91e-01 98.5% 61.3%
3974030 1075.5.1.1 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › MatE 0.58 41.0 3.88e-01 97.0% 60.0%
4086267 1075.5.1.1 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › MatE 0.58 41.0 3.89e-01 97.0% 60.0%
3607601 1075.5.1.1 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › MatE 0.58 41.0 3.89e-01 97.0% 58.7%
3278851 3538.1.1.4 extended segments › MerF › MerF › MerF › LysE 0.58 46.0 4.60e-01 83.9% 86.5%
4169514 5050.1.1.54 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Mntp 0.58 45.0 4.66e-01 82.4% 88.1%
4099500 1075.5.1.1 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › MatE 0.58 40.0 3.89e-01 97.0% 62.2%
3195546 1075.1.1.5 alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › ABCG5/ABCG8 transmembrane domain › STIMATE 0.57 46.0 4.78e-01 84.9% 100.0%
3349368 1075.5.1.1 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › MatE 0.57 41.0 3.90e-01 97.0% 62.2%
4554168 1079.1.1.13 alpha complex topology › Transmembrane reductase CcdA › Transmembrane reductase CcdA › Transmembrane reductase CcdA › Mntp 0.56 40.0 4.29e-01 82.4% 84.0%
3963223 1075.5.1.1 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › MatE 0.56 39.0 3.75e-01 97.0% 60.0%
5007071 5051.1.1.3 alpha complex topology › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › SSF 0.56 43.0 3.26e-01 80.4% 60.2%
4955442 1075.5.1.1 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › MatE 0.56 40.0 3.90e-01 98.0% 66.5%
3320854 1075.5.1.1 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › MatE 0.56 40.0 3.68e-01 98.0% 56.3%
3279638 1075.5.1.1 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › MatE 0.56 39.0 3.71e-01 97.0% 60.0%
3337490 1075.5.1.1 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › MatE 0.55 39.0 3.71e-01 98.0% 58.4%
4004547 1075.5.1.1 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › MatE 0.55 38.0 3.61e-01 97.0% 56.4%
3964144 1079.1.1.9 alpha complex topology › Transmembrane reductase CcdA › Transmembrane reductase CcdA › Transmembrane reductase CcdA › Cad 0.53 43.0 4.31e-01 89.4% 82.8%
4238557 1188.1.1.3 alpha bundles › ZIP zinc transporter › ZIP zinc transporter › ZIP zinc transporter › Mntp 0.53 40.0 4.19e-01 78.9% 85.0%
3589113 1075.5.1.2 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › MurJ 0.53 38.0 3.36e-01 97.0% 48.8%
3785556 5051.1.1.9 alpha complex topology › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › Transp_cyt_pur 0.53 42.0 3.18e-01 83.4% 53.7%
4986380 1075.5.1.0 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter 0.53 36.0 3.65e-01 97.0% 67.5%
4932476 1079.1.1.0 alpha complex topology › Transmembrane reductase CcdA › Transmembrane reductase CcdA › Transmembrane reductase CcdA 0.51 42.0 4.22e-01 89.4% 86.2%
3955855 1079.1.1.0 alpha complex topology › Transmembrane reductase CcdA › Transmembrane reductase CcdA › Transmembrane reductase CcdA 0.51 44.0 4.19e-01 92.0% 83.9%
3742401 5050.1.1.0 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.51 41.0 4.04e-01 86.9% 78.6%
4196666 5050.1.1.0 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.50 41.0 4.01e-01 84.9% 99.1%
4015065 1075.4.1.0 alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold 0.50 42.0 3.54e-01 98.0% 52.8%
D3 medium residues 168-257_451-543
PDB
Domain cluster: representative
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF01384.26 best PHO4 79.0 4.90e-22 47.5% 23.0%
PF01384.26 PHO4 50.5 2.30e-13 43.7% 17.6%
CATH (13)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3g0oA02 1.10.1040.10 Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 0.67 29.0 3.52e-01 78.7% 59.5%
4dllB02 1.10.1040.10 Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 0.63 29.0 3.43e-01 79.8% 59.2%
2uyyA02 1.10.1040.10 Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 0.63 28.0 3.35e-01 72.1% 58.5%
4hehA01 1.10.1240.10 Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › Methionine synthase domain 0.59 23.0 3.35e-01 92.9% 77.1%
4c1bA02 3.40.50.12700 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.58 28.0 3.56e-01 72.1% 78.6%
8cdaC01 1.10.540.10 Mainly Alpha › Orthogonal Bundle › Butyryl-Coa Dehydrogenase, subunit A; domain 1 › Acyl-CoA dehydrogenase/oxidase, N-terminal domain 0.57 26.0 3.15e-01 94.0% 63.2%
1f0jA00 1.10.1300.10 Mainly Alpha › Orthogonal Bundle › Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b › 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain 0.54 34.0 2.76e-01 92.3% 32.2%
2yfaA02 1.20.1440.210 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 0.52 32.0 3.89e-01 77.0% 94.8%
2zy9A03 1.10.357.20 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › SLC41 divalent cation transporters, integral membrane domain 0.52 40.0 4.08e-01 89.6% 82.8%
3vkgA15 1.10.8.1220 Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › 0.52 28.0 3.68e-01 88.0% 98.9%
8ex5A01 1.20.1250.20 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains 0.51 42.0 4.14e-01 100.0% 80.6%
3w6zA02 1.10.1040.10 Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 0.51 27.0 3.15e-01 94.5% 71.1%
5je8B02 1.10.1040.10 Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 0.50 26.0 3.05e-01 94.5% 67.2%
ECOD (27)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3285707 5051.1.1.28 alpha complex topology › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › PHO4 0.85 83.0 6.31e-01 100.0% 63.8%
3732153 3567.1.1.119 a+b duplicates or obligate multimers › MPER trimer › MPER trimer › MPER trimer › PHO4 0.81 77.0 6.01e-01 99.5% 70.7%
4627351 5051.1.1.28 alpha complex topology › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › PHO4 0.80 75.0 5.62e-01 97.3% 74.9%
3174202 5067.1.1.28 alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › PHO4 0.78 76.0 5.94e-01 100.0% 69.7%
3164754 1078.1.1.7 extended segments › Bd-type quinol oxidase transmembrane helix subunit › Bd-type quinol oxidase transmembrane helix subunit › Bd-type quinol oxidase transmembrane helix subunit › PHO4 0.77 74.0 5.91e-01 100.0% 67.7%
5000600 1075.5.1.4 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › Polysacc_synt 0.59 45.0 4.25e-01 86.9% 65.9%
4997858 1075.1.2.0 alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › MacB transmembrane domain 0.58 37.0 3.85e-01 98.9% 67.6%
3937657 3236.1.1.1 alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Na_H_Exchanger 0.57 49.0 3.70e-01 98.9% 39.8%
3171523 5086.1.1.119 alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › RRG1_C 0.56 41.0 4.60e-01 96.2% 97.1%
5044316 1075.1.1.68 alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › ABCG5/ABCG8 transmembrane domain › ABC_tran_2 0.55 42.0 3.56e-01 78.7% 67.8%
4025640 3236.1.1.1 alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Na_H_Exchanger 0.55 45.0 3.42e-01 98.9% 37.4%
3966956 5059.1.1.1 alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › EamA 0.54 39.0 3.38e-01 72.7% 100.0%
4945171 1075.5.1.0 alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter 0.54 41.0 3.96e-01 91.8% 68.6%
3732454 5050.1.1.0 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.54 45.0 4.21e-01 96.2% 72.4%
3974312 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.53 43.0 4.21e-01 96.2% 78.5%
3599108 3236.1.1.0 alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) 0.53 43.0 3.36e-01 97.8% 38.8%
3165509 3470.1.1.41 extended segments › Glycophorin-A transmembrane domain › Glycophorin-A transmembrane domain › Glycophorin-A transmembrane domain › VTT_dom 0.53 38.0 4.06e-01 95.6% 82.4%
3988357 1075.4.1.1 alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane 0.52 41.0 3.51e-01 83.1% 74.8%
4023191 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.52 42.0 3.65e-01 98.4% 56.0%
3284641 5050.1.1.0 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.52 40.0 4.02e-01 98.4% 78.4%
3736631 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.52 43.0 4.02e-01 97.8% 70.0%
4334900 3615.1.1.1 alpha bundles › Bacterial dynamin-like protein helical domain › Bacterial dynamin-like protein helical domain › Bacterial dynamin-like protein helical domain › Fzo_mitofusin 0.52 43.0 3.97e-01 89.1% 82.1%
4859375 3236.1.1.1 alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Na_H_Exchanger 0.51 42.0 3.64e-01 100.0% 56.0%
5062416 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.51 41.0 3.99e-01 100.0% 75.1%
3437048 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.51 44.0 3.94e-01 100.0% 65.9%
4645505 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.51 40.0 4.05e-01 98.4% 81.6%
5066876 1079.1.1.12 alpha complex topology › Transmembrane reductase CcdA › Transmembrane reductase CcdA › Transmembrane reductase CcdA › GDT1 0.51 38.0 3.97e-01 97.8% 81.1%