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CAKLQF020000025.1__CAH1092122.1__SAMEA5780031_03489__00026
Bact-VirCAKLQF020000025.1__CAH1092122.1__SAMEA5780031_03489__00026
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 24-104
Domain cluster:
rep: OP186293.1__UVD36581.1__RCXUPER_163__00134__D32-101
CATH (32)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1rp3A01 | 1.10.1740.10 | Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › RNA polymerase sigma factor, region 2, helix turn helix motif | 0.84 | 48.0 | 4.78e-01 | 100.0% | 55.3% |
| 1vkeB00 | 1.20.1290.10 | Mainly Alpha › Up-down Bundle › AhpD-like › AhpD-like | 0.70 | 51.0 | 4.73e-01 | 76.5% | 62.4% |
| 6vxcA01 | 3.20.70.20 | Alpha Beta › Alpha-Beta Barrel › Anaerobic Ribonucleotide-triphosphate Reductase Large Chain › | 0.69 | 49.0 | 2.82e-01 | 100.0% | 7.8% |
| 3cr3A00 | 1.25.40.340 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › DhaL domain | 0.65 | 46.0 | 3.55e-01 | 75.3% | 37.0% |
| 3q5dA02 | 1.20.58.420 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › AHSP | 0.65 | 44.0 | 4.21e-01 | 70.4% | 85.6% |
| 4im7A02 | 1.10.1040.10 | Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 | 0.64 | 49.0 | 3.64e-01 | 82.7% | 44.7% |
| 3kp9A01 | 1.20.1440.130 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › VKOR domain | 0.64 | 46.0 | 3.71e-01 | 76.5% | 96.3% |
| 2c0kB00 | 1.10.490.10 | Mainly Alpha › Orthogonal Bundle › Globin-like › Globins | 0.61 | 43.0 | 3.48e-01 | 72.8% | 79.9% |
| 3oziB00 | 3.40.50.10140 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Toll/interleukin-1 receptor homology (TIR) domain | 0.61 | 43.0 | 3.42e-01 | 74.1% | 65.5% |
| 3g0oA02 | 1.10.1040.10 | Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 | 0.60 | 45.0 | 3.98e-01 | 100.0% | 53.7% |
| 6wfqC01 | 1.20.120.530 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › GntR ligand-binding domain-like | 0.58 | 49.0 | 4.09e-01 | 93.8% | 88.7% |
| 4nooB00 | 1.10.8.1160 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › | 0.57 | 44.0 | 4.16e-01 | 96.3% | 69.5% |
| 1r9dA01 | 3.20.70.20 | Alpha Beta › Alpha-Beta Barrel › Anaerobic Ribonucleotide-triphosphate Reductase Large Chain › | 0.56 | 50.0 | 2.88e-01 | 98.8% | 38.4% |
| 2vsgA02 | 1.10.470.10 | Mainly Alpha › Orthogonal Bundle › Variant Surface Glycoprotein, subunit A; domain 2 › Variant Surface Glycoprotein, subunit A, domain 2 | 0.56 | 42.0 | 3.37e-01 | 79.0% | 67.5% |
| 2vk9A04 | 1.10.274.80 | Mainly Alpha › Orthogonal Bundle › Enzyme I; Chain A, domain 2 › | 0.56 | 49.0 | 4.53e-01 | 100.0% | 76.0% |
| 3ckdA02 | 1.20.58.360 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Shigella T3SS effector IpaH defines | 0.56 | 41.0 | 3.62e-01 | 79.0% | 62.9% |
| 2uyyA02 | 1.10.1040.10 | Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 | 0.55 | 48.0 | 4.18e-01 | 95.1% | 83.7% |
| 1lb3A00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.54 | 46.0 | 3.62e-01 | 92.6% | 56.9% |
| 4nqfA00 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.54 | 41.0 | 3.39e-01 | 80.2% | 68.3% |
| 2f3oA00 | 3.20.70.20 | Alpha Beta › Alpha-Beta Barrel › Anaerobic Ribonucleotide-triphosphate Reductase Large Chain › | 0.54 | 46.0 | 2.73e-01 | 100.0% | 46.7% |
| 1wwmA00 | 1.20.910.10 | Mainly Alpha › Up-down Bundle › Heme Oxygenase; Chain A › Heme oxygenase-like | 0.54 | 44.0 | 3.39e-01 | 87.7% | 50.0% |
| 1z6oM00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.53 | 45.0 | 3.41e-01 | 92.6% | 51.8% |
| 2rd3D00 | 1.20.910.10 | Mainly Alpha › Up-down Bundle › Heme Oxygenase; Chain A › Heme oxygenase-like | 0.53 | 44.0 | 3.31e-01 | 93.8% | 88.1% |
| 5kdiA00 | 1.10.3520.10 | Mainly Alpha › Orthogonal Bundle › Glycolipid transfer protein, GLTP › Glycolipid transfer protein | 0.53 | 43.0 | 3.25e-01 | 91.4% | 41.7% |
| 2oh3A01 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.53 | 45.0 | 3.70e-01 | 92.6% | 70.1% |
| 3wctD00 | 1.10.490.10 | Mainly Alpha › Orthogonal Bundle › Globin-like › Globins | 0.53 | 43.0 | 3.51e-01 | 100.0% | 48.3% |
| 3iieB03 | 1.10.1740.10 | Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › RNA polymerase sigma factor, region 2, helix turn helix motif | 0.52 | 40.0 | 4.03e-01 | 84.0% | 89.4% |
| 5jazA03 | 1.10.1740.10 | Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › RNA polymerase sigma factor, region 2, helix turn helix motif | 0.52 | 40.0 | 3.91e-01 | 84.0% | 90.1% |
| 3a06B03 | 1.10.1740.10 | Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › RNA polymerase sigma factor, region 2, helix turn helix motif | 0.52 | 39.0 | 3.89e-01 | 82.7% | 85.2% |
| 1aepA00 | 1.20.120.20 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein | 0.52 | 47.0 | 3.80e-01 | 100.0% | 68.6% |
| 4i8qA01 | 3.40.605.10 | Alpha Beta › 3-Layer(aba) Sandwich › Aldehyde Dehydrogenase; Chain A, domain 1 › Aldehyde Dehydrogenase; Chain A, domain 1 | 0.51 | 41.0 | 2.83e-01 | 88.9% | 35.4% |
| 1otkA00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.50 | 43.0 | 3.11e-01 | 96.3% | 73.8% |
ECOD (33)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 61904 | 142.1.1.3 ↗ | alpha complex topology › Sigma2 domain-like › Sigma2 domain of RNA polymerase sigma factors › Sigma2 domain of RNA polymerase sigma factors › Sigma70_r2 | 0.85 | 49.0 | 4.81e-01 | 100.0% | 54.7% |
| 5058468 | 5058.1.1.0 ↗ | alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region | 0.81 | 47.0 | 4.91e-01 | 100.0% | 62.7% |
| 4438504 | 7000.1.1.0 ↗ | alpha arrays › inserted region in the C-terminal domain of the archeal LeuRS › inserted region in the C-terminal domain of the archeal LeuRS › inserted region in the C-terminal domain of the archeal LeuRS | 0.68 | 51.0 | 5.65e-01 | 88.9% | 100.0% |
| 5037128 | 7000.1.1.0 ↗ | alpha arrays › inserted region in the C-terminal domain of the archeal LeuRS › inserted region in the C-terminal domain of the archeal LeuRS › inserted region in the C-terminal domain of the archeal LeuRS | 0.68 | 48.0 | 5.37e-01 | 72.8% | 98.3% |
| 3940867 | 632.22.1.67 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats › DUF842 | 0.65 | 44.0 | 4.22e-01 | 100.0% | 60.0% |
| 4024626 | 545.1.2.2 ↗ | alpha bundles › Gametocyte protein Pfg27-related › Gametocyte protein Pfg27-related › Sporozoite protein UIS3 soluble domain › ETRAMP | 0.65 | 47.0 | 3.97e-01 | 79.0% | 57.2% |
| 3713371 | 5054.1.1.9 ↗ | alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels › PKD_channel | 0.64 | 44.0 | 2.85e-01 | 70.4% | 20.8% |
| 3584199 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.64 | 45.0 | 2.85e-01 | 74.1% | 35.1% |
| 3703824 | 5054.1.1.9 ↗ | alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels › PKD_channel | 0.64 | 44.0 | 3.01e-01 | 70.4% | 26.9% |
| 5072135 | 2498.1.1.10 ↗ | mixed a+b and a/b › Zincin-like › "Metalloproteases (""zincins"") catalytic domain" › "Metalloproteases (""zincins"") catalytic domain" › Peptidase_M48 | 0.62 | 49.0 | 3.71e-01 | 85.2% | 85.1% |
| 3645559 | 650.1.1.1 ↗ | alpha bundles › Chaperone J-domain › Chaperone J-domain › Chaperone J-domain › DnaJ | 0.61 | 44.0 | 4.26e-01 | 74.1% | 77.8% |
| 4025126 | 192.27.1.0 ↗ | alpha bundles › Long alpha-hairpin › Helical hairpin in putative tRNA methyltransferase › Helical hairpin in putative tRNA methyltransferase | 0.61 | 55.0 | 4.50e-01 | 100.0% | 93.8% |
| 3307116 | 109.4.1.1280 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR, PPR_2, PPR_long | 0.59 | 45.0 | 2.76e-01 | 80.2% | 19.8% |
| 3870171 | 192.17.1.0 ↗ | alpha bundles › Long alpha-hairpin › Rabenosyn-5 Rab-binding domain-like › Rabenosyn-5 Rab-binding domain-like | 0.59 | 41.0 | 4.36e-01 | 74.1% | 82.9% |
| 4085263 | 547.1.1.1 ↗ | alpha duplicates or obligate multimers › Glutamyl tRNA-reductase dimerization domain › Glutamyl tRNA-reductase dimerization domain › Glutamyl tRNA-reductase dimerization domain › GlutR_dimer | 0.58 | 40.0 | 3.77e-01 | 100.0% | 58.0% |
| 3601984 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.58 | 40.0 | 3.56e-01 | 71.6% | 82.5% |
| 4962699 | 101.1.2.924 ↗ | alpha arrays › HTH › HTH › winged helix domain › DUF7342 | 0.56 | 38.0 | 3.15e-01 | 71.6% | 87.3% |
| 3366724 | 605.4.1.16 ↗ | alpha duplicates or obligate multimers › ROP-like › ROP protein › ROP protein › NEPRO_N | 0.56 | 39.0 | 3.52e-01 | 74.1% | 77.5% |
| 3409854 | 129.1.1.16 ↗ | alpha arrays › 6-phosphogluconate dehydrogenase C-terminal domain-like › 6-phosphogluconate dehydrogenase C-terminal domain-like › 6-phosphogluconate dehydrogenase C-terminal domain-like › NAD_binding_11 | 0.56 | 49.0 | 4.13e-01 | 95.1% | 79.2% |
| 3981456 | 2500.1.1.0 ↗ | a/b barrels › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel › Ten stranded beta/alpha barrel | 0.56 | 49.0 | 2.85e-01 | 97.5% | 38.7% |
| 3342572 | 3684.1.1.18 ↗ | alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › ROH1-like | 0.55 | 43.0 | 2.91e-01 | 84.0% | 71.3% |
| 3413892 | 632.19.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Choline binding protein A › Choline binding protein A | 0.54 | 43.0 | 3.76e-01 | 84.0% | 79.2% |
| 3317090 | 3758.1.1.0 ↗ | alpha bundles › Bacterial hemolysins-like › Bacterial hemolysins › Bacterial hemolysins | 0.54 | 43.0 | 3.06e-01 | 87.7% | 78.1% |
| 4953715 | 5054.1.1.6 ↗ | alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels › TrkH | 0.54 | 40.0 | 3.29e-01 | 79.0% | 56.7% |
| 3801576 | 4953.1.1.0 ↗ | beta barrels › L-aspartase C-terminal domain-like › L-aspartase C-terminal domain-like › L-aspartase C-terminal domain-like | 0.53 | 40.0 | 3.74e-01 | 79.0% | 64.0% |
| 3620069 | 633.1.1.0 ↗ | alpha bundles › Bromodomain-like › Bromodomain › Bromodomain | 0.53 | 40.0 | 3.69e-01 | 80.2% | 61.9% |
| 5055566 | 3922.1.1.0 ↗ | alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 | 0.53 | 36.0 | 3.28e-01 | 71.6% | 88.7% |
| 3987380 | 5060.2.1.1 ↗ | alpha bundles › V-type ATP synthase subunit C › Toxin coregulated pilus biosynthesis protein E cytoplasmic domain › Toxin coregulated pilus biosynthesis protein E cytoplasmic domain › T2SSF | 0.53 | 44.0 | 3.81e-01 | 96.3% | 74.8% |
| 5051840 | 601.28.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › VPS28 C-terminal domain-like › VPS28 C-terminal domain-like | 0.53 | 45.0 | 4.45e-01 | 100.0% | 94.1% |
| 3584894 | 605.1.1.238 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › CNNM | 0.52 | 36.0 | 3.58e-01 | 100.0% | 65.6% |
| 3462175 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.52 | 43.0 | 3.63e-01 | 98.8% | 55.4% |
| 4201591 | 166.1.1.1 ↗ | alpha superhelices › 1-deoxy-D-xylulose-5-phosphate reductoisomerase-C › 1-deoxy-D-xylulose-5-phosphate reductoisomerase-C › 1-deoxy-D-xylulose-5-phosphate reductoisomerase-C › DXPR_C | 0.51 | 40.0 | 3.83e-01 | 88.9% | 82.0% |
| 2617307 | 1075.4.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane | 0.50 | 42.0 | 2.82e-01 | 93.8% | 70.7% |