←Back to structures

CAKLQH020000005.1CAH1078860.1SAMEA5780036_01142__00124

Bact-Vir

CAKLQH020000005.1__CAH1078860.1__SAMEA5780036_01142__00124

Identity

Kingdom:: phage

Quality

87.6 mean pLDDT

Cluster

View cluster (4 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 17-158_377-484

PDB

Domain cluster: representative

Pfam (3)

Accession	Name	Score	E-value	Q cov	HMM cov
PF13245.13 best	AAA_19	48.6	1.30e-12	88.8%	90.3%
PF00580.28	UvrD-helicase	69.0	7.90e-19	66.4%	33.2%
PF00580.28	UvrD-helicase	70.0	3.80e-19	39.6%	30.6%

CATH (60)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1w36B01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.91	84.0	8.44e-01	98.8%	94.4%
1pjrA01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.91	66.0	7.32e-01	98.8%	90.1%
3u4qA01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.84	71.0	7.44e-01	98.8%	94.7%
2o0jA02	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.78	51.0	5.09e-01	98.8%	64.2%
4ceiB01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.78	56.0	6.54e-01	98.0%	100.0%
2orwB01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.76	39.0	5.50e-01	98.4%	99.2%
1l8qA01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.74	40.0	4.97e-01	99.6%	81.2%
2kjqA01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.72	35.0	4.88e-01	99.6%	91.3%
2xauA02	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.72	48.0	4.97e-01	100.0%	71.1%
6vsxA00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.71	40.0	5.04e-01	98.0%	88.1%
3llmA01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.71	46.0	4.89e-01	98.8%	72.4%
3berA00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.70	48.0	5.17e-01	100.0%	78.6%
8alzB05	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.70	48.0	5.34e-01	98.4%	84.9%
3dkpA00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.69	49.0	5.03e-01	100.0%	74.2%
5bq5B00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.69	40.0	4.58e-01	100.0%	74.9%
2kbeA00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.68	46.0	4.83e-01	99.6%	74.8%
3co5A00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.68	32.0	4.27e-01	96.0%	82.1%
5supC01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.68	48.0	5.19e-01	100.0%	84.0%
1w36D02	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.67	49.0	5.06e-01	98.8%	78.2%
7jgsG01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.67	42.0	5.11e-01	98.8%	93.9%
1wp9A02	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.65	38.0	4.95e-01	92.0%	98.0%
7w0bA01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.64	48.0	5.20e-01	100.0%	90.5%
1gm5A05	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.64	39.0	4.71e-01	95.6%	91.4%
3u31A01	3.40.50.1220	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › TPP-binding domain	0.63	35.0	4.21e-01	100.0%	79.9%
4nh0A03	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.62	46.0	4.74e-01	100.0%	78.1%
1cr2A00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.61	45.0	4.67e-01	100.0%	78.2%
2ht1A02	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.61	45.0	4.72e-01	100.0%	83.1%
3h1tA03	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.60	45.0	4.90e-01	99.6%	91.3%
2a3nA01	3.40.50.10490	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Glucose-6-phosphate isomerase like protein; domain 1	0.59	33.0	3.98e-01	96.4%	81.5%
3u4qB03	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.58	43.0	4.58e-01	98.8%	86.2%
1o20A02	3.40.309.10	Alpha Beta › 3-Layer(aba) Sandwich › Aldehyde Dehydrogenase; Chain A, domain 2 › Aldehyde Dehydrogenase; Chain A, domain 2	0.57	34.0	4.23e-01	98.0%	95.3%
4c7oA02	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.57	37.0	4.13e-01	100.0%	82.5%
6j19A00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.56	46.0	4.58e-01	100.0%	80.8%
1vctA01	1.20.58.220	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2	0.56	24.0	3.65e-01	71.6%	92.7%
1fx0B02	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.56	45.0	4.39e-01	100.0%	75.8%
6qv4A04	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.55	42.0	4.77e-01	95.2%	100.0%
6k10A02	3.40.309.10	Alpha Beta › 3-Layer(aba) Sandwich › Aldehyde Dehydrogenase; Chain A, domain 2 › Aldehyde Dehydrogenase; Chain A, domain 2	0.54	39.0	4.30e-01	98.4%	90.4%
2o2pA02	3.40.309.10	Alpha Beta › 3-Layer(aba) Sandwich › Aldehyde Dehydrogenase; Chain A, domain 2 › Aldehyde Dehydrogenase; Chain A, domain 2	0.54	40.0	4.48e-01	98.8%	97.4%
2j6lA02	3.40.309.10	Alpha Beta › 3-Layer(aba) Sandwich › Aldehyde Dehydrogenase; Chain A, domain 2 › Aldehyde Dehydrogenase; Chain A, domain 2	0.54	40.0	4.44e-01	98.8%	96.9%
4f3xA02	3.40.309.10	Alpha Beta › 3-Layer(aba) Sandwich › Aldehyde Dehydrogenase; Chain A, domain 2 › Aldehyde Dehydrogenase; Chain A, domain 2	0.53	39.0	4.40e-01	98.8%	97.4%
4idsA02	3.40.309.10	Alpha Beta › 3-Layer(aba) Sandwich › Aldehyde Dehydrogenase; Chain A, domain 2 › Aldehyde Dehydrogenase; Chain A, domain 2	0.53	40.0	4.42e-01	98.8%	97.0%
3rjlA02	3.40.309.10	Alpha Beta › 3-Layer(aba) Sandwich › Aldehyde Dehydrogenase; Chain A, domain 2 › Aldehyde Dehydrogenase; Chain A, domain 2	0.53	39.0	4.35e-01	98.8%	96.9%
1d5cA00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.53	33.0	3.94e-01	89.2%	92.6%
5vbfA02	3.40.309.10	Alpha Beta › 3-Layer(aba) Sandwich › Aldehyde Dehydrogenase; Chain A, domain 2 › Aldehyde Dehydrogenase; Chain A, domain 2	0.53	39.0	4.36e-01	98.4%	97.4%
1ig3A02	3.40.50.10240	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Thiamin pyrophosphokinase, catalytic domain	0.53	31.0	3.93e-01	100.0%	96.6%
1euhA02	3.40.309.10	Alpha Beta › 3-Layer(aba) Sandwich › Aldehyde Dehydrogenase; Chain A, domain 2 › Aldehyde Dehydrogenase; Chain A, domain 2	0.53	38.0	4.20e-01	98.4%	93.3%
4yweA02	3.40.309.10	Alpha Beta › 3-Layer(aba) Sandwich › Aldehyde Dehydrogenase; Chain A, domain 2 › Aldehyde Dehydrogenase; Chain A, domain 2	0.53	39.0	4.34e-01	98.8%	96.9%
4oe6B02	3.40.309.10	Alpha Beta › 3-Layer(aba) Sandwich › Aldehyde Dehydrogenase; Chain A, domain 2 › Aldehyde Dehydrogenase; Chain A, domain 2	0.53	39.0	4.35e-01	98.8%	97.9%
5kloA02	3.40.309.10	Alpha Beta › 3-Layer(aba) Sandwich › Aldehyde Dehydrogenase; Chain A, domain 2 › Aldehyde Dehydrogenase; Chain A, domain 2	0.53	39.0	4.34e-01	98.8%	97.4%
1t90A02	3.40.309.10	Alpha Beta › 3-Layer(aba) Sandwich › Aldehyde Dehydrogenase; Chain A, domain 2 › Aldehyde Dehydrogenase; Chain A, domain 2	0.52	38.0	4.24e-01	98.4%	93.5%
4jz6A02	3.40.309.10	Alpha Beta › 3-Layer(aba) Sandwich › Aldehyde Dehydrogenase; Chain A, domain 2 › Aldehyde Dehydrogenase; Chain A, domain 2	0.52	38.0	3.94e-01	98.8%	79.2%
6aonA02	3.50.50.60	Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain	0.52	25.0	3.45e-01	83.6%	89.4%
3iwjA02	3.40.309.10	Alpha Beta › 3-Layer(aba) Sandwich › Aldehyde Dehydrogenase; Chain A, domain 2 › Aldehyde Dehydrogenase; Chain A, domain 2	0.52	38.0	4.29e-01	98.8%	97.4%
6bjpA02	3.40.309.10	Alpha Beta › 3-Layer(aba) Sandwich › Aldehyde Dehydrogenase; Chain A, domain 2 › Aldehyde Dehydrogenase; Chain A, domain 2	0.52	38.0	4.17e-01	98.4%	90.0%
3ty7A02	3.40.309.10	Alpha Beta › 3-Layer(aba) Sandwich › Aldehyde Dehydrogenase; Chain A, domain 2 › Aldehyde Dehydrogenase; Chain A, domain 2	0.52	38.0	4.33e-01	99.2%	100.0%
3k2wB02	3.40.309.10	Alpha Beta › 3-Layer(aba) Sandwich › Aldehyde Dehydrogenase; Chain A, domain 2 › Aldehyde Dehydrogenase; Chain A, domain 2	0.51	38.0	4.24e-01	98.8%	97.4%
3of5B00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.51	39.0	4.19e-01	100.0%	92.2%
3b85A00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.51	33.0	3.75e-01	100.0%	86.1%
2nq2D00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.51	39.0	3.97e-01	100.0%	79.8%
1kk1A01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.50	35.0	3.93e-01	89.6%	90.3%

ECOD (92)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3965247	2004.1.1.49 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase	0.92	90.0	6.83e-01	100.0%	89.0%
3164644	2004.1.1.363 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase+UvrD_C	0.91	89.0	5.76e-01	100.0%	51.7%
3973583	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.89	87.0	5.64e-01	100.0%	49.9%
3287099	2004.1.1.363 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase+UvrD_C	0.88	86.0	5.75e-01	100.0%	39.0%
3948292	2004.1.1.363 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase+UvrD_C	0.88	86.0	5.61e-01	100.0%	49.1%
3981160	2004.1.1.483 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase, AAA_19, UvrD_C	0.88	86.0	5.60e-01	100.0%	48.8%
102676	2004.1.1.49 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase	0.88	86.0	6.67e-01	100.0%	88.7%
4615457	2004.1.1.363 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase+UvrD_C	0.86	84.0	5.69e-01	100.0%	41.3%
4353243	2004.1.1.49 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase	0.85	84.0	6.70e-01	100.0%	97.0%
4400828	2004.1.1.49 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase	0.85	83.0	7.19e-01	100.0%	87.0%
4044381	2004.1.1.363 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase+UvrD_C	0.85	83.0	5.41e-01	100.0%	48.0%
4306615	2004.1.1.49 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase	0.82	74.0	7.49e-01	100.0%	94.3%
3386657	2004.1.1.483 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase, AAA_19, UvrD_C	0.80	77.0	5.34e-01	99.6%	56.0%
3838734	2004.1.1.483 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase, AAA_19, UvrD_C	0.80	77.0	5.25e-01	100.0%	55.6%
4493028	2004.1.1.483 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase, AAA_19, UvrD_C	0.79	76.0	4.90e-01	100.0%	46.2%
3587595	2004.1.1.363 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase+UvrD_C	0.79	76.0	4.87e-01	100.0%	46.0%
3285073	2004.1.1.363 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase+UvrD_C	0.78	75.0	5.07e-01	100.0%	38.1%
4302341	2004.1.1.363 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase+UvrD_C	0.78	76.0	4.89e-01	100.0%	48.0%
4131324	2004.1.1.470 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD, UvrD-helicase, UvrD_C	0.78	75.0	4.81e-01	100.0%	45.8%
4520419	2004.1.1.470 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD, UvrD-helicase, UvrD_C	0.78	75.0	4.85e-01	100.0%	47.2%
4472619	2004.1.1.483 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase, AAA_19, UvrD_C	0.78	75.0	4.85e-01	100.0%	47.3%
4468234	2004.1.1.363 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase+UvrD_C	0.77	75.0	4.78e-01	100.0%	46.8%
4641844	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.77	75.0	4.58e-01	100.0%	36.3%
3988343	2004.1.1.363 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase+UvrD_C	0.77	75.0	4.77e-01	100.0%	44.4%
4589426	2004.1.1.470 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD, UvrD-helicase, UvrD_C	0.77	75.0	4.81e-01	100.0%	46.5%
4040709	2004.1.1.483 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase, AAA_19, UvrD_C	0.77	75.0	4.80e-01	100.0%	47.2%
None	—		0.77	75.0	4.59e-01	100.0%	37.2%
4411976	2004.1.1.363 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase+UvrD_C	0.77	75.0	4.80e-01	100.0%	47.0%
4113259	2004.1.1.470 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD, UvrD-helicase, UvrD_C	0.77	75.0	4.79e-01	100.0%	46.3%
4077920	2004.1.1.470 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD, UvrD-helicase, UvrD_C	0.77	75.0	4.79e-01	100.0%	46.9%
4490768	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.77	75.0	4.59e-01	100.0%	36.2%
4533235	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.77	75.0	4.57e-01	100.0%	36.4%
4105640	2004.1.1.483 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase, AAA_19, UvrD_C	0.77	74.0	4.77e-01	100.0%	46.9%
4289468	2004.1.1.363 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase+UvrD_C	0.77	74.0	4.78e-01	100.0%	47.4%
4885968	2008.1.1.203 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › UvrD-helicase, AAA_19, UvrD_C	0.77	74.0	4.77e-01	100.0%	45.4%
4225958	2004.1.1.363 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase+UvrD_C	0.77	74.0	4.84e-01	100.0%	48.6%
4067536	2004.1.1.363 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase+UvrD_C	0.77	74.0	4.78e-01	100.0%	45.8%
4638111	2004.1.1.483 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase, AAA_19, UvrD_C	0.76	74.0	4.74e-01	100.0%	45.6%
None	—		0.76	74.0	4.77e-01	100.0%	46.6%
4943726	2004.1.1.195 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD_C	0.76	74.0	4.82e-01	100.0%	43.1%
4282858	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.76	74.0	4.55e-01	100.0%	36.9%
4950790	2004.1.1.49 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase	0.76	74.0	4.82e-01	100.0%	47.8%
3955944	2004.1.1.363 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase+UvrD_C	0.76	73.0	4.86e-01	100.0%	37.6%
4952353	2004.1.1.49 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase	0.75	73.0	4.92e-01	100.0%	40.1%
4462677	2004.1.1.363 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase+UvrD_C	0.75	73.0	4.72e-01	100.0%	46.8%
3702647	4156.1.1.0 ↗	alpha arrays › Sec63 N-terminal subdomain-like › Sec63 N-terminal subdomain-like › Sec63 N-terminal subdomain-like	0.74	48.0	3.49e-01	100.0%	26.1%
3916692	2004.1.1.29 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD	0.74	48.0	4.73e-01	100.0%	61.9%
3403635	2004.1.1.29 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD	0.73	49.0	5.20e-01	100.0%	75.9%
3601917	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.72	47.0	4.92e-01	100.0%	69.8%
3703321	2004.1.1.49 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase	0.72	70.0	6.25e-01	100.0%	81.2%
3760903	2004.1.1.203 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD_C_2	0.72	40.0	4.75e-01	87.2%	76.5%
3956572	2004.1.1.68 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › IstB_IS21	0.72	42.0	4.86e-01	100.0%	77.3%
3501860	2004.1.1.29 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD	0.72	48.0	4.87e-01	100.0%	67.2%
5052224	2004.1.1.49 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase	0.72	70.0	6.14e-01	100.0%	79.7%
3916976	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.71	48.0	5.23e-01	100.0%	79.5%
4881420	2004.1.1.49 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase	0.71	69.0	6.15e-01	100.0%	83.8%
4013629	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.71	48.0	5.09e-01	100.0%	76.0%
3969482	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.71	68.0	5.15e-01	100.0%	64.5%
3702837	2004.1.1.292 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AFG1_ATPase	0.71	42.0	5.20e-01	99.6%	91.3%
5005259	2004.1.1.49 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase	0.70	68.0	4.77e-01	100.0%	41.8%
3965541	2004.1.1.522 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_11, AAA_19	0.70	53.0	5.17e-01	100.0%	70.5%
3832703	2004.1.1.363 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase+UvrD_C	0.70	68.0	4.68e-01	100.0%	40.3%
3293050	2004.1.1.49 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase	0.70	68.0	5.94e-01	100.0%	81.2%
3202677	2004.1.1.29 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD	0.69	48.0	5.26e-01	98.8%	83.8%
3675939	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.69	49.0	3.63e-01	100.0%	30.5%
3306502	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.68	49.0	3.61e-01	100.0%	31.1%
4030700	2004.1.1.292 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AFG1_ATPase	0.67	42.0	4.79e-01	100.0%	81.1%
3386265	2004.1.1.49 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase	0.66	64.0	5.96e-01	100.0%	85.7%
3840082	2004.1.1.455 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase, UvrD_C, UvrD_C_2	0.65	63.0	4.49e-01	100.0%	39.4%
3597434	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.65	41.0	4.65e-01	100.0%	81.6%
5025063	2004.1.1.49 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase	0.65	63.0	4.47e-01	99.6%	43.7%
5064107	2004.1.1.49 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase	0.65	53.0	5.07e-01	83.6%	100.0%
3969172	2004.1.1.292 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AFG1_ATPase	0.64	40.0	4.58e-01	100.0%	81.6%
4295930	2004.1.1.292 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AFG1_ATPase	0.63	42.0	4.43e-01	100.0%	72.6%
3942031	2004.1.1.102 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › TerL_ATPase	0.62	49.0	4.52e-01	100.0%	64.1%
4932842	2004.1.1.49 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase	0.62	60.0	4.32e-01	100.0%	42.1%
3472181	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.61	45.0	4.75e-01	100.0%	84.5%
3917034	2004.1.1.292 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AFG1_ATPase	0.61	41.0	3.42e-01	100.0%	40.2%
3599788	2004.1.1.292 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AFG1_ATPase	0.60	43.0	4.42e-01	100.0%	76.2%
3788321	2004.1.1.292 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AFG1_ATPase	0.60	43.0	3.52e-01	100.0%	41.1%
3989603	2004.1.1.226 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ADDB_N	0.57	54.0	3.76e-01	98.8%	36.4%
5013271	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.56	52.0	4.30e-01	100.0%	93.8%
3713638	2004.1.1.292 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AFG1_ATPase	0.55	42.0	4.32e-01	100.0%	82.5%
4027853	2004.1.1.499 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD_2, Helicase_C_2	0.54	51.0	3.86e-01	100.0%	79.5%
4030463	2004.1.1.184 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_11	0.53	51.0	3.81e-01	100.0%	59.1%
2724312	7524.1.1.1 ↗	a/b three-layered sandwiches › ALDH-like › ALDH-like › ALDH-like › Aldedh	0.53	40.0	4.10e-01	98.8%	80.9%
3398192	7524.1.1.1 ↗	a/b three-layered sandwiches › ALDH-like › ALDH-like › ALDH-like › Aldedh	0.53	40.0	4.30e-01	99.2%	92.4%
3634946	2004.1.1.499 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD_2, Helicase_C_2	0.52	50.0	3.81e-01	100.0%	76.2%
2562520	7524.1.1.1 ↗	a/b three-layered sandwiches › ALDH-like › ALDH-like › ALDH-like › Aldedh	0.52	39.0	3.97e-01	98.8%	77.6%
3910068	2004.1.1.19 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Ras	0.52	34.0	3.90e-01	88.4%	88.3%
3438442	2004.1.1.292 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AFG1_ATPase	0.52	42.0	4.47e-01	100.0%	93.8%
4974227	7524.1.1.0 ↗	a/b three-layered sandwiches › ALDH-like › ALDH-like › ALDH-like	0.51	38.0	4.04e-01	99.6%	85.3%

D2 high residues 229-350

PDB

Domain cluster: representative

CATH (23)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1u89A00	1.20.120.230	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like	0.65	56.0	5.35e-01	97.5%	82.0%
7p5hB03	1.20.1440.230	Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain	0.63	42.0	4.72e-01	95.1%	91.0%
3eabE00	1.20.58.80	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit	0.62	43.0	4.85e-01	77.9%	100.0%
1nzeA00	1.20.120.290	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Oxygen-evolving enhancer protein 3 (PsbQ), four-helix up-down bundle	0.60	41.0	4.30e-01	79.5%	76.8%
3dbyL00	1.20.1260.120	Mainly Alpha › Up-down Bundle › Ferritin › Protein of unknown function DUF2935	0.59	51.0	4.03e-01	98.4%	44.6%
4gouA03	1.20.900.10	Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain	0.58	52.0	4.48e-01	100.0%	92.9%
3d19B00	1.20.1260.120	Mainly Alpha › Up-down Bundle › Ferritin › Protein of unknown function DUF2935	0.58	52.0	4.09e-01	100.0%	49.2%
3uitA02	1.20.1270.460	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 ›	0.58	51.0	5.03e-01	100.0%	93.8%
4etrB00	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.57	42.0	4.29e-01	78.7%	96.7%
1r2jA03	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.57	50.0	4.79e-01	100.0%	88.9%
2z1qB04	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.56	48.0	4.71e-01	97.5%	87.5%
1aepA00	1.20.120.20	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein	0.56	47.0	4.36e-01	91.8%	81.7%
2r9rH02	1.20.120.350	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Voltage-gated potassium channels. Chain C	0.55	41.0	3.89e-01	78.7%	75.0%
8f76A01	1.20.1070.10	Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins	0.55	46.0	3.55e-01	93.4%	90.5%
1xwmA00	1.20.58.220	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2	0.55	48.0	4.08e-01	99.2%	63.2%
8hk0B03	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.54	48.0	4.64e-01	100.0%	94.9%
1qkrB00	1.20.120.230	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like	0.54	44.0	3.89e-01	91.0%	60.0%
4nuuB02	1.20.58.830	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.53	38.0	3.86e-01	73.8%	90.2%
1rtwB00	1.20.910.10	Mainly Alpha › Up-down Bundle › Heme Oxygenase; Chain A › Heme oxygenase-like	0.53	44.0	3.73e-01	91.8%	84.1%
1uddA00	1.20.910.10	Mainly Alpha › Up-down Bundle › Heme Oxygenase; Chain A › Heme oxygenase-like	0.53	42.0	3.58e-01	88.5%	82.3%
2lmgA00	1.20.1270.10	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 ›	0.52	32.0	3.92e-01	82.0%	100.0%
5k29A00	1.20.920.10	Mainly Alpha › Up-down Bundle › Histone Acetyltransferase; Chain A › Bromodomain-like	0.52	34.0	3.74e-01	91.0%	83.5%
5nl6B01	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.51	38.0	3.85e-01	77.9%	87.6%

ECOD (31)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3225511	633.23.1.0 ↗	alpha bundles › Bromodomain-like › Claudin › Claudin	0.63	57.0	5.23e-01	100.0%	86.3%
4019691	174.1.1.0 ↗	few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain	0.63	56.0	5.34e-01	98.4%	85.7%
4019714	633.21.1.0 ↗	alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107	0.62	54.0	5.53e-01	99.2%	99.2%
3470828	601.1.2.4 ↗	alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › Talin_R4	0.62	55.0	5.44e-01	100.0%	96.2%
3625559	633.21.1.0 ↗	alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107	0.62	54.0	5.17e-01	99.2%	100.0%
3845930	633.23.1.22 ↗	alpha bundles › Bromodomain-like › Claudin › Claudin › MARVEL	0.61	53.0	5.14e-01	98.4%	92.9%
3478235	633.23.1.0 ↗	alpha bundles › Bromodomain-like › Claudin › Claudin	0.60	53.0	5.28e-01	98.4%	94.5%
3270837	174.1.1.33 ↗	few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Erg28	0.60	53.0	5.33e-01	99.2%	99.2%
3656	633.7.1.1 ↗	alpha bundles › Bromodomain-like › Bacillus cereus metalloprotein-like › Bacillus cereus metalloprotein-like › DUF2935	0.60	51.0	5.18e-01	98.4%	95.9%
3187449	633.23.1.22 ↗	alpha bundles › Bromodomain-like › Claudin › Claudin › MARVEL	0.60	53.0	5.05e-01	100.0%	83.4%
3412240	174.1.1.33 ↗	few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Erg28	0.60	53.0	5.25e-01	100.0%	97.7%
3422310	150.1.1.87 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › Erg28	0.59	53.0	5.19e-01	99.2%	91.0%
3364022	174.1.1.33 ↗	few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Erg28	0.59	53.0	5.22e-01	99.2%	94.6%
3721324	633.21.1.25 ↗	alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 › DUF7598	0.59	53.0	5.01e-01	100.0%	92.4%
3803559	633.4.1.1 ↗	alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI	0.58	51.0	4.69e-01	97.5%	93.8%
3655	633.7.1.1 ↗	alpha bundles › Bromodomain-like › Bacillus cereus metalloprotein-like › Bacillus cereus metalloprotein-like › DUF2935	0.58	52.0	5.10e-01	100.0%	98.5%
3831865	633.4.1.1 ↗	alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI	0.58	51.0	5.07e-01	100.0%	98.5%
3515526	174.1.1.0 ↗	few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain	0.58	51.0	5.00e-01	100.0%	93.3%
3797233	603.5.1.0 ↗	alpha bundles › STAT-like › FlgN-like › FlgN-like	0.58	43.0	3.78e-01	77.0%	60.6%
4991722	3543.1.1.14 ↗	alpha complex topology › Acid-activated urea channel › Acid-activated urea channel › Acid-activated urea channel › DUF981	0.58	44.0	3.77e-01	80.3%	85.5%
3585004	174.1.1.0 ↗	few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain	0.58	51.0	5.09e-01	100.0%	100.0%
3703524	174.1.1.0 ↗	few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain	0.58	51.0	5.13e-01	99.2%	100.0%
3218229	109.1.1.16 ↗	alpha superhelices › Repetitive alpha hairpins › Glutathione S-transferase (GST)-C › Glutathione S-transferase (GST)-C › GST_C_6	0.55	41.0	3.75e-01	78.7%	85.5%
4025439	150.1.1.0 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin	0.54	44.0	4.24e-01	89.3%	80.7%
3502871	174.1.1.1 ↗	few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin	0.53	47.0	4.60e-01	98.4%	95.5%
5035912	1075.1.1.4 ↗	alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › ABCG5/ABCG8 transmembrane domain › ABC2_membrane_3	0.53	38.0	3.03e-01	73.8%	83.5%
3612275	5057.1.1.0 ↗	alpha bundles › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore	0.53	42.0	3.93e-01	100.0%	67.7%
3267624	192.29.1.19 ↗	alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › Cornichon	0.53	39.0	3.79e-01	77.0%	69.6%
3600074	603.2.1.0 ↗	alpha bundles › STAT-like › STAT › STAT	0.52	41.0	3.97e-01	83.6%	80.0%
3619915	109.3.1.282 ↗	alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat › CPG4	0.52	43.0	3.65e-01	90.2%	86.8%
3183435	109.4.1.1126 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_SYO1	0.51	40.0	3.24e-01	86.9%	64.3%

D3 medium residues 534-610_762-791_852-893

PDB

Domain cluster: rep: aot2015-NO19_SRR1761693_USA_trim_clean_trim_clean_scaffold_5_curated_closed_complete_reversed_prodigal-single.1__X__X__00231__D500-555_733-767_803-875

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF13361.13 best	UvrD_C	29.4	8.20e-07	24.2%	6.9%

CATH (65)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1w36B03	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.89	85.0	6.57e-01	100.0%	76.9%
3u4qA04	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.84	80.0	6.44e-01	100.0%	81.4%
1pjrA03	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.76	71.0	6.34e-01	98.0%	82.0%
2ykgA02	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.74	52.0	5.99e-01	79.2%	97.2%
5eanA02	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.73	70.0	6.11e-01	100.0%	77.8%
3u4qB03	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.73	68.0	5.89e-01	98.7%	85.3%
2xzlA05	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.73	69.0	6.04e-01	100.0%	75.5%
4b3fX03	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.72	69.0	6.08e-01	100.0%	75.2%
3dmnA00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.72	63.0	6.15e-01	98.0%	85.7%
6vsxA00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.71	62.0	6.09e-01	97.3%	86.8%
1w36B01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.69	64.0	5.33e-01	98.7%	93.5%
1wp9A02	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.68	58.0	5.89e-01	89.3%	98.0%
1pjrA01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.68	63.0	5.65e-01	98.7%	89.1%
2gk6A01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.68	64.0	5.19e-01	100.0%	60.8%
6fwrA01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.68	62.0	5.52e-01	96.0%	97.5%
2ocaA03	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.68	63.0	5.61e-01	100.0%	99.0%
3jb9X01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.68	64.0	5.42e-01	100.0%	79.0%
3sxuA00	3.40.50.10110	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › DNA polymerase III subunit chi	0.67	62.0	6.29e-01	99.3%	99.3%
2o0jA02	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.67	62.0	5.12e-01	98.7%	63.0%
6b4kB02	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.67	63.0	6.00e-01	100.0%	92.9%
6jytA01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.67	59.0	5.63e-01	91.9%	91.0%
2p6nA00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.66	61.0	5.99e-01	98.0%	93.8%
7xexC01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.66	58.0	5.17e-01	93.3%	96.5%
6jdrA01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.65	56.0	5.72e-01	100.0%	93.7%
1w36D03	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.65	54.0	5.09e-01	86.6%	82.7%
2kbeA00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.65	61.0	5.21e-01	100.0%	73.0%
3mwyW04	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.65	60.0	4.84e-01	98.7%	95.9%
5agaA02	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.64	56.0	4.89e-01	91.9%	99.5%
6yhrA02	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.64	58.0	5.13e-01	96.6%	96.7%
3rc3A03	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.62	56.0	5.55e-01	100.0%	91.8%
2p6rA02	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.61	53.0	4.82e-01	91.9%	98.5%
2vl7A03	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.61	57.0	5.31e-01	98.7%	98.3%
1m6nA03	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.60	56.0	5.28e-01	98.7%	96.6%
1yksA02	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.59	47.0	4.95e-01	87.2%	91.1%
3pp8A02	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.59	51.0	4.77e-01	93.3%	99.5%
4e5mA02	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.59	51.0	4.66e-01	94.6%	99.5%
1dxyA02	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.58	50.0	4.56e-01	92.6%	98.5%
4xcvA02	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.58	49.0	4.60e-01	93.3%	99.5%
5mh6A02	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.58	50.0	4.64e-01	94.0%	99.5%
4i9fA02	3.40.50.1000	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HAD superfamily/HAD-like	0.57	41.0	4.64e-01	91.3%	100.0%
3evtA02	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.57	49.0	4.62e-01	93.3%	99.5%
6aqoA00	3.40.50.2020	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold ›	0.57	49.0	4.39e-01	94.0%	68.7%
1xdwA02	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.57	49.0	4.47e-01	94.0%	100.0%
2gsdA02	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.57	49.0	4.52e-01	94.6%	100.0%
4cujA02	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.56	48.0	4.45e-01	94.0%	100.0%
5tx7A02	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.56	48.0	4.50e-01	94.6%	100.0%
3rc3A04	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.56	47.0	4.80e-01	89.3%	95.9%
3gvxA02	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.56	48.0	4.59e-01	94.0%	98.9%
6p2iA02	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.56	48.0	4.58e-01	94.6%	100.0%
1pjcA02	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.56	48.0	4.61e-01	95.3%	98.9%
4njmA02	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.55	48.0	4.66e-01	94.0%	100.0%
2eklA02	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.55	48.0	4.45e-01	94.6%	98.4%
2d0iA02	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.55	48.0	4.43e-01	94.6%	99.0%
4g2nA02	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.55	47.0	4.44e-01	92.6%	100.0%
3om0A02	3.40.50.2300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator	0.55	47.0	4.66e-01	93.3%	98.8%
3a11B02	3.40.50.10470	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Translation initiation factor eif-2b; domain 2	0.54	48.0	4.37e-01	96.6%	89.3%
4dgsA02	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.53	46.0	4.58e-01	94.0%	100.0%
3ecsD02	3.40.50.10470	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Translation initiation factor eif-2b; domain 2	0.53	46.0	4.26e-01	96.0%	87.2%
3pwzA02	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.52	40.0	4.36e-01	97.3%	100.0%
1nytA02	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.52	42.0	4.36e-01	100.0%	91.6%
2qorA01	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.52	36.0	3.91e-01	71.8%	94.6%
1h1lD03	3.40.50.1980	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Nitrogenase molybdenum iron protein domain	0.52	36.0	3.77e-01	85.2%	78.9%
3tw8A02	3.40.50.11500	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › DENN domain, C-terminal lobe	0.52	41.0	3.99e-01	94.6%	75.6%
3uenA01	3.40.50.10190	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › BRCT domain	0.51	29.0	3.61e-01	84.6%	92.2%
4zeoH02	3.40.50.10470	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Translation initiation factor eif-2b; domain 2	0.50	44.0	4.36e-01	96.0%	94.4%

ECOD (93)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3981160	2004.1.1.483 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase, AAA_19, UvrD_C	0.90	86.0	5.15e-01	100.0%	42.4%
1230977	2004.1.1.195 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD_C	0.89	86.0	6.00e-01	100.0%	91.5%
3948292	2004.1.1.363 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase+UvrD_C	0.89	86.0	5.12e-01	100.0%	42.3%
3164644	2004.1.1.363 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase+UvrD_C	0.89	85.0	5.08e-01	100.0%	41.0%
3287099	2004.1.1.363 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase+UvrD_C	0.88	85.0	5.15e-01	100.0%	52.6%
4044381	2004.1.1.363 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase+UvrD_C	0.88	84.0	5.03e-01	100.0%	42.6%
3965712	2004.1.1.195 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD_C	0.87	84.0	5.94e-01	100.0%	95.3%
3587595	2004.1.1.363 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase+UvrD_C	0.86	83.0	4.86e-01	100.0%	44.5%
4225958	2004.1.1.363 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase+UvrD_C	0.86	82.0	4.88e-01	100.0%	44.8%
4493028	2004.1.1.483 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase, AAA_19, UvrD_C	0.86	82.0	4.84e-01	100.0%	46.6%
4950790	2004.1.1.49 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase	0.85	81.0	4.86e-01	100.0%	43.2%
4615457	2004.1.1.363 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase+UvrD_C	0.85	82.0	5.01e-01	100.0%	50.3%
4077920	2004.1.1.470 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD, UvrD-helicase, UvrD_C	0.85	81.0	4.78e-01	100.0%	45.2%
4426454	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.85	81.0	4.63e-01	100.0%	35.7%
4105640	2004.1.1.483 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase, AAA_19, UvrD_C	0.85	81.0	4.77e-01	100.0%	45.2%
4299476	2004.1.1.195 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD_C	0.85	81.0	5.87e-01	100.0%	96.7%
4677652	2004.1.1.1017 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_12, UvrD_C	0.85	81.0	6.28e-01	100.0%	79.7%
4131324	2004.1.1.470 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD, UvrD-helicase, UvrD_C	0.85	80.0	4.73e-01	100.0%	46.5%
4113259	2004.1.1.470 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD, UvrD-helicase, UvrD_C	0.84	80.0	4.74e-01	100.0%	44.7%
1204325	2004.1.1.195 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD_C	0.84	80.0	5.56e-01	100.0%	97.4%
4282858	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.84	80.0	4.58e-01	100.0%	35.6%
4943726	2004.1.1.195 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD_C	0.82	78.0	4.69e-01	100.0%	46.4%
4064402	2004.1.1.363 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase+UvrD_C	0.82	78.0	4.70e-01	100.0%	40.2%
4927000	2008.1.1.217 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › UvrD-helicase	0.81	77.0	4.47e-01	100.0%	36.3%
5064458	2004.1.1.195 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD_C	0.79	73.0	5.33e-01	96.6%	96.4%
None	—		0.77	66.0	6.01e-01	88.6%	79.5%
5005259	2004.1.1.49 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase	0.77	74.0	4.62e-01	100.0%	50.1%
4930401	2004.1.1.49 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase	0.77	74.0	4.51e-01	100.0%	42.1%
3981214	2004.1.1.186 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_12	0.77	73.0	6.39e-01	100.0%	80.0%
3639517	2004.1.1.768 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_11, AAA_12, AAA_19	0.77	73.0	4.58e-01	100.0%	25.9%
5041155	2004.1.1.49 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase	0.76	72.0	4.41e-01	100.0%	42.7%
3677754	2004.1.1.24 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SNF2-rel_dom,Helicase_C	0.75	65.0	4.22e-01	89.3%	41.8%
3955473	2004.1.1.186 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_12	0.75	69.0	6.18e-01	95.3%	80.5%
3810871	2004.1.1.186 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_12	0.74	70.0	6.04e-01	100.0%	77.7%
3386657	2004.1.1.483 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase, AAA_19, UvrD_C	0.73	67.0	4.16e-01	95.3%	38.2%
3615142	2004.1.1.30 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C	0.73	69.0	5.70e-01	100.0%	74.4%
3825238	2004.1.1.186 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_12	0.73	69.0	5.80e-01	100.0%	71.5%
3581421	376.1.1.0 ↗	few secondary structure elements › RING/U-box-like › RING/U-box-like › RING/U-box	0.73	69.0	4.36e-01	100.0%	24.2%
3917194	2004.1.1.185 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_11,AAA_12	0.72	69.0	4.48e-01	100.0%	27.8%
3247933	2004.1.1.186 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_12	0.72	69.0	5.73e-01	100.0%	66.7%
1230975	2004.1.1.203 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD_C_2	0.72	63.0	6.15e-01	98.0%	85.7%
3485645	2004.1.1.186 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_12	0.72	68.0	5.44e-01	100.0%	75.9%
4533353	2004.1.1.30 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C	0.71	64.0	5.73e-01	94.6%	96.0%
4029838	2004.1.1.186 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_12	0.71	68.0	4.23e-01	100.0%	26.2%
3629102	2004.1.1.186 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_12	0.71	68.0	5.55e-01	100.0%	75.2%
3391041	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.71	67.0	4.12e-01	100.0%	23.3%
3733478	2004.1.1.30 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C	0.71	61.0	4.95e-01	89.3%	85.1%
3549903	2004.1.1.1002 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ResIII, AAA_11, AAA_12	0.71	67.0	4.18e-01	100.0%	25.9%
4029978	2004.1.1.910 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Viral_helicase1, AAA_12	0.70	67.0	4.58e-01	100.0%	41.3%
4026005	2004.1.1.184 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_11	0.70	66.0	4.90e-01	100.0%	57.1%
3567663	2004.1.1.185 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_11,AAA_12	0.70	66.0	4.36e-01	100.0%	37.7%
4953858	2004.1.1.30 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C	0.70	60.0	4.24e-01	89.3%	41.2%
4024203	2004.1.1.30 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C	0.70	64.0	6.04e-01	97.3%	98.3%
4797722	2004.1.1.151 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Flavi_DEAD	0.70	56.0	5.88e-01	82.6%	98.5%
None	—		0.70	65.0	4.98e-01	100.0%	74.7%
3243600	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.69	60.0	5.98e-01	90.6%	96.8%
3375012	2004.1.1.364 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD+Helicase_C	0.69	63.0	4.29e-01	96.6%	32.4%
3699161	2004.1.1.29 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD	0.69	63.0	5.42e-01	98.7%	80.0%
3612231	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.69	64.0	5.63e-01	100.0%	84.3%
3785149	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.68	64.0	5.97e-01	100.0%	84.4%
3256710	2004.1.1.29 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD	0.67	62.0	5.11e-01	100.0%	83.8%
3885274	2004.1.1.364 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD+Helicase_C	0.67	63.0	4.41e-01	100.0%	38.4%
3480374	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.67	61.0	5.21e-01	95.3%	96.9%
4014805	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.67	62.0	5.09e-01	99.3%	78.1%
5079727	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.65	57.0	5.31e-01	91.9%	81.1%
5064205	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.64	60.0	4.39e-01	99.3%	87.5%
4458848	2003.1.1.37 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 2-Hacid_dh_C	0.60	52.0	4.87e-01	94.0%	98.9%
3831653	2004.1.1.462 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › NBD_SMAX1	0.60	42.0	2.98e-01	71.8%	38.1%
3225997	2004.1.1.1 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA	0.59	42.0	3.60e-01	73.2%	75.4%
3207687	2003.1.1.37 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 2-Hacid_dh_C	0.58	50.0	4.55e-01	94.6%	98.5%
980655	2003.1.1.37 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 2-Hacid_dh_C	0.57	49.0	4.48e-01	93.3%	98.5%
1669134	2003.1.1.37 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 2-Hacid_dh_C	0.57	49.0	4.61e-01	94.6%	100.0%
3687325	2003.1.1.5 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › ADH_zinc_N	0.57	49.0	4.53e-01	94.6%	87.2%
3782971	2003.1.1.48 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › YjeF_N	0.57	50.0	4.23e-01	96.6%	97.2%
3822047	2004.1.1.432 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA, Rad17	0.57	41.0	3.42e-01	73.8%	73.6%
2523279	2003.1.1.37 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 2-Hacid_dh_C	0.57	49.0	4.40e-01	94.6%	89.5%
5063283	2003.1.1.37 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 2-Hacid_dh_C	0.57	49.0	4.53e-01	94.6%	100.0%
4996519	2003.1.1.37 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 2-Hacid_dh_C	0.57	49.0	4.47e-01	94.6%	98.0%
3709153	2004.1.1.1 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA	0.56	41.0	3.63e-01	73.8%	88.1%
3586459	2003.1.1.37 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 2-Hacid_dh_C	0.56	48.0	4.11e-01	94.0%	74.4%
4944493	2003.1.1.37 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 2-Hacid_dh_C	0.56	48.0	4.38e-01	94.0%	97.6%
3595479	2003.1.1.0 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains	0.56	48.0	4.47e-01	94.0%	99.5%
4978873	2003.1.1.37 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 2-Hacid_dh_C	0.56	48.0	4.38e-01	94.6%	98.5%
5011894	2003.1.1.37 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 2-Hacid_dh_C	0.56	48.0	4.51e-01	94.6%	98.9%
5025271	2003.1.1.37 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 2-Hacid_dh_C	0.56	48.0	4.54e-01	94.6%	99.4%
9144	2003.1.1.37 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 2-Hacid_dh_C	0.56	48.0	4.45e-01	94.6%	98.4%
5013923	2004.1.1.343 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_14	0.55	46.0	3.95e-01	100.0%	57.0%
3259523	2003.1.1.37 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 2-Hacid_dh_C	0.55	48.0	4.39e-01	94.6%	99.0%
None	—		0.55	47.0	4.36e-01	94.6%	100.0%
4944613	2003.1.1.37 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 2-Hacid_dh_C	0.55	46.0	4.33e-01	91.9%	99.5%
3667897	2003.1.1.37 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 2-Hacid_dh_C	0.55	47.0	4.19e-01	94.6%	99.1%
None	—		0.53	45.0	4.24e-01	93.3%	97.3%
5064439	7524.1.1.3 ↗	a/b three-layered sandwiches › ALDH-like › ALDH-like › ALDH-like › LuxC	0.52	37.0	3.24e-01	98.0%	48.0%

D4 medium residues 611-655_676-694

PDB

Domain cluster: representative

CATH (1)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1w36B04	1.10.486.10	Mainly Alpha › Orthogonal Bundle › PCRA; domain 4 › PCRA; domain 4	0.91	85.0	6.33e-01	100.0%	57.5%

ECOD (13)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3948292	2004.1.1.363 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase+UvrD_C	0.93	87.0	4.72e-01	100.0%	9.5%
3981160	2004.1.1.483 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase, AAA_19, UvrD_C	0.92	86.0	4.67e-01	100.0%	9.5%
1230977	2004.1.1.195 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD_C	0.91	85.0	5.03e-01	100.0%	20.4%
3965712	2004.1.1.195 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD_C	0.91	84.0	5.02e-01	100.0%	21.8%
3973583	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.88	82.0	4.48e-01	100.0%	9.2%
4615457	2004.1.1.363 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase+UvrD_C	0.82	73.0	4.10e-01	100.0%	10.9%
4299476	2004.1.1.195 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD_C	0.82	72.0	4.47e-01	100.0%	22.5%
5063118	2004.1.1.195 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD_C	0.78	67.0	4.12e-01	96.9%	23.9%
5064458	2004.1.1.195 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD_C	0.77	67.0	4.20e-01	100.0%	31.7%
4520419	2004.1.1.470 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD, UvrD-helicase, UvrD_C	0.74	64.0	3.52e-01	100.0%	11.1%
4040709	2004.1.1.483 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase, AAA_19, UvrD_C	0.74	64.0	3.51e-01	100.0%	10.7%
4950790	2004.1.1.49 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase	0.74	63.0	3.53e-01	100.0%	10.6%
4282858	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.70	61.0	3.30e-01	100.0%	9.4%

D5 medium residues 695-761

PDB

Domain cluster: representative

CATH (7)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1s8nA02	1.10.10.10	Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	0.68	46.0	4.93e-01	70.1%	89.7%
3no6A00	1.20.910.10	Mainly Alpha › Up-down Bundle › Heme Oxygenase; Chain A › Heme oxygenase-like	0.59	41.0	2.86e-01	74.6%	83.4%
3f4sA02	1.10.40.80	Mainly Alpha › Orthogonal Bundle › Ribonucleotide Reductase Protein R1; domain 1 ›	0.57	36.0	3.69e-01	80.6%	65.6%
1ufhA00	3.40.630.30	Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT)	0.56	42.0	3.27e-01	82.1%	41.3%
2om6A02	1.10.150.400	Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 ›	0.55	45.0	4.25e-01	91.0%	75.9%
2b3yA02	3.40.1060.10	Alpha Beta › 3-Layer(aba) Sandwich › Aconitase; Domain 2 › Aconitase, Domain 2	0.54	39.0	3.19e-01	77.6%	90.6%
1m4rB00	1.20.1250.10	Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; ›	0.51	38.0	3.05e-01	80.6%	55.3%

ECOD (4)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3948292	2004.1.1.363 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase+UvrD_C	0.88	83.0	4.53e-01	100.0%	7.7%
3735188	5050.1.1.0 ↗	alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter	0.63	50.0	3.47e-01	89.6%	81.2%
4950777	101.1.1.371 ↗	alpha arrays › HTH › HTH › Three-helical HTH › UPF0175	0.60	36.0	3.62e-01	89.6%	57.1%
3977796	186.1.1.15 ↗	alpha arrays › lambda integrase-N-like › lambda integrase-N › lambda integrase-N › Int_N	0.53	40.0	3.50e-01	88.1%	52.2%

D6 medium residues 792-851

PDB

Domain cluster: representative

CATH (29)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3ihpA03	3.90.70.10	Alpha Beta › Alpha-Beta Complex › Cathepsin B; Chain A › Cysteine proteinases	0.71	41.0	2.51e-01	93.3%	10.4%
5mu3B00	3.40.50.12050	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold ›	0.69	46.0	3.31e-01	100.0%	25.2%
1kf6B01	3.10.20.30	Alpha Beta › Roll › Ubiquitin-like (UB roll) › Beta-grasp domain	0.68	47.0	3.94e-01	73.3%	83.7%
3lltA02	1.10.510.10	Mainly Alpha › Orthogonal Bundle › Transferase(Phosphotransferase); domain 1 › Transferase(Phosphotransferase) domain 1	0.67	42.0	2.72e-01	91.7%	15.3%
1lhpA00	3.40.1190.20	Alpha Beta › 3-Layer(aba) Sandwich › UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase › Ribokinase	0.67	51.0	3.25e-01	83.3%	64.1%
5aj3Q00	2.40.50.140	Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins	0.59	44.0	3.62e-01	80.0%	64.2%
2bs2B01	3.10.20.30	Alpha Beta › Roll › Ubiquitin-like (UB roll) › Beta-grasp domain	0.59	42.0	3.51e-01	73.3%	83.0%
4a55A01	3.10.20.770	Alpha Beta › Roll › Ubiquitin-like (UB roll) ›	0.57	40.0	2.61e-01	75.0%	32.3%
6vq6H01	1.10.287.3240	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.57	48.0	3.29e-01	93.3%	42.6%
1iicA01	3.40.630.30	Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT)	0.56	42.0	3.00e-01	80.0%	72.8%
2gfoA00	3.90.70.10	Alpha Beta › Alpha-Beta Complex › Cathepsin B; Chain A › Cysteine proteinases	0.56	40.0	2.58e-01	78.3%	37.2%
3rhtA00	3.40.50.880	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Class I glutamine amidotransferase (GATase) domain	0.55	45.0	3.00e-01	90.0%	99.6%
2nlkA02	3.90.190.10	Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily	0.55	44.0	2.93e-01	90.0%	60.0%
1t3yA00	3.40.20.10	Alpha Beta › 3-Layer(aba) Sandwich › Severin › Severin	0.55	41.0	3.25e-01	83.3%	68.7%
3aonA00	1.10.287.3240	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.54	45.0	3.12e-01	90.0%	59.0%
2xc8A00	2.60.40.2980	Mainly Beta › Sandwich › Immunoglobulin-like ›	0.54	39.0	3.12e-01	76.7%	46.3%
3hhmA03	3.10.20.90	Alpha Beta › Roll › Ubiquitin-like (UB roll) › Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1	0.54	39.0	3.15e-01	83.3%	70.2%
1pvgA01	3.30.565.10	Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain	0.54	41.0	2.72e-01	83.3%	88.5%
5hc2B00	3.40.50.1820	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain	0.53	43.0	2.69e-01	88.3%	70.2%
5uh0A01	3.40.190.10	Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II	0.53	41.0	3.15e-01	83.3%	93.6%
2bzlA00	3.90.190.10	Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily	0.53	47.0	3.01e-01	98.3%	44.0%
1oi2A02	3.30.1180.20	Alpha Beta › 2-Layer Sandwich › Hypothetical Protein Tm841; Chain: A;domain 3 › Dihydroxyacetone kinase; domain 2	0.53	44.0	3.17e-01	90.0%	69.8%
2zylA02	3.90.380.10	Alpha Beta › Alpha-Beta Complex › Naphthalene 1,2-dioxygenase Alpha Subunit; Chain A, domain 1 › Naphthalene 1,2-dioxygenase Alpha Subunit; Chain A, domain 1	0.52	45.0	3.12e-01	100.0%	32.3%
4mh4A02	3.30.300.20	Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › K homology (KH) domain	0.52	42.0	3.66e-01	90.0%	75.5%
5axmB00	3.30.70.3000	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › tRNA(His) guanylyltransferase (Thg1)	0.52	41.0	2.74e-01	86.7%	47.3%
3bzwF00	3.40.50.1110	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › SGNH hydrolase	0.51	44.0	2.99e-01	100.0%	94.7%
2fggA01	3.30.160.240	Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › Rv1738	0.51	46.0	4.27e-01	96.7%	98.7%
2bjoA02	3.30.300.20	Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › K homology (KH) domain	0.51	40.0	3.54e-01	90.0%	75.5%
2qlzA02	6.10.250.2960	Special › Helix non-globular › Single alpha-helices involved in coiled-coils or other helix-helix interfaces ›	0.51	46.0	4.06e-01	100.0%	74.4%

ECOD (45)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
5049862	101.1.2.0 ↗	alpha arrays › HTH › HTH › winged helix domain	0.83	50.0	3.46e-01	100.0%	21.1%
3608646	4096.1.1.1 ↗	a+b two layers › NAP-like › NAP-like › NAP-like › NAP	0.80	47.0	2.99e-01	98.3%	13.3%
4935472	330.4.1.0 ↗	a+b two layers › dsRBD-like › Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain › Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain	0.78	37.0	3.49e-01	91.7%	38.6%
3927497	2484.5.1.3 ↗	mixed a+b and a/b › Ribonuclease H-like › RNaseH-like domain in reverse transcriptase › RNaseH-like domain in reverse transcriptase › RT_RNaseH_2	0.75	36.0	3.28e-01	93.3%	36.3%
3246511	219.1.1.3 ↗	a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › UCH	0.74	49.0	3.05e-01	100.0%	12.7%
4235295	219.1.1.3 ↗	a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › UCH	0.70	44.0	2.73e-01	93.3%	11.9%
3969662	5085.1.1.1 ↗	a+b duplicates or obligate multimers › Outer membrane efflux proteins (OEP) › Outer membrane efflux proteins (OEP) › Outer membrane efflux proteins (OEP) › OEP	0.69	50.0	2.96e-01	100.0%	11.5%
4213219	109.21.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain › Nucleoporin NUP85/Nucleoporin NUP145 C-terminal domain	0.67	51.0	2.86e-01	81.7%	41.5%
3701672	2004.1.1.26 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Kinesin	0.67	47.0	3.32e-01	73.3%	50.0%
3618372	2484.1.1.99 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › Peptidase_A17	0.67	43.0	3.36e-01	98.3%	32.5%
3484809	4096.1.1.1 ↗	a+b two layers › NAP-like › NAP-like › NAP-like › NAP	0.63	57.0	4.31e-01	100.0%	75.0%
3199254	604.6.1.41 ↗	alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain › DUF846	0.62	49.0	3.77e-01	86.7%	83.0%
3923319	2484.1.1.13 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RNase_T	0.61	42.0	2.75e-01	71.7%	56.2%
3632364	603.1.1.120 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins › DUF846	0.60	50.0	3.60e-01	90.0%	90.3%
4886985	7523.1.1.16 ↗	a/b three-layered sandwiches › Periplasmic binding protein-like II › Periplasmic binding protein-like II › Periplasmic binding protein-like II › DctP	0.59	35.0	2.70e-01	83.3%	28.0%
3634542	4099.1.1.0 ↗	a+b two layers › Kinetochore globular domain-like › Kinetochore globular domain-like › Kinetochore globular domain-like	0.59	46.0	3.32e-01	83.3%	47.3%
4309308	275.1.1.0 ↗	a+b two layers › MoeA-I/Ornithine decarboxylase-C/Reverse ferredoxin-like domain in RNA-polymerase › MoeA-I/Ornithine decarboxylase-C/Reverse ferredoxin-like domain in RNA-polymerase › MoeA-I/Ornithine decarboxylase-C/Reverse ferredoxin-like domain in RNA-polymerase	0.59	42.0	3.86e-01	76.7%	70.0%
3558274	4096.1.1.1 ↗	a+b two layers › NAP-like › NAP-like › NAP-like › NAP	0.58	49.0	3.23e-01	100.0%	35.0%
5050213	192.2.1.87 ↗	alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin › ATP-synt_D	0.57	45.0	3.07e-01	83.3%	53.2%
4972532	878.1.1.1 ↗	a+b two layers › Hypothetical protein MTH677 › Hypothetical protein MTH677 › Hypothetical protein MTH677 › DUF3194	0.57	52.0	4.49e-01	100.0%	88.9%
3740226	5051.1.1.7 ↗	alpha complex topology › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › Nramp	0.57	50.0	2.97e-01	98.3%	52.0%
1827072	223.1.1.1 ↗	a+b three layers › Profilin-like › sensor domains › sensor domains › PHY	0.57	44.0	3.15e-01	85.0%	100.0%
3728856	171.1.1.9 ↗	alpha arrays › RNase III catalytic domain-like › RNase III catalytic domain-like › RNase III catalytic domain-like › Ribonuclease_3, Ribonucleas_3_3	0.57	43.0	2.91e-01	81.7%	28.0%
4954522	878.1.1.1 ↗	a+b two layers › Hypothetical protein MTH677 › Hypothetical protein MTH677 › Hypothetical protein MTH677 › DUF3194	0.56	50.0	4.27e-01	98.3%	79.8%
3670739	101.1.2.98 ↗	alpha arrays › HTH › HTH › winged helix domain › CDT1	0.56	48.0	3.48e-01	93.3%	70.6%
3595936	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.55	47.0	2.93e-01	93.3%	60.6%
3265334	216.1.1.0 ↗	a+b two layers › UBC-like › UBC-like › UBC-like	0.55	40.0	3.25e-01	76.7%	55.5%
5065294	4051.1.1.0 ↗	a+b two layers › a+b domain in Capz › a+b domain in Capz › a+b domain in Capz	0.55	50.0	3.58e-01	100.0%	71.8%
3632975	3447.1.1.1 ↗	alpha bundles › Isoprenylcysteine carboxyl methyltransferase (ICMT) › Isoprenylcysteine carboxyl methyltransferase (ICMT) › Isoprenylcysteine carboxyl methyltransferase (ICMT) › ERG4_ERG24	0.55	47.0	3.17e-01	95.0%	85.2%
4023691	4096.1.1.1 ↗	a+b two layers › NAP-like › NAP-like › NAP-like › NAP	0.55	51.0	3.29e-01	100.0%	36.0%
5037750	3926.1.1.1 ↗	alpha bundles › V-type proton ATPase subunit D › V-type proton ATPase subunit D › V-type proton ATPase subunit D › ATP-synt_D	0.54	50.0	3.38e-01	98.3%	99.0%
4597941	3926.1.1.0 ↗	alpha bundles › V-type proton ATPase subunit D › V-type proton ATPase subunit D › V-type proton ATPase subunit D	0.54	45.0	3.10e-01	90.0%	55.1%
3328712	4964.1.1.0 ↗	alpha arrays › helical bundle in Bacillus stearothermophilus-like DNA polymerase I › helical bundle in Bacillus stearothermophilus-like DNA polymerase I › helical bundle in Bacillus stearothermophilus-like DNA polymerase I	0.53	45.0	3.10e-01	96.7%	38.7%
4995231	101.1.2.914 ↗	alpha arrays › HTH › HTH › winged helix domain › DUF6015	0.53	35.0	3.10e-01	70.0%	57.8%
3961814	604.2.1.1 ↗	alpha bundles › Spectrin repeat-like › Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain › Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain › Succ_DH_flav_C	0.52	44.0	3.29e-01	91.7%	61.4%
3717255	4096.1.1.1 ↗	a+b two layers › NAP-like › NAP-like › NAP-like › NAP	0.52	45.0	2.94e-01	100.0%	32.3%
4984373	3926.1.1.1 ↗	alpha bundles › V-type proton ATPase subunit D › V-type proton ATPase subunit D › V-type proton ATPase subunit D › ATP-synt_D	0.51	47.0	3.17e-01	100.0%	65.9%
3390596	3926.1.1.1 ↗	alpha bundles › V-type proton ATPase subunit D › V-type proton ATPase subunit D › V-type proton ATPase subunit D › ATP-synt_D	0.51	47.0	3.10e-01	100.0%	48.3%
4933528	3926.1.1.1 ↗	alpha bundles › V-type proton ATPase subunit D › V-type proton ATPase subunit D › V-type proton ATPase subunit D › ATP-synt_D	0.51	46.0	3.13e-01	100.0%	66.7%
3646079	331.3.1.0 ↗	a+b two layers › TBP-like › Bet v1-like › Bet v1-like	0.51	43.0	3.44e-01	95.0%	95.0%
3793204	219.1.1.3 ↗	a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › UCH	0.50	45.0	2.89e-01	100.0%	23.5%
3638181	2003.1.5.81 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_25	0.50	38.0	2.45e-01	81.7%	46.2%
4609849	242.1.1.0 ↗	a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases	0.50	37.0	3.28e-01	80.0%	80.0%
3593809	304.31.1.0 ↗	a+b two layers › Alpha-beta plaits › HMG-CoA reductase › NAD-binding domain of HMG-CoA reductase	0.50	43.0	3.53e-01	95.0%	88.2%
3982740	5086.1.1.190 ↗	alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › OEP	0.50	45.0	3.12e-01	100.0%	39.0%

D7 medium residues 969-1067

PDB

Domain cluster: representative

CATH (8)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3s64A00	1.10.225.10	Mainly Alpha › Orthogonal Bundle › NK-Lysin › Saposin-like	0.64	44.0	4.82e-01	84.8%	87.7%
2c42A03	3.40.920.10	Alpha Beta › 3-Layer(aba) Sandwich › Pyruvate-ferredoxin Oxidoreductase; domain 3 › Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	0.55	39.0	3.10e-01	85.9%	34.0%
5jxxA02	1.20.1180.10	Mainly Alpha › Up-down Bundle › Udp N-acetylglucosamine O-acyltransferase; Domain 2 › Udp N-acetylglucosamine O-acyltransferase, C-terminal domain	0.54	33.0	3.92e-01	89.9%	92.4%
6ynwH01	1.20.20.10	Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C	0.54	30.0	3.40e-01	90.9%	73.0%
3h36A00	1.10.10.400	Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Polyribonucleotide nucleotidyltransferase, RNA-binding domain	0.53	39.0	4.23e-01	93.9%	100.0%
3egqA00	1.10.357.10	Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2	0.52	40.0	3.47e-01	87.9%	50.6%
3gyuA00	1.10.565.10	Mainly Alpha › Orthogonal Bundle › Retinoid X Receptor › Retinoid X Receptor	0.52	44.0	3.39e-01	96.0%	57.9%
3eupB00	1.10.357.10	Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2	0.50	42.0	3.35e-01	90.9%	49.5%

ECOD (11)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4426191	101.1.3.26 ↗	alpha arrays › HTH › HTH › tetra-helical, LuxR-like › YcbB	0.59	47.0	4.07e-01	86.9%	95.6%
5044421	592.2.1.0 ↗	alpha arrays › PWI domain-like › YugE-like › YugE-like	0.58	40.0	4.29e-01	93.9%	87.5%
3518340	2004.1.3.2 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › Pyruvate-ferredoxin oxidoreductase, PFOR, domain III › POR,EKR	0.57	40.0	3.01e-01	85.9%	28.4%
3990043	5069.1.1.4 ↗	alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes › Ferric_reduct	0.56	41.0	3.45e-01	78.8%	91.7%
4049391	101.11.1.1 ↗	alpha arrays › HTH › Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 › Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 › PNPase	0.55	42.0	4.25e-01	94.9%	85.3%
3219867	101.1.1.0 ↗	alpha arrays › HTH › HTH › Three-helical HTH	0.55	36.0	3.84e-01	87.9%	77.6%
3264555	532.2.1.0 ↗	alpha arrays › Type III secretion system domain-like › Type III secretion system domains › Type III secretion system domains	0.54	32.0	3.66e-01	86.9%	81.4%
3228275	109.4.1.32 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › MIF4G	0.53	38.0	2.67e-01	72.7%	57.4%
3590851	181.2.1.1 ↗	alpha bundles › Domain of the SRP/SRP receptor G proteins-like › CtsR dimerization domain › CtsR dimerization domain › CtsR_C	0.52	35.0	3.78e-01	72.7%	85.0%
4011398	633.24.1.0 ↗	alpha bundles › Bromodomain-like › RABEX-5 helical domain › RABEX-5 helical domain	0.51	36.0	3.87e-01	85.9%	87.1%
3940293	188.1.1.0 ↗	alpha arrays › Nuclear receptor ligand-binding domain › Nuclear receptor ligand-binding domain › Nuclear receptor ligand-binding domain	0.51	43.0	3.38e-01	94.9%	78.2%

D8 medium residues 1068-1232

PDB

Domain cluster: rep: MN698246.1__QGZ18180.1__HTVC112P_gp03__00003__D120-243

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF12705.14 best	PDDEXK_1	27.5	4.20e-06	93.3%	37.2%

CATH (24)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1w36B05	3.90.320.10	Alpha Beta › Alpha-Beta Complex › Lambda Exonuclease; Chain A ›	0.92	87.0	6.96e-01	97.6%	56.3%
3fovA00	3.40.1350.10	Alpha Beta › 3-Layer(aba) Sandwich › Trna Endonuclease; Chain: A, domain 1 ›	0.72	41.0	5.09e-01	89.1%	90.2%
7mi4A01	3.90.320.10	Alpha Beta › Alpha-Beta Complex › Lambda Exonuclease; Chain A ›	0.72	47.0	4.46e-01	95.2%	56.4%
3h4rA00	3.90.320.10	Alpha Beta › Alpha-Beta Complex › Lambda Exonuclease; Chain A ›	0.71	48.0	4.31e-01	95.2%	51.1%
2eo0B00	3.40.1350.10	Alpha Beta › 3-Layer(aba) Sandwich › Trna Endonuclease; Chain: A, domain 1 ›	0.65	32.0	3.60e-01	87.9%	59.7%
3u4qA06	3.90.320.10	Alpha Beta › Alpha-Beta Complex › Lambda Exonuclease; Chain A ›	0.63	53.0	4.72e-01	86.1%	70.9%
4aukA01	3.30.70.2810	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.63	27.0	3.76e-01	89.1%	81.0%
2azpA02	3.10.310.10	Alpha Beta › Roll › Diaminopimelate Epimerase; Chain A, domain 1 › Diaminopimelate Epimerase; Chain A, domain 1	0.59	36.0	3.66e-01	90.3%	60.5%
2fgyA03	3.30.1330.140	Alpha Beta › 2-Layer Sandwich › 60s Ribosomal Protein L30; Chain: A; › Carboxysome Shell Carbonic Anhydrase, C-terminal domain	0.58	35.0	4.13e-01	89.7%	85.5%
1rznA00	3.40.1350.10	Alpha Beta › 3-Layer(aba) Sandwich › Trna Endonuclease; Chain: A, domain 1 ›	0.57	33.0	3.50e-01	89.7%	61.3%
4i1tA02	3.30.70.2640	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Arenavirus RNA polymerase	0.56	30.0	3.96e-01	77.0%	100.0%
1xmxA02	3.40.1350.10	Alpha Beta › 3-Layer(aba) Sandwich › Trna Endonuclease; Chain: A, domain 1 ›	0.56	38.0	4.04e-01	85.5%	77.2%
3trgA00	3.30.70.100	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.55	25.0	3.20e-01	77.6%	70.2%
1y88A01	3.40.1350.10	Alpha Beta › 3-Layer(aba) Sandwich › Trna Endonuclease; Chain: A, domain 1 ›	0.55	32.0	3.65e-01	89.7%	75.2%
4g1iA03	3.30.70.1770	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.55	25.0	3.58e-01	76.4%	97.1%
3sm4A00	3.90.320.10	Alpha Beta › Alpha-Beta Complex › Lambda Exonuclease; Chain A ›	0.54	48.0	4.29e-01	94.5%	85.8%
3vtiA01	3.30.70.100	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.54	26.0	3.20e-01	77.0%	71.9%
3ezjA02	3.30.1370.120	Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 ›	0.54	23.0	3.33e-01	92.7%	89.7%
3ewgA00	3.30.70.940	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › NusG, N-terminal domain	0.54	24.0	3.18e-01	90.9%	78.8%
3ajvC02	3.40.1350.10	Alpha Beta › 3-Layer(aba) Sandwich › Trna Endonuclease; Chain: A, domain 1 ›	0.53	29.0	3.83e-01	92.1%	96.7%
3odhA00	3.40.91.20	Alpha Beta › 3-Layer(aba) Sandwich › Restriction Endonuclease ›	0.53	33.0	3.17e-01	90.3%	52.1%
6p4wB01	3.40.91.30	Alpha Beta › 3-Layer(aba) Sandwich › Restriction Endonuclease ›	0.52	31.0	3.73e-01	85.5%	89.0%
1darA04	3.30.230.10	Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 ›	0.50	30.0	3.48e-01	94.5%	81.5%
4da2A02	3.40.1350.60	Alpha Beta › 3-Layer(aba) Sandwich › Trna Endonuclease; Chain: A, domain 1 ›	0.50	34.0	3.57e-01	88.5%	74.3%

ECOD (92)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3166039	2008.1.1.59 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › PDDEXK_1	0.95	87.0	6.85e-01	93.9%	52.5%
4441625	2008.1.1.0 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like	0.94	87.0	6.98e-01	95.2%	56.3%
4501322	2008.1.1.0 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like	0.94	66.0	5.74e-01	95.2%	51.3%
4287226	2008.1.1.0 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like	0.93	86.0	6.79e-01	95.2%	53.6%
3961440	2008.1.1.0 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like	0.93	85.0	6.43e-01	94.5%	57.1%
3973582	2008.1.1.0 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like	0.92	84.0	6.65e-01	93.3%	70.8%
3954921	2008.1.1.59 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › PDDEXK_1	0.92	87.0	6.61e-01	97.6%	55.5%
1230978	2008.1.1.59 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › PDDEXK_1	0.92	87.0	6.90e-01	97.6%	54.8%
4387318	2008.1.1.59 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › PDDEXK_1	0.87	49.0	4.22e-01	86.1%	39.1%
4310493	2008.1.1.0 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like	0.84	50.0	4.31e-01	85.5%	40.4%
4490768	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.84	48.0	2.79e-01	84.8%	7.7%
4181314	2008.1.1.59 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › PDDEXK_1	0.83	51.0	4.45e-01	87.3%	44.0%
4477991	2008.1.1.59 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › PDDEXK_1	0.83	51.0	4.36e-01	85.5%	41.6%
4457776	2008.1.1.59 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › PDDEXK_1	0.82	52.0	4.38e-01	85.5%	40.8%
4626907	2008.1.1.0 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like	0.82	53.0	4.47e-01	86.7%	41.7%
4497527	2008.1.1.59 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › PDDEXK_1	0.81	50.0	4.29e-01	86.1%	42.0%
4607429	2008.1.1.59 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › PDDEXK_1	0.81	53.0	4.42e-01	87.3%	41.9%
4058806	2008.1.1.59 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › PDDEXK_1	0.80	53.0	4.31e-01	87.3%	39.1%
4556841	2008.1.1.59 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › PDDEXK_1	0.80	51.0	4.28e-01	84.8%	40.8%
4943737	2008.1.1.0 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like	0.80	55.0	5.59e-01	95.2%	71.2%
4489809	2008.1.1.59 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › PDDEXK_1	0.79	71.0	5.67e-01	95.2%	52.4%
4414555	2008.1.1.59 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › PDDEXK_1	0.78	50.0	4.17e-01	86.1%	40.9%
5005960	2008.1.1.4 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › Cas_Cas4	0.75	48.0	4.59e-01	95.2%	57.1%
4533235	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.74	55.0	3.18e-01	85.5%	10.0%
3976411	2008.1.1.58 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › DUF3799	0.73	51.0	4.37e-01	95.2%	46.5%
4991917	2008.1.1.107 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › NERD	0.73	40.0	4.39e-01	87.9%	63.6%
3509755	2008.1.1.0 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like	0.71	42.0	4.45e-01	86.7%	64.7%
5076295	2008.1.1.107 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › NERD	0.71	44.0	4.90e-01	86.7%	76.3%
4046812	2008.1.1.4 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › Cas_Cas4	0.71	45.0	4.29e-01	95.2%	55.8%
4604110	2008.1.1.0 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like	0.70	42.0	4.06e-01	86.1%	53.9%
4411889	2008.1.1.0 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like	0.69	41.0	3.70e-01	86.1%	43.6%
4209016	2008.1.1.0 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like	0.69	41.0	3.66e-01	85.5%	42.2%
4930402	2008.1.1.59 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › PDDEXK_1	0.68	50.0	4.91e-01	94.5%	70.3%
5041156	2008.1.1.59 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › PDDEXK_1	0.68	50.0	5.06e-01	95.2%	75.8%
4239877	2008.1.1.97 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › Exo5	0.67	53.0	4.17e-01	95.2%	41.9%
5044802	2008.1.1.0 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like	0.66	42.0	3.88e-01	87.3%	50.0%
4958249	2008.1.1.97 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › Exo5	0.65	53.0	4.46e-01	95.2%	54.1%
4426454	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.64	54.0	3.14e-01	86.7%	13.1%
4937277	2008.1.1.108 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › DUF234	0.64	35.0	3.92e-01	87.3%	65.9%
4941691	2008.1.1.16 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › Mrr_cat	0.64	45.0	4.66e-01	88.5%	76.6%
3102571	2008.1.1.0 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like	0.63	37.0	3.97e-01	89.1%	66.4%
4933915	2008.1.1.16 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › Mrr_cat	0.63	46.0	4.74e-01	89.1%	78.1%
4943984	2008.1.1.0 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like	0.62	45.0	4.35e-01	87.9%	65.9%
4467601	2008.1.1.59 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › PDDEXK_1	0.62	52.0	4.35e-01	86.7%	59.6%
4960251	2008.1.1.16 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › Mrr_cat	0.62	42.0	4.68e-01	88.5%	85.7%
5011600	2008.1.1.108 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › DUF234	0.62	35.0	4.32e-01	81.2%	85.5%
3813800	2008.1.1.107 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › NERD	0.62	46.0	4.90e-01	81.8%	85.3%
4402765	2008.1.1.0 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like	0.61	42.0	4.71e-01	88.5%	88.4%
4929290	2008.1.1.0 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like	0.61	33.0	3.72e-01	87.3%	67.2%
5081063	2008.1.1.0 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like	0.61	47.0	4.27e-01	96.4%	60.0%
4999640	2008.1.1.4 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › Cas_Cas4	0.61	47.0	4.34e-01	96.4%	62.9%
4998336	2008.1.1.107 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › NERD	0.61	45.0	4.83e-01	87.3%	86.2%
4389411	2008.1.1.59 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › PDDEXK_1	0.61	51.0	4.26e-01	86.1%	58.9%
5031791	2008.1.1.16 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › Mrr_cat	0.61	36.0	4.44e-01	81.8%	91.4%
5079137	2008.1.1.16 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › Mrr_cat	0.61	44.0	4.79e-01	85.5%	87.1%
5051988	2008.1.1.0 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like	0.61	36.0	4.15e-01	81.8%	80.0%
4956304	2008.1.1.0 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like	0.60	45.0	4.23e-01	89.1%	63.5%
4641844	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.60	50.0	2.93e-01	86.7%	12.4%
4946571	2008.1.1.85 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › RE_TdeIII	0.60	37.0	3.48e-01	90.3%	48.8%
4047845	2008.1.1.59 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › PDDEXK_1	0.60	50.0	4.27e-01	84.8%	62.9%
4951715	2008.1.1.16 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › Mrr_cat	0.60	36.0	4.25e-01	81.2%	85.2%
5073133	2008.1.1.16 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › Mrr_cat	0.60	44.0	4.66e-01	87.3%	83.3%
4101307	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.60	50.0	2.91e-01	86.7%	12.5%
4096358	2008.1.1.59 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › PDDEXK_1	0.60	50.0	4.60e-01	85.5%	72.0%
4282858	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.59	49.0	2.88e-01	86.7%	13.2%
4979146	2008.1.1.107 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › NERD	0.59	44.0	4.48e-01	88.5%	79.4%
5078940	2008.1.1.0 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like	0.58	38.0	3.99e-01	88.5%	69.7%
3839413	2008.1.1.34 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › Card1_endonuc	0.58	39.0	4.21e-01	85.5%	77.9%
5074941	2008.1.1.0 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like	0.58	32.0	3.91e-01	82.4%	81.8%
4031223	2008.1.1.204 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › DUF2800	0.58	51.0	4.39e-01	95.2%	61.6%
5021943	2008.1.1.59 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › PDDEXK_1	0.57	50.0	4.34e-01	95.2%	62.5%
5005553	2008.1.1.59 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › PDDEXK_1	0.57	52.0	4.31e-01	95.2%	60.4%
4212352	2008.1.1.59 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › PDDEXK_1	0.57	47.0	3.93e-01	84.8%	59.6%
4060254	2008.1.1.59 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › PDDEXK_1	0.57	47.0	4.05e-01	86.7%	58.0%
5029280	2008.1.1.59 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › PDDEXK_1	0.57	50.0	4.62e-01	92.1%	91.2%
5025064	2008.1.1.59 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › PDDEXK_1	0.57	49.0	4.26e-01	95.2%	62.1%
4968040	2008.1.1.235 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › PF26618	0.57	39.0	4.38e-01	83.0%	89.2%
4975459	2008.1.1.0 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like	0.56	43.0	4.41e-01	88.5%	83.9%
4969306	2008.1.1.0 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like	0.56	50.0	4.15e-01	95.2%	58.1%
1030945	2008.1.1.34 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › Card1_endonuc	0.56	38.0	4.22e-01	85.5%	85.2%
5072639	2008.1.1.0 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like	0.55	43.0	4.39e-01	86.7%	83.0%
4597944	2008.1.1.0 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like	0.55	50.0	3.86e-01	95.2%	57.1%
4579488	2008.1.1.59 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › PDDEXK_1	0.55	50.0	3.86e-01	95.2%	57.1%
4676615	2008.1.1.85 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › RE_TdeIII	0.55	45.0	3.77e-01	86.7%	55.6%
5057728	2008.1.1.0 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like	0.54	36.0	4.15e-01	87.3%	89.6%
4955318	2008.1.1.16 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › Mrr_cat	0.54	34.0	3.85e-01	85.5%	81.2%
4926971	2008.1.1.0 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like	0.54	36.0	3.72e-01	87.3%	71.6%
5063088	2008.1.1.59 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › PDDEXK_1	0.54	49.0	3.96e-01	95.2%	57.2%
5064206	2008.1.1.59 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › PDDEXK_1	0.54	47.0	3.98e-01	95.2%	58.5%
5053352	2008.1.1.0 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like	0.52	43.0	4.41e-01	89.1%	91.9%
2983287	2008.1.1.0 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like	0.52	37.0	4.11e-01	88.5%	90.2%
3387986	2008.1.1.59 ↗	a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › PDDEXK_1	0.50	42.0	3.64e-01	95.2%	59.2%