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CPXV075_protein
Euk-VirCowpox_virus
CPXV075_protein__NP_619862__Cowpox_virus__10243
Identity
- Accession:
- NP_619862 ↗
- Protein ID:
- CPXV075_protein
- Kingdom:
- euk
Quality
83.0
mean pLDDT
Taxonomy
Bamfordvirae›
Nucleocytoviricota›
Pokkesviricetes›
Chitovirales›
Poxviridae›
Orthopoxvirus›
Cowpox_virus
TaxID: 10243
Cluster
View cluster (158 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 162-344_437-485
Domain cluster:
rep: DNA_polymerase_catalytic_subunit__YP_401712__Human_gammaherpesvirus_4__10376__D288-457
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF03104.26 best | DNA_pol_B_exo1 | 77.5 | 1.50e-21 | 80.6% | 70.2% |
| PF08408.17 | DNA_pol_B_3 | 73.2 | 3.30e-20 | 33.2% | 32.8% |
CATH (16)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3iayA03 | 3.30.420.10 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H | 0.80 | 70.0 | 7.36e-01 | 95.3% | 98.6% |
| 1s5jA02 | 3.30.420.10 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H | 0.76 | 62.0 | 6.75e-01 | 93.5% | 99.5% |
| 4qclA03 | 3.30.420.10 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H | 0.75 | 71.0 | 6.71e-01 | 100.0% | 84.5% |
| 2gv9A03 | 3.30.420.10 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H | 0.74 | 68.0 | 6.98e-01 | 95.7% | 99.5% |
| 2p1jA01 | 3.30.420.10 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H | 0.71 | 42.0 | 5.45e-01 | 94.8% | 98.6% |
| 1noyB02 | 3.30.420.10 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H | 0.71 | 65.0 | 6.64e-01 | 96.1% | 99.6% |
| 1j54A00 | 3.30.420.10 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H | 0.67 | 49.0 | 5.65e-01 | 96.6% | 99.4% |
| 2qxfA01 | 3.30.420.10 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H | 0.66 | 52.0 | 5.72e-01 | 97.0% | 97.9% |
| 3ci0J02 | 2.10.70.20 | Mainly Beta › Ribbon › Complement Module; domain 1 › gspk-gspi-gspj complex like domains | 0.64 | 15.0 | 3.47e-01 | 83.6% | 96.0% |
| 4fzxC00 | 3.30.420.10 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H | 0.63 | 43.0 | 5.12e-01 | 99.1% | 97.0% |
| 1x9mA01 | 3.30.420.10 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H | 0.63 | 54.0 | 5.47e-01 | 100.0% | 90.7% |
| 2f96A00 | 3.30.420.10 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H | 0.62 | 49.0 | 5.25e-01 | 99.1% | 94.0% |
| 3ctzA02 | 3.40.350.10 | Alpha Beta › 3-Layer(aba) Sandwich › Creatine Amidinohydrolase; Chain A, domain 1 › Creatinase/prolidase N-terminal domain | 0.56 | 31.0 | 3.67e-01 | 91.4% | 76.2% |
| 3cetB01 | 3.30.420.40 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain | 0.53 | 26.0 | 3.69e-01 | 78.9% | 97.3% |
| 7r7jA01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.51 | 30.0 | 3.27e-01 | 86.2% | 67.7% |
| 2g1lA00 | 2.60.200.20 | Mainly Beta › Sandwich › Tumour Suppressor Smad4 › | 0.51 | 21.0 | 2.99e-01 | 90.9% | 78.6% |
ECOD (40)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3089543 | 2484.1.1.34 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1 | 0.88 | 72.0 | 7.61e-01 | 94.4% | 91.5% |
| 4492006 | 2484.1.1.34 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1 | 0.83 | 65.0 | 6.12e-01 | 100.0% | 68.9% |
| 4502019 | 2484.1.1.197 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1, DNA_pol_B_exo2 | 0.83 | 71.0 | 5.67e-01 | 100.0% | 49.4% |
| 4988803 | 2484.1.1.34 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1 | 0.82 | 71.0 | 5.72e-01 | 100.0% | 51.6% |
| 4972474 | 2484.1.1.0 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like | 0.82 | 73.0 | 5.05e-01 | 100.0% | 31.7% |
| 4939488 | 2484.1.1.34 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1 | 0.81 | 66.0 | 6.08e-01 | 100.0% | 67.6% |
| 4990754 | 2484.1.1.34 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1 | 0.81 | 65.0 | 6.69e-01 | 100.0% | 85.8% |
| 5019480 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.80 | 73.0 | 4.92e-01 | 100.0% | 29.9% |
| 5036329 | 2484.1.1.34 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1 | 0.80 | 63.0 | 6.34e-01 | 100.0% | 80.0% |
| None | — | 0.80 | 76.0 | 5.28e-01 | 100.0% | 35.7% | |
| 5073475 | 2484.1.1.0 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like | 0.80 | 45.0 | 4.06e-01 | 100.0% | 41.9% |
| 5029084 | 2484.1.1.34 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1 | 0.79 | 69.0 | 7.02e-01 | 100.0% | 91.6% |
| 3558197 | 2484.1.1.34 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1 | 0.79 | 75.0 | 7.39e-01 | 100.0% | 92.7% |
| 3368695 | 2484.1.1.0 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like | 0.79 | 75.0 | 6.12e-01 | 100.0% | 58.2% |
| None | — | 0.79 | 75.0 | 5.23e-01 | 100.0% | 35.5% | |
| 3710418 | 2484.1.1.34 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1 | 0.79 | 75.0 | 6.23e-01 | 100.0% | 61.1% |
| None | — | 0.79 | 75.0 | 6.29e-01 | 100.0% | 62.7% | |
| 3584771 | 2484.1.1.197 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1, DNA_pol_B_exo2 | 0.78 | 70.0 | 6.34e-01 | 100.0% | 72.5% |
| 3619240 | 304.48.1.59 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B_exo1, DNA_pol_B_exo2 | 0.78 | 70.0 | 4.67e-01 | 100.0% | 28.2% |
| 3798596 | 2484.1.1.0 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like | 0.78 | 70.0 | 7.14e-01 | 100.0% | 95.1% |
| 4649118 | 2484.1.1.197 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1, DNA_pol_B_exo2 | 0.78 | 70.0 | 5.65e-01 | 100.0% | 54.2% |
| 3784398 | 2484.1.1.34 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1 | 0.78 | 74.0 | 7.19e-01 | 100.0% | 93.3% |
| 3802227 | 2484.1.1.197 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1, DNA_pol_B_exo2 | 0.78 | 70.0 | 4.55e-01 | 100.0% | 25.1% |
| 3206356 | 304.114.1.0 ↗ | a+b two layers › Alpha-beta plaits › Family B DNA polymerase insertion domain › Family B DNA polymerase insertion domain | 0.77 | 74.0 | 6.00e-01 | 100.0% | 60.3% |
| 3684974 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.77 | 74.0 | 5.15e-01 | 100.0% | 36.5% |
| 4023334 | 2484.1.1.34 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1 | 0.77 | 73.0 | 6.82e-01 | 100.0% | 86.1% |
| 5000651 | 2484.1.1.34 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1 | 0.76 | 73.0 | 5.95e-01 | 100.0% | 61.3% |
| 3496492 | 2484.1.1.0 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like | 0.73 | 70.0 | 6.44e-01 | 100.0% | 81.4% |
| 3705562 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.73 | 69.0 | 4.80e-01 | 100.0% | 34.7% |
| 4932453 | 2484.1.1.34 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1 | 0.73 | 70.0 | 6.18e-01 | 100.0% | 76.9% |
| 4891100 | 2484.1.1.161 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like | 0.72 | 66.0 | 6.25e-01 | 100.0% | 81.7% |
| 4037317 | 2484.1.1.13 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RNase_T | 0.69 | 50.0 | 5.36e-01 | 99.6% | 83.9% |
| 4103309 | 2484.1.1.13 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RNase_T | 0.67 | 50.0 | 5.28e-01 | 100.0% | 84.3% |
| 3951189 | 2484.1.1.68 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RNase_H_2 | 0.67 | 57.0 | 5.73e-01 | 99.6% | 88.3% |
| 3226038 | 2484.1.1.0 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like | 0.62 | 39.0 | 4.39e-01 | 99.6% | 79.4% |
| 4432712 | 12.1.1.0 ↗ | beta sandwiches › Glycosyl hydrolase domain-like › Glycosyl hydrolase domain › Glycosyl hydrolase domain | 0.59 | 17.0 | 3.05e-01 | 90.1% | 78.6% |
| 3287981 | 2.1.1.94 ↗ | beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › TLP1_add_C | 0.58 | 18.0 | 3.24e-01 | 87.5% | 85.3% |
| 3827585 | 2.1.1.130 ↗ | beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › DUF223 | 0.58 | 20.0 | 2.97e-01 | 91.4% | 67.6% |
| 4428763 | 2484.1.1.36 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_2 | 0.57 | 54.0 | 5.33e-01 | 99.6% | 95.4% |
| 4003494 | 221.14.1.1 ↗ | a+b two layers › beta-Grasp › TAR DNA-binding protein 43 N-terminal domain › TAR DNA-binding protein 43 N-terminal domain › TDP43_N | 0.53 | 23.0 | 3.32e-01 | 71.6% | 91.6% |
D2
high
residues 357-430
Domain cluster:
rep: DNA_polymerase_elongation_subunit_family_B__YP_009162448__Salmon_gill_poxvirus__1680908__D388-474
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF08408.17 best | DNA_pol_B_3 | 65.0 | 1.10e-17 | 100.0% | 54.7% |
D3
high
residues 831-996
Domain cluster:
rep: IMGVR_UViG_3300021255_003095-3300021255-Ga0223825_1010595139__D209-342
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00136.27 best | DNA_pol_B | 113.6 | 1.50e-32 | 93.4% | 32.7% |
D4
medium
residues 489-522_620-645
Domain cluster:
representative
CATH (14)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2ckwA03 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.68 | 43.0 | 3.47e-01 | 86.7% | 33.6% |
| 2q5zB00 | 1.10.287.1080 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › MazG-like | 0.68 | 46.0 | 3.92e-01 | 98.3% | 44.7% |
| 3h6pC00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.67 | 45.0 | 4.69e-01 | 76.7% | 75.0% |
| 2fnaA02 | 1.10.8.60 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › | 0.67 | 53.0 | 4.91e-01 | 86.7% | 100.0% |
| 3zgzA04 | 1.10.730.10 | Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1 | 0.62 | 49.0 | 3.51e-01 | 86.7% | 31.1% |
| 2oq1A02 | 1.10.930.10 | Mainly Alpha › Orthogonal Bundle › Syk Kinase; Chain A, domain 2 › Syk Kinase; Chain A, domain 2 | 0.61 | 40.0 | 4.44e-01 | 71.7% | 88.9% |
| 3kcuD00 | 1.20.1080.10 | Mainly Alpha › Up-down Bundle › Glycerol uptake facilitator protein › Glycerol uptake facilitator protein. | 0.60 | 49.0 | 3.27e-01 | 91.7% | 98.0% |
| 1m3sB00 | 3.40.50.10490 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Glucose-6-phosphate isomerase like protein; domain 1 | 0.59 | 48.0 | 3.41e-01 | 88.3% | 47.5% |
| 2rkhA02 | 1.20.1280.20 | Mainly Alpha › Up-down Bundle › Monooxygenase › HscB, C-terminal domain | 0.58 | 42.0 | 3.87e-01 | 75.0% | 65.8% |
| 7abaA01 | 1.10.630.10 | Mainly Alpha › Orthogonal Bundle › Cytochrome p450 › Cytochrome P450 | 0.58 | 50.0 | 3.07e-01 | 96.7% | 38.1% |
| 2i7uA00 | 6.10.250.1010 | Special › Helix non-globular › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › | 0.56 | 39.0 | 3.95e-01 | 75.0% | 79.0% |
| 1h2tC03 | 1.25.40.180 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.54 | 46.0 | 3.07e-01 | 95.0% | 36.8% |
| 8alzB08 | 1.10.3380.10 | Mainly Alpha › Orthogonal Bundle › Sec63 N-terminal domain-like fold › Sec63 N-terminal domain-like domain | 0.53 | 38.0 | 3.13e-01 | 81.7% | 69.5% |
| 1qsaA03 | 1.10.530.10 | Mainly Alpha › Orthogonal Bundle › Lysozyme › | 0.51 | 40.0 | 2.97e-01 | 88.3% | 69.9% |
ECOD (4)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4120246 | 3664.1.1.1 ↗ | alpha arrays › Small, acid-soluble spore protein C › Small, acid-soluble spore protein C › Small, acid-soluble spore protein C › SASP | 0.79 | 58.0 | 6.07e-01 | 78.3% | 98.2% |
| 4931716 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.66 | 46.0 | 4.66e-01 | 75.0% | 73.3% |
| 3268369 | 142.1.1.0 ↗ | alpha complex topology › Sigma2 domain-like › Sigma2 domain of RNA polymerase sigma factors › Sigma2 domain of RNA polymerase sigma factors | 0.59 | 48.0 | 4.11e-01 | 88.3% | 60.0% |
| 3957955 | 605.1.1.13 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › Transposase_mut | 0.59 | 42.0 | 3.67e-01 | 78.3% | 50.0% |
D5
medium
residues 523-555_679-830
Domain cluster:
rep: NC_004735.1__NP_835679.1__Rm378p092__00092__D1-33_185-289
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00136.27 best | DNA_pol_B | 126.8 | 1.40e-36 | 82.2% | 28.3% |
| PF00136.27 | DNA_pol_B | 39.1 | 6.00e-10 | 17.8% | 6.6% |