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CPXV142_protein

Euk-Vir

Cowpox_virus

CPXV142_protein__NP_619925__Cowpox_virus__10243

Identity

Accession:
NP_619925 ↗
Protein ID:
CPXV142_protein
Kingdom:
euk

Quality

73.9 mean pLDDT

Taxonomy

Bamfordvirae› Nucleocytoviricota› Pokkesviricetes› Chitovirales› Poxviridae› Orthopoxvirus› Cowpox_virus

TaxID: 10243

Cluster

View cluster (29 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 41-184
PDB
Domain cluster: rep: 101L_protein__NP_073486__Yaba-like_disease_virus__132475__D42-179
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF03395.20 best Pox_P4A 180.6 4.90e-53 100.0% 15.9%
D2 medium residues 185-272_348-358
PDB
Domain cluster: rep: HSPV130__ABH08236__Horsepox_virus__397342__D190-271
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF03395.20 best Pox_P4A 86.6 1.20e-24 98.0% 9.6%
D3 medium residues 273-347
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF03395.20 best Pox_P4A 44.1 8.70e-12 100.0% 8.4%
CATH (23)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
4hh2C04 3.30.450.20 Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › PAS domain 0.67 43.0 3.71e-01 84.0% 41.9%
1z47A03 2.40.50.140 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins 0.67 34.0 4.14e-01 85.3% 75.5%
5c7qB00 3.90.79.10 Alpha Beta › Alpha-Beta Complex › Nucleoside Triphosphate Pyrophosphohydrolase › Nucleoside Triphosphate Pyrophosphohydrolase 0.66 36.0 2.68e-01 81.3% 22.8%
1gutA00 2.40.50.100 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain 0.65 33.0 3.53e-01 84.0% 53.7%
4dj3B02 3.30.450.20 Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › PAS domain 0.65 44.0 3.46e-01 84.0% 34.4%
7a6pB01 3.30.450.20 Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › PAS domain 0.65 43.0 3.53e-01 84.0% 37.0%
2kr7A02 2.40.10.330 Mainly Beta › Beta Barrel › Thrombin, subunit H › 0.62 29.0 3.24e-01 82.7% 54.4%
2r78C00 3.30.450.20 Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › PAS domain 0.61 40.0 3.48e-01 85.3% 43.1%
1ci3M02 2.40.50.100 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain 0.60 34.0 3.73e-01 85.3% 69.0%
1lomA00 2.30.60.10 Mainly Beta › Roll › HIV-inactivating Protein, Cyanovirin-n › Cyanovirin-N 0.59 34.0 3.07e-01 86.7% 40.6%
1p97A00 3.30.450.20 Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › PAS domain 0.59 37.0 3.30e-01 85.3% 42.1%
3mr0A01 3.30.450.20 Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › PAS domain 0.57 43.0 3.76e-01 80.0% 61.8%
4hh3A01 3.30.450.20 Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › PAS domain 0.57 44.0 3.86e-01 84.0% 64.9%
3nixB00 3.50.50.60 Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain 0.55 41.0 2.67e-01 84.0% 16.0%
1y8tA03 2.30.42.10 Mainly Beta › Roll › Pdz3 Domain › PDZ domain 0.54 44.0 4.18e-01 88.0% 87.5%
3mfxB00 3.30.450.20 Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › PAS domain 0.54 35.0 3.14e-01 85.3% 43.0%
1b9mA03 2.40.50.100 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain 0.53 35.0 3.64e-01 86.7% 71.8%
3f4lA02 3.30.360.10 Alpha Beta › 2-Layer Sandwich › Dihydrodipicolinate Reductase; domain 2 › Dihydrodipicolinate Reductase; domain 2 0.53 40.0 2.90e-01 82.7% 71.3%
1s67L00 3.30.450.20 Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › PAS domain 0.52 35.0 3.11e-01 85.3% 44.5%
5kiqA02 3.10.20.890 Alpha Beta › Roll › Ubiquitin-like (UB roll) › 0.51 28.0 2.92e-01 100.0% 56.9%
2bhkA00 2.10.90.10 Mainly Beta › Ribbon › Cystine Knot Cytokines, subunit B › Cystine-knot cytokines 0.51 44.0 3.87e-01 92.0% 82.9%
1uzxA00 3.10.110.10 Alpha Beta › Roll › Ubiquitin Conjugating Enzyme › Ubiquitin Conjugating Enzyme 0.51 36.0 2.96e-01 74.7% 77.9%
3bwlB00 3.30.450.20 Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › PAS domain 0.50 39.0 3.38e-01 85.3% 60.2%
ECOD (48)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4949076 223.1.1.14 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS_4 0.72 47.0 4.09e-01 86.7% 45.5%
4986861 223.1.1.2 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS 0.70 46.0 4.40e-01 86.7% 57.3%
4862817 223.1.1.13 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS_3 0.69 45.0 4.08e-01 84.0% 49.5%
4061009 223.1.1.25 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS_9 0.69 45.0 3.60e-01 84.0% 34.0%
5080415 223.1.1.2 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS 0.68 45.0 3.84e-01 84.0% 42.5%
1271812 223.1.1.25 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS_9 0.67 43.0 3.71e-01 84.0% 41.9%
5046745 223.1.1.25 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS_9 0.67 42.0 3.78e-01 85.3% 45.7%
4980700 223.1.1.0 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains 0.67 44.0 3.69e-01 84.0% 40.8%
5049663 223.1.1.25 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS_9 0.66 43.0 3.54e-01 82.7% 37.0%
5065472 223.1.1.2 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS 0.66 42.0 3.88e-01 84.0% 50.5%
4980664 223.1.1.25 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS_9 0.66 43.0 3.69e-01 84.0% 41.7%
5080323 223.1.1.0 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains 0.66 43.0 3.48e-01 85.3% 34.0%
4999273 223.1.1.13 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS_3 0.66 44.0 2.60e-01 86.7% 8.2%
5034550 223.1.1.25 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS_9 0.65 44.0 3.82e-01 85.3% 45.2%
5044350 223.1.1.13 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS_3 0.65 46.0 3.78e-01 86.7% 40.7%
4951094 223.1.1.14 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS_4 0.65 51.0 4.08e-01 82.7% 55.7%
5049432 223.1.1.13 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS_3 0.65 42.0 2.72e-01 82.7% 14.3%
5008603 223.1.1.2 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS 0.64 42.0 3.18e-01 84.0% 26.8%
5083224 223.1.1.0 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains 0.64 43.0 3.88e-01 85.3% 49.5%
4999858 223.1.1.0 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains 0.64 44.0 3.17e-01 88.0% 24.5%
4999864 223.1.1.0 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains 0.64 42.0 3.53e-01 82.7% 39.2%
5006121 223.1.1.14 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS_4 0.63 43.0 3.77e-01 84.0% 47.3%
5050614 223.1.1.25 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS_9 0.63 41.0 3.63e-01 84.0% 45.5%
3480307 223.1.1.29 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS_11 0.62 41.0 4.04e-01 82.7% 62.5%
4988947 223.1.1.2 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS 0.62 41.0 3.35e-01 85.3% 35.2%
3949731 223.1.1.2 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS 0.62 41.0 3.45e-01 82.7% 39.2%
4974734 223.1.1.2 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS 0.61 41.0 3.57e-01 84.0% 44.3%
4958946 223.1.1.24 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS_8 0.61 44.0 3.68e-01 85.3% 44.8%
5049839 223.1.1.13 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS_3 0.61 46.0 2.86e-01 85.3% 15.1%
4984593 223.1.1.25 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS_9 0.58 41.0 3.42e-01 85.3% 41.5%
3494230 385.1.1.0 ↗ few secondary structure elements › Cystine-knot cytokines › Cystine-knot cytokines › Cystine-knot cytokines 0.58 40.0 4.20e-01 88.0% 78.6%
4980678 223.1.1.0 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains 0.58 44.0 3.90e-01 86.7% 56.4%
5062858 223.1.1.25 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS_9 0.58 42.0 3.68e-01 86.7% 50.4%
4962732 223.1.1.2 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS 0.57 42.0 3.70e-01 85.3% 50.8%
3972836 223.1.1.13 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS_3 0.56 44.0 3.53e-01 85.3% 43.4%
4072334 218.1.1.8 ↗ a+b two layers › Enolase-N/ribosomal protein › Enolase N-terminal domain-like › Enolase N-terminal domain-like › HrcA 0.56 34.0 3.11e-01 92.0% 44.0%
4183744 218.1.1.8 ↗ a+b two layers › Enolase-N/ribosomal protein › Enolase N-terminal domain-like › Enolase N-terminal domain-like › HrcA 0.55 33.0 3.06e-01 92.0% 44.0%
4360311 7577.1.1.2 ↗ a/b three-layered sandwiches › PLP-dependent transferases › PLP-dependent transferases › PLP-dependent transferases › Aminotran_3 0.54 39.0 2.56e-01 77.3% 58.9%
4426619 218.1.1.8 ↗ a+b two layers › Enolase-N/ribosomal protein › Enolase N-terminal domain-like › Enolase N-terminal domain-like › HrcA 0.54 33.0 3.08e-01 92.0% 47.4%
3701641 323.1.1.3 ↗ a+b complex topology › CoA-dependent acyltransferases › CoA-dependent acyltransferases › CoA-dependent acyltransferases › AMP-binding 0.54 36.0 2.51e-01 70.7% 94.6%
4207916 223.1.1.14 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains › PAS_4 0.53 42.0 3.43e-01 85.3% 52.1%
4931190 2004.1.1.162 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Rad51 0.52 38.0 2.88e-01 80.0% 80.0%
4236900 2.4.1.2 ↗ beta barrels › OB-fold › MOP-like › MOP-like › TOBE_2 0.52 35.0 2.95e-01 85.3% 41.1%
5737 211.1.1.21 ↗ a+b two layers › Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase › Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase › Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase › At5g48480-like_N 0.52 32.0 3.45e-01 96.0% 76.7%
3934103 385.1.1.0 ↗ few secondary structure elements › Cystine-knot cytokines › Cystine-knot cytokines › Cystine-knot cytokines 0.51 39.0 3.79e-01 90.7% 72.9%
1125646 385.1.1.8 ↗ few secondary structure elements › Cystine-knot cytokines › Cystine-knot cytokines › Cystine-knot cytokines › DAN 0.51 41.0 3.84e-01 88.0% 75.3%
4039929 325.1.7.0 ↗ a+b complex topology › alpha/beta-Hammerhead/Barrel-sandwich hybrid › alpha/beta-Hammerhead/Barrel-sandwich hybrid › Single hybrid motif 0.50 29.0 3.07e-01 86.7% 63.1%
4334405 7531.1.1.1 ↗ a/b three-layered sandwiches › Carbamate kinase-like › Carbamate kinase-like › Carbamate kinase-like › AA_kinase 0.50 41.0 2.96e-01 97.3% 48.7%
D4 medium residues 359-442
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF03395.20 best Pox_P4A 150.6 5.80e-44 100.0% 9.6%
CATH (18)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2eixA01 2.40.30.10 Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › Translation factors 0.64 45.0 4.18e-01 72.6% 95.3%
4d8mA02 2.60.120.260 Mainly Beta › Sandwich › Jelly Rolls › Galactose-binding domain-like 0.60 44.0 3.47e-01 77.4% 97.6%
1vhvA02 3.30.950.10 Alpha Beta › 2-Layer Sandwich › Methyltransferase, Cobalt-precorrin-4 Transmethylase; Domain 2 › Tetrapyrrole methylase, C-terminal domain 0.58 43.0 3.69e-01 78.6% 71.2%
4pytA02 3.30.465.10 Alpha Beta › 2-Layer Sandwich › Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 › 0.58 45.0 3.99e-01 86.9% 84.4%
4ybnB00 2.30.110.10 Mainly Beta › Roll › Pnp Oxidase; Chain A › Electron Transport, Fmn-binding Protein; Chain A 0.56 39.0 3.03e-01 73.8% 99.0%
1w1oA02 3.30.465.10 Alpha Beta › 2-Layer Sandwich › Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 › 0.55 46.0 4.05e-01 92.9% 93.7%
1zr6A02 3.30.465.10 Alpha Beta › 2-Layer Sandwich › Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 › 0.55 44.0 3.75e-01 88.1% 80.9%
3hsuA01 3.30.465.10 Alpha Beta › 2-Layer Sandwich › Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 › 0.55 44.0 3.19e-01 88.1% 46.9%
1e0yA02 3.30.465.10 Alpha Beta › 2-Layer Sandwich › Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 › 0.55 43.0 3.98e-01 86.9% 98.2%
2vfrA02 3.30.465.10 Alpha Beta › 2-Layer Sandwich › Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 › 0.55 43.0 3.79e-01 86.9% 84.6%
3v10A02 2.60.40.740 Mainly Beta › Sandwich › Immunoglobulin-like › 0.55 44.0 3.65e-01 86.9% 69.2%
1n6uA02 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.54 38.0 3.52e-01 72.6% 77.4%
1oeyA00 3.10.20.90 Alpha Beta › Roll › Ubiquitin-like (UB roll) › Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 0.51 36.0 3.64e-01 72.6% 89.0%
3ddcB00 3.10.20.90 Alpha Beta › Roll › Ubiquitin-like (UB roll) › Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 0.51 36.0 3.16e-01 73.8% 71.4%
2e0nB02 3.30.950.10 Alpha Beta › 2-Layer Sandwich › Methyltransferase, Cobalt-precorrin-4 Transmethylase; Domain 2 › Tetrapyrrole methylase, C-terminal domain 0.51 37.0 3.41e-01 77.4% 73.2%
4d0qA00 2.60.120.260 Mainly Beta › Sandwich › Jelly Rolls › Galactose-binding domain-like 0.51 40.0 3.33e-01 88.1% 81.4%
2htdB00 2.30.110.10 Mainly Beta › Roll › Pnp Oxidase; Chain A › Electron Transport, Fmn-binding Protein; Chain A 0.50 40.0 3.58e-01 88.1% 66.9%
2d9rA00 2.40.30.100 Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › AF2212/PG0164-like 0.50 35.0 3.58e-01 73.8% 100.0%
ECOD (15)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4944194 217.1.1.1 ↗ a+b complex topology › FAD-binding domain-like › FAD-binding domain › FAD-binding domain › FAD_binding_5 0.62 44.0 3.48e-01 75.0% 61.7%
3266917 862.1.1.1 ↗ a+b complex topology › Prim-pol domain › Prim-pol domain › Prim-pol domain › DNA_primase_S 0.61 44.0 3.03e-01 76.2% 55.8%
3974587 11.1.1.561 ↗ beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › DUF6776 0.61 42.0 3.73e-01 71.4% 88.2%
3257775 4988.1.1.0 ↗ a+b two layers › Ribosomal protein S8, C-terminal domain › Ribosomal protein S8, C-terminal domain › Ribosomal protein S8, C-terminal domain 0.58 40.0 4.45e-01 73.8% 93.8%
3597792 221.7.1.0 ↗ a+b two layers › beta-Grasp › E2-binding domain of E1 › E2-binding domain of E1 0.56 39.0 3.61e-01 72.6% 91.8%
3610841 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.55 40.0 2.49e-01 77.4% 28.4%
3534443 221.1.1.12 ↗ a+b two layers › beta-Grasp › Ubiquitin-related › Ubiquitin-like › RBD 0.55 39.0 3.96e-01 73.8% 84.7%
3748643 221.1.1.0 ↗ a+b two layers › beta-Grasp › Ubiquitin-related › Ubiquitin-like 0.55 39.0 3.98e-01 73.8% 90.0%
3787756 1.1.5.8 ↗ beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel › Putative_PNPOx 0.54 37.0 3.12e-01 71.4% 53.2%
4514555 1.1.5.18 ↗ beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel › FMN_bind_2 0.54 37.0 2.91e-01 70.2% 96.4%
3251038 221.1.1.2 ↗ a+b two layers › beta-Grasp › Ubiquitin-related › Ubiquitin-like › ubiquitin 0.54 38.0 3.65e-01 72.6% 77.9%
4989335 1137.1.1.1 ↗ a+b two layers › Tetrapyrrole methylase C-terminal domain-like › Tetrapyrrole methylase C-terminal domain › Tetrapyrrole methylase C-terminal domain › TP_methylase 0.53 39.0 3.75e-01 78.6% 87.0%
4104901 1.1.7.4 ↗ beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C › FAD_binding_1 0.53 43.0 3.61e-01 86.9% 81.4%
3204956 221.1.1.0 ↗ a+b two layers › beta-Grasp › Ubiquitin-related › Ubiquitin-like 0.53 39.0 3.56e-01 79.8% 73.3%
5065071 210.1.3.5 ↗ a+b four layers › Ntn/PP2C › Ntn › Class II glutamine amidotransferases › GATase_7 0.50 36.0 2.72e-01 75.0% 31.9%
D5 medium residues 443-460_634-702
PDB
D6 medium residues 461-528
PDB
Domain cluster: rep: P4a_precursor__YP_010085236__Western_grey_kangaroopox_virus__1566307__D457-509
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF03395.20 best Pox_P4A 111.4 4.10e-32 100.0% 7.5%
D7 medium residues 706-711_713-893
PDB