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CPXV208_protein

Euk-Vir

Cowpox_virus

CPXV208_protein__NP_619989__Cowpox_virus__10243

Identity

Accession:
NP_619989 ↗
Protein ID:
CPXV208_protein
Kingdom:
euk

Quality

86.2 mean pLDDT

Taxonomy

Bamfordvirae› Nucleocytoviricota› Pokkesviricetes› Chitovirales› Poxviridae› Orthopoxvirus› Cowpox_virus

TaxID: 10243

Cluster

View cluster (59 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 65-149
PDB
Domain cluster: rep: hypothetical_protein_DpV83gp172__YP_227547__Deerpox_virus_W-848-83__305674__D58-154
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF06227.18 best Poxv_Bcl-2-like 56.5 4.10e-15 92.9% 49.4%
CATH (41)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2vvyA01 1.10.437.20 Mainly Alpha › Orthogonal Bundle › Apoptosis Regulator Bcl-x › dsDNA poxvirus 0.98 95.0 7.88e-01 100.0% 63.4%
8f7aA01 1.25.10.10 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant 0.66 58.0 3.46e-01 100.0% 17.4%
4l8iB00 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.64 49.0 4.52e-01 82.4% 90.2%
2qsbA00 1.20.1440.50 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › Ta0600-like 0.63 43.0 4.40e-01 82.4% 71.8%
4hwhE00 1.20.58.120 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain 0.63 49.0 4.90e-01 84.7% 89.8%
1s2xA00 1.20.190.30 Mainly Alpha › Up-down Bundle › Delta-Endotoxin; domain 1 › CAG pathogenicity island protein, CagZ 0.62 51.0 4.10e-01 92.9% 94.4%
3bvoB01 1.10.287.110 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › DnaJ domain 0.62 48.0 4.62e-01 84.7% 82.7%
2yksA02 1.20.58.390 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Neurotransmitter-gated ion-channel transmembrane domain 0.62 47.0 4.26e-01 82.4% 65.0%
1e3wA00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.61 53.0 3.87e-01 100.0% 90.8%
2lm9A00 1.20.58.970 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.60 47.0 4.56e-01 84.7% 95.8%
2cfuA02 1.25.40.880 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Alkyl sulfatase, dimerisation domain 0.60 43.0 3.67e-01 91.8% 45.4%
6wb9201 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.60 54.0 3.69e-01 100.0% 36.0%
2mtqA00 1.20.58.130 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.59 45.0 4.78e-01 88.2% 95.9%
3pmcA00 1.10.490.70 Mainly Alpha › Orthogonal Bundle › Globin-like › Histidine kinase N-terminal domain 0.59 47.0 4.15e-01 88.2% 85.6%
1u89A00 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.59 46.0 3.97e-01 84.7% 77.0%
4aifA00 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.59 48.0 4.14e-01 95.3% 54.2%
2qr4A01 1.20.140.70 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Oligopeptidase f, N-terminal domain 0.58 49.0 4.05e-01 94.1% 71.8%
3kavA00 1.20.1270.360 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.58 43.0 4.12e-01 89.4% 66.7%
2rbdA01 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.58 48.0 3.97e-01 90.6% 91.3%
2fzfA01 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.57 50.0 4.14e-01 96.5% 96.7%
2ib0A01 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.57 47.0 4.06e-01 91.8% 94.8%
3fmcC01 3.40.630.10 Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Zn peptidases 0.57 50.0 3.46e-01 98.8% 62.4%
3l09A01 1.20.58.1460 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.56 47.0 4.52e-01 92.9% 94.9%
2ys8A00 1.10.287.110 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › DnaJ domain 0.56 43.0 4.24e-01 84.7% 80.0%
2osxA02 3.20.20.80 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Glycosidases 0.56 47.0 3.23e-01 98.8% 72.0%
1yo7A00 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.56 46.0 4.12e-01 90.6% 72.5%
2z1qB04 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.56 44.0 3.82e-01 87.1% 75.7%
1exzB00 1.20.1250.10 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › 0.56 42.0 3.58e-01 81.2% 62.9%
1hciA03 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.55 43.0 3.85e-01 83.5% 85.0%
3sbtB02 1.25.40.550 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Aar2, C-terminal domain-like 0.55 47.0 3.99e-01 100.0% 88.5%
2gw1A02 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.55 43.0 2.88e-01 94.1% 20.3%
3q5dA02 1.20.58.420 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › AHSP 0.55 41.0 3.95e-01 78.8% 81.4%
1n4kA02 1.25.10.30 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › IP3 receptor type 1 binding core, RIH domain 0.55 47.0 4.00e-01 98.8% 74.3%
3wctD00 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.55 44.0 3.80e-01 92.9% 68.0%
4cqiA00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.55 41.0 3.86e-01 82.4% 95.3%
1zoyA03 1.20.58.100 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain 0.55 43.0 3.93e-01 87.1% 69.2%
4rv1F00 1.25.10.10 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant 0.54 46.0 3.06e-01 100.0% 28.2%
6xkyA01 1.20.1330.10 Mainly Alpha › Up-down Bundle › f41 fragment of flagellin, N-terminal domain › f41 fragment of flagellin, N-terminal domain 0.53 41.0 3.25e-01 84.7% 53.5%
7qocA01 1.10.3210.10 Mainly Alpha › Orthogonal Bundle › Hypothetical protein af1432 › Hypothetical protein af1432 0.53 44.0 3.53e-01 96.5% 52.9%
3fseB02 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.53 42.0 3.67e-01 91.8% 95.1%
3vw4A01 1.10.340.50 Mainly Alpha › Orthogonal Bundle › Endonuclease III; domain 1 › 0.53 38.0 3.73e-01 75.3% 70.7%
ECOD (58)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
1157195 5000.3.1.3 ↗ alpha arrays › Toxins' membrane translocation domains › Bcl-2 inhibitors of programmed cell death › Bcl-2 inhibitors of programmed cell death › Poxv_Bcl-2-like 0.98 95.0 7.70e-01 100.0% 59.9%
3679762 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.71 64.0 3.65e-01 100.0% 16.4%
3881044 621.1.1.8 ↗ alpha bundles › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › GVIN1 0.66 48.0 4.40e-01 76.5% 81.8%
5075806 4995.1.1.1 ↗ alpha arrays › Methionine synthase domain-like › Methionine synthase domain-like › Methionine synthase domain-like › B12-binding_2 0.66 54.0 5.52e-01 89.4% 100.0%
3487928 3277.2.1.0 ↗ alpha arrays › Thymine dioxygenase JBP1 DNA-binding domain-like › a C-terminal domain in chromodomain helicase DNA-binding protein 1 › a C-terminal domain in chromodomain helicase DNA-binding protein 1 0.65 51.0 4.64e-01 84.7% 75.7%
3473298 3277.2.1.1 ↗ alpha arrays › Thymine dioxygenase JBP1 DNA-binding domain-like › a C-terminal domain in chromodomain helicase DNA-binding protein 1 › a C-terminal domain in chromodomain helicase DNA-binding protein 1 › CHD1-like_C 0.65 51.0 4.61e-01 84.7% 75.7%
3591764 109.4.1.70 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › CID 0.63 55.0 4.69e-01 98.8% 67.6%
3389963 1134.1.1.0 ↗ alpha bundles › C-terminal helical domain of alanine-tRNA ligase › C-terminal helical domain of alanine-tRNA ligase › Eukaryotic C-Ala helical domain 0.63 46.0 5.01e-01 87.1% 95.7%
5076363 4995.1.1.1 ↗ alpha arrays › Methionine synthase domain-like › Methionine synthase domain-like › Methionine synthase domain-like › B12-binding_2 0.63 54.0 5.40e-01 95.3% 95.3%
5004518 4995.1.1.1 ↗ alpha arrays › Methionine synthase domain-like › Methionine synthase domain-like › Methionine synthase domain-like › B12-binding_2 0.62 49.0 5.15e-01 89.4% 96.0%
3827951 650.1.1.0 ↗ alpha bundles › Chaperone J-domain › Chaperone J-domain › Chaperone J-domain 0.62 48.0 4.51e-01 85.9% 73.6%
4270038 109.4.1.1687 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › AP5B1_N, AP5B1_middle 0.62 54.0 3.28e-01 100.0% 13.7%
3920855 3861.1.1.3 ↗ alpha bundles › Mitochondrial translocator protein (TSPO) › Mitochondrial translocator protein (TSPO) › Mitochondrial translocator protein (TSPO) › PF30661 0.62 52.0 3.68e-01 94.1% 36.7%
3263668 174.1.1.0 ↗ few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain 0.62 48.0 4.50e-01 83.5% 80.0%
3609850 310.2.1.1 ↗ a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF › RRF 0.62 48.0 3.65e-01 83.5% 85.4%
3314919 109.4.1.853 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › AP5B1_middle 0.62 53.0 4.26e-01 100.0% 48.2%
4487472 4995.1.1.1 ↗ alpha arrays › Methionine synthase domain-like › Methionine synthase domain-like › Methionine synthase domain-like › B12-binding_2 0.61 52.0 4.53e-01 94.1% 63.8%
3333216 604.3.1.1 ↗ alpha bundles › Spectrin repeat-like › BAG domain › BAG domain › BAG 0.61 49.0 4.72e-01 85.9% 83.2%
3689712 5050.1.1.0 ↗ alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.61 48.0 3.63e-01 85.9% 63.3%
3678146 604.3.1.1 ↗ alpha bundles › Spectrin repeat-like › BAG domain › BAG domain › BAG 0.61 52.0 4.41e-01 94.1% 69.3%
3404886 6155.1.1.0 ↗ alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter 0.60 45.0 4.69e-01 81.2% 96.2%
5053481 633.12.1.1 ↗ alpha bundles › Bromodomain-like › Ta0600-like › Ta0600-like › UPF0147 0.60 41.0 4.16e-01 84.7% 70.6%
5075578 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.60 53.0 3.67e-01 98.8% 35.2%
5054723 633.12.1.1 ↗ alpha bundles › Bromodomain-like › Ta0600-like › Ta0600-like › UPF0147 0.60 43.0 4.38e-01 87.1% 77.4%
3602716 604.5.1.2 ↗ alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PhoU 0.60 48.0 4.27e-01 88.2% 75.2%
4281149 633.12.1.1 ↗ alpha bundles › Bromodomain-like › Ta0600-like › Ta0600-like › UPF0147 0.60 40.0 3.92e-01 81.2% 62.1%
4997097 4995.1.1.1 ↗ alpha arrays › Methionine synthase domain-like › Methionine synthase domain-like › Methionine synthase domain-like › B12-binding_2 0.60 47.0 4.98e-01 92.9% 100.0%
3361553 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.60 46.0 4.69e-01 87.1% 84.7%
4083216 101.11.1.1 ↗ alpha arrays › HTH › Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 › Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 › PNPase 0.59 41.0 4.04e-01 71.8% 80.0%
4021636 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.59 49.0 4.41e-01 98.8% 64.8%
3258587 150.1.1.0 ↗ alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin 0.59 52.0 4.13e-01 100.0% 86.7%
5060908 150.1.1.0 ↗ alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin 0.59 48.0 4.01e-01 88.2% 68.9%
4616546 6155.1.1.4 ↗ alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter › MPC 0.59 45.0 4.23e-01 82.4% 69.5%
3788219 109.4.1.1633 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › UTP20_C 0.59 51.0 3.05e-01 98.8% 14.2%
3170239 604.12.1.0 ↗ alpha bundles › Spectrin repeat-like › MIT domain › MIT domain 0.58 46.0 4.58e-01 87.1% 95.6%
3742626 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.58 52.0 3.11e-01 100.0% 14.4%
3560153 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.58 51.0 3.77e-01 100.0% 41.3%
3963862 4033.1.1.1 ↗ alpha arrays › Acyl-CoA dehydrogenase N-terminal domain-like › Acyl-CoA dehydrogenase N-terminal domain-like › Acyl-CoA dehydrogenase N-terminal domain-like › Acyl-CoA_dh_N 0.58 48.0 4.50e-01 92.9% 76.4%
3261159 604.17.1.0 ↗ alpha bundles › Spectrin repeat-like › MTH_863 C-terminal domain-like › MTH_863 C-terminal domain-like 0.58 49.0 4.05e-01 94.1% 75.5%
4937811 150.1.1.7 ↗ alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › DUF892 0.58 49.0 3.99e-01 92.9% 91.9%
3603613 604.2.1.1 ↗ alpha bundles › Spectrin repeat-like › Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain › Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain › Succ_DH_flav_C 0.58 45.0 4.03e-01 84.7% 59.7%
3503534 5057.1.1.1 ↗ alpha bundles › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore › Neur_chan_memb 0.58 45.0 3.84e-01 85.9% 55.9%
5008560 4995.1.1.1 ↗ alpha arrays › Methionine synthase domain-like › Methionine synthase domain-like › Methionine synthase domain-like › B12-binding_2 0.58 47.0 4.48e-01 94.1% 77.1%
3733446 6155.1.1.2 ↗ alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter › PQ-loop 0.57 44.0 4.34e-01 82.4% 84.4%
3976607 604.34.1.1 ↗ alpha bundles › Spectrin repeat-like › Helical bundle domain in arginine decarboxylase › Helical bundle domain in arginine decarboxylase › Arg_decarb_HB 0.57 47.0 4.50e-01 92.9% 83.0%
4990095 604.6.1.0 ↗ alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain 0.57 41.0 4.19e-01 77.6% 81.2%
4020357 6155.1.1.0 ↗ alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter 0.57 43.0 4.44e-01 83.5% 91.3%
3730497 6155.1.1.4 ↗ alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter › MPC 0.56 43.0 4.05e-01 84.7% 77.3%
3270478 6155.1.1.4 ↗ alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter › MPC 0.56 42.0 3.98e-01 81.2% 74.3%
3690615 6155.1.1.2 ↗ alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter › PQ-loop 0.56 41.0 3.66e-01 80.0% 60.0%
3204604 6155.1.1.4 ↗ alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter › MPC 0.56 42.0 4.47e-01 82.4% 94.7%
3810721 6155.1.1.2 ↗ alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter › PQ-loop 0.56 42.0 4.09e-01 81.2% 81.1%
3598135 6155.1.1.0 ↗ alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter 0.55 43.0 4.34e-01 85.9% 89.4%
3718498 604.6.1.0 ↗ alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain 0.54 44.0 4.39e-01 90.6% 93.3%
3914072 633.23.1.19 ↗ alpha bundles › Bromodomain-like › Claudin › Claudin › TMEM37 0.54 43.0 3.42e-01 88.2% 51.1%
3937526 7015.1.1.0 ↗ alpha bundles › Palmitoyltransferase DHHC transmembrane domain › Palmitoyltransferase DHHC transmembrane domain › Palmitoyltransferase DHHC transmembrane domain 0.52 44.0 3.74e-01 91.8% 71.4%
3604682 2004.1.1.73 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › MMR_HSR1 0.52 40.0 2.73e-01 85.9% 26.8%
3164843 138.1.1.5 ↗ alpha arrays › DNA polymerase III clamp loader subunits, C-terminal domain › DNA polymerase III clamp loader subunits, C-terminal domain › DNA polymerase III clamp loader subunits, C-terminal domain › DNA_pol3_gamma3 0.51 41.0 3.57e-01 94.1% 66.2%