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DNA-dependent_RNA_polymerase_subunit_rpo132
Euk-VirMonkeypox_virus
DNA-dependent_RNA_polymerase_subunit_rpo132__YP_010377133__Monkeypox_virus__10244
Identity
- Accession:
- YP_010377133 ↗
- Protein ID:
- DNA-dependent_RNA_polymerase_subunit_rpo132
- Kingdom:
- euk
Quality
70.9
mean pLDDT
Taxonomy
Bamfordvirae›
Nucleocytoviricota›
Pokkesviricetes›
Chitovirales›
Poxviridae›
Orthopoxvirus›
Monkeypox_virus
TaxID: 10244
Cluster
View cluster (58 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 179-342
Domain cluster:
rep: DNA-directed_RNA_polymerase_subunit_beta__YP_009162498__Salmon_gill_poxvirus__1680908__D173-349
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF12415.15 best | rpo132 | 66.5 | 1.40e-18 | 19.5% | 100.0% |
D2
high
residues 1053-1134
D3
medium
residues 30-50_354-420
D4
medium
residues 51-135
D5
medium
residues 474-549
Domain cluster:
representative
CATH (6)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2fbhA00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.59 | 38.0 | 3.19e-01 | 82.9% | 36.5% |
| 5yk4A04 | 1.10.1420.10 | Mainly Alpha › Orthogonal Bundle › MutS, DNA mismatch repair protein; Chain A, domain 3 › | 0.54 | 37.0 | 3.09e-01 | 71.1% | 39.7% |
| 3ungC03 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.54 | 37.0 | 3.15e-01 | 72.4% | 42.9% |
| 2cdqA03 | 3.30.70.260 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain | 0.54 | 36.0 | 3.57e-01 | 71.1% | 88.1% |
| 1vchD00 | 3.40.50.2020 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › | 0.51 | 37.0 | 2.99e-01 | 81.6% | 85.5% |
| 3c0wA02 | 3.10.28.10 | Alpha Beta › Roll › Endonuclease I-creI › Homing endonucleases | 0.51 | 32.0 | 2.95e-01 | 73.7% | 47.6% |
ECOD (7)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2773896 | 4961.1.1.0 ↗ | a+b complex topology › inserted a+b domain in yeast RNA polymerase beta subunit › inserted a+b domain in yeast RNA polymerase beta subunit › inserted a+b domain in yeast RNA polymerase beta subunit | 0.99 | 75.0 | 6.81e-01 | 77.6% | 62.8% |
| 3247723 | 206.1.1.20 ↗ | a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › PK_Tyr_Ser-Thr | 0.53 | 38.0 | 2.46e-01 | 75.0% | 37.3% |
| 4096955 | 314.1.1.9 ↗ | a+b three layers › Class II aaRS and biotin synthetases › Class II aaRS and biotin synthetases › Class II aaRS and biotin synthetases › tRNA-synt_His | 0.53 | 38.0 | 2.53e-01 | 76.3% | 90.9% |
| 4210625 | 2002.1.1.0 ↗ | a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels | 0.53 | 41.0 | 2.49e-01 | 82.9% | 37.0% |
| 4022740 | 109.6.1.1 ↗ | alpha superhelices › Repetitive alpha hairpins › Ras GEF › Ras GEF › RasGEF | 0.53 | 38.0 | 2.89e-01 | 75.0% | 76.8% |
| 2562506 | 7524.1.1.1 ↗ | a/b three-layered sandwiches › ALDH-like › ALDH-like › ALDH-like › Aldedh | 0.52 | 42.0 | 2.99e-01 | 92.1% | 80.5% |
| 3733384 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.51 | 43.0 | 2.63e-01 | 94.7% | 36.5% |
D6
medium
residues 550-662
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF04567.23 best | RNA_pol_Rpb2_5 | 32.8 | 1.40e-07 | 41.6% | 59.1% |
ECOD (5)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4949110 | 4961.1.1.1 ↗ | a+b complex topology › inserted a+b domain in yeast RNA polymerase beta subunit › inserted a+b domain in yeast RNA polymerase beta subunit › inserted a+b domain in yeast RNA polymerase beta subunit › RNA_pol_Rpb2_4 | 0.87 | 62.0 | 6.57e-01 | 76.1% | 82.0% |
| 4948672 | 4961.1.1.1 ↗ | a+b complex topology › inserted a+b domain in yeast RNA polymerase beta subunit › inserted a+b domain in yeast RNA polymerase beta subunit › inserted a+b domain in yeast RNA polymerase beta subunit › RNA_pol_Rpb2_4 | 0.87 | 58.0 | 5.31e-01 | 71.7% | 53.8% |
| 3187714 | 4042.1.1.2 ↗ | a+b complex topology › barrel domain in beta subunit of DNA dependent RNA-polymerase › barrel domain in beta subunit of DNA dependent RNA-polymerase › barrel domain in beta subunit of DNA dependent RNA-polymerase › RNA_pol_Rpb2_6,RNA_pol_Rpb2_5 | 0.82 | 57.0 | 4.61e-01 | 70.8% | 62.6% |
| 3335721 | 4042.1.1.2 ↗ | a+b complex topology › barrel domain in beta subunit of DNA dependent RNA-polymerase › barrel domain in beta subunit of DNA dependent RNA-polymerase › barrel domain in beta subunit of DNA dependent RNA-polymerase › RNA_pol_Rpb2_6,RNA_pol_Rpb2_5 | 0.80 | 50.0 | 4.43e-01 | 70.8% | 45.0% |
| 3344680 | 4042.1.1.3 ↗ | a+b complex topology › barrel domain in beta subunit of DNA dependent RNA-polymerase › barrel domain in beta subunit of DNA dependent RNA-polymerase › barrel domain in beta subunit of DNA dependent RNA-polymerase › RNA_pol_Rpb2_5 | 0.71 | 49.0 | 4.79e-01 | 87.6% | 64.8% |
D7
medium
residues 742-775_871-921_1007-1021
Domain cluster:
rep: RNA_polymerase_subunit_RPO132__YP_009046186__Penguinpox_virus__648998__D714-766_870-915_991-1015
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00562.34 best | RNA_pol_Rpb2_6 | 53.9 | 2.30e-14 | 57.0% | 13.4% |
D8
medium
residues 922-1006
Domain cluster:
representative
CATH (8)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1wvtA00 | 1.20.1200.10 | Mainly Alpha › Up-down Bundle › Hypothetical Protein Ta1238; Chain: A; › Cobalamin adenosyltransferase-like | 0.62 | 43.0 | 3.62e-01 | 71.8% | 98.6% |
| 3tjmA02 | 1.10.1470.20 | Mainly Alpha › Orthogonal Bundle › Protein Yjbj; Chain: A; › Fatty acid synthase; domain 2 | 0.60 | 45.0 | 4.43e-01 | 85.9% | 76.7% |
| 8hk0B03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.59 | 45.0 | 3.90e-01 | 82.4% | 76.8% |
| 6d5xA00 | 1.20.1200.10 | Mainly Alpha › Up-down Bundle › Hypothetical Protein Ta1238; Chain: A; › Cobalamin adenosyltransferase-like | 0.56 | 39.0 | 3.33e-01 | 72.9% | 98.0% |
| 2pkeA02 | 1.10.150.240 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 | 0.56 | 40.0 | 4.21e-01 | 75.3% | 89.7% |
| 4gltA02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.54 | 40.0 | 3.68e-01 | 80.0% | 89.5% |
| 1oxjA02 | 1.25.40.170 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Smaug, PHAT domain | 0.53 | 37.0 | 3.49e-01 | 74.1% | 72.5% |
| 2wyoC01 | 3.30.1490.250 | Alpha Beta › 2-Layer Sandwich › Dna Ligase; domain 1 › | 0.53 | 38.0 | 3.53e-01 | 74.1% | 75.0% |
ECOD (11)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3725136 | 601.1.1.77 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › DUF3176 | 0.61 | 42.0 | 3.33e-01 | 70.6% | 66.1% |
| 3477079 | 3832.1.1.1 ↗ | alpha bundles › Tumor necrosis factor alpha-induced protein 8-like protein 2 › Tumor necrosis factor alpha-induced protein 8-like protein 2 › Tumor necrosis factor alpha-induced protein 8-like protein 2 › DUF758 | 0.60 | 45.0 | 3.66e-01 | 81.2% | 98.8% |
| 3862724 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.60 | 41.0 | 3.84e-01 | 70.6% | 96.2% |
| 5059533 | 148.1.3.0 ↗ | alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain | 0.59 | 44.0 | 4.38e-01 | 80.0% | 98.9% |
| 4984579 | 2004.1.1.42 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › T2SSE | 0.57 | 43.0 | 2.75e-01 | 83.5% | 48.9% |
| 3701043 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.56 | 40.0 | 3.04e-01 | 74.1% | 83.6% |
| 4977777 | 101.1.10.0 ↗ | alpha arrays › HTH › HTH › Cyclin-like | 0.54 | 39.0 | 3.50e-01 | 74.1% | 89.2% |
| 3184221 | 109.4.1.681 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Fungal_trans_2 | 0.52 | 38.0 | 2.49e-01 | 78.8% | 86.5% |
| 3480406 | 193.1.1.0 ↗ | alpha bundles › CH domain-like › Calponin-homology domain-like › Calponin-homology domain-like | 0.51 | 44.0 | 4.04e-01 | 95.3% | 81.8% |
| 3830052 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.50 | 38.0 | 2.85e-01 | 82.4% | 43.0% |
| 3425013 | 101.1.1.65 ↗ | alpha arrays › HTH › HTH › Three-helical HTH › Myb_DNA-bind_4 | 0.50 | 39.0 | 3.30e-01 | 85.9% | 76.0% |