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DNA_packaging_terminase_subunit_2

Euk-Vir

Human_alphaherpesvirus_2

DNA_packaging_terminase_subunit_2__YP_009137180__Human_alphaherpesvirus_2__10310

Identity

Accession:
YP_009137180 ↗
Protein ID:
DNA_packaging_terminase_subunit_2
Kingdom:
euk

Quality

73.5 mean pLDDT

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 13-122
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF01366.24 best PRTP 111.9 3.50e-32 97.3% 16.0%
D2 medium residues 123-186
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF01366.24 best PRTP 80.5 1.10e-22 100.0% 9.8%
CATH (44)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
4ctaA02 3.30.70.2860 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.72 51.0 4.86e-01 75.0% 98.7%
4djhA01 1.20.1070.10 Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins 0.66 57.0 3.74e-01 100.0% 50.9%
3cm1A00 2.30.31.20 Mainly Beta › Roll › Transcriptional Co-activator pc4; Chain A › Sporulation-specific cell division protein SsgB 0.66 55.0 4.44e-01 98.4% 91.2%
1qysA00 3.30.1710.10 Alpha Beta › 2-Layer Sandwich › top7, de novo designed protein › top7, de novo designed protein 0.65 55.0 4.85e-01 93.8% 69.6%
3wiwA00 1.50.10.10 Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase › 0.63 47.0 2.94e-01 81.2% 15.4%
4kyzA00 3.30.70.600 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Ribosomal protein S10 0.62 53.0 3.92e-01 96.9% 36.5%
3bm4A00 3.90.79.10 Alpha Beta › Alpha-Beta Complex › Nucleoside Triphosphate Pyrophosphohydrolase › Nucleoside Triphosphate Pyrophosphohydrolase 0.60 47.0 3.43e-01 89.1% 69.0%
2jmkA00 3.30.420.600 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Thermoplasma acidophilum protein TA0956 0.60 50.0 4.32e-01 96.9% 78.2%
2jvfA00 3.30.1710.10 Alpha Beta › 2-Layer Sandwich › top7, de novo designed protein › top7, de novo designed protein 0.60 49.0 4.43e-01 95.3% 66.0%
3vtiA01 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.59 45.0 4.03e-01 85.9% 81.2%
3cjlA00 3.10.20.850 Alpha Beta › Roll › Ubiquitin-like (UB roll) › Protein of unknown function DUF3861 0.59 41.0 3.74e-01 92.2% 53.4%
1x5aA01 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.59 39.0 3.52e-01 87.5% 48.4%
2uvaG01 1.20.1050.120 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.58 50.0 3.97e-01 98.4% 68.4%
3n89A02 3.30.310.210 Alpha Beta › 2-Layer Sandwich › TATA-Binding Protein › 0.58 45.0 3.74e-01 93.8% 100.0%
1h0hB01 3.30.70.20 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.57 42.0 3.33e-01 82.8% 88.0%
2b4vA03 3.30.70.1970 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.57 47.0 4.19e-01 98.4% 98.0%
6uqjA02 3.20.20.80 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Glycosidases 0.56 45.0 2.83e-01 87.5% 23.2%
4lq0A02 3.10.28.10 Alpha Beta › Roll › Endonuclease I-creI › Homing endonucleases 0.56 47.0 3.72e-01 100.0% 62.6%
1txdA02 2.30.29.30 Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) 0.56 47.0 3.91e-01 96.9% 88.4%
3ezjA02 3.30.1370.120 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › 0.55 44.0 4.33e-01 95.3% 80.9%
2zihC00 1.10.3630.10 Mainly Alpha › Orthogonal Bundle › yeast vps74-n-term truncation variant fold › yeast vps74-n-term truncation variant domain like 0.55 44.0 2.92e-01 89.1% 24.0%
3w3aG00 1.10.287.3240 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.55 42.0 3.03e-01 85.9% 33.8%
3nt7A00 3.40.470.10 Alpha Beta › 3-Layer(aba) Sandwich › Uracil-DNA Glycosylase, subunit E › Uracil-DNA glycosylase-like domain 0.55 41.0 2.90e-01 81.2% 57.1%
7uzsX02 3.90.260.10 Alpha Beta › Alpha-Beta Complex › Coagulation Factor XIII; Chain A, domain 2 › Transglutaminase-like 0.55 44.0 2.98e-01 95.3% 42.4%
4e1pA00 3.30.60.230 Alpha Beta › 2-Layer Sandwich › Wheat Germ Agglutinin (Isolectin 2); domain 1 › Lsr2, dimerisation domain 0.55 37.0 3.99e-01 82.8% 83.6%
6scxC01 3.90.79.20 Alpha Beta › Alpha-Beta Complex › Nucleoside Triphosphate Pyrophosphohydrolase › 0.54 43.0 3.22e-01 89.1% 65.7%
1euvB00 3.10.20.90 Alpha Beta › Roll › Ubiquitin-like (UB roll) › Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 0.54 43.0 4.10e-01 92.2% 78.5%
2lpeA01 6.10.140.1120 Special › Helix non-globular › Helix Hairpins › 0.54 40.0 3.87e-01 100.0% 69.2%
2if1A00 3.30.780.10 Alpha Beta › 2-Layer Sandwich › Translation Initiation Factor Eif1 › SUI1-like domain 0.54 41.0 3.39e-01 85.9% 59.5%
5hn3A00 3.40.718.10 Alpha Beta › 3-Layer(aba) Sandwich › Isopropylmalate Dehydrogenase › Isopropylmalate Dehydrogenase 0.53 42.0 2.70e-01 89.1% 86.1%
1e7uA01 3.10.20.90 Alpha Beta › Roll › Ubiquitin-like (UB roll) › Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 0.52 43.0 3.23e-01 93.8% 40.1%
4dqnA01 3.30.470.10 Alpha Beta › 2-Layer Sandwich › D-amino Acid Aminotransferase; Chain A, domain 1 › Aminotransferase class 4, branched-chain amino acid transferase, N-terminal domain 0.52 43.0 3.29e-01 93.8% 62.7%
3q8pB04 3.30.1490.100 Alpha Beta › 2-Layer Sandwich › Dna Ligase; domain 1 › DNA polymerase, Y-family, little finger domain 0.52 37.0 3.23e-01 79.7% 63.0%
3l7wA00 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.51 38.0 3.20e-01 87.5% 47.6%
5f7pA01 3.30.420.40 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain 0.51 40.0 3.42e-01 93.8% 63.4%
1rybA00 3.40.50.1470 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Peptidyl-tRNA hydrolase 0.51 43.0 3.21e-01 100.0% 69.4%
5tkwA01 3.30.420.380 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › 0.51 38.0 2.83e-01 81.2% 71.2%
4fw9A01 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.51 41.0 2.78e-01 93.8% 28.4%
1rzmA01 3.30.70.1140 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Phospho-2-dehydro-3-deoxyheptonate aldolase; domain 1 0.51 36.0 3.41e-01 76.6% 85.0%
5u3fB01 3.30.470.10 Alpha Beta › 2-Layer Sandwich › D-amino Acid Aminotransferase; Chain A, domain 1 › Aminotransferase class 4, branched-chain amino acid transferase, N-terminal domain 0.51 42.0 3.33e-01 93.8% 70.7%
5t1dB00 3.10.390.20 Alpha Beta › Roll › SAND domain › Viral glycoprotein L 0.50 42.0 3.73e-01 98.4% 86.9%
4iajA00 3.30.1490.390 Alpha Beta › 2-Layer Sandwich › Dna Ligase; domain 1 › Protein of unknown function DUF4649 0.50 42.0 4.01e-01 98.4% 100.0%
1l1lA01 3.20.70.20 Alpha Beta › Alpha-Beta Barrel › Anaerobic Ribonucleotide-triphosphate Reductase Large Chain › 0.50 40.0 2.44e-01 90.6% 40.5%
1wx8A00 3.10.20.90 Alpha Beta › Roll › Ubiquitin-like (UB roll) › Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 0.50 40.0 3.52e-01 87.5% 64.6%
ECOD (58)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4317544 4967.1.1.0 alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases 0.73 56.0 4.85e-01 82.8% 85.0%
3240839 5001.1.1.1 alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 0.71 61.0 3.91e-01 100.0% 45.2%
3590189 4967.1.1.0 alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases 0.70 53.0 3.96e-01 82.8% 53.8%
5007155 304.163.1.0 a+b two layers › Alpha-beta plaits › ATP-binding protein TM_1403 insertion domain › ATP-binding protein TM_1403 insertion domain 0.68 45.0 4.95e-01 85.9% 97.8%
3753321 5001.1.1.1 alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 0.66 57.0 3.65e-01 100.0% 51.2%
3848636 5001.1.1.1 alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 0.66 57.0 3.63e-01 100.0% 53.6%
4607845 5001.1.1.1 alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 0.65 55.0 3.51e-01 100.0% 50.7%
3707811 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.63 45.0 2.85e-01 78.1% 23.2%
5027271 210.1.3.3 a+b four layers › Ntn/PP2C › Ntn › Class II glutamine amidotransferases › GATase_4 0.63 45.0 3.06e-01 90.6% 19.6%
3530542 5001.1.1.1 alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 0.63 54.0 3.48e-01 100.0% 43.0%
3364252 109.4.1.1331 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR, PPR_2, PPR_long, E_motif 0.63 51.0 3.23e-01 89.1% 32.5%
3672250 207.1.1.116 beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Leucine-rich repeats › Leucine-rich repeats › LRR_FBXL15 0.63 50.0 3.63e-01 98.4% 30.5%
3415024 5001.1.1.1 alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 0.62 54.0 3.47e-01 100.0% 43.4%
4134039 304.162.1.1 a+b two layers › Alpha-beta plaits › Competence or damage-inducible protein CinA middle domain › Competence or damage-inducible protein CinA middle domain › CinA_KH 0.62 46.0 4.40e-01 79.7% 98.7%
4934840 2484.1.1.0 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.62 53.0 4.27e-01 95.3% 84.8%
3907411 5001.1.1.111 alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1, 7TM_GPCR_Srw 0.62 52.0 3.36e-01 100.0% 52.1%
3558619 5001.1.1.1 alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 0.61 52.0 3.37e-01 100.0% 46.2%
3388590 379.1.1.0 few secondary structure elements › Kazal-type serine protease inhibitors-like › Kazal-type serine protease inhibitors › Kazal-type serine protease inhibitors 0.61 37.0 3.81e-01 78.1% 63.3%
3872321 5001.1.1.1 alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 0.60 50.0 3.29e-01 100.0% 56.8%
5043867 304.126.1.0 a+b two layers › Alpha-beta plaits › ferredoxin-like domain in vacuolar ATP synthase subunit C › ferredoxin-like domain in vacuolar ATP synthase subunit C 0.60 42.0 4.05e-01 75.0% 90.7%
4959407 304.163.1.3 a+b two layers › Alpha-beta plaits › ATP-binding protein TM_1403 insertion domain › ATP-binding protein TM_1403 insertion domain › PF31118 0.58 40.0 4.38e-01 81.2% 92.0%
4985048 304.126.1.0 a+b two layers › Alpha-beta plaits › ferredoxin-like domain in vacuolar ATP synthase subunit C › ferredoxin-like domain in vacuolar ATP synthase subunit C 0.58 41.0 3.90e-01 76.6% 82.5%
3690077 2003.1.2.0 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › FAD/NAD(P)-binding domain 0.58 40.0 2.65e-01 71.9% 19.2%
3217638 2484.1.1.0 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.58 44.0 4.21e-01 95.3% 72.0%
5018480 1104.1.1.0 a+b complex topology › Helicase Cch N-terminal domain › Helicase Cch N-terminal domain › Helicase Cch N-terminal domain 0.57 48.0 3.56e-01 96.9% 72.2%
5006971 304.126.1.0 a+b two layers › Alpha-beta plaits › ferredoxin-like domain in vacuolar ATP synthase subunit C › ferredoxin-like domain in vacuolar ATP synthase subunit C 0.57 40.0 3.82e-01 76.6% 82.5%
3389034 379.1.1.0 few secondary structure elements › Kazal-type serine protease inhibitors-like › Kazal-type serine protease inhibitors › Kazal-type serine protease inhibitors 0.57 37.0 3.94e-01 82.8% 78.2%
4004088 389.1.1.0 few secondary structure elements › EGF-like › EGF-related › EGF/Laminin 0.56 30.0 3.59e-01 92.2% 77.5%
3702727 101.1.1.0 alpha arrays › HTH › HTH › Three-helical HTH 0.56 40.0 3.56e-01 84.4% 50.0%
4975762 101.1.8.1 alpha arrays › HTH › HTH › DNA breaking-rejoining enzymes › Phage_integrase 0.55 41.0 3.32e-01 81.2% 54.4%
3958077 244.1.1.0 a+b two layers › FAD-linked reductases, C-terminal domain-like › FAD-linked reductases-C › FAD-linked reductases-C 0.55 39.0 2.94e-01 76.6% 87.9%
3627479 221.1.1.4 a+b two layers › beta-Grasp › Ubiquitin-related › Ubiquitin-like › PB1 0.54 44.0 3.66e-01 93.8% 57.6%
4295958 5001.1.1.1 alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 0.54 46.0 3.33e-01 98.4% 80.5%
3995931 207.1.1.0 beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Leucine-rich repeats › Leucine-rich repeats 0.54 38.0 2.37e-01 78.1% 11.4%
2665702 3146.1.1.3 a+b complex topology › gH main domain › gH main domain › gH main domain › Phage_glycop_gL 0.54 47.0 3.96e-01 100.0% 80.0%
4964910 300.1.1.25 a+b three layers › Phospholipase D/nuclease › Phospholipase D/nuclease › Phospholipase D/nuclease › TbsP_N 0.54 38.0 3.04e-01 76.6% 90.0%
4999908 3501.1.1.0 a+b two layers › protein PCC1 › protein PCC1 › protein PCC1 0.54 40.0 4.08e-01 96.9% 83.1%
4458233 5001.1.1.0 alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like 0.54 48.0 2.94e-01 100.0% 42.8%
2035461 3380.1.1.1 a+b duplicates or obligate multimers › Dimerization domain of Lsr2 › Dimerization domain of Lsr2 › Dimerization domain of Lsr2 › Lsr2 0.54 36.0 3.75e-01 70.3% 94.6%
3590522 2004.1.1.87 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N 0.54 45.0 2.78e-01 95.3% 44.7%
4973804 220.1.1.0 beta barrels › PH domain-like › PH domain-like › PH domain-like 0.53 41.0 3.96e-01 87.5% 88.0%
4875850 4967.1.1.14 alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › Flavi_NS5_thumb 0.53 38.0 3.64e-01 78.1% 70.5%
3623124 3346.1.1.1 a+b two layers › N-terminal domain in ubiquitin-fold modifier 1 specific protease UfSP2 › N-terminal domain in ubiquitin-fold modifier 1 specific protease UfSP2 › N-terminal domain in ubiquitin-fold modifier 1 specific protease UfSP2 › UfSP2_N 0.53 41.0 2.84e-01 84.4% 45.5%
3781912 221.1.1.2 a+b two layers › beta-Grasp › Ubiquitin-related › Ubiquitin-like › ubiquitin 0.52 40.0 3.94e-01 85.9% 85.7%
3254503 221.1.1.0 a+b two layers › beta-Grasp › Ubiquitin-related › Ubiquitin-like 0.52 42.0 3.83e-01 93.8% 72.2%
3220364 6166.1.1.1 alpha bundles › N-terminal domain of Delta(14)-sterol reductase, MaSR1 › N-terminal domain of Delta(14)-sterol reductase, MaSR1 › N-terminal domain of Delta(14)-sterol reductase, MaSR1 › ERG4_ERG24 0.51 43.0 3.10e-01 96.9% 66.5%
224066 822.3.1.1 a+b two layers › GYF/BRK domain-like › conserved domain protein SP_1775 › conserved domain protein SP_1775 › DUF4649 0.51 43.0 4.09e-01 98.4% 100.0%
4880209 5001.1.1.1 alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 0.51 44.0 3.17e-01 100.0% 71.8%
3389022 379.1.1.0 few secondary structure elements › Kazal-type serine protease inhibitors-like › Kazal-type serine protease inhibitors › Kazal-type serine protease inhibitors 0.51 33.0 3.52e-01 79.7% 84.0%
4238208 2004.1.1.481 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N, AAA_29 0.51 42.0 2.61e-01 93.8% 52.1%
None 0.51 43.0 2.79e-01 100.0% 44.0%
5008091 221.10.1.1 a+b two layers › beta-Grasp › FdhD/NarQ beta-grasp fold domain › FdhD/NarQ beta-grasp fold domain › FdhD-NarQ 0.51 39.0 3.82e-01 84.4% 91.4%
4954188 2492.1.1.7 a+b three layers › Cytidine deaminase-like › Cytidine deaminase-like › Cytidine deaminase-like › FdhD-NarQ 0.51 40.0 3.18e-01 92.2% 48.3%
None 0.50 43.0 2.72e-01 100.0% 39.5%
3935348 2004.1.1.0 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.50 40.0 2.93e-01 92.2% 54.7%
5056226 304.126.1.0 a+b two layers › Alpha-beta plaits › ferredoxin-like domain in vacuolar ATP synthase subunit C › ferredoxin-like domain in vacuolar ATP synthase subunit C 0.50 38.0 3.71e-01 92.2% 75.7%
3484326 7579.1.1.0 a/b three-layered sandwiches › alpha/beta-Hydrolases › alpha/beta-Hydrolases › alpha/beta-Hydrolases 0.50 41.0 2.69e-01 92.2% 30.7%
4986894 310.3.1.0 a+b two layers › RRF/tRNA synthetase additional domain-like › General secretion pathway protein M (EpsM) periplasmic domain-related › General secretion pathway protein M (EpsM) periplasmic domain-related 0.50 34.0 3.55e-01 89.1% 76.7%
D3 medium residues 187-209_228-254
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF01366.24 best PRTP 27.8 9.70e-07 100.0% 10.2%
D4 medium residues 255-272_332-392
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF01366.24 best PRTP 42.3 4.20e-11 96.2% 9.4%
D5 medium residues 393-435_496-530
PDB
D7 medium residues 591-704
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF01366.24 best PRTP 136.6 1.20e-39 80.7% 13.9%