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DNA_pol

Euk-Vir

Mamestra_brassicae_multiple_nucleopolyhedrovirus

DNA_pol__YP_009011170__Mamestra_brassicae_multiple_nucleopolyhedrovirus__78219

Identity

Accession:: YP_009011170 ↗
Protein ID:: DNA_pol
Kingdom:: euk

Quality

85.9 mean pLDDT

Taxonomy

Naldaviricetes› Lefavirales› Baculoviridae› Alphabaculovirus› Mamestra_brassicae_multiple_nucleopolyhedrovirus

TaxID: 78219

Cluster

View cluster (158 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 212-310

PDB

Domain cluster: rep: NC_074638__YP_010771999.1__QIT35-gp09__00009__D105-204

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF03104.26 best	DNA_pol_B_exo1	49.9	4.10e-13	100.0%	40.1%

CATH (15)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3iayA03	3.30.420.10	Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H	0.85	70.0	5.29e-01	100.0%	39.9%
4fvmA03	3.30.420.10	Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H	0.77	72.0	5.30e-01	100.0%	49.6%
4qclA03	3.30.420.10	Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H	0.76	71.0	5.07e-01	100.0%	41.7%
2gv9A03	3.30.420.10	Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H	0.73	67.0	5.05e-01	100.0%	43.9%
1noyB02	3.30.420.10	Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H	0.72	66.0	4.94e-01	98.0%	47.3%
3cb6A01	3.40.350.10	Alpha Beta › 3-Layer(aba) Sandwich › Creatine Amidinohydrolase; Chain A, domain 1 › Creatinase/prolidase N-terminal domain	0.61	49.0	4.08e-01	87.9%	63.4%
2ql8A00	3.30.300.20	Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › K homology (KH) domain	0.56	36.0	3.20e-01	89.9%	46.4%
2qjtB01	3.40.50.620	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HUPs	0.55	41.0	3.34e-01	79.8%	59.7%
2vsqA06	3.30.300.30	Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › ANL, C-terminal domain	0.54	35.0	3.45e-01	83.8%	61.9%
3bioA02	3.30.360.10	Alpha Beta › 2-Layer Sandwich › Dihydrodipicolinate Reductase; domain 2 › Dihydrodipicolinate Reductase; domain 2	0.53	36.0	3.48e-01	70.7%	82.5%
3lyeA00	3.20.20.60	Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Phosphoenolpyruvate-binding domains	0.51	36.0	2.66e-01	72.7%	76.1%
1ez0A02	3.40.309.10	Alpha Beta › 3-Layer(aba) Sandwich › Aldehyde Dehydrogenase; Chain A, domain 2 › Aldehyde Dehydrogenase; Chain A, domain 2	0.51	40.0	3.31e-01	83.8%	87.0%
3ausA00	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.51	37.0	2.80e-01	77.8%	65.6%
2imqX00	3.60.10.10	Alpha Beta › 4-Layer Sandwich › Deoxyribonuclease I; Chain A › Endonuclease/exonuclease/phosphatase	0.50	34.0	2.57e-01	70.7%	86.8%
2y27A02	3.30.300.30	Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › ANL, C-terminal domain	0.50	35.0	3.53e-01	81.8%	69.9%

ECOD (34)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
None	—		0.85	72.0	4.70e-01	100.0%	23.8%
4799493	2.1.1.25 ↗	beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › DNA_pol_B_exo1	0.85	70.0	6.51e-01	100.0%	70.2%
3168836	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.79	68.0	4.95e-01	91.9%	38.0%
3193111	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.79	74.0	4.81e-01	100.0%	30.0%
4323378	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.78	73.0	5.06e-01	100.0%	39.3%
3692564	2.1.1.25 ↗	beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › DNA_pol_B_exo1	0.77	72.0	4.65e-01	100.0%	27.8%
3167764	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.77	72.0	4.95e-01	100.0%	38.0%
3597964	2484.1.1.0 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like	0.76	71.0	4.91e-01	100.0%	37.7%
3702504	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.76	71.0	4.93e-01	100.0%	39.0%
4888481	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.75	64.0	4.52e-01	96.0%	33.1%
1790898	2484.1.1.34 ↗	mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1	0.75	70.0	4.99e-01	100.0%	42.1%
4874454	2.1.1.25 ↗	beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › DNA_pol_B_exo1	0.74	69.0	4.94e-01	100.0%	42.6%
3705562	304.48.1.0 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like	0.73	63.0	3.77e-01	100.0%	14.0%
3469756	2484.3.1.0 ↗	mixed a+b and a/b › Ribonuclease H-like › Creatinase/prolidase N-terminal domain › Creatinase/prolidase N-terminal domain	0.61	48.0	4.19e-01	84.8%	71.0%
3481944	2484.3.1.3 ↗	mixed a+b and a/b › Ribonuclease H-like › Creatinase/prolidase N-terminal domain › Creatinase/prolidase N-terminal domain › FACT-Spt16_Nlob	0.61	48.0	4.17e-01	84.8%	71.0%
3285846	327.5.1.0 ↗	a+b two layers › Alpha-lytic protease prodomain-like › a+b domain in acetyl-CoA synthetase-like proteins › a+b domain in acetyl-CoA synthetase-like proteins	0.59	34.0	3.82e-01	85.9%	74.7%
4980263	327.7.1.0 ↗	a+b two layers › Alpha-lytic protease prodomain-like › Cation efflux protein cytoplasmic domain-like › Cation efflux protein cytoplasmic domain-like	0.57	35.0	3.87e-01	88.9%	76.2%
3867661	323.1.1.0 ↗	a+b complex topology › CoA-dependent acyltransferases › CoA-dependent acyltransferases › CoA-dependent acyltransferases	0.56	40.0	2.69e-01	75.8%	76.7%
3602517	327.13.1.0 ↗	a+b two layers › Alpha-lytic protease prodomain-like › Ring-building motif I in type III secretion system › Ring-building motif I in type III secretion system	0.55	35.0	3.87e-01	89.9%	80.0%
4934708	327.7.1.1 ↗	a+b two layers › Alpha-lytic protease prodomain-like › Cation efflux protein cytoplasmic domain-like › Cation efflux protein cytoplasmic domain-like › ZT_dimer	0.55	36.0	3.81e-01	87.9%	74.4%
5081029	327.7.1.1 ↗	a+b two layers › Alpha-lytic protease prodomain-like › Cation efflux protein cytoplasmic domain-like › Cation efflux protein cytoplasmic domain-like › ZT_dimer	0.53	33.0	3.58e-01	88.9%	73.8%
5030854	327.7.1.1 ↗	a+b two layers › Alpha-lytic protease prodomain-like › Cation efflux protein cytoplasmic domain-like › Cation efflux protein cytoplasmic domain-like › ZT_dimer	0.53	35.0	3.75e-01	94.9%	79.5%
4594294	327.7.1.1 ↗	a+b two layers › Alpha-lytic protease prodomain-like › Cation efflux protein cytoplasmic domain-like › Cation efflux protein cytoplasmic domain-like › ZT_dimer	0.53	38.0	3.86e-01	79.8%	76.8%
5077924	327.7.1.1 ↗	a+b two layers › Alpha-lytic protease prodomain-like › Cation efflux protein cytoplasmic domain-like › Cation efflux protein cytoplasmic domain-like › ZT_dimer	0.53	33.0	3.61e-01	88.9%	77.5%
5051077	327.7.1.1 ↗	a+b two layers › Alpha-lytic protease prodomain-like › Cation efflux protein cytoplasmic domain-like › Cation efflux protein cytoplasmic domain-like › ZT_dimer	0.53	35.0	3.70e-01	99.0%	75.6%
4016686	232.1.1.3 ↗	a+b duplicates or obligate multimers › Pentein › Pentein › Pentein › PAD	0.52	42.0	2.84e-01	87.9%	30.1%
5072459	327.7.1.1 ↗	a+b two layers › Alpha-lytic protease prodomain-like › Cation efflux protein cytoplasmic domain-like › Cation efflux protein cytoplasmic domain-like › ZT_dimer	0.52	33.0	3.69e-01	88.9%	82.7%
4975755	327.7.1.1 ↗	a+b two layers › Alpha-lytic protease prodomain-like › Cation efflux protein cytoplasmic domain-like › Cation efflux protein cytoplasmic domain-like › ZT_dimer	0.52	33.0	3.60e-01	92.9%	76.5%
5017891	327.7.1.1 ↗	a+b two layers › Alpha-lytic protease prodomain-like › Cation efflux protein cytoplasmic domain-like › Cation efflux protein cytoplasmic domain-like › ZT_dimer	0.52	36.0	3.79e-01	97.0%	78.9%
3631027	232.1.1.3 ↗	a+b duplicates or obligate multimers › Pentein › Pentein › Pentein › PAD	0.52	41.0	2.84e-01	87.9%	30.5%
4949378	327.7.1.1 ↗	a+b two layers › Alpha-lytic protease prodomain-like › Cation efflux protein cytoplasmic domain-like › Cation efflux protein cytoplasmic domain-like › ZT_dimer	0.51	32.0	3.32e-01	89.9%	66.3%
4971758	327.7.1.1 ↗	a+b two layers › Alpha-lytic protease prodomain-like › Cation efflux protein cytoplasmic domain-like › Cation efflux protein cytoplasmic domain-like › ZT_dimer	0.51	32.0	3.58e-01	91.9%	80.0%
4955281	327.7.1.1 ↗	a+b two layers › Alpha-lytic protease prodomain-like › Cation efflux protein cytoplasmic domain-like › Cation efflux protein cytoplasmic domain-like › ZT_dimer	0.50	34.0	3.63e-01	88.9%	80.0%
5081028	327.7.1.1 ↗	a+b two layers › Alpha-lytic protease prodomain-like › Cation efflux protein cytoplasmic domain-like › Cation efflux protein cytoplasmic domain-like › ZT_dimer	0.50	33.0	3.51e-01	94.9%	74.4%

D2 medium residues 423-494

PDB

Domain cluster: rep: DNA_polymerase__YP_009552625__Operophtera_brumata_nucleopolyhedrovirus__1046267__D407-471

D3 medium residues 495-532_555-654

PDB

Domain cluster: rep: DNA_polymerase__YP_010086932__Cryptophlebia_peltastica_nucleopolyhedrovirus__2304025__D494-537_560-649

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00136.27 best	DNA_pol_B	36.2	4.50e-09	73.9%	16.8%

D4 medium residues 533-554_655-709_748-765

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00136.27 best	DNA_pol_B	23.6	3.00e-05	64.2%	9.9%

CATH (27)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2gv9B04	3.90.1600.10	Alpha Beta › Alpha-Beta Complex › Palm domain of DNA polymerase › B family DNA polymerase, palm domain	0.82	74.0	5.64e-01	94.7%	99.0%
1q8iA04	3.90.1600.10	Alpha Beta › Alpha-Beta Complex › Palm domain of DNA polymerase › B family DNA polymerase, palm domain	0.74	71.0	5.26e-01	100.0%	74.2%
4fxdA05	3.90.1600.10	Alpha Beta › Alpha-Beta Complex › Palm domain of DNA polymerase › B family DNA polymerase, palm domain	0.67	60.0	5.52e-01	94.7%	95.7%
5wpjA02	3.30.70.420	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain	0.61	45.0	4.32e-01	77.9%	92.6%
2mq8A00	3.30.70.600	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Ribosomal protein S10	0.59	44.0	4.22e-01	78.9%	83.9%
3w9kA00	3.30.530.20	Alpha Beta › 2-Layer Sandwich › Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4 › START domain	0.59	43.0	3.90e-01	77.9%	83.0%
6oqrA01	2.40.30.20	Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 ›	0.59	32.0	3.35e-01	77.9%	55.6%
1q2lA04	3.30.830.10	Alpha Beta › 2-Layer Sandwich › Cytochrome Bc1 Complex; Chain A, domain 1 › Metalloenzyme, LuxS/M16 peptidase-like	0.58	47.0	3.64e-01	91.6%	92.1%
5abxA00	3.30.760.10	Alpha Beta › 2-Layer Sandwich › RNA Cap, Translation Initiation Factor Eif4e › RNA Cap, Translation Initiation Factor Eif4e	0.57	47.0	3.87e-01	89.5%	69.4%
1lq9A00	3.30.70.100	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.56	42.0	4.03e-01	80.0%	89.3%
4l3tA03	3.30.830.10	Alpha Beta › 2-Layer Sandwich › Cytochrome Bc1 Complex; Chain A, domain 1 › Metalloenzyme, LuxS/M16 peptidase-like	0.56	42.0	3.24e-01	81.1%	76.5%
6ofsA02	3.30.830.10	Alpha Beta › 2-Layer Sandwich › Cytochrome Bc1 Complex; Chain A, domain 1 › Metalloenzyme, LuxS/M16 peptidase-like	0.55	42.0	3.24e-01	81.1%	90.4%
1zxfA00	3.30.530.20	Alpha Beta › 2-Layer Sandwich › Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4 › START domain	0.55	40.0	3.41e-01	76.8%	87.7%
1bccB01	3.30.830.10	Alpha Beta › 2-Layer Sandwich › Cytochrome Bc1 Complex; Chain A, domain 1 › Metalloenzyme, LuxS/M16 peptidase-like	0.54	40.0	3.16e-01	78.9%	82.4%
4ae5C00	3.30.70.100	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.54	41.0	3.55e-01	83.2%	96.2%
2op5B01	3.30.70.100	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.53	39.0	3.91e-01	78.9%	97.0%
2k3iA01	3.30.70.860	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.53	38.0	4.03e-01	77.9%	95.3%
3gz7B00	3.30.70.100	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.53	39.0	3.88e-01	78.9%	89.8%
2nyiA01	3.30.70.260	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain	0.52	39.0	4.16e-01	76.8%	90.1%
1gx5A03	3.30.70.270	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain	0.52	44.0	4.13e-01	94.7%	96.7%
5k9fA00	3.30.70.100	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.52	38.0	3.71e-01	76.8%	89.3%
7r3eB02	3.30.450.80	Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › Transcription factor LuxR-like, autoinducer-binding domain	0.52	43.0	3.59e-01	89.5%	94.5%
5l09B00	3.30.450.80	Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › Transcription factor LuxR-like, autoinducer-binding domain	0.52	42.0	3.55e-01	88.4%	88.4%
5ixuA00	3.30.70.100	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.51	38.0	3.72e-01	77.9%	90.2%
5yppA00	3.30.70.260	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain	0.51	37.0	3.84e-01	75.8%	87.8%
2pmbA01	3.30.1850.10	Alpha Beta › 2-Layer Sandwich › MCP/YpsA-like › MoCo carrier protein-like	0.51	38.0	3.68e-01	78.9%	79.4%
3rrkA03	3.30.70.2750	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.51	38.0	4.24e-01	78.9%	100.0%

ECOD (30)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
5019480	304.48.1.3 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B	0.84	80.0	4.61e-01	100.0%	36.3%
5005286	304.48.1.3 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B	0.84	78.0	5.30e-01	98.9%	88.5%
5025843	304.48.1.3 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B	0.71	68.0	5.06e-01	100.0%	91.0%
3882670	304.47.1.1 ↗	a+b two layers › Alpha-beta plaits › SEA domain › SEA domain › SEA	0.61	44.0	4.25e-01	76.8%	97.3%
5070629	328.8.1.1 ↗	a+b two layers › IF3-like › Schlafen 8 › Schlafen 8 › SLFN_AlbA_2	0.60	44.0	3.86e-01	77.9%	62.8%
3593926	304.6.1.0 ↗	a+b two layers › Alpha-beta plaits › FAD-linked oxidases, C-terminal domain › FAD-linked oxidases, C-terminal domain	0.59	49.0	3.54e-01	92.6%	72.1%
3367922	304.8.1.45 ↗	a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant	0.59	37.0	3.72e-01	76.8%	62.1%
4518792	304.28.1.4 ↗	a+b two layers › Alpha-beta plaits › Ferredoxin domains in multidrug efflux transporter › Multidrug efflux transporter AcrB pore domain › SecD_1st	0.59	43.0	4.13e-01	76.8%	91.8%
3394262	304.47.1.1 ↗	a+b two layers › Alpha-beta plaits › SEA domain › SEA domain › SEA	0.58	43.0	4.00e-01	78.9%	89.4%
4083044	1.1.7.17 ↗	beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C › ATP-synt_ab_N	0.57	33.0	3.68e-01	77.9%	72.0%
4932448	304.28.1.0 ↗	a+b two layers › Alpha-beta plaits › Ferredoxin domains in multidrug efflux transporter › Multidrug efflux transporter AcrB pore domain	0.57	41.0	4.22e-01	76.8%	92.2%
3271422	304.159.1.0 ↗	a+b two layers › Alpha-beta plaits › Alpha-beta plait domain in NisB › Alpha-beta plait domain in NisB	0.56	40.0	4.25e-01	75.8%	98.8%
3519528	304.55.2.0 ↗	a+b two layers › Alpha-beta plaits › Origin of replication-binding domains › Transposase IS200-like	0.56	41.0	3.61e-01	77.9%	94.5%
4556741	309.1.1.11 ↗	a+b two layers › LuxS, MPP, ThrRS/AlaRS common domain › LuxS, MPP, ThrRS/AlaRS common domain › LuxS/MPP-like metallohydrolase › PqqF-like_C_4	0.56	41.0	3.37e-01	76.8%	86.3%
3537609	304.47.1.1 ↗	a+b two layers › Alpha-beta plaits › SEA domain › SEA domain › SEA	0.56	43.0	4.07e-01	82.1%	97.4%
3759364	304.51.1.0 ↗	a+b two layers › Alpha-beta plaits › CRISPR transcript (pre-crRNA) processing endoribonuclease-related › CRISPR transcript (pre-crRNA) processing endoribonuclease-related	0.55	41.0	4.00e-01	78.9%	98.1%
4979070	304.4.1.0 ↗	a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel	0.55	40.0	3.93e-01	77.9%	85.7%
3520411	304.47.1.0 ↗	a+b two layers › Alpha-beta plaits › SEA domain › SEA domain	0.55	40.0	3.86e-01	77.9%	89.1%
4031210	304.159.1.1 ↗	a+b two layers › Alpha-beta plaits › Alpha-beta plait domain in NisB › Alpha-beta plait domain in NisB › Lant_dehydr_C	0.55	41.0	3.97e-01	78.9%	84.8%
5070214	304.57.1.0 ↗	a+b two layers › Alpha-beta plaits › Rpp14/Pop5-like › Rpp14/Pop5-like	0.55	44.0	4.28e-01	86.3%	96.2%
3737983	309.1.1.13 ↗	a+b two layers › LuxS, MPP, ThrRS/AlaRS common domain › LuxS, MPP, ThrRS/AlaRS common domain › LuxS/MPP-like metallohydrolase › Peptidase_M16,Peptidase_M16_C,M16C_assoc	0.54	42.0	2.46e-01	84.2%	45.3%
3662789	331.2.1.0 ↗	a+b two layers › TBP-like › Phosphoglucomutase, C-terminal domain › Phosphoglucomutase, C-terminal domain	0.53	39.0	4.13e-01	77.9%	97.6%
3703868	11.1.1.944 ↗	beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › DUF7498	0.53	39.0	3.70e-01	78.9%	77.4%
5042991	304.8.1.2 ↗	a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › ACT	0.53	37.0	4.07e-01	76.8%	93.3%
3634393	304.4.1.4 ↗	a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel › ABM	0.51	38.0	3.77e-01	77.9%	84.0%
4118693	304.24.1.0 ↗	a+b two layers › Alpha-beta plaits › EF-G C-terminal domain-like › EF-G C-terminal domain-like	0.51	36.0	3.92e-01	80.0%	92.0%
3289745	304.4.1.4 ↗	a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel › ABM	0.51	37.0	3.77e-01	77.9%	92.6%
3616177	304.9.1.1 ↗	a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1	0.51	38.0	3.59e-01	81.1%	75.8%
4034527	304.8.1.0 ↗	a+b two layers › Alpha-beta plaits › ACT-like › ACT-like	0.50	35.0	3.76e-01	82.1%	88.5%
3257993	206.1.1.1 ↗	a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase	0.50	40.0	2.74e-01	88.4%	97.6%

D5 medium residues 790-807_882-1000

PDB

Domain cluster: representative

CATH (8)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4k3cA01	3.10.20.310	Alpha Beta › Roll › Ubiquitin-like (UB roll) › membrane protein fhac	0.61	33.0	4.01e-01	71.5%	84.1%
6wimA02	3.10.20.310	Alpha Beta › Roll › Ubiquitin-like (UB roll) › membrane protein fhac	0.57	29.0	3.66e-01	70.1%	85.1%
2ek0A00	3.30.110.20	Alpha Beta › 2-Layer Sandwich › Translation Initiation Factor IF3 › Alba-like domain	0.55	34.0	3.99e-01	83.2%	91.1%
3u6yA00	3.30.110.20	Alpha Beta › 2-Layer Sandwich › Translation Initiation Factor IF3 › Alba-like domain	0.55	34.0	3.86e-01	81.0%	83.8%
5jjxA01	1.25.40.1040	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat ›	0.53	39.0	3.00e-01	75.9%	91.6%
2qr4A01	1.20.140.70	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Oligopeptidase f, N-terminal domain	0.53	38.0	3.69e-01	75.2%	100.0%
6q9jB02	1.20.1440.230	Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain	0.52	28.0	3.32e-01	74.5%	76.1%
4i4cB00	3.40.50.1820	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain	0.51	42.0	2.99e-01	86.9%	39.2%

ECOD (3)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
5046705	328.1.1.0 ↗	a+b two layers › IF3-like › AlbA-like › AlbA-like	0.58	34.0	3.82e-01	82.5%	74.3%
327528	328.1.1.2 ↗	a+b two layers › IF3-like › AlbA-like › AlbA-like › SpoVS	0.55	34.0	3.99e-01	83.2%	91.1%
4629438	230.1.1.5 ↗	a+b two layers › T-fold › Tetrahydrobiopterin biosynthesis enzymes-like › Tetrahydrobiopterin biosynthesis enzymes-like › GCHY-1	0.54	30.0	3.29e-01	74.5%	65.5%

D6 medium residues 808-832_847-881

PDB

Domain cluster: representative

CATH (2)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3iayA07	1.10.132.60	Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › B family DNA polymerase, thumb domain	0.77	66.0	4.81e-01	100.0%	36.8%
4qclA05	1.10.132.60	Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › B family DNA polymerase, thumb domain	0.71	62.0	4.51e-01	100.0%	35.7%

ECOD (9)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3480544	4969.1.1.0 ↗	alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I	0.74	66.0	4.77e-01	100.0%	36.4%
5002819	4969.1.1.1 ↗	alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B	0.73	65.0	4.75e-01	100.0%	40.0%
3797774	4969.1.1.1 ↗	alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B	0.73	62.0	4.63e-01	100.0%	38.6%
4956225	4969.1.1.1 ↗	alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B	0.72	64.0	4.78e-01	100.0%	40.7%
4939490	4969.1.1.0 ↗	alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I	0.72	62.0	4.59e-01	100.0%	42.9%
3404727	4969.1.1.1 ↗	alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B	0.70	62.0	4.31e-01	100.0%	30.9%
5027092	4969.1.1.1 ↗	alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B	0.69	60.0	4.57e-01	100.0%	42.1%
3366699	376.1.1.21 ↗	few secondary structure elements › RING/U-box-like › RING/U-box-like › RING/U-box › zf-RING_2	0.52	42.0	3.80e-01	90.0%	67.1%
3604368	7592.1.1.3 ↗	a/b three-layered sandwiches › CARF (CRISPR-associated Rossmann fold) domains › CARF (CRISPR-associated Rossmann fold) domains › CARF (CRISPR-associated Rossmann fold) domains › DUF6293_N	0.52	41.0	3.15e-01	96.7%	95.4%