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DNA_polymerase

Euk-Vir

Variola_virus

DNA_polymerase__NP_042094__Variola_virus__10255

Identity

Accession:
NP_042094 ↗
Protein ID:
DNA_polymerase
Kingdom:
euk

Quality

82.7 mean pLDDT

Taxonomy

Bamfordvirae› Nucleocytoviricota› Pokkesviricetes› Chitovirales› Poxviridae› Orthopoxvirus› Variola_virus

TaxID: 10255

Cluster

View cluster (158 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 2-157
PDB
Domain cluster: rep: DNA_polymerase__YP_784249__Nile_crocodilepox_virus__1285600__D2-148
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF08452.17 best DNAP_B_exo_N 48.6 5.80e-13 13.5% 95.5%
CATH (9)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2pi2D00 2.40.50.140 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins 0.72 32.0 3.65e-01 97.4% 53.7%
4b08A01 2.40.50.730 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › 0.68 35.0 4.73e-01 100.0% 95.1%
3u4vA00 2.40.50.140 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins 0.68 37.0 4.25e-01 98.1% 71.6%
2gu3A02 3.10.450.40 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.66 22.0 3.42e-01 88.5% 73.0%
4gs3A00 2.40.50.140 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins 0.63 34.0 4.39e-01 97.4% 91.1%
3n8bA00 3.10.450.700 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.57 23.0 3.31e-01 75.6% 77.3%
1xjvA01 2.40.50.140 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins 0.51 36.0 3.84e-01 100.0% 81.7%
2y1sA00 2.30.60.10 Mainly Beta › Roll › HIV-inactivating Protein, Cyanovirin-n › Cyanovirin-N 0.51 34.0 3.93e-01 94.9% 97.2%
3u6yA00 3.30.110.20 Alpha Beta › 2-Layer Sandwich › Translation Initiation Factor IF3 › Alba-like domain 0.50 26.0 3.10e-01 84.0% 73.7%
ECOD (44)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
5055355 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.73 40.0 5.26e-01 98.1% 94.4%
5025207 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.72 39.0 5.18e-01 96.8% 96.5%
3964458 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.72 35.0 4.52e-01 96.8% 80.0%
3788812 304.114.1.6 ↗ a+b two layers › Alpha-beta plaits › Family B DNA polymerase insertion domain › Family B DNA polymerase insertion domain › DNA_pol_B_exo1 0.70 64.0 5.54e-01 100.0% 77.5%
4997715 2484.1.1.0 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.69 64.0 6.26e-01 100.0% 97.1%
4213053 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.69 35.0 4.35e-01 97.4% 77.9%
4024809 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.69 38.0 4.93e-01 98.1% 94.4%
4449302 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.68 35.0 4.22e-01 98.1% 73.3%
4504110 2484.1.1.197 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1, DNA_pol_B_exo2 0.68 63.0 4.58e-01 100.0% 39.5%
5005284 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.68 41.0 5.17e-01 100.0% 98.9%
3654541 2.1.1.223 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › PF28721 0.67 39.0 4.52e-01 100.0% 80.0%
4942684 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.67 61.0 5.94e-01 98.1% 97.6%
4299557 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.67 62.0 5.71e-01 100.0% 87.2%
3791987 2.1.1.25 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › DNA_pol_B_exo1 0.66 42.0 4.88e-01 100.0% 87.0%
4500300 2484.1.1.34 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1 0.66 61.0 4.50e-01 99.4% 90.6%
3991931 2.1.1.130 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › DUF223 0.64 39.0 4.39e-01 100.0% 77.5%
4972474 2484.1.1.0 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.64 59.0 3.84e-01 100.0% 24.9%
5019480 304.48.1.3 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B 0.64 59.0 3.78e-01 100.0% 25.7%
4999027 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.64 31.0 4.32e-01 91.7% 96.0%
3214780 2.1.1.15 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › tRNA_anti-codon 0.64 37.0 4.47e-01 100.0% 85.7%
3247575 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.63 35.0 4.01e-01 97.4% 70.8%
4026723 2.1.1.15 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › tRNA_anti-codon 0.63 38.0 4.44e-01 100.0% 84.5%
3630622 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.63 38.0 4.29e-01 100.0% 78.3%
4970159 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.62 32.0 4.03e-01 97.4% 81.1%
5054128 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.62 38.0 4.32e-01 100.0% 80.9%
3661180 2.1.1.223 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › PF28721 0.62 37.0 4.57e-01 100.0% 93.0%
3934534 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.62 41.0 4.32e-01 96.8% 74.3%
3935835 2.1.1.68 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › RMI1_C 0.62 41.0 4.36e-01 96.8% 75.7%
4988803 2484.1.1.34 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1 0.61 57.0 4.17e-01 99.4% 87.3%
3621460 2.1.1.68 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › RMI1_C 0.61 41.0 4.28e-01 96.2% 73.1%
3675935 2.1.1.223 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › PF28721 0.60 38.0 4.10e-01 100.0% 73.3%
3331695 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.59 34.0 4.04e-01 100.0% 82.9%
4976869 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.59 40.0 4.64e-01 100.0% 93.9%
3657721 2.1.1.223 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › PF28721 0.58 37.0 3.83e-01 100.0% 66.7%
3585893 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.58 41.0 4.27e-01 96.2% 78.6%
3650904 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.57 35.0 4.36e-01 98.7% 100.0%
5058885 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.57 33.0 3.35e-01 100.0% 55.6%
4982659 2484.1.1.34 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1 0.57 53.0 3.99e-01 99.4% 91.4%
3679986 2.1.1.305 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › Rep_fac-A_C, REPA_OB_2 0.54 37.0 2.95e-01 100.0% 35.4%
3963716 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.54 33.0 3.86e-01 100.0% 86.4%
3296675 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.53 35.0 3.84e-01 100.0% 81.6%
3330560 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.52 35.0 3.52e-01 100.0% 66.3%
3359808 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.52 35.0 3.79e-01 100.0% 81.5%
3168835 2.1.1.0 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.51 38.0 4.24e-01 96.2% 96.0%
D2 high residues 162-343_465-472
PDB
Domain cluster: rep: DNA_polymerase_catalytic_subunit__YP_401712__Human_gammaherpesvirus_4__10376__D288-457
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF03104.26 best DNA_pol_B_exo1 74.4 1.30e-20 97.9% 69.4%
D3 high residues 346-432
PDB
Domain cluster: rep: DNA_polymerase_elongation_subunit_family_B__YP_009162448__Salmon_gill_poxvirus__1680908__D388-474
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF08408.17 best DNA_pol_B_3 89.2 3.60e-25 95.4% 66.4%
D4 high residues 828-996
PDB
Domain cluster: rep: IMGVR_UViG_3300021255_003095-3300021255-Ga0223825_1010595139__D209-342
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00136.27 best DNA_pol_B 114.7 6.80e-33 93.5% 32.9%
D5 medium residues 519-549_787-827
PDB
Domain cluster: representative
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF00136.27 best DNA_pol_B 34.9 1.10e-08 58.3% 8.4%
PF00136.27 DNA_pol_B 27.4 2.10e-06 44.4% 6.8%
CATH (10)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
4fxdA05 3.90.1600.10 Alpha Beta › Alpha-Beta Complex › Palm domain of DNA polymerase › B family DNA polymerase, palm domain 0.82 63.0 5.29e-01 81.9% 95.7%
2py5A02 3.90.1600.10 Alpha Beta › Alpha-Beta Complex › Palm domain of DNA polymerase › B family DNA polymerase, palm domain 0.81 75.0 5.47e-01 100.0% 86.0%
3qexA03 3.90.1600.10 Alpha Beta › Alpha-Beta Complex › Palm domain of DNA polymerase › B family DNA polymerase, palm domain 0.78 71.0 4.81e-01 98.6% 99.6%
2au3A02 3.90.980.10 Alpha Beta › Alpha-Beta Complex › DNA primase DNAg catalytic core, N-terminal domain › DNA primase, catalytic core, N-terminal domain 0.59 46.0 3.94e-01 87.5% 100.0%
5w36B01 3.90.980.10 Alpha Beta › Alpha-Beta Complex › DNA primase DNAg catalytic core, N-terminal domain › DNA primase, catalytic core, N-terminal domain 0.58 45.0 3.75e-01 87.5% 100.0%
3lltA01 3.30.200.20 Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1 0.56 36.0 3.35e-01 79.2% 49.5%
1tuhA00 3.10.450.50 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.56 40.0 3.39e-01 79.2% 77.1%
1kbpA02 3.60.21.10 Alpha Beta › 4-Layer Sandwich › Purple Acid Phosphatase; chain A, domain 2 › Metallo-dependent phosphatases 0.53 38.0 2.61e-01 79.2% 96.8%
2qggA02 2.30.30.240 Mainly Beta › Roll › SH3 type barrels. › PRC-barrel domain 0.52 38.0 3.72e-01 80.6% 72.3%
6gitA02 3.60.21.10 Alpha Beta › 4-Layer Sandwich › Purple Acid Phosphatase; chain A, domain 2 › Metallo-dependent phosphatases 0.51 37.0 2.40e-01 77.8% 98.0%
ECOD (40)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4231530 304.48.1.3 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B 0.90 76.0 5.23e-01 87.5% 99.0%
3993981 304.48.1.3 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B 0.89 74.0 5.00e-01 87.5% 100.0%
3597965 304.48.1.0 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.89 74.0 4.97e-01 88.9% 100.0%
3484036 304.48.1.0 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.87 73.0 4.74e-01 88.9% 100.0%
4276636 304.48.1.3 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B 0.85 75.0 4.70e-01 93.1% 78.2%
3801150 304.48.1.3 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B 0.85 78.0 5.02e-01 98.6% 85.4%
3784383 304.48.1.3 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B 0.84 78.0 4.78e-01 98.6% 74.3%
3558196 304.48.1.3 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B 0.84 79.0 5.08e-01 100.0% 90.2%
3705695 304.48.1.24 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DUF1744 0.84 75.0 5.03e-01 95.8% 91.4%
4029141 304.48.1.3 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B 0.84 76.0 5.01e-01 97.2% 95.0%
3480546 304.48.1.0 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.84 77.0 5.01e-01 97.2% 100.0%
3705562 304.48.1.0 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.83 78.0 4.42e-01 100.0% 85.3%
3684974 304.48.1.0 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.83 76.0 4.34e-01 98.6% 85.3%
3615419 304.48.1.3 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B 0.83 78.0 4.88e-01 100.0% 90.9%
4022366 2484.1.1.161 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.83 76.0 4.34e-01 98.6% 40.5%
3628202 304.48.1.0 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.82 77.0 4.36e-01 100.0% 38.9%
None — 0.82 77.0 4.39e-01 100.0% 40.5%
None — 0.82 75.0 4.25e-01 97.2% 40.0%
3466667 2484.1.1.161 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.81 76.0 4.32e-01 100.0% 86.9%
4972474 2484.1.1.0 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.81 76.0 4.30e-01 100.0% 82.8%
5005286 304.48.1.3 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B 0.80 71.0 4.59e-01 95.8% 91.8%
3349591 304.48.1.3 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B 0.80 74.0 4.75e-01 98.6% 85.9%
3506687 304.48.1.17 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B_2 0.79 72.0 4.40e-01 100.0% 76.3%
5019480 304.48.1.3 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B 0.79 73.0 4.14e-01 100.0% 83.7%
3741560 304.48.1.24 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DUF1744 0.75 69.0 4.57e-01 100.0% 91.1%
4243736 304.48.1.17 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B_2 0.74 68.0 5.14e-01 100.0% 92.1%
4958554 304.48.1.3 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B 0.74 66.0 4.53e-01 97.2% 99.1%
3230422 304.48.1.17 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B_2 0.71 64.0 3.86e-01 100.0% 32.4%
3536187 219.1.1.41 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › Peptidase_C78 0.62 47.0 3.86e-01 83.3% 55.7%
5076458 331.3.1.9 ↗ a+b two layers › TBP-like › Bet v1-like › Bet v1-like › AHSA1 0.58 45.0 3.72e-01 87.5% 55.0%
3451171 4.1.1.0 ↗ beta barrels › SH3 › SH3 › SH3 0.55 39.0 4.06e-01 80.6% 83.1%
3614247 220.1.1.0 ↗ beta barrels › PH domain-like › PH domain-like › PH domain-like 0.55 40.0 3.31e-01 76.4% 72.0%
3695858 206.1.1.1 ↗ a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase 0.55 37.0 2.47e-01 81.9% 15.9%
3607981 4.1.1.0 ↗ beta barrels › SH3 › SH3 › SH3 0.54 39.0 3.91e-01 79.2% 78.4%
4996733 4.6.1.0 ↗ beta barrels › SH3 › PRC-barrel domain › PRC-barrel domain 0.53 35.0 3.57e-01 70.8% 70.0%
3357709 4.1.1.42 ↗ beta barrels › SH3 › SH3 › SH3 › Agenet 0.52 38.0 3.65e-01 80.6% 72.9%
4848140 222.1.1.17 ↗ a+b two layers › Thioesterase/thiol ester dehydrase-isomerase-like › Thioesterase/thiol ester dehydrase-isomerase › Thioesterase/thiol ester dehydrase-isomerase › PKS_DH_N 0.51 38.0 3.13e-01 81.9% 80.1%
4170432 4998.1.1.1 ↗ beta sandwiches › Flagellar hook protein flgE D2 domain-like › Flagellar hook protein flgE D2 domain › Flagellar hook protein flgE D2 domain › FlgE_D2 0.51 38.0 3.26e-01 83.3% 58.4%
3208529 206.1.1.1 ↗ a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase 0.51 37.0 2.37e-01 80.6% 46.1%
3339170 5.1.3.116 ↗ beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 6-bladed › Kelch_KLHDC2_KLHL20_DRC7 0.50 40.0 2.72e-01 93.1% 54.2%
D6 medium residues 550-562_620-682
PDB
Domain cluster: rep: hypothetical_protein_FR483_N023L__YP_001425655__Paramecium_bursaria_Chlorella_virus_FR483__399781__D557-623
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00136.27 best DNA_pol_B 84.6 9.30e-24 84.2% 13.7%
D7 medium residues 563-619
PDB
Domain cluster: rep: putative_E9L_protein__YP_010085734__Orthopoxvirus_Abatino__2478919__D552-603_680-702
D8 medium residues 683-786
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00136.27 best DNA_pol_B 65.3 6.80e-18 100.0% 18.5%
CATH (13)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
5mmiG01 3.90.930.12 Alpha Beta › Alpha-Beta Complex › Outer Surface Protein A; domain 3 › Ribosomal protein L6 0.59 40.0 4.28e-01 95.2% 85.7%
2k3iA01 3.30.70.860 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.59 39.0 4.26e-01 97.1% 83.5%
6le1A01 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.56 35.0 4.08e-01 86.5% 95.6%
1hbxA01 3.40.1810.10 Alpha Beta › 3-Layer(aba) Sandwich › SRF-like › Transcription factor, MADS-box 0.55 29.0 3.38e-01 75.0% 71.8%
2v8qA01 3.30.310.80 Alpha Beta › 2-Layer Sandwich › TATA-Binding Protein › Kinase associated domain 1, KA1 0.54 41.0 4.38e-01 96.2% 95.5%
1bqgA01 3.30.390.10 Alpha Beta › 2-Layer Sandwich › Enolase-like; domain 1 › Enolase-like, N-terminal domain 0.53 45.0 4.13e-01 94.2% 85.5%
4it1B01 3.30.390.10 Alpha Beta › 2-Layer Sandwich › Enolase-like; domain 1 › Enolase-like, N-terminal domain 0.52 42.0 3.74e-01 90.4% 87.6%
2r7dA03 2.40.50.140 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins 0.51 27.0 3.45e-01 84.6% 88.3%
4jn7A01 3.30.390.10 Alpha Beta › 2-Layer Sandwich › Enolase-like; domain 1 › Enolase-like, N-terminal domain 0.51 41.0 3.94e-01 86.5% 84.9%
2qgyB01 3.30.390.10 Alpha Beta › 2-Layer Sandwich › Enolase-like; domain 1 › Enolase-like, N-terminal domain 0.51 43.0 3.94e-01 93.3% 82.5%
2ehbD00 3.30.310.80 Alpha Beta › 2-Layer Sandwich › TATA-Binding Protein › Kinase associated domain 1, KA1 0.51 40.0 3.78e-01 94.2% 69.8%
2nqlA01 3.30.390.10 Alpha Beta › 2-Layer Sandwich › Enolase-like; domain 1 › Enolase-like, N-terminal domain 0.50 42.0 3.65e-01 94.2% 86.3%
1xfsA00 3.30.530.20 Alpha Beta › 2-Layer Sandwich › Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4 › START domain 0.50 41.0 3.64e-01 90.4% 89.6%
ECOD (14)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3089539 304.48.1.3 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B 0.95 92.0 6.36e-01 100.0% 35.7%
4449508 331.2.1.13 ↗ a+b two layers › TBP-like › Phosphoglucomutase, C-terminal domain › Phosphoglucomutase, C-terminal domain › DinI 0.66 42.0 4.71e-01 91.3% 85.0%
4947615 3604.1.1.0 ↗ a+b two layers › Uncharacterized protein MK0293 C-terminal domain › Uncharacterized protein MK0293 C-terminal domain › Uncharacterized protein MK0293 C-terminal domain 0.60 37.0 4.51e-01 77.9% 100.0%
4927894 304.48.1.4 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Guanylate_cyc 0.57 43.0 3.35e-01 100.0% 36.1%
1235359 331.1.1.8 ↗ a+b two layers › TBP-like › TATA-box binding protein-like › TATA-box binding protein-like › AfAlkA-like_TBP-like 0.55 41.0 4.19e-01 93.3% 81.8%
4584323 3604.1.1.1 ↗ a+b two layers › Uncharacterized protein MK0293 C-terminal domain › Uncharacterized protein MK0293 C-terminal domain › Uncharacterized protein MK0293 C-terminal domain › Ni_insertion 0.54 32.0 3.97e-01 76.9% 100.0%
4394739 330.4.1.1 ↗ a+b two layers › dsRBD-like › Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain › Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain › Porphobil_deamC 0.53 31.0 3.61e-01 94.2% 84.3%
3284788 331.1.1.0 ↗ a+b two layers › TBP-like › TATA-box binding protein-like › TATA-box binding protein-like 0.53 36.0 3.99e-01 85.6% 90.0%
3357798 3082.1.1.3 ↗ extended segments › C-terminal region of nonsense mediated decay factor UPF2 › C-terminal region of nonsense mediated decay factor UPF2 › C-terminal region of nonsense mediated decay factor UPF2 › Pro_isomerase 0.53 21.0 3.11e-01 73.1% 84.1%
5045335 283.1.1.1 ↗ a+b duplicates or obligate multimers › Creatinase/aminopeptidase-like › Creatinase/aminopeptidase › Creatinase/aminopeptidase › Peptidase_M24 0.53 42.0 3.15e-01 84.6% 89.1%
2130268 4099.1.1.7 ↗ a+b two layers › Kinetochore globular domain-like › Kinetochore globular domain-like › Kinetochore globular domain-like › Ctf19_RWD1 0.52 29.0 3.15e-01 94.2% 64.7%
4680096 4099.1.1.0 ↗ a+b two layers › Kinetochore globular domain-like › Kinetochore globular domain-like › Kinetochore globular domain-like 0.51 29.0 3.28e-01 90.4% 71.2%
4024979 304.48.1.0 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.51 43.0 3.25e-01 100.0% 38.0%
165020 218.1.1.1 ↗ a+b two layers › Enolase-N/ribosomal protein › Enolase N-terminal domain-like › Enolase N-terminal domain-like › MR_MLE_N 0.51 43.0 4.10e-01 94.2% 95.2%