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DNA_polymerase
Euk-VirPseudalatia_unipuncta_granulovirus
DNA_polymerase__YP_003422477__Pseudalatia_unipuncta_granulovirus__36355
Identity
- Accession:
- YP_003422477 ↗
- Protein ID:
- DNA_polymerase
- Kingdom:
- euk
Quality
81.7
mean pLDDT
Taxonomy
TaxID: 36355
Cluster
View cluster (158 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 39-203
Domain cluster:
rep: DNA_polymerase__YP_010084862__Shrimp_hemocyte_iridescent_virus__2039780__D2-200
D2
high
residues 207-431
Domain cluster:
rep: DNA_polymerase__YP_009118564__Condylorrhiza_vestigialis_MNPV__1592576__D196-404
Pfam (3)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF10108.16 best | DNA_pol_B_exo2 | 43.4 | 4.60e-11 | 88.0% | 61.3% |
| PF03104.26 | DNA_pol_B_exo1 | 86.3 | 3.20e-24 | 79.1% | 73.1% |
| PF13482.13 | RNase_H_2 | 25.2 | 2.00e-05 | 75.1% | 72.1% |
D3
medium
residues 476-493_512-675
Domain cluster:
rep: DNA_polymerase__YP_010086932__Cryptophlebia_peltastica_nucleopolyhedrovirus__2304025__D494-537_560-649
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00136.27 best | DNA_pol_B | 59.8 | 3.10e-16 | 86.8% | 33.6% |
D4
medium
residues 676-752
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00136.27 best | DNA_pol_B | 25.9 | 6.00e-06 | 85.7% | 9.5% |
CATH (35)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1rwuA00 | 3.30.70.260 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain | 0.71 | 54.0 | 5.20e-01 | 100.0% | 72.4% |
| 4djbA00 | 3.30.70.2870 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Mastadenovirus E4 ORF3 | 0.70 | 62.0 | 5.40e-01 | 100.0% | 69.5% |
| 5u89A01 | 3.30.300.30 | Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › ANL, C-terminal domain | 0.64 | 45.0 | 4.32e-01 | 100.0% | 63.0% |
| 4oycB00 | 3.30.300.30 | Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › ANL, C-terminal domain | 0.64 | 54.0 | 5.15e-01 | 100.0% | 82.0% |
| 2kz0A01 | 3.30.300.90 | Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › BolA-like | 0.63 | 47.0 | 4.82e-01 | 100.0% | 87.3% |
| 1vehA01 | 3.30.300.130 | Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › Fe-S cluster assembly (FSCA) | 0.61 | 47.0 | 4.75e-01 | 100.0% | 86.7% |
| 7lscA01 | 3.30.450.40 | Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › GAF domain | 0.61 | 49.0 | 4.00e-01 | 89.6% | 97.3% |
| 1nnnA02 | 3.30.300.30 | Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › ANL, C-terminal domain | 0.61 | 52.0 | 4.51e-01 | 100.0% | 62.0% |
| 6h1bA02 | 3.30.300.30 | Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › ANL, C-terminal domain | 0.60 | 51.0 | 4.66e-01 | 100.0% | 70.6% |
| 8affD01 | 3.30.300.30 | Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › ANL, C-terminal domain | 0.60 | 50.0 | 5.03e-01 | 100.0% | 92.3% |
| 5uptA02 | 3.30.300.30 | Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › ANL, C-terminal domain | 0.60 | 49.0 | 4.49e-01 | 100.0% | 67.3% |
| 3nyqA02 | 3.30.300.30 | Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › ANL, C-terminal domain | 0.59 | 49.0 | 4.81e-01 | 100.0% | 84.9% |
| 6oqrA01 | 2.40.30.20 | Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › | 0.59 | 37.0 | 3.58e-01 | 83.1% | 53.3% |
| 6ijbA01 | 3.30.300.30 | Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › ANL, C-terminal domain | 0.59 | 49.0 | 4.54e-01 | 100.0% | 73.5% |
| 3tviA02 | 3.30.2130.10 | Alpha Beta › 2-Layer Sandwich › VC0802-like › VC0802-like | 0.59 | 42.0 | 3.44e-01 | 100.0% | 37.7% |
| 2le1A00 | 3.30.530.20 | Alpha Beta › 2-Layer Sandwich › Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4 › START domain | 0.58 | 49.0 | 4.09e-01 | 100.0% | 91.4% |
| 2wssA01 | 2.40.30.20 | Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › | 0.58 | 36.0 | 3.42e-01 | 79.2% | 50.5% |
| 4isbB02 | 3.30.300.30 | Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › ANL, C-terminal domain | 0.58 | 50.0 | 4.57e-01 | 100.0% | 72.0% |
| 3eeaA00 | 3.30.450.40 | Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › GAF domain | 0.58 | 48.0 | 3.92e-01 | 93.5% | 94.8% |
| 1cksB00 | 3.30.170.10 | Alpha Beta › 2-Layer Sandwich › Cyclin-Dependent Kinase Subunit Type 2 › Cyclin-dependent kinase, regulatory subunit | 0.58 | 39.0 | 3.92e-01 | 76.6% | 67.9% |
| 3dbaA00 | 3.30.450.40 | Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › GAF domain | 0.57 | 48.0 | 3.75e-01 | 93.5% | 88.3% |
| 2jvrA00 | 3.30.70.330 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain | 0.57 | 41.0 | 4.08e-01 | 97.4% | 75.0% |
| 1haeA00 | 2.10.25.10 | Mainly Beta › Ribbon › Laminin › Laminin | 0.55 | 31.0 | 3.35e-01 | 70.1% | 63.5% |
| 1xttB00 | 3.40.50.2020 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › | 0.55 | 44.0 | 3.35e-01 | 92.2% | 56.2% |
| 2o5aA01 | 3.30.460.10 | Alpha Beta › 2-Layer Sandwich › Beta Polymerase; domain 2 › Beta Polymerase, domain 2 | 0.55 | 42.0 | 3.93e-01 | 100.0% | 64.7% |
| 6le1A01 | 3.30.70.330 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain | 0.54 | 40.0 | 4.16e-01 | 87.0% | 91.2% |
| 4k59A00 | 2.60.40.4380 | Mainly Beta › Sandwich › Immunoglobulin-like › Translational regulator CsrA | 0.54 | 34.0 | 3.72e-01 | 83.1% | 75.8% |
| 2v8qA01 | 3.30.310.80 | Alpha Beta › 2-Layer Sandwich › TATA-Binding Protein › Kinase associated domain 1, KA1 | 0.54 | 45.0 | 4.36e-01 | 96.1% | 88.8% |
| 7uclA01 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.54 | 40.0 | 3.73e-01 | 81.8% | 63.7% |
| 1hp7A01 | 2.30.39.10 | Mainly Beta › Roll › Alpha-1-antitrypsin; domain 1 › Alpha-1-antitrypsin, domain 1 | 0.53 | 42.0 | 4.00e-01 | 88.3% | 90.5% |
| 2op5B01 | 3.30.70.100 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.53 | 42.0 | 4.02e-01 | 100.0% | 74.0% |
| 1nz8A00 | 3.30.70.940 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › NusG, N-terminal domain | 0.52 | 45.0 | 3.99e-01 | 100.0% | 67.2% |
| 2zy2A01 | 3.90.1150.10 | Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 | 0.52 | 43.0 | 3.52e-01 | 94.8% | 47.7% |
| 3h4rA00 | 3.90.320.10 | Alpha Beta › Alpha-Beta Complex › Lambda Exonuclease; Chain A › | 0.51 | 42.0 | 3.09e-01 | 92.2% | 90.4% |
| 8d8lE01 | 3.30.230.10 | Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › | 0.51 | 40.0 | 3.93e-01 | 90.9% | 91.9% |
ECOD (48)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4973750 | 304.18.1.0 ↗ | a+b two layers › Alpha-beta plaits › Anticodon-binding domain of PheRS › Anticodon-binding domain of PheRS | 0.75 | 55.0 | 5.62e-01 | 100.0% | 80.8% |
| 4982759 | 327.18.1.0 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › 40S ribosomal protein S7-A › 40S ribosomal protein S7-A | 0.73 | 54.0 | 5.73e-01 | 97.4% | 93.8% |
| 3799886 | 304.8.1.49 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › R1_ABCA1 | 0.70 | 49.0 | 5.17e-01 | 100.0% | 81.4% |
| 5019384 | 304.39.1.0 ↗ | a+b two layers › Alpha-beta plaits › Mechanosensitive channel protein MscS (YggB), C-terminal domain › Mechanosensitive channel protein MscS (YggB), C-terminal domain | 0.68 | 56.0 | 5.23e-01 | 100.0% | 73.7% |
| 2495100 | 327.5.1.2 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › a+b domain in acetyl-CoA synthetase-like proteins › a+b domain in acetyl-CoA synthetase-like proteins › AMP-binding_C | 0.65 | 55.0 | 4.49e-01 | 100.0% | 50.7% |
| 4130841 | 304.28.1.2 ↗ | a+b two layers › Alpha-beta plaits › Ferredoxin domains in multidrug efflux transporter › Multidrug efflux transporter AcrB pore domain › Sec_GG | 0.63 | 48.0 | 4.60e-01 | 100.0% | 71.1% |
| 5036264 | 304.39.1.1 ↗ | a+b two layers › Alpha-beta plaits › Mechanosensitive channel protein MscS (YggB), C-terminal domain › Mechanosensitive channel protein MscS (YggB), C-terminal domain › MS_channel_3rd | 0.63 | 54.0 | 4.96e-01 | 100.0% | 72.4% |
| 4556741 | 309.1.1.11 ↗ | a+b two layers › LuxS, MPP, ThrRS/AlaRS common domain › LuxS, MPP, ThrRS/AlaRS common domain › LuxS/MPP-like metallohydrolase › PqqF-like_C_4 | 0.63 | 55.0 | 4.30e-01 | 100.0% | 72.0% |
| 4943823 | 304.162.1.0 ↗ | a+b two layers › Alpha-beta plaits › Competence or damage-inducible protein CinA middle domain › Competence or damage-inducible protein CinA middle domain | 0.62 | 49.0 | 4.92e-01 | 97.4% | 85.0% |
| 1125575 | 223.1.1.3 ↗ | a+b three layers › Profilin-like › sensor domains › sensor domains › GAF | 0.61 | 51.0 | 4.03e-01 | 93.5% | 89.1% |
| 3617823 | 3016.1.1.0 ↗ | a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases | 0.61 | 47.0 | 4.46e-01 | 93.5% | 69.9% |
| 4799073 | 309.1.1.4 ↗ | a+b two layers › LuxS, MPP, ThrRS/AlaRS common domain › LuxS, MPP, ThrRS/AlaRS common domain › LuxS/MPP-like metallohydrolase › Peptidase_M16_C | 0.61 | 48.0 | 4.47e-01 | 89.6% | 68.4% |
| 3962577 | 327.5.1.0 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › a+b domain in acetyl-CoA synthetase-like proteins › a+b domain in acetyl-CoA synthetase-like proteins | 0.60 | 47.0 | 4.94e-01 | 87.0% | 95.7% |
| 5053617 | 327.5.1.2 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › a+b domain in acetyl-CoA synthetase-like proteins › a+b domain in acetyl-CoA synthetase-like proteins › AMP-binding_C | 0.60 | 50.0 | 4.56e-01 | 100.0% | 67.6% |
| 4388283 | 304.162.1.1 ↗ | a+b two layers › Alpha-beta plaits › Competence or damage-inducible protein CinA middle domain › Competence or damage-inducible protein CinA middle domain › CinA_KH | 0.60 | 45.0 | 4.64e-01 | 100.0% | 88.6% |
| 5001360 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.60 | 47.0 | 3.07e-01 | 88.3% | 20.0% |
| 3744741 | 327.5.1.2 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › a+b domain in acetyl-CoA synthetase-like proteins › a+b domain in acetyl-CoA synthetase-like proteins › AMP-binding_C | 0.60 | 50.0 | 4.61e-01 | 100.0% | 72.0% |
| 3483105 | 327.11.2.1 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Eukaryotic type KH-domain (KH-domain type I) › KH_1 | 0.60 | 46.0 | 4.19e-01 | 89.6% | 60.0% |
| 3957699 | 304.4.1.0 ↗ | a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel | 0.60 | 45.0 | 4.50e-01 | 100.0% | 78.8% |
| 4602065 | 327.5.1.2 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › a+b domain in acetyl-CoA synthetase-like proteins › a+b domain in acetyl-CoA synthetase-like proteins › AMP-binding_C | 0.59 | 48.0 | 4.27e-01 | 100.0% | 60.9% |
| 3650594 | 304.8.1.47 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › ACT_ACR9_3rd | 0.59 | 49.0 | 3.80e-01 | 100.0% | 40.0% |
| 4886051 | 304.8.1.8 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › ACT_4 | 0.59 | 44.0 | 4.36e-01 | 100.0% | 78.8% |
| 5886 | 327.2.1.1 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › BolA-like › BolA-like › BolA | 0.59 | 47.0 | 4.25e-01 | 100.0% | 61.9% |
| 3992245 | 304.9.1.0 ↗ | a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD | 0.59 | 46.0 | 4.66e-01 | 100.0% | 89.3% |
| 5073850 | 304.43.1.6 ↗ | a+b two layers › Alpha-beta plaits › Hypothetical protein TT1725 › Hypothetical protein TT1725 › FLAD1_M | 0.59 | 45.0 | 4.59e-01 | 83.1% | 85.3% |
| 3482558 | 327.11.2.0 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Eukaryotic type KH-domain (KH-domain type I) | 0.58 | 49.0 | 4.78e-01 | 94.8% | 88.2% |
| 3970968 | 327.5.1.2 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › a+b domain in acetyl-CoA synthetase-like proteins › a+b domain in acetyl-CoA synthetase-like proteins › AMP-binding_C | 0.58 | 49.0 | 4.45e-01 | 100.0% | 68.2% |
| 3705453 | 213.1.1.0 ↗ | a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) | 0.58 | 49.0 | 3.55e-01 | 100.0% | 60.8% |
| 3467262 | 1.1.11.0 ↗ | beta barrels › cradle loop barrel › RIFT-related › Type II restriction endonuclease effector domain | 0.58 | 37.0 | 3.06e-01 | 75.3% | 34.5% |
| 3959346 | 327.5.1.2 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › a+b domain in acetyl-CoA synthetase-like proteins › a+b domain in acetyl-CoA synthetase-like proteins › AMP-binding_C | 0.57 | 50.0 | 4.32e-01 | 100.0% | 88.0% |
| 3363114 | 325.1.7.25 ↗ | a+b complex topology › alpha/beta-Hammerhead/Barrel-sandwich hybrid › alpha/beta-Hammerhead/Barrel-sandwich hybrid › Single hybrid motif › PORR | 0.57 | 32.0 | 3.09e-01 | 100.0% | 46.7% |
| 3684154 | 327.5.1.2 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › a+b domain in acetyl-CoA synthetase-like proteins › a+b domain in acetyl-CoA synthetase-like proteins › AMP-binding_C | 0.56 | 48.0 | 4.81e-01 | 98.7% | 96.2% |
| 3957515 | 327.5.1.2 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › a+b domain in acetyl-CoA synthetase-like proteins › a+b domain in acetyl-CoA synthetase-like proteins › AMP-binding_C | 0.56 | 46.0 | 4.14e-01 | 100.0% | 63.5% |
| 4957785 | 7523.1.1.0 ↗ | a/b three-layered sandwiches › Periplasmic binding protein-like II › Periplasmic binding protein-like II › Periplasmic binding protein-like II | 0.56 | 45.0 | 4.11e-01 | 92.2% | 80.0% |
| 1211453 | 2498.1.1.23 ↗ | mixed a+b and a/b › Zincin-like › "Metalloproteases (""zincins"") catalytic domain" › "Metalloproteases (""zincins"") catalytic domain" › Peptidase_M49 | 0.55 | 47.0 | 2.78e-01 | 100.0% | 30.5% |
| 5065308 | 101.1.2.101 ↗ | alpha arrays › HTH › HTH › winged helix domain › Cdc6_C | 0.55 | 38.0 | 3.32e-01 | 72.7% | 95.0% |
| 4963939 | 304.8.1.0 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like | 0.54 | 38.0 | 3.99e-01 | 93.5% | 87.7% |
| 3446538 | 5061.1.1.1 ↗ | alpha complex topology › Preprotein translocase SecY subunit › Preprotein translocase SecY subunit › Preprotein translocase SecY subunit › SecY | 0.54 | 42.0 | 2.66e-01 | 87.0% | 22.0% |
| 1224463 | 305.1.1.1 ↗ | a+b two layers › DCoH-like › RBP11-like subunits of RNA polymerase › RBP11-like subunits of RNA polymerase › RNA_pol_L | 0.53 | 32.0 | 3.75e-01 | 70.1% | 93.9% |
| 3657148 | 305.1.1.2 ↗ | a+b two layers › DCoH-like › RBP11-like subunits of RNA polymerase › RBP11-like subunits of RNA polymerase › RNA_pol_L_2 | 0.53 | 36.0 | 3.78e-01 | 79.2% | 78.6% |
| 3587631 | 186.1.1.0 ↗ | alpha arrays › lambda integrase-N-like › lambda integrase-N › lambda integrase-N | 0.52 | 45.0 | 3.77e-01 | 100.0% | 81.4% |
| 3685475 | 304.4.1.0 ↗ | a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel | 0.52 | 43.0 | 4.28e-01 | 100.0% | 93.8% |
| 3853169 | 5001.1.1.1 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 | 0.51 | 42.0 | 2.74e-01 | 89.6% | 38.0% |
| 3180028 | 2003.1.1.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains | 0.51 | 41.0 | 2.68e-01 | 88.3% | 77.0% |
| 1834407 | 3218.1.1.1 ↗ | a+b duplicates or obligate multimers › small terminase oligomerization domain › small terminase oligomerization domain › small terminase oligomerization domain › Terminase_2 | 0.51 | 35.0 | 3.51e-01 | 93.5% | 69.2% |
| 5040059 | 101.1.2.0 ↗ | alpha arrays › HTH › HTH › winged helix domain | 0.51 | 39.0 | 3.41e-01 | 81.8% | 96.5% |
| 3627409 | 6166.1.1.1 ↗ | alpha bundles › N-terminal domain of Delta(14)-sterol reductase, MaSR1 › N-terminal domain of Delta(14)-sterol reductase, MaSR1 › N-terminal domain of Delta(14)-sterol reductase, MaSR1 › ERG4_ERG24 | 0.51 | 42.0 | 3.18e-01 | 94.8% | 74.5% |
| 4994432 | 101.1.2.0 ↗ | alpha arrays › HTH › HTH › winged helix domain | 0.50 | 34.0 | 3.09e-01 | 87.0% | 50.5% |