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DNA_polymerase
Euk-VirOstreococcus_tauri_virus_2
DNA_polymerase__YP_004063640__Ostreococcus_tauri_virus_2__696472
Identity
- Accession:
- YP_004063640 ↗
- Protein ID:
- DNA_polymerase
- Kingdom:
- euk
Quality
84.9
mean pLDDT
Taxonomy
Bamfordvirae›
Nucleocytoviricota›
Megaviricetes›
Algavirales›
Phycodnaviridae›
Prasinovirus›
Ostreococcus_tauri_virus_2
TaxID: 696472
Cluster
View cluster (158 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 2-182
Domain cluster:
rep: DNA_polymerase__YP_010084862__Shrimp_hemocyte_iridescent_virus__2039780__D2-200
D2
high
residues 192-411
Domain cluster:
rep: B-family_DNA_polymerase__YP_009507574__Heterosigma_akashiwo_virus_01__97195__D190-438
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF03104.26 best | DNA_pol_B_exo1 | 123.9 | 1.00e-35 | 77.7% | 73.1% |
D3
medium
residues 412-455_543-591
Domain cluster:
rep: DNA_polymerase__YP_008052566__Phaeocystis_globosa_virus__251749__D724-746_869-928
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00136.27 best | DNA_pol_B | 39.9 | 3.50e-10 | 54.8% | 11.0% |
D4
medium
residues 470-490_629-718
Domain cluster:
rep: DNA_polymerase_catalytic_subunit__YP_002608259__Human_herpesvirus_5__10359__D703-718_902-984
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00136.27 best | DNA_pol_B | 64.2 | 1.40e-17 | 84.7% | 17.9% |
D5
medium
residues 491-542_592-628
Domain cluster:
rep: rh87__YP_068180__Macacine_betaherpesvirus_3__47929__D595-644_698-744
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00136.27 best | DNA_pol_B | 32.2 | 7.50e-08 | 58.4% | 10.6% |
| PF00136.27 | DNA_pol_B | 30.2 | 3.00e-07 | 42.7% | 7.5% |
D6
medium
residues 719-765_857-874
Domain cluster:
representative
CATH (22)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3iayA07 | 1.10.132.60 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › B family DNA polymerase, thumb domain | 0.92 | 85.0 | 6.30e-01 | 100.0% | 90.1% |
| 4qclA05 | 1.10.132.60 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › B family DNA polymerase, thumb domain | 0.88 | 80.0 | 5.84e-01 | 100.0% | 88.7% |
| 1tgoA05 | 1.10.132.60 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › B family DNA polymerase, thumb domain | 0.84 | 77.0 | 5.60e-01 | 100.0% | 83.8% |
| 1o0sA02 | 1.20.1370.30 | Mainly Alpha › Up-down Bundle › Hemocyanin, N-terminal domain › | 0.74 | 53.0 | 4.47e-01 | 90.8% | 45.4% |
| 2yfaA02 | 1.20.1440.210 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › | 0.69 | 59.0 | 4.96e-01 | 100.0% | 87.1% |
| 3nbxX03 | 1.20.58.1510 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.68 | 56.0 | 4.89e-01 | 93.8% | 84.2% |
| 5o5jT00 | 1.20.58.110 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Ribosomal protein S20 | 0.65 | 52.0 | 4.83e-01 | 89.2% | 72.9% |
| 6jkvA00 | 3.60.40.10 | Alpha Beta › 4-Layer Sandwich › Phosphatase 2c; domain 1 › PPM-type phosphatase domain | 0.62 | 54.0 | 3.73e-01 | 100.0% | 40.4% |
| 3kd4A02 | 3.10.620.30 | Alpha Beta › Roll › C8orf32 fold › | 0.62 | 51.0 | 3.91e-01 | 93.8% | 69.4% |
| 1x8zB00 | 1.20.140.40 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Invertase/pectin methylesterase inhibitor family protein | 0.62 | 53.0 | 4.20e-01 | 100.0% | 61.2% |
| 1go3F02 | 6.10.140.10 | Special › Helix non-globular › Helix Hairpins › | 0.61 | 33.0 | 3.76e-01 | 70.8% | 70.2% |
| 1xg2B00 | 1.20.140.40 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Invertase/pectin methylesterase inhibitor family protein | 0.61 | 52.0 | 4.09e-01 | 100.0% | 72.2% |
| 2ebfX02 | 1.20.140.180 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › | 0.61 | 51.0 | 4.12e-01 | 100.0% | 53.8% |
| 2kobA01 | 1.10.150.130 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Tyrosine recombinase, N-terminal domain | 0.61 | 53.0 | 4.75e-01 | 100.0% | 79.6% |
| 4gbjC02 | 1.10.1040.10 | Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 | 0.60 | 47.0 | 3.81e-01 | 89.2% | 80.7% |
| 2hz8A00 | 1.20.120.660 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › IL-4 antagonist (De novo design) like domain | 0.60 | 43.0 | 3.60e-01 | 76.9% | 57.4% |
| 4wzxA01 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.58 | 46.0 | 4.45e-01 | 87.7% | 85.3% |
| 3qsgA02 | 1.10.1040.10 | Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 | 0.57 | 44.0 | 3.72e-01 | 86.2% | 77.4% |
| 4wr4A02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.56 | 45.0 | 3.95e-01 | 92.3% | 76.2% |
| 3u4qB04 | 6.10.140.1030 | Special › Helix non-globular › Helix Hairpins › | 0.54 | 39.0 | 3.85e-01 | 87.7% | 73.9% |
| 1vgpA02 | 1.10.230.10 | Mainly Alpha › Orthogonal Bundle › Cytochrome p450-Terp; domain 2 › Cytochrome P450-Terp, domain 2 | 0.53 | 45.0 | 3.93e-01 | 98.5% | 76.9% |
| 2ibpA02 | 1.10.230.10 | Mainly Alpha › Orthogonal Bundle › Cytochrome p450-Terp; domain 2 › Cytochrome P450-Terp, domain 2 | 0.53 | 48.0 | 4.04e-01 | 100.0% | 96.2% |
ECOD (32)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3167790 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.93 | 87.0 | 6.40e-01 | 100.0% | 91.3% |
| 4674133 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.92 | 86.0 | 6.09e-01 | 100.0% | 87.4% |
| 5031722 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.90 | 82.0 | 6.02e-01 | 100.0% | 85.6% |
| 4547010 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.89 | 81.0 | 5.75e-01 | 100.0% | 80.0% |
| 3705557 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.88 | 80.0 | 5.90e-01 | 100.0% | 91.9% |
| 4959102 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.87 | 80.0 | 5.75e-01 | 100.0% | 82.8% |
| 4931233 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.85 | 78.0 | 5.88e-01 | 100.0% | 96.6% |
| 5044378 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.83 | 75.0 | 5.67e-01 | 100.0% | 96.0% |
| 5046396 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.82 | 73.0 | 5.40e-01 | 100.0% | 89.0% |
| 5076363 | 4995.1.1.1 ↗ | alpha arrays › Methionine synthase domain-like › Methionine synthase domain-like › Methionine synthase domain-like › B12-binding_2 | 0.73 | 59.0 | 5.46e-01 | 89.2% | 76.5% |
| 3574413 | 603.2.1.0 ↗ | alpha bundles › STAT-like › STAT › STAT | 0.72 | 58.0 | 5.25e-01 | 90.8% | 76.7% |
| 5012498 | 3843.1.1.28 ↗ | alpha complex topology › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › MbhD | 0.70 | 49.0 | 4.90e-01 | 72.3% | 93.8% |
| 4999823 | 4995.1.1.1 ↗ | alpha arrays › Methionine synthase domain-like › Methionine synthase domain-like › Methionine synthase domain-like › B12-binding_2 | 0.70 | 55.0 | 5.24e-01 | 89.2% | 81.2% |
| 4323909 | 101.11.1.1 ↗ | alpha arrays › HTH › Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 › Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 › PNPase | 0.70 | 57.0 | 5.09e-01 | 92.3% | 86.3% |
| 5045531 | 604.12.1.0 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain | 0.68 | 56.0 | 5.18e-01 | 90.8% | 81.2% |
| 4012210 | 601.14.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Hemerythrin › Hemerythrin | 0.67 | 57.0 | 4.47e-01 | 100.0% | 75.3% |
| 4629067 | 633.24.1.5 ↗ | alpha bundles › Bromodomain-like › RABEX-5 helical domain › RABEX-5 helical domain › PF29080 | 0.64 | 51.0 | 4.80e-01 | 92.3% | 91.8% |
| 3576407 | 622.4.1.0 ↗ | alpha bundles › YvfG-like › Mite allergen Der p 5-related › Mite allergen Der p 5-related | 0.64 | 50.0 | 4.27e-01 | 89.2% | 86.1% |
| 4004067 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.64 | 50.0 | 4.64e-01 | 89.2% | 80.0% |
| 5044747 | 3236.1.1.1 ↗ | alpha complex topology › Cation-proton antiporter › Cation-proton antiporter (CPA) › Cation-proton antiporter (CPA) › Na_H_Exchanger | 0.63 | 54.0 | 3.31e-01 | 98.5% | 70.8% |
| 3704188 | 192.15.1.1 ↗ | alpha bundles › Long alpha-hairpin › Endosomal sorting complex assembly domains › Endosomal sorting complex assembly domains › VPS28 | 0.62 | 49.0 | 4.40e-01 | 89.2% | 81.1% |
| 3669 | 633.16.1.1 ↗ | alpha bundles › Bromodomain-like › PMT helical bundle domain-like › PMT helical bundle domain-like › MLD | 0.61 | 51.0 | 4.60e-01 | 100.0% | 78.6% |
| 4298721 | 633.24.1.2 ↗ | alpha bundles › Bromodomain-like › RABEX-5 helical domain › RABEX-5 helical domain › DUF5601 | 0.61 | 49.0 | 4.49e-01 | 92.3% | 91.1% |
| 3701020 | 604.12.1.0 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain | 0.61 | 48.0 | 4.54e-01 | 89.2% | 87.5% |
| 4990095 | 604.6.1.0 ↗ | alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain | 0.60 | 46.0 | 4.27e-01 | 83.1% | 76.5% |
| 5049361 | 192.15.1.0 ↗ | alpha bundles › Long alpha-hairpin › Endosomal sorting complex assembly domains › Endosomal sorting complex assembly domains | 0.60 | 47.0 | 4.49e-01 | 89.2% | 90.0% |
| 3815499 | 633.4.1.1 ↗ | alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI | 0.60 | 52.0 | 4.17e-01 | 100.0% | 75.0% |
| 3771070 | 627.1.1.1 ↗ | alpha complex topology › VPS9 domain › VPS9 domain › VPS9 domain › VPS9 | 0.59 | 50.0 | 3.93e-01 | 100.0% | 57.4% |
| 3962601 | 172.1.1.0 ↗ | alpha complex topology › Citrate synthase-like › Citrate synthase › Citrate synthase | 0.56 | 49.0 | 2.98e-01 | 96.9% | 25.9% |
| 3427035 | 622.1.1.30 ↗ | alpha bundles › YvfG-like › HSC20 (HSCB), C-terminal oligomerisation domain › HSC20 (HSCB), C-terminal oligomerisation domain › PF26575 | 0.56 | 46.0 | 4.63e-01 | 93.8% | 100.0% |
| 3559718 | 604.1.1.1 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin | 0.55 | 42.0 | 3.66e-01 | 87.7% | 80.0% |
| 3592539 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.55 | 43.0 | 3.66e-01 | 87.7% | 56.5% |
D7
medium
residues 766-856
Domain cluster:
rep: hypothetical_protein_PBCV1_A188aR__YP_004678908__Paramecium_bursaria_Chlorella_virus_1__10506__D2-70
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00136.27 best | DNA_pol_B | 45.1 | 8.80e-12 | 83.5% | 14.8% |
D8
medium
residues 897-954