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DNA_polymerase

Euk-Vir

Murmansk_poxvirus

DNA_polymerase__YP_009408242__Murmansk_poxvirus__2025359

Identity

Accession:
YP_009408242 ↗
Protein ID:
DNA_polymerase
Kingdom:
euk

Quality

83.5 mean pLDDT

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 162-304_318-344
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF03104.26 best DNA_pol_B_exo1 75.7 5.30e-21 100.0% 69.4%
D2 high residues 830-999
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00136.27 best DNA_pol_B 106.5 2.20e-30 92.9% 32.7%
CATH (7)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3iayA07 1.10.132.60 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › B family DNA polymerase, thumb domain 0.83 70.0 7.43e-01 99.4% 98.7%
4fxdA06 1.10.132.60 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › B family DNA polymerase, thumb domain 0.80 71.0 7.39e-01 100.0% 99.4%
4qclA05 1.10.132.60 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › B family DNA polymerase, thumb domain 0.77 71.0 7.18e-01 100.0% 98.2%
2gv9B06 1.10.132.60 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › B family DNA polymerase, thumb domain 0.76 72.0 6.71e-01 100.0% 100.0%
1tgoA05 1.10.132.60 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › B family DNA polymerase, thumb domain 0.76 65.0 6.62e-01 100.0% 92.8%
1yxrA01 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.60 25.0 3.69e-01 85.3% 87.8%
4q5nA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.55 33.0 3.93e-01 97.6% 89.3%
ECOD (42)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3109906 4969.1.1.1 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B 0.95 92.0 9.04e-01 100.0% 94.9%
3167790 4969.1.1.1 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B 0.83 70.0 7.47e-01 99.4% 100.0%
4931233 4969.1.1.1 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B 0.82 66.0 7.13e-01 92.9% 97.9%
3214821 4969.1.1.1 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B 0.81 68.0 7.29e-01 99.4% 99.3%
4547010 4969.1.1.1 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B 0.81 73.0 7.15e-01 100.0% 88.9%
2140410 4969.1.1.1 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B 0.81 68.0 6.86e-01 99.4% 88.6%
4865217 304.48.1.3 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B 0.81 65.0 7.10e-01 96.5% 100.0%
5031722 4969.1.1.1 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B 0.81 68.0 7.01e-01 99.4% 93.1%
5035330 4969.1.1.1 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B 0.81 66.0 7.07e-01 98.8% 96.7%
3597971 4969.1.1.0 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I 0.81 72.0 7.12e-01 100.0% 88.9%
4297578 4969.1.1.1 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B 0.81 68.0 7.11e-01 99.4% 96.1%
4956225 4969.1.1.1 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B 0.81 64.0 6.89e-01 93.5% 95.9%
4982341 4969.1.1.0 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I 0.80 67.0 7.13e-01 100.0% 98.7%
5044378 4969.1.1.1 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B 0.80 67.0 7.14e-01 94.1% 99.3%
3797774 4969.1.1.1 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B 0.80 65.0 7.07e-01 97.6% 100.0%
3404727 4969.1.1.1 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B 0.80 70.0 6.72e-01 99.4% 81.4%
3584203 4969.1.1.1 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B 0.79 74.0 7.33e-01 100.0% 94.9%
3403078 4969.1.1.1 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B 0.79 74.0 6.68e-01 100.0% 75.5%
5035013 4969.1.1.1 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B 0.79 69.0 7.15e-01 99.4% 98.7%
3484038 4969.1.1.0 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I 0.79 74.0 6.86e-01 100.0% 96.7%
5025844 4969.1.1.0 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I 0.79 61.0 6.51e-01 92.9% 91.3%
4961845 4969.1.1.1 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B 0.79 66.0 7.02e-01 98.2% 99.3%
5058883 4969.1.1.0 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I 0.79 68.0 7.13e-01 98.2% 100.0%
5073668 4969.1.1.1 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B 0.78 64.0 6.92e-01 91.2% 100.0%
5048997 4969.1.1.1 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B 0.78 70.0 6.96e-01 99.4% 92.0%
3993980 4969.1.1.1 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B 0.78 74.0 6.93e-01 100.0% 93.5%
5041309 4969.1.1.0 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I 0.78 69.0 7.00e-01 98.8% 94.6%
3185070 4969.1.1.1 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B 0.77 72.0 7.04e-01 98.8% 94.6%
3178384 4969.1.1.1 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B 0.77 73.0 7.06e-01 100.0% 93.5%
3256266 4969.1.1.1 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B 0.77 71.0 6.96e-01 100.0% 91.7%
5002819 4969.1.1.1 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B 0.77 66.0 6.82e-01 98.2% 96.2%
4978606 4969.1.1.0 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I 0.76 66.0 6.97e-01 98.8% 100.0%
4959102 4969.1.1.1 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B 0.76 68.0 6.86e-01 100.0% 94.7%
57819 4969.1.1.0 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I 0.76 65.0 6.64e-01 100.0% 93.9%
4939490 4969.1.1.0 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I 0.75 65.0 6.64e-01 98.2% 93.9%
4221968 4969.1.1.1 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B 0.75 70.0 6.81e-01 98.8% 92.4%
4949768 4969.1.1.0 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I 0.75 65.0 6.70e-01 98.8% 96.9%
4674133 4969.1.1.1 alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B 0.75 69.0 6.83e-01 98.8% 93.7%
3617759 529.1.1.2 few secondary structure elements › Anaphylotoxins (complement system) › Anaphylotoxins (complement system) › Anaphylotoxins (complement system) › BSMAP 0.70 29.0 4.34e-01 91.2% 90.0%
3924719 371.1.1.0 few secondary structure elements › Phospholipase A2, PLA2 › Phospholipase A2, PLA2 › Phospholipase A2, PLA2 0.70 33.0 4.43e-01 92.4% 82.1%
4554420 3008.1.1.0 a+b three layers › A subdomain in the anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › A subdomain in the anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › A subdomain in the anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 0.60 25.0 3.65e-01 96.5% 85.3%
3721280 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.55 33.0 3.27e-01 100.0% 55.4%
D3 medium residues 2-157
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF08452.17 best DNAP_B_exo_N 51.0 1.00e-13 13.5% 95.5%
D4 medium residues 347-478
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF08408.17 best DNA_pol_B_3 178.0 1.30e-52 96.2% 100.0%
CATH (10)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2dyiA01 2.40.30.60 Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › RimM 0.70 44.0 5.43e-01 91.7% 100.0%
4ac9C04 2.40.10.190 Mainly Beta › Beta Barrel › Thrombin, subunit H › translation elongation factor selb, chain A, domain 4 0.65 40.0 4.86e-01 98.5% 100.0%
1vw3C01 2.40.30.10 Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › Translation factors 0.62 45.0 4.52e-01 84.8% 74.8%
3t05A02 2.40.33.10 Mainly Beta › Beta Barrel › M1 Pyruvate Kinase; Domain 3 › PK beta-barrel domain-like 0.60 43.0 4.84e-01 91.7% 100.0%
3bn3B01 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.59 32.0 3.89e-01 89.4% 81.4%
4psrA02 2.60.40.1180 Mainly Beta › Sandwich › Immunoglobulin-like › Golgi alpha-mannosidase II 0.58 38.0 3.94e-01 95.5% 71.3%
4qjvA01 3.30.1360.10 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › RNA polymerase, RBP11-like subunit 0.54 33.0 3.91e-01 86.4% 88.8%
3zn6A02 2.60.40.3410 Mainly Beta › Sandwich › Immunoglobulin-like › 0.54 35.0 4.16e-01 90.9% 100.0%
3rghA01 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.51 31.0 3.50e-01 88.6% 81.2%
2waoA01 2.60.120.260 Mainly Beta › Sandwich › Jelly Rolls › Galactose-binding domain-like 0.50 30.0 3.18e-01 93.9% 66.7%
ECOD (28)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4316004 1.1.7.0 beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C 0.74 41.0 5.00e-01 81.8% 84.7%
3555622 1.1.7.21 beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C › RIBIOP_C 0.70 41.0 5.14e-01 87.1% 100.0%
163768 1.1.7.11 beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C › RimM 0.70 45.0 5.42e-01 94.7% 100.0%
4642133 1.1.7.21 beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C › RIBIOP_C 0.70 41.0 4.50e-01 91.7% 70.0%
3358216 1.1.7.21 beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C › RIBIOP_C 0.69 41.0 4.48e-01 89.4% 70.0%
5024154 1.1.7.0 beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C 0.69 44.0 5.23e-01 91.7% 97.6%
5046975 1.1.7.21 beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C › RIBIOP_C 0.69 42.0 5.10e-01 91.7% 98.8%
5073223 1.1.7.0 beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C 0.68 43.0 5.18e-01 99.2% 98.8%
3600462 1.1.7.0 beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C 0.68 41.0 5.16e-01 94.7% 100.0%
4955533 1.1.7.0 beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C 0.66 42.0 4.62e-01 84.1% 79.0%
5040562 1.1.7.0 beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C 0.63 38.0 4.49e-01 85.6% 87.8%
3688711 1.1.7.81 beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C › SEN1_barrel 0.62 48.0 5.24e-01 85.6% 97.3%
4563164 1.1.7.9 beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C › tRNA-synt_2c 0.62 40.0 4.26e-01 86.4% 74.8%
2883135 1.1.7.2 beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C › Ribosomal_L3 0.60 53.0 4.04e-01 95.5% 75.3%
4955177 11.1.5.0 beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Common fold of diphtheria toxin/transcription factors/cytochrome f 0.60 38.0 4.18e-01 95.5% 79.0%
4521518 1.1.7.121 beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C › Phage_BR0599 0.60 48.0 5.11e-01 98.5% 96.5%
5002657 12.1.1.114 beta sandwiches › Glycosyl hydrolase domain-like › Glycosyl hydrolase domain › Glycosyl hydrolase domain › DUF2341 0.59 37.0 4.43e-01 88.6% 97.6%
3172185 1.1.7.0 beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C 0.57 40.0 4.30e-01 85.6% 85.5%
3247750 206.1.1.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase 0.56 46.0 3.31e-01 88.6% 84.4%
3742569 1.1.7.24 beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C › FAD_binding_8 0.55 43.0 4.71e-01 87.9% 100.0%
3861216 11.1.1.3 beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › ig 0.55 35.0 3.94e-01 90.9% 85.0%
3937376 11.1.1.12 beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › Filamin 0.55 34.0 3.75e-01 86.4% 80.0%
1560729 1.1.5.35 beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel › YwpF 0.54 42.0 4.08e-01 80.3% 89.6%
3542635 1.1.7.9 beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C › tRNA-synt_2c 0.54 41.0 4.08e-01 87.9% 76.3%
3933157 11.1.1.1085 beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › GBD_IRG7_N 0.54 31.0 3.48e-01 91.7% 73.0%
3991566 11.1.1.12 beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › Filamin 0.53 32.0 3.72e-01 88.6% 85.6%
3709965 1.1.7.9 beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C › tRNA-synt_2c 0.53 39.0 4.22e-01 87.1% 90.9%
3936404 10.32.1.0 beta sandwiches › jelly-roll › Galactose-binding domain-like › Galactose-binding domain-like 0.52 32.0 3.58e-01 94.7% 80.0%
D5 medium residues 479-516_619-660
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00136.27 best DNA_pol_B 37.6 1.60e-09 56.2% 9.5%
D6 medium residues 529-553_682-815
PDB
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF00136.27 best DNA_pol_B 118.1 6.20e-34 84.9% 24.9%
PF00136.27 DNA_pol_B 25.5 8.00e-06 17.0% 5.5%
D7 medium residues 554-618_661-681
PDB
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF00136.27 best DNA_pol_B 27.9 1.40e-06 72.1% 9.9%
PF00136.27 DNA_pol_B 23.4 3.40e-05 27.9% 4.6%