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DNA_polymerase_catalytic_subunit
Euk-VirHuman_alphaherpesvirus_2
DNA_polymerase_catalytic_subunit__YP_009137182__Human_alphaherpesvirus_2__10310
Identity
- Accession:
- YP_009137182 ↗
- Protein ID:
- DNA_polymerase_catalytic_subunit
- Kingdom:
- euk
Quality
78.1
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Simplexvirus›
Human_alphaherpesvirus_2
TaxID: 10310
Cluster
View cluster (158 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 204-300
D2
high
residues 712-737_777-958
Domain cluster:
rep: NC_042352.1__YP_009639584.1__FGG68_gp42__00043__D422-604
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00136.27 best | DNA_pol_B | 220.9 | 4.20e-65 | 87.5% | 38.0% |
| PF00136.27 | DNA_pol_B | 40.0 | 3.20e-10 | 13.0% | 5.7% |
CATH (31)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2gv9B04 | 3.90.1600.10 | Alpha Beta › Alpha-Beta Complex › Palm domain of DNA polymerase › B family DNA polymerase, palm domain | 0.81 | 72.0 | 7.49e-01 | 100.0% | 95.4% |
| 1q8iA04 | 3.90.1600.10 | Alpha Beta › Alpha-Beta Complex › Palm domain of DNA polymerase › B family DNA polymerase, palm domain | 0.81 | 55.0 | 5.54e-01 | 100.0% | 68.9% |
| 3rq9A00 | 1.10.287.2500 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.73 | 26.0 | 4.41e-01 | 73.6% | 89.7% |
| 1d5aA03 | 3.90.1600.10 | Alpha Beta › Alpha-Beta Complex › Palm domain of DNA polymerase › B family DNA polymerase, palm domain | 0.72 | 48.0 | 5.39e-01 | 89.9% | 84.8% |
| 2raqA01 | 3.30.70.1340 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › MTH889-like domain | 0.71 | 28.0 | 4.36e-01 | 88.0% | 88.2% |
| 2mq8A00 | 3.30.70.600 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Ribosomal protein S10 | 0.70 | 35.0 | 4.70e-01 | 96.2% | 88.4% |
| 2r4fA03 | 3.30.70.420 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain | 0.70 | 38.0 | 4.96e-01 | 98.1% | 93.2% |
| 1zpvA00 | 3.30.70.260 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain | 0.68 | 30.0 | 4.55e-01 | 97.6% | 100.0% |
| 3onjA00 | 1.20.58.400 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › t-snare proteins | 0.67 | 29.0 | 4.28e-01 | 75.5% | 87.6% |
| 2lqjA00 | 3.30.70.260 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain | 0.67 | 32.0 | 4.68e-01 | 98.1% | 100.0% |
| 6hbzA02 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.67 | 42.0 | 4.80e-01 | 99.5% | 82.4% |
| 3ibwA00 | 3.30.70.260 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain | 0.64 | 27.0 | 4.12e-01 | 94.2% | 97.5% |
| 1zu0A02 | 3.90.76.10 | Alpha Beta › Alpha-Beta Complex › Dipeptide-binding Protein; domain 1 › Dipeptide-binding Protein; Domain 1 | 0.64 | 29.0 | 3.83e-01 | 81.7% | 77.6% |
| 3gz7B00 | 3.30.70.100 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.64 | 31.0 | 4.33e-01 | 89.4% | 96.9% |
| 2khdA00 | 3.30.70.860 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.63 | 27.0 | 3.60e-01 | 81.7% | 73.1% |
| 2od4B01 | 3.30.70.100 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.63 | 29.0 | 4.19e-01 | 95.7% | 97.8% |
| 1vcsA00 | 1.20.58.400 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › t-snare proteins | 0.63 | 25.0 | 3.70e-01 | 75.0% | 79.4% |
| 5yppA00 | 3.30.70.260 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain | 0.62 | 28.0 | 4.06e-01 | 90.9% | 95.6% |
| 8gk4C02 | 3.30.70.1430 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Multidrug efflux transporter AcrB pore domain | 0.61 | 30.0 | 4.24e-01 | 86.5% | 100.0% |
| 3hx9B00 | 3.30.70.100 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.61 | 30.0 | 4.23e-01 | 89.9% | 99.0% |
| 2fb0A00 | 3.30.70.100 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.60 | 29.0 | 4.04e-01 | 88.5% | 97.9% |
| 6eibD00 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.59 | 41.0 | 4.71e-01 | 98.1% | 93.6% |
| 2gffA00 | 3.30.70.100 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.58 | 29.0 | 3.95e-01 | 88.0% | 96.9% |
| 6lynD01 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.58 | 21.0 | 3.22e-01 | 95.7% | 77.0% |
| 2gsqA02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.57 | 26.0 | 3.47e-01 | 76.9% | 79.6% |
| 2di7A01 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.57 | 25.0 | 3.29e-01 | 86.1% | 73.8% |
| 6ztgA01 | 3.30.70.1070 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Sporulation related repeat | 0.56 | 23.0 | 3.60e-01 | 86.5% | 100.0% |
| 1sqeA00 | 3.30.70.100 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.56 | 28.0 | 3.89e-01 | 89.9% | 97.0% |
| 3edvA02 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.55 | 26.0 | 2.75e-01 | 76.9% | 49.7% |
| 2k3iA01 | 3.30.70.860 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.54 | 25.0 | 3.55e-01 | 86.5% | 97.6% |
| 4zgnB00 | 2.40.30.10 | Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › Translation factors | 0.51 | 26.0 | 3.52e-01 | 95.7% | 96.1% |
ECOD (60)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4891101 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.95 | 70.0 | 7.76e-01 | 84.6% | 90.7% |
| 3628202 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.91 | 89.0 | 5.90e-01 | 100.0% | 35.6% |
| 5019480 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.90 | 87.0 | 5.73e-01 | 100.0% | 34.6% |
| 3484036 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.90 | 88.0 | 7.78e-01 | 100.0% | 95.3% |
| None | — | 0.90 | 88.0 | 5.89e-01 | 100.0% | 36.7% | |
| 3480546 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.89 | 87.0 | 7.88e-01 | 100.0% | 93.6% |
| 3558196 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.89 | 87.0 | 7.64e-01 | 100.0% | 82.8% |
| None | — | 0.89 | 87.0 | 5.88e-01 | 100.0% | 37.2% | |
| 5005286 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.89 | 86.0 | 7.36e-01 | 100.0% | 84.9% |
| 3684974 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.87 | 85.0 | 5.69e-01 | 100.0% | 37.6% |
| 3615419 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.87 | 85.0 | 7.02e-01 | 100.0% | 83.3% |
| 3784383 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.87 | 85.0 | 6.73e-01 | 100.0% | 67.8% |
| 3089539 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.87 | 82.0 | 7.14e-01 | 97.6% | 94.5% |
| 3705562 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.87 | 85.0 | 5.67e-01 | 100.0% | 39.8% |
| 3801150 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.86 | 85.0 | 7.29e-01 | 100.0% | 78.3% |
| 4022366 | 2484.1.1.161 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like | 0.86 | 84.0 | 5.68e-01 | 100.0% | 37.2% |
| 3597965 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.85 | 84.0 | 7.79e-01 | 100.0% | 94.7% |
| 3466667 | 2484.1.1.161 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like | 0.85 | 83.0 | 5.56e-01 | 100.0% | 32.5% |
| 3993981 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.85 | 83.0 | 8.04e-01 | 100.0% | 94.7% |
| 5025843 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.85 | 71.0 | 7.17e-01 | 100.0% | 85.7% |
| 3349591 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.85 | 83.0 | 7.18e-01 | 100.0% | 75.5% |
| 4029141 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.83 | 81.0 | 7.35e-01 | 100.0% | 88.1% |
| 5017083 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.82 | 80.0 | 7.16e-01 | 100.0% | 82.6% |
| 5025209 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.82 | 79.0 | 7.56e-01 | 100.0% | 91.1% |
| 4972474 | 2484.1.1.0 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like | 0.81 | 79.0 | 5.24e-01 | 100.0% | 32.4% |
| 4981193 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.81 | 78.0 | 7.20e-01 | 100.0% | 81.6% |
| 4942685 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.81 | 78.0 | 5.70e-01 | 100.0% | 43.5% |
| 3831499 | 304.48.1.63 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B, DUF1744 | 0.78 | 75.0 | 4.97e-01 | 100.0% | 55.0% |
| 4282509 | 2484.1.1.0 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like | 0.74 | 59.0 | 4.11e-01 | 100.0% | 29.7% |
| 4231530 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.74 | 66.0 | 6.74e-01 | 100.0% | 93.2% |
| 5012084 | 304.48.1.3 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B | 0.73 | 67.0 | 6.56e-01 | 100.0% | 89.3% |
| 4100823 | 4970.1.1.1 ↗ | alpha bundles › fingers domain in bacteriophage RB69-like DNA polymerase I › fingers domain in bacteriophage RB69-like DNA polymerase I › fingers domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.73 | 67.0 | 6.26e-01 | 100.0% | 80.0% |
| 4182409 | 304.48.1.24 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DUF1744 | 0.72 | 46.0 | 5.19e-01 | 97.6% | 83.1% |
| 5070214 | 304.57.1.0 ↗ | a+b two layers › Alpha-beta plaits › Rpp14/Pop5-like › Rpp14/Pop5-like | 0.71 | 36.0 | 5.00e-01 | 98.6% | 96.2% |
| 4629010 | 304.48.1.24 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DUF1744 | 0.69 | 57.0 | 5.60e-01 | 96.6% | 80.0% |
| 3477313 | 304.9.1.0 ↗ | a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD | 0.68 | 34.0 | 4.77e-01 | 89.9% | 99.0% |
| 3794795 | 603.1.1.3 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins › V-SNARE | 0.68 | 29.0 | 4.22e-01 | 76.0% | 85.0% |
| 3533309 | 603.1.1.3 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins › V-SNARE | 0.67 | 28.0 | 4.02e-01 | 76.0% | 79.0% |
| 3786136 | 603.1.1.3 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins › V-SNARE | 0.66 | 28.0 | 3.79e-01 | 76.4% | 73.0% |
| 3464384 | 304.48.1.24 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DUF1744 | 0.65 | 59.0 | 5.53e-01 | 98.1% | 78.4% |
| 4144335 | 304.48.1.24 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DUF1744 | 0.65 | 60.0 | 5.53e-01 | 97.1% | 81.2% |
| 3705695 | 304.48.1.24 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DUF1744 | 0.65 | 60.0 | 5.64e-01 | 100.0% | 82.4% |
| 3187995 | 603.1.1.3 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins › V-SNARE | 0.65 | 27.0 | 3.84e-01 | 76.4% | 76.4% |
| 4022145 | 2484.1.1.153 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DUF1744 | 0.65 | 58.0 | 4.09e-01 | 97.6% | 32.1% |
| 3206807 | 304.48.1.24 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DUF1744 | 0.64 | 59.0 | 5.35e-01 | 97.6% | 74.8% |
| 3741560 | 304.48.1.24 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DUF1744 | 0.63 | 59.0 | 5.40e-01 | 100.0% | 80.4% |
| 4587011 | 304.9.1.1 ↗ | a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 | 0.63 | 28.0 | 4.19e-01 | 93.3% | 98.8% |
| 3508610 | 304.48.1.24 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DUF1744 | 0.63 | 57.0 | 5.26e-01 | 95.2% | 78.4% |
| 3797416 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.62 | 58.0 | 5.27e-01 | 98.6% | 78.5% |
| 3578106 | 304.48.1.24 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DUF1744 | 0.62 | 59.0 | 5.30e-01 | 100.0% | 78.5% |
| 3189629 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.62 | 58.0 | 4.34e-01 | 99.5% | 48.0% |
| 3266689 | 304.48.1.24 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DUF1744 | 0.62 | 56.0 | 5.15e-01 | 95.7% | 80.4% |
| 3924217 | 304.48.1.24 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DUF1744 | 0.61 | 55.0 | 5.09e-01 | 94.7% | 77.3% |
| 3877126 | 304.48.1.24 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DUF1744 | 0.60 | 58.0 | 3.88e-01 | 100.0% | 53.0% |
| 3738492 | 327.11.2.0 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Eukaryotic type KH-domain (KH-domain type I) | 0.58 | 24.0 | 3.71e-01 | 81.7% | 100.0% |
| 4011229 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.58 | 25.0 | 3.64e-01 | 80.3% | 90.0% |
| 3713509 | 304.48.1.10 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › IMS | 0.58 | 47.0 | 4.59e-01 | 98.6% | 77.4% |
| 4589038 | 5001.1.1.6 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Bac_rhodopsin | 0.57 | 37.0 | 3.59e-01 | 77.9% | 59.6% |
| 3615907 | 3560.1.1.1 ↗ | a+b complex topology › Mediator of RNA polymerase II transcription subunit 8 › Mediator of RNA polymerase II transcription subunit 8 › Mediator of RNA polymerase II transcription subunit 8 › Med8 | 0.51 | 33.0 | 3.39e-01 | 83.7% | 67.2% |
| 5047074 | 2004.1.1.87 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N | 0.51 | 38.0 | 3.18e-01 | 77.9% | 82.4% |
D3
medium
residues 75-135
D4
medium
residues 147-201_306-353
D5
medium
residues 364-593
Domain cluster:
rep: DNA_polymerase_catalytic_subunit__YP_401712__Human_gammaherpesvirus_4__10376__D288-457
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF03104.26 best | DNA_pol_B_exo1 | 198.2 | 2.00e-58 | 78.7% | 73.1% |
D6
medium
residues 1032-1100_1141-1161
Domain cluster:
rep: hypothetical_protein_PBCV1_A188aR__YP_004678908__Paramecium_bursaria_Chlorella_virus_1__10506__D2-70
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00136.27 best | DNA_pol_B | 61.3 | 1.10e-16 | 100.0% | 16.6% |
CATH (8)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2gv9B06 | 1.10.132.60 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › B family DNA polymerase, thumb domain | 0.97 | 94.0 | 6.88e-01 | 100.0% | 45.3% |
| 3iayA07 | 1.10.132.60 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › B family DNA polymerase, thumb domain | 0.92 | 69.0 | 5.62e-01 | 100.0% | 46.1% |
| 4fxdA06 | 1.10.132.60 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › B family DNA polymerase, thumb domain | 0.88 | 70.0 | 5.60e-01 | 100.0% | 46.3% |
| 4b08A08 | 3.40.1820.20 | Alpha Beta › 3-Layer(aba) Sandwich › Ribonuclease H-like motif › B family DNA polymerase, thumb domain, alpha/beta motif | 0.87 | 70.0 | 7.47e-01 | 100.0% | 95.0% |
| 4qclA05 | 1.10.132.60 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › B family DNA polymerase, thumb domain | 0.83 | 68.0 | 5.44e-01 | 100.0% | 46.4% |
| 1tgoA05 | 1.10.132.60 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › B family DNA polymerase, thumb domain | 0.80 | 61.0 | 4.88e-01 | 100.0% | 43.1% |
| 3qexA06 | 3.40.1820.10 | Alpha Beta › 3-Layer(aba) Sandwich › Ribonuclease H-like motif › DnaQ-like 3'-5' exonuclease | 0.61 | 55.0 | 5.46e-01 | 100.0% | 100.0% |
| 1b3qA04 | 2.40.50.180 | Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › CheA-289, Domain 4 | 0.53 | 36.0 | 4.10e-01 | 87.8% | 100.0% |
ECOD (38)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1821876 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.97 | 94.0 | 6.88e-01 | 100.0% | 45.3% |
| 3167790 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.92 | 70.0 | 5.69e-01 | 100.0% | 46.7% |
| 5002819 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.91 | 74.0 | 5.86e-01 | 100.0% | 46.9% |
| 3314223 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.91 | 74.0 | 5.89e-01 | 100.0% | 47.5% |
| 3514097 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.91 | 74.0 | 5.76e-01 | 100.0% | 44.7% |
| 4956225 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.90 | 69.0 | 5.75e-01 | 100.0% | 49.7% |
| 3480544 | 4969.1.1.0 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I | 0.89 | 74.0 | 5.82e-01 | 100.0% | 46.7% |
| 5031722 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.89 | 67.0 | 5.41e-01 | 100.0% | 44.4% |
| 3584203 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.88 | 72.0 | 5.62e-01 | 100.0% | 44.0% |
| 3597971 | 4969.1.1.0 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I | 0.87 | 68.0 | 5.23e-01 | 100.0% | 40.6% |
| 4547010 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.87 | 67.0 | 5.22e-01 | 100.0% | 40.6% |
| 2732226 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.86 | 64.0 | 5.38e-01 | 76.7% | 49.6% |
| 3256266 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.85 | 72.0 | 5.52e-01 | 100.0% | 43.9% |
| 5051936 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.85 | 62.0 | 4.98e-01 | 100.0% | 42.5% |
| 3185070 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.84 | 72.0 | 5.54e-01 | 100.0% | 43.8% |
| 5027092 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.84 | 59.0 | 5.05e-01 | 100.0% | 47.1% |
| 3403078 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.84 | 71.0 | 5.15e-01 | 100.0% | 36.4% |
| 5046396 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.84 | 62.0 | 5.02e-01 | 100.0% | 42.9% |
| 4978606 | 4969.1.1.0 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I | 0.84 | 66.0 | 5.42e-01 | 100.0% | 48.4% |
| 3993980 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.83 | 68.0 | 5.15e-01 | 100.0% | 39.0% |
| 5009174 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.82 | 60.0 | 4.87e-01 | 100.0% | 42.5% |
| 4030147 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.82 | 74.0 | 5.61e-01 | 100.0% | 44.1% |
| 4884450 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.81 | 66.0 | 6.08e-01 | 100.0% | 67.8% |
| 3404727 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.81 | 66.0 | 5.06e-01 | 100.0% | 40.2% |
| 5040511 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.81 | 57.0 | 4.91e-01 | 100.0% | 47.8% |
| 3178384 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.81 | 73.0 | 5.60e-01 | 100.0% | 46.5% |
| 5025210 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.80 | 62.0 | 5.13e-01 | 100.0% | 48.7% |
| 5041309 | 4969.1.1.0 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I | 0.80 | 61.0 | 4.87e-01 | 100.0% | 42.9% |
| 4507132 | 4969.1.1.2 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › POL2_thumb | 0.76 | 70.0 | 5.23e-01 | 100.0% | 54.3% |
| 4674133 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.75 | 68.0 | 5.32e-01 | 100.0% | 49.1% |
| 4025114 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.74 | 67.0 | 5.29e-01 | 100.0% | 50.6% |
| 4939490 | 4969.1.1.0 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I | 0.74 | 60.0 | 4.86e-01 | 100.0% | 47.9% |
| 3932597 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.72 | 63.0 | 5.21e-01 | 100.0% | 54.8% |
| 3578105 | 4969.1.1.2 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › POL2_thumb | 0.69 | 64.0 | 4.73e-01 | 100.0% | 50.9% |
| 3484038 | 4969.1.1.0 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I | 0.69 | 64.0 | 4.77e-01 | 100.0% | 43.3% |
| 3800764 | 4969.1.1.0 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I | 0.69 | 64.0 | 4.71e-01 | 100.0% | 46.4% |
| 3189629 | 304.48.1.0 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like | 0.69 | 64.0 | 3.92e-01 | 100.0% | 20.4% |
| 3109906 | 4969.1.1.1 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.68 | 57.0 | 4.52e-01 | 100.0% | 45.5% |