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DNA_polymerase_catalytic_subunit

Euk-Vir

Human_betaherpesvirus_7

DNA_polymerase_catalytic_subunit__YP_073778__Human_betaherpesvirus_7__10372

Identity

Accession:
YP_073778 ↗
Protein ID:
DNA_polymerase_catalytic_subunit
Kingdom:
euk

Quality

86.5 mean pLDDT

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 81-270
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF03104.26 best DNA_pol_B_exo1 39.9 4.40e-10 31.1% 21.9%
D2 medium residues 277-339
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF03104.26 best DNA_pol_B_exo1 53.5 3.20e-14 100.0% 31.4%
CATH (40)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3iayA03 3.30.420.10 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H 0.91 85.0 5.65e-01 100.0% 29.1%
2gv9A03 3.30.420.10 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H 0.91 85.0 5.63e-01 100.0% 35.7%
6j9eJ00 3.30.160.560 Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › 0.72 41.0 4.07e-01 100.0% 53.0%
7r0kB01 3.30.420.10 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H 0.69 54.0 3.58e-01 100.0% 21.0%
3mswA00 2.40.128.720 Mainly Beta › Beta Barrel › Lipocalin › 0.68 55.0 4.18e-01 92.1% 38.8%
2f9wA01 3.30.420.40 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain 0.67 39.0 3.03e-01 93.7% 28.2%
3vskA01 3.90.1310.10 Alpha Beta › Alpha-Beta Complex › Penicillin-binding protein 2a (Domain 2) › Penicillin-binding protein 2a (Domain 2) 0.65 46.0 3.71e-01 76.2% 84.2%
4iglB00 2.180.10.10 Mainly Beta › Shell › RHS repeat-associated core › RHS repeat-associated core 0.64 50.0 2.90e-01 87.3% 53.3%
3eb7A03 2.100.10.10 Mainly Beta › Aligned Prism › Vitelline Membrane Outer Layer Protein I, subunit A › Pesticidal crystal protein, central domain 0.64 44.0 3.10e-01 77.8% 23.4%
2jjqA03 2.40.50.1070 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › 0.62 54.0 4.22e-01 100.0% 75.4%
5jr6A02 3.40.350.10 Alpha Beta › 3-Layer(aba) Sandwich › Creatine Amidinohydrolase; Chain A, domain 1 › Creatinase/prolidase N-terminal domain 0.62 54.0 4.07e-01 98.4% 46.8%
1j54A00 3.30.420.10 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H 0.60 54.0 3.92e-01 100.0% 41.4%
4bq6F00 3.40.1000.10 Alpha Beta › 3-Layer(aba) Sandwich › Protein Transport Mog1p; Chain A › Mog1/PsbP, alpha/beta/alpha sandwich 0.59 52.0 4.00e-01 100.0% 59.1%
3ci0J02 2.10.70.20 Mainly Beta › Ribbon › Complement Module; domain 1 › gspk-gspi-gspj complex like domains 0.59 41.0 4.41e-01 100.0% 92.0%
1iicA02 3.40.630.30 Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) 0.59 49.0 3.29e-01 93.7% 57.3%
7ovuA01 3.40.630.30 Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) 0.59 45.0 3.33e-01 88.9% 61.1%
1ffvB02 3.30.365.10 Alpha Beta › 2-Layer Sandwich › Aldehyde Oxidoreductase; domain 4 › Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain 0.58 52.0 3.96e-01 100.0% 53.8%
4r8oA00 2.40.128.720 Mainly Beta › Beta Barrel › Lipocalin › 0.57 48.0 4.17e-01 93.7% 72.4%
2e1qC08 3.30.365.10 Alpha Beta › 2-Layer Sandwich › Aldehyde Oxidoreductase; domain 4 › Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain 0.57 50.0 3.66e-01 100.0% 45.9%
1rm6A03 3.30.365.10 Alpha Beta › 2-Layer Sandwich › Aldehyde Oxidoreductase; domain 4 › Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain 0.57 49.0 3.94e-01 100.0% 58.3%
1hqz800 3.40.20.10 Alpha Beta › 3-Layer(aba) Sandwich › Severin › Severin 0.56 50.0 3.97e-01 100.0% 72.0%
5f47B00 3.40.630.30 Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) 0.56 44.0 3.34e-01 87.3% 57.9%
1dgjA04 3.30.365.10 Alpha Beta › 2-Layer Sandwich › Aldehyde Oxidoreductase; domain 4 › Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain 0.55 48.0 3.65e-01 100.0% 49.4%
2qubA01 3.40.50.1820 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain 0.54 48.0 3.04e-01 100.0% 36.8%
2w3sB02 3.30.365.10 Alpha Beta › 2-Layer Sandwich › Aldehyde Oxidoreductase; domain 4 › Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain 0.54 46.0 3.52e-01 100.0% 49.7%
3hrdA02 3.30.365.10 Alpha Beta › 2-Layer Sandwich › Aldehyde Oxidoreductase; domain 4 › Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain 0.54 46.0 3.44e-01 100.0% 41.3%
2iafA00 3.30.1330.90 Alpha Beta › 2-Layer Sandwich › 60s Ribosomal Protein L30; Chain: A; › D-3-phosphoglycerate dehydrogenase; domain 3 0.54 46.0 3.55e-01 95.2% 78.6%
3n2qA02 3.30.300.190 Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › 0.54 47.0 3.88e-01 100.0% 81.0%
1x67A01 3.40.20.10 Alpha Beta › 3-Layer(aba) Sandwich › Severin › Severin 0.53 46.0 3.67e-01 98.4% 70.7%
4f0qA02 3.40.1350.10 Alpha Beta › 3-Layer(aba) Sandwich › Trna Endonuclease; Chain: A, domain 1 › 0.53 44.0 3.25e-01 100.0% 37.0%
4ka7A01 1.10.1370.40 Mainly Alpha › Orthogonal Bundle › Neurolysin; domain 3 › 0.52 45.0 2.78e-01 100.0% 18.5%
3ijlA01 3.30.390.10 Alpha Beta › 2-Layer Sandwich › Enolase-like; domain 1 › Enolase-like, N-terminal domain 0.52 39.0 3.23e-01 100.0% 46.3%
3eliA00 3.30.530.20 Alpha Beta › 2-Layer Sandwich › Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4 › START domain 0.52 40.0 3.18e-01 88.9% 37.5%
3my2A00 2.60.450.10 Mainly Beta › Sandwich › lipopolysaccharide transport protein A fold › Lipopolysaccharide (LPS) transport protein A like domain 0.52 44.0 3.57e-01 96.8% 59.5%
1m4jA00 3.40.20.10 Alpha Beta › 3-Layer(aba) Sandwich › Severin › Severin 0.52 45.0 3.59e-01 100.0% 77.4%
4zohA02 3.30.365.10 Alpha Beta › 2-Layer Sandwich › Aldehyde Oxidoreductase; domain 4 › Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain 0.51 43.0 3.51e-01 100.0% 60.2%
4r0mA02 3.30.300.30 Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › ANL, C-terminal domain 0.51 45.0 3.81e-01 100.0% 80.6%
2zadA01 3.30.390.10 Alpha Beta › 2-Layer Sandwich › Enolase-like; domain 1 › Enolase-like, N-terminal domain 0.51 37.0 3.01e-01 100.0% 42.1%
1lrzA01 3.40.630.30 Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) 0.51 42.0 3.34e-01 96.8% 51.7%
4mh4A02 3.30.300.20 Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › K homology (KH) domain 0.50 41.0 3.72e-01 96.8% 98.9%
ECOD (54)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3368695 2484.1.1.0 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.91 85.0 5.03e-01 100.0% 15.9%
None 0.91 85.0 4.73e-01 100.0% 9.7%
3628202 304.48.1.0 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.91 85.0 4.70e-01 100.0% 9.3%
3558197 2484.1.1.34 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1 0.91 84.0 5.43e-01 100.0% 25.3%
None 0.91 84.0 4.70e-01 100.0% 9.8%
4022366 2484.1.1.161 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.90 83.0 4.66e-01 100.0% 9.8%
3710418 2484.1.1.34 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1 0.89 84.0 5.00e-01 100.0% 16.8%
4799493 2.1.1.25 beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › DNA_pol_B_exo1 0.89 72.0 5.64e-01 87.3% 44.6%
None 0.88 83.0 4.95e-01 100.0% 17.3%
3825992 2484.1.1.34 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1 0.82 76.0 4.93e-01 100.0% 27.2%
4029124 2484.1.1.34 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1 0.79 72.0 4.60e-01 98.4% 25.8%
5000651 2484.1.1.34 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1 0.78 71.0 4.28e-01 100.0% 22.8%
3606428 2484.1.1.34 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1 0.78 71.0 4.70e-01 100.0% 30.6%
3705562 304.48.1.0 a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.77 70.0 3.98e-01 100.0% 10.5%
3546198 5.1.4.149 beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › WDR54 0.76 41.0 2.53e-01 100.0% 9.9%
4932453 2484.1.1.34 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1 0.72 63.0 3.97e-01 100.0% 19.1%
3564453 2484.1.1.104 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DDE_1 0.72 64.0 4.16e-01 100.0% 26.9%
3719170 2484.1.1.0 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.72 64.0 4.30e-01 100.0% 47.2%
4929239 2484.1.1.34 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1 0.71 64.0 4.00e-01 100.0% 19.4%
3477637 2484.1.1.104 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DDE_1 0.69 60.0 3.99e-01 100.0% 29.6%
185414 3347.1.1.1 beta meanders › Uncharacterized protein BF3112 › Uncharacterized protein BF3112 › Uncharacterized protein BF3112 › DUF3836 0.68 55.0 4.19e-01 92.1% 39.1%
3809436 2484.1.1.45 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › CAF1 0.66 61.0 3.88e-01 100.0% 33.6%
4250269 231.1.1.3 a+b two layers › MocoBD/DmpA-related › MocoBD/DmpA-related › Molybdenum cofactor-binding domain › MoCoBD_1, MoCoBD_2 0.65 59.0 3.38e-01 100.0% 30.3%
3507296 2484.1.1.104 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DDE_1 0.64 57.0 4.47e-01 100.0% 57.9%
4156661 213.1.1.1 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_1 0.64 50.0 3.52e-01 87.3% 61.9%
4944088 231.1.1.2 a+b two layers › MocoBD/DmpA-related › MocoBD/DmpA-related › Molybdenum cofactor-binding domain › MoCoBD_2 0.64 57.0 3.66e-01 100.0% 76.0%
3820137 213.1.1.1 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_1 0.64 50.0 3.52e-01 87.3% 60.6%
3838393 2484.1.1.132 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo2 0.63 57.0 4.20e-01 100.0% 53.8%
3637018 213.1.1.0 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) 0.62 49.0 3.57e-01 87.3% 62.6%
5041077 213.1.1.1 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_1 0.62 49.0 3.50e-01 87.3% 61.6%
4019543 2484.1.1.104 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DDE_1 0.61 52.0 3.52e-01 100.0% 25.5%
5018285 213.1.1.25 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_3 0.61 48.0 4.06e-01 87.3% 93.6%
4959341 2008.1.1.152 a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › DUF2130 0.61 54.0 4.35e-01 100.0% 52.8%
3607058 213.1.1.1 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_1 0.61 47.0 3.55e-01 85.7% 59.4%
3781897 2484.1.1.175 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › FGGY_N+FGGY_C 0.60 44.0 2.56e-01 100.0% 8.5%
3624820 2484.1.1.65 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › Maelstrom 0.59 54.0 3.38e-01 100.0% 26.5%
5016375 2484.1.1.13 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RNase_T 0.59 53.0 3.75e-01 100.0% 35.8%
1873839 231.1.1.1 a+b two layers › MocoBD/DmpA-related › MocoBD/DmpA-related › Molybdenum cofactor-binding domain › MoCoBD_1 0.59 50.0 3.42e-01 100.0% 68.0%
3627091 2484.1.1.0 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.59 53.0 3.53e-01 100.0% 33.3%
3734660 213.1.1.1 a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_1 0.58 46.0 3.31e-01 87.3% 54.2%
2393265 3735.1.1.1 beta meanders › Rearrangement hotspot (RHS) repeats protein › Rearrangement hotspot (RHS) repeats protein › Rearrangement hotspot (RHS) repeats protein › SpvB 0.58 49.0 3.10e-01 100.0% 39.5%
3560360 11.1.1.1370 beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › C1-set, V-set 0.58 51.0 3.61e-01 100.0% 83.6%
3989767 2008.1.1.152 a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › DUF2130 0.57 51.0 3.66e-01 100.0% 41.7%
3822302 2484.1.1.67 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RVT_3 0.56 49.0 3.74e-01 96.8% 91.7%
3256346 224.1.1.1 a+b three layers › Gelsolin-like › Gelsolin-like › Gelsolin-like › Cofilin_ADF 0.55 48.0 3.82e-01 98.4% 71.5%
3519901 3369.1.1.0 beta meanders › lysosome-associated membrane protein LAMP-3 › lysosome-associated membrane protein LAMP-3 › lysosome-associated membrane protein LAMP-3 0.55 46.0 3.43e-01 93.7% 47.3%
3192440 11.1.1.0 beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like 0.55 48.0 4.02e-01 100.0% 62.7%
3896642 11.1.1.99 beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › V-set 0.54 45.0 3.15e-01 100.0% 67.8%
1226964 7579.1.1.0 a/b three-layered sandwiches › alpha/beta-Hydrolases › alpha/beta-Hydrolases › alpha/beta-Hydrolases 0.54 47.0 2.98e-01 100.0% 33.3%
3838296 378.1.1.1 few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases › Endonuclease_NS 0.54 42.0 3.51e-01 85.7% 57.4%
1239743 218.1.1.1 a+b two layers › Enolase-N/ribosomal protein › Enolase N-terminal domain-like › Enolase N-terminal domain-like › MR_MLE_N 0.54 39.0 3.16e-01 100.0% 39.8%
3622516 11.1.4.0 beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Prealbumin-like 0.53 40.0 3.43e-01 84.1% 80.7%
3665695 2498.1.1.6 mixed a+b and a/b › Zincin-like › "Metalloproteases (""zincins"") catalytic domain" › "Metalloproteases (""zincins"") catalytic domain" › Peptidase_M3 0.51 45.0 2.71e-01 100.0% 16.6%
339669 218.1.1.1 a+b two layers › Enolase-N/ribosomal protein › Enolase N-terminal domain-like › Enolase N-terminal domain-like › MR_MLE_N 0.51 37.0 2.94e-01 100.0% 39.0%
D3 medium residues 360-413
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF03104.26 best DNA_pol_B_exo1 38.0 1.80e-09 98.2% 17.8%
CATH (2)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2gv9A03 3.30.420.10 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H 0.92 68.0 4.32e-01 100.0% 19.0%
4kv2A00 3.10.20.90 Alpha Beta › Roll › Ubiquitin-like (UB roll) › Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 0.59 34.0 2.92e-01 70.4% 34.4%
ECOD (3)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
1822623 2484.1.1.34 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DNA_pol_B_exo1 0.92 68.0 4.15e-01 100.0% 15.3%
3191972 109.4.1.356 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Fungal_trans 0.54 43.0 2.57e-01 90.7% 22.7%
3817314 10.12.1.0 beta sandwiches › jelly-roll › Double-stranded beta-helix › Double-stranded beta-helix 0.51 44.0 2.47e-01 100.0% 16.3%
D4 medium residues 554-577_702-816
PDB
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF00136.27 best DNA_pol_B 95.6 4.20e-27 82.7% 24.7%
PF00136.27 DNA_pol_B 25.0 1.10e-05 20.1% 5.5%
D5 medium residues 578-701
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00136.27 best DNA_pol_B 170.0 1.10e-49 100.0% 27.2%
D6 medium residues 817-1009
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00136.27 best DNA_pol_B 117.9 7.30e-34 85.0% 31.8%