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DNA_replication_origin-binding_helicase
Euk-VirHuman_alphaherpesvirus_3
DNA_replication_origin-binding_helicase__NP_040173__Human_alphaherpesvirus_3__10335
Identity
- Accession:
- NP_040173 ↗
- Protein ID:
- DNA_replication_origin-binding_helicase
- Kingdom:
- euk
Quality
87.0
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Varicellovirus›
Human_alphaherpesvirus_3
TaxID: 10335
Cluster
View cluster (36 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 38-219
Domain cluster:
rep: MK064563__AZI75768.1__SBFV2-gp01__00001__D223-383
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02399.22 best | Herpes_ori_bp | 341.4 | 1.50e-101 | 100.0% | 22.7% |
| PF00270.36 | DEAD | 30.1 | 5.20e-07 | 86.3% | 88.6% |
D2
medium
residues 237-392
Domain cluster:
rep: MK064563__AZI75768.1__SBFV2-gp01__00001__D223-383
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02399.22 best | Herpes_ori_bp | 279.1 | 1.10e-82 | 100.0% | 19.3% |
D3
medium
residues 393-453
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02399.22 best | Herpes_ori_bp | 87.5 | 8.90e-25 | 100.0% | 7.6% |
CATH (4)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4ad9A02 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.68 | 44.0 | 3.99e-01 | 73.8% | 48.8% |
| 4c9yA00 | 1.10.10.1890 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Ska1 microtubule binding domain-like | 0.61 | 49.0 | 3.90e-01 | 88.5% | 60.2% |
| 2qv6B02 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.59 | 50.0 | 4.09e-01 | 98.4% | 58.2% |
| 6q9jB02 | 1.20.1440.230 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain | 0.55 | 36.0 | 3.24e-01 | 86.9% | 46.6% |
ECOD (4)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3650642 | 101.1.2.374 ↗ | alpha arrays › HTH › HTH › winged helix domain › MCM4_WHD | 0.64 | 46.0 | 4.21e-01 | 83.6% | 56.5% |
| 3819816 | 7579.1.1.42 ↗ | a/b three-layered sandwiches › alpha/beta-Hydrolases › alpha/beta-Hydrolases › alpha/beta-Hydrolases › Hydrolase_4 | 0.64 | 47.0 | 2.87e-01 | 77.0% | 65.1% |
| 3406875 | 518.1.1.0 ↗ | alpha arrays › Chemotaxis receptor methyltransferase CheR, N-terminal domain › Chemotaxis receptor methyltransferase CheR, N-terminal domain › Chemotaxis receptor methyltransferase CheR, N-terminal domain | 0.55 | 47.0 | 4.65e-01 | 95.1% | 90.8% |
| 4154674 | 2004.1.1.5 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ABC_tran | 0.51 | 41.0 | 2.86e-01 | 96.7% | 61.6% |
D4
medium
residues 541-650_663-678_795-825
Domain cluster:
rep: DNA_replication_origin-binding_helicase__YP_009042071__Fruit_bat_alphaherpesvirus_1__1343901__D544-675_809-842
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02399.22 best | Herpes_ori_bp | 141.9 | 3.30e-41 | 85.4% | 17.3% |