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DNA_replication_origin-binding_helicase

Euk-Vir

Macropodid_alphaherpesvirus_1

DNA_replication_origin-binding_helicase__YP_009227242__Macropodid_alphaherpesvirus_1__137443

Identity

Accession:
YP_009227242 ↗
Protein ID:
DNA_replication_origin-binding_helicase
Kingdom:
euk

Quality

76.8 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Simplexvirus› Macropodid_alphaherpesvirus_1

TaxID: 137443

Cluster

View cluster (36 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 53-70_214-253
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02399.22 best Herpes_ori_bp 56.3 2.40e-15 74.1% 4.8%
CATH (20)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3b85A00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.64 46.0 3.24e-01 77.6% 70.6%
1wiwA02 3.40.50.10490 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Glucose-6-phosphate isomerase like protein; domain 1 0.61 44.0 3.36e-01 75.9% 76.7%
6riwA01 3.40.47.10 Alpha Beta › 3-Layer(aba) Sandwich › Peroxisomal Thiolase; Chain A, domain 1 › Thiolase/Chalcone synthase 0.60 46.0 2.79e-01 87.9% 49.5%
6n2aB02 3.20.20.10 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Alanine racemase 0.59 46.0 3.19e-01 91.4% 96.1%
1xg8A00 3.40.30.30 Alpha Beta › 3-Layer(aba) Sandwich › Glutaredoxin › Hypothetical protein sa0798. 0.58 43.0 3.58e-01 81.0% 68.5%
3ej7H00 3.30.429.10 Alpha Beta › 2-Layer Sandwich › Macrophage Migration Inhibitory Factor › Macrophage Migration Inhibitory Factor 0.57 35.0 3.66e-01 100.0% 66.7%
2f9aA01 3.40.47.10 Alpha Beta › 3-Layer(aba) Sandwich › Peroxisomal Thiolase; Chain A, domain 1 › Thiolase/Chalcone synthase 0.56 43.0 2.70e-01 89.7% 36.4%
3k2hA01 3.40.430.10 Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A 0.56 43.0 3.15e-01 89.7% 80.2%
3gffA00 3.40.50.1820 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain 0.56 40.0 2.59e-01 79.3% 54.7%
2yv9A01 3.40.30.10 Alpha Beta › 3-Layer(aba) Sandwich › Glutaredoxin › Glutaredoxin 0.56 39.0 3.26e-01 75.9% 75.5%
1cvrA02 3.40.50.1460 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.56 38.0 2.54e-01 70.7% 59.3%
7bobA01 3.20.20.80 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Glycosidases 0.55 41.0 2.57e-01 82.8% 67.0%
3simA00 3.20.20.80 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Glycosidases 0.55 39.0 2.58e-01 77.6% 94.9%
1g01A00 3.20.20.80 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Glycosidases 0.54 39.0 2.52e-01 82.8% 84.0%
1jp4A01 3.30.540.10 Alpha Beta › 2-Layer Sandwich › Fructose-1,6-Bisphosphatase; Chain A, domain 1 › Fructose-1,6-Bisphosphatase, subunit A, domain 1 0.53 47.0 3.36e-01 100.0% 37.0%
4kw2A00 3.20.20.150 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Divalent-metal-dependent TIM barrel enzymes 0.53 38.0 2.71e-01 84.5% 92.9%
2jh3A02 3.40.50.1400 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.53 36.0 2.94e-01 74.1% 91.1%
3g1pA00 3.60.15.10 Alpha Beta › 4-Layer Sandwich › Metallo-beta-lactamase; Chain A › Ribonuclease Z/Hydroxyacylglutathione hydrolase-like 0.52 36.0 2.44e-01 70.7% 87.1%
2h29A00 3.40.50.620 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HUPs 0.51 38.0 2.70e-01 81.0% 82.4%
3p24C02 3.40.390.10 Alpha Beta › 3-Layer(aba) Sandwich › Collagenase (Catalytic Domain) › Collagenase (Catalytic Domain) 0.50 36.0 2.68e-01 84.5% 73.1%
ECOD (18)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
5063485 7512.1.1.6 ↗ a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › Glyco_transf_20 0.62 43.0 3.04e-01 74.1% 63.0%
3642358 2007.2.3.12 ↗ a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › Tc-R-P 0.62 47.0 3.24e-01 86.2% 64.5%
3979937 2004.1.1.0 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.60 43.0 3.79e-01 77.6% 63.3%
4962866 2004.1.1.146 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ATPase 0.60 43.0 2.99e-01 79.3% 46.7%
2773175 7581.1.1.0 ↗ a/b three-layered sandwiches › Thiolase-like › Thiolase-like › Thiolase-like 0.59 46.0 3.47e-01 87.9% 84.7%
3781860 2007.2.3.4 ↗ a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › Y_phosphatase2 0.59 45.0 3.20e-01 84.5% 61.6%
4275795 7512.1.1.15 ↗ a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › Glyphos_transf 0.58 40.0 2.87e-01 74.1% 59.0%
3838340 2004.1.1.88 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › cobW 0.57 41.0 2.85e-01 79.3% 71.4%
4938435 2004.1.1.29 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD 0.57 41.0 2.79e-01 79.3% 72.7%
1406851 2007.1.2.10 ↗ a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Peripla_BP_3 0.56 37.0 2.98e-01 70.7% 91.8%
4026875 2485.1.1.0 ↗ a+b three layers › Thioredoxin-like › Thioredoxin-like › Thioredoxin-like 0.56 39.0 3.60e-01 75.9% 92.5%
1153678 2485.1.1.59 ↗ a+b three layers › Thioredoxin-like › Thioredoxin-like › Thioredoxin-like › CLIC-like_N 0.56 39.0 3.26e-01 75.9% 75.5%
3283119 7581.1.1.13 ↗ a/b three-layered sandwiches › Thiolase-like › Thiolase-like › Thiolase-like › ACP_syn_III 0.55 42.0 2.99e-01 87.9% 76.0%
3613818 2004.1.1.30 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C 0.55 39.0 2.88e-01 79.3% 95.0%
4025795 2008.1.1.86 ↗ a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › RAP 0.52 35.0 2.87e-01 72.4% 82.3%
3608647 2488.1.1.1 ↗ a/b three-layered sandwiches › alpha/beta knot › alpha/beta knot › alpha/beta knot › SpoU_methylase 0.52 41.0 2.94e-01 94.8% 48.3%
5048915 2004.1.3.1 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › Pyruvate-ferredoxin oxidoreductase, PFOR, domain III › POR 0.51 36.0 2.62e-01 77.6% 75.8%
4961024 2006.1.1.0 ↗ a/b three-layered sandwiches › HAD domain-like › HAD domain-related › HAD-like 0.50 36.0 2.68e-01 79.3% 68.2%
D2 medium residues 112-213
PDB
Domain cluster: rep: DNA_replication_origin-binding_helicase__YP_009352913__Columbid_alphaherpesvirus_1__93386__D112-191
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02399.22 best Herpes_ori_bp 177.7 4.80e-52 100.0% 12.3%
D3 medium residues 426-466_480-506
PDB
D4 medium residues 595-656_674-684_827-861
PDB
Domain cluster: rep: DNA_replication_origin-binding_helicase__YP_010084982__Beluga_whale_alphaherpesvirus_1__1434720__D546-648
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02399.22 best Herpes_ori_bp 57.9 7.80e-16 63.9% 7.6%
D5 medium residues 657-673_685-768
PDB
Domain cluster: rep: DNA_replication_origin-binding_helicase__YP_010087593__Cervid_alphaherpesvirus_3__2115790__D666-744
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02399.22 best Herpes_ori_bp 70.1 1.60e-19 100.0% 10.6%
CATH (8)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2dk4A00 4.10.280.110 Few Secondary Structures › Irregular › MYOD Basic-Helix-Loop-Helix Domain, subunit B › Pre-mRNA processing factor 4 domain 0.59 37.0 4.12e-01 88.1% 82.9%
2copA00 1.20.80.10 Mainly Alpha › Up-down Bundle › Acyl-CoA Binding Protein › 0.59 42.0 4.15e-01 75.2% 80.7%
1u8bA02 1.10.10.60 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Homeodomain-like 0.56 34.0 4.15e-01 99.0% 98.4%
5dukB00 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.56 33.0 3.82e-01 99.0% 85.1%
1akhB00 1.10.10.60 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Homeodomain-like 0.54 30.0 3.30e-01 92.1% 66.7%
2jnsA01 1.20.1270.220 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.52 37.0 4.00e-01 76.2% 92.6%
8g0lB01 1.25.40.1040 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.52 35.0 2.47e-01 70.3% 34.7%
6nmnA02 1.20.120.330 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 0.50 42.0 3.90e-01 93.1% 82.8%
ECOD (3)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3880529 130.1.1.0 ↗ alpha arrays › LEM/SAP HeH motif-like › LEM/SAP HeH motif › LEM/SAP HeH motif 0.61 37.0 4.34e-01 91.1% 92.3%
4059355 185.1.1.1 ↗ alpha superhelices › Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin-like › Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin/Protein HNS-dependent expression A HdeA › Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin › Tryp_alpha_amyl 0.56 30.0 2.91e-01 88.1% 46.4%
3321734 633.1.1.0 ↗ alpha bundles › Bromodomain-like › Bromodomain › Bromodomain 0.51 35.0 3.35e-01 93.1% 61.7%