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DNA_topoisomerase_1

Euk-Vir

Acanthamoeba_polyphaga_moumouvirus

DNA_topoisomerase_1__YP_007354228__Acanthamoeba_polyphaga_moumouvirus__1269028

Identity

Accession:: YP_007354228 ↗
Protein ID:: DNA_topoisomerase_1
Kingdom:: euk

Quality

71.7 mean pLDDT

Taxonomy

Bamfordvirae› Nucleocytoviricota› Megaviricetes› Imitervirales› Mimiviridae› Moumouvirus› Acanthamoeba_polyphaga_moumouvirus

TaxID: 1269028

Cluster

View cluster (9 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 3-131

PDB

Domain cluster: rep: IMGVR_UViG_3300014887_000003-3300014887-Ga0180302_1000002739__D2-143

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF01751.29 best	Toprim	64.4	1.20e-17	82.2%	97.9%

D2 high residues 267-383

PDB

Domain cluster: rep: KX077896.1__ANM47700.1__X__00069__D72-191

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF01131.26 best	Topoisom_bac	113.0	2.50e-32	100.0%	29.8%

D3 medium residues 136-217_552-622

PDB

Domain cluster: representative

Pfam (2)

Accession	Name	Score	E-value	Q cov	HMM cov
PF01131.26 best	Topoisom_bac	43.1	4.20e-11	52.3%	15.3%
PF01131.26	Topoisom_bac	36.5	4.30e-09	45.8%	15.0%

CATH (4)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1mw9X02	1.10.460.10	Mainly Alpha › Orthogonal Bundle › Topoisomerase I; domain 2 › Topoisomerase I, domain 2	0.70	64.0	6.31e-01	95.4%	93.3%
2rajA02	3.30.1520.10	Alpha Beta › 2-Layer Sandwich › PX Domain › Phox-like domain	0.59	29.0	3.23e-01	100.0%	56.3%
3zgzA04	1.10.730.10	Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1	0.54	28.0	2.72e-01	93.5%	41.2%
1i1rB00	1.20.1250.10	Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; ›	0.53	33.0	3.27e-01	100.0%	55.7%

ECOD (18)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3654747	101.1.2.19 ↗	alpha arrays › HTH › HTH › winged helix domain › Topoisom_bac	0.73	40.0	4.34e-01	79.1%	63.0%
4006756	101.1.2.19 ↗	alpha arrays › HTH › HTH › winged helix domain › Topoisom_bac	0.72	67.0	5.10e-01	95.4%	92.8%
4264627	101.1.2.19 ↗	alpha arrays › HTH › HTH › winged helix domain › Topoisom_bac	0.71	66.0	6.18e-01	96.1%	85.0%
5054506	101.1.2.19 ↗	alpha arrays › HTH › HTH › winged helix domain › Topoisom_bac	0.70	65.0	5.92e-01	96.1%	83.1%
4534098	101.1.2.19 ↗	alpha arrays › HTH › HTH › winged helix domain › Topoisom_bac	0.68	63.0	5.99e-01	96.1%	90.3%
4369057	101.1.2.19 ↗	alpha arrays › HTH › HTH › winged helix domain › Topoisom_bac	0.68	64.0	6.19e-01	96.7%	92.7%
4942681	101.1.2.19 ↗	alpha arrays › HTH › HTH › winged helix domain › Topoisom_bac	0.68	63.0	5.81e-01	96.1%	87.6%
5008813	101.1.2.0 ↗	alpha arrays › HTH › HTH › winged helix domain	0.67	62.0	6.05e-01	95.4%	92.7%
3317228	101.1.2.0 ↗	alpha arrays › HTH › HTH › winged helix domain	0.67	36.0	4.76e-01	83.0%	94.1%
5003642	101.1.2.19 ↗	alpha arrays › HTH › HTH › winged helix domain › Topoisom_bac	0.67	62.0	4.64e-01	96.1%	47.2%
4930522	101.1.2.19 ↗	alpha arrays › HTH › HTH › winged helix domain › Topoisom_bac	0.66	61.0	5.73e-01	96.1%	87.8%
4956004	2004.1.1.1195 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Topoisom_bac	0.66	58.0	4.10e-01	90.8%	35.1%
4943300	101.1.2.0 ↗	alpha arrays › HTH › HTH › winged helix domain	0.65	60.0	5.63e-01	96.1%	87.8%
4990155	101.1.2.19 ↗	alpha arrays › HTH › HTH › winged helix domain › Topoisom_bac	0.64	59.0	5.47e-01	96.1%	88.1%
4971257	101.1.2.0 ↗	alpha arrays › HTH › HTH › winged helix domain	0.63	58.0	5.39e-01	96.1%	85.4%
3993	150.3.1.3 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › 4-helical cytokines › 4-helical cytokine › IL6	0.53	33.0	3.27e-01	100.0%	55.7%
3212520	174.1.1.1 ↗	few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin	0.52	37.0	3.78e-01	100.0%	75.3%
3338424	633.1.1.1 ↗	alpha bundles › Bromodomain-like › Bromodomain › Bromodomain › Bromodomain	0.50	31.0	3.35e-01	100.0%	70.8%

D4 medium residues 218-264_388-436

PDB

D5 medium residues 452-551

PDB

Domain cluster: rep: putative_DNA_topoisomerase_IA__YP_003969716__Cafeteria_roenbergensis_virus_BV-PW1__693272__D174-185_438-516

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF01131.26 best	Topoisom_bac	55.4	7.80e-15	90.0%	13.8%

D6 medium residues 623-793

PDB

Domain cluster: rep: DNA_topoisomerase_1__YP_003986717__Acanthamoeba_polyphaga_mimivirus__212035__D624-781

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF13368.12 best	Toprim_C_rpt	23.7	5.30e-05	30.4%	66.7%