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DNA_topoisomerase_2
Euk-VirAcanthamoeba_polyphaga_mimivirus
DNA_topoisomerase_2__YP_003986988__Acanthamoeba_polyphaga_mimivirus__212035
Identity
- Accession:
- YP_003986988 ↗
- Protein ID:
- DNA_topoisomerase_2
- Kingdom:
- euk
Quality
82.9
mean pLDDT
Taxonomy
Bamfordvirae›
Nucleocytoviricota›
Megaviricetes›
Imitervirales›
Mimiviridae›
Mimivirus›
Acanthamoeba_polyphaga_mimivirus
TaxID: 212035
Cluster
View cluster (39 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 68-252
Domain cluster:
rep: IMGVR_UViG_3300039190_000305-3300039190-Ga0399989_003201_3_1937__D82-97_167-336
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02518.32 best | HATPase_c | 36.5 | 8.10e-09 | 77.8% | 88.3% |
D2
high
residues 286-408
Domain cluster:
rep: DNA_gyrase_subunit_B__YP_009352802__Kaumoebavirus_Viruses.__X__D311-415
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00204.32 best | DNA_gyraseB | 74.2 | 1.30e-20 | 99.2% | 69.0% |
D3
high
residues 1115-1212
Domain cluster:
representative
CATH (42)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 8gccA03 | 1.10.268.10 | Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3 | 0.86 | 78.0 | 7.65e-01 | 99.0% | 89.4% |
| 1bgwA03 | 1.10.268.10 | Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3 | 0.86 | 81.0 | 7.78e-01 | 100.0% | 96.4% |
| 3qx3A04 | 1.10.268.10 | Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3 | 0.83 | 78.0 | 7.74e-01 | 99.0% | 97.0% |
| 1ykhA00 | 6.10.140.200 | Special › Helix non-globular › Helix Hairpins › | 0.81 | 49.0 | 5.05e-01 | 100.0% | 63.2% |
| 1lvfB00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.80 | 41.0 | 4.07e-01 | 100.0% | 47.1% |
| 1zvuA03 | 1.10.268.10 | Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3 | 0.80 | 66.0 | 5.78e-01 | 100.0% | 61.4% |
| 4aflA00 | 6.10.140.1740 | Special › Helix non-globular › Helix Hairpins › | 0.77 | 47.0 | 4.65e-01 | 100.0% | 59.8% |
| 3lpxA03 | 1.10.268.10 | Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3 | 0.71 | 65.0 | 6.45e-01 | 99.0% | 97.1% |
| 2p5tA00 | 1.10.8.130 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › | 0.71 | 40.0 | 4.17e-01 | 96.9% | 60.9% |
| 4abmD00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.71 | 39.0 | 4.37e-01 | 100.0% | 68.8% |
| 1e1dA02 | 1.20.1270.20 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.71 | 36.0 | 3.95e-01 | 90.8% | 59.5% |
| 1egdA03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.70 | 40.0 | 3.58e-01 | 100.0% | 39.0% |
| 2xppA00 | 1.20.930.10 | Mainly Alpha › Up-down Bundle › Transcription Elongation Factor S-II; Chain A › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0.69 | 38.0 | 3.37e-01 | 100.0% | 37.2% |
| 1hciA04 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.68 | 41.0 | 3.94e-01 | 100.0% | 52.6% |
| 7wu7601 | 1.10.287.370 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.65 | 39.0 | 3.96e-01 | 100.0% | 60.0% |
| 3qa8A04 | 1.20.1270.250 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.64 | 41.0 | 3.08e-01 | 100.0% | 27.5% |
| 2odvA01 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.63 | 39.0 | 3.77e-01 | 100.0% | 54.5% |
| 2xokP00 | 1.20.20.10 | Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C | 0.63 | 40.0 | 4.54e-01 | 100.0% | 86.5% |
| 4id0A02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.62 | 38.0 | 3.69e-01 | 100.0% | 53.6% |
| 8b70A01 | 1.20.1740.10 | Mainly Alpha › Up-down Bundle › Amino acid/polyamine transporter I › Amino acid/polyamine transporter I | 0.62 | 54.0 | 3.62e-01 | 100.0% | 65.1% |
| 2jifA03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.61 | 42.0 | 3.60e-01 | 100.0% | 44.8% |
| 5nl6B01 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.60 | 41.0 | 3.82e-01 | 100.0% | 57.0% |
| 2uyyA02 | 1.10.1040.10 | Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 | 0.60 | 47.0 | 4.41e-01 | 100.0% | 67.5% |
| 4dllB02 | 1.10.1040.10 | Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 | 0.59 | 48.0 | 4.37e-01 | 100.0% | 65.4% |
| 2hujA00 | 1.20.120.440 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › YppE-like | 0.58 | 52.0 | 4.79e-01 | 100.0% | 96.8% |
| 2g5cB02 | 1.10.3660.10 | Mainly Alpha › Orthogonal Bundle › 6-phosphogluconate dehydrogenase C-terminal fold › 6-phosphogluconate dehydrogenase C-terminal like domain | 0.57 | 38.0 | 3.70e-01 | 95.9% | 60.0% |
| 2l2oA00 | 1.10.10.1540 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Costar domain | 0.57 | 39.0 | 4.20e-01 | 72.4% | 98.8% |
| 4yonA01 | 1.20.900.10 | Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain | 0.56 | 42.0 | 3.23e-01 | 100.0% | 35.6% |
| 1dxrL02 | 1.20.85.10 | Mainly Alpha › Up-down Bundle › Photosynthetic Reaction Center, subunit M; domain 1 › Photosystem II protein D1-like | 0.56 | 42.0 | 4.15e-01 | 100.0% | 73.1% |
| 4nsmA00 | 6.10.250.2770 | Special › Helix non-globular › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › | 0.55 | 39.0 | 4.52e-01 | 94.9% | 100.0% |
| 3b1fA02 | 1.10.3660.10 | Mainly Alpha › Orthogonal Bundle › 6-phosphogluconate dehydrogenase C-terminal fold › 6-phosphogluconate dehydrogenase C-terminal like domain | 0.55 | 36.0 | 3.53e-01 | 95.9% | 59.5% |
| 1auwA02 | 1.20.200.10 | Mainly Alpha › Up-down Bundle › Fumarase C; Chain A, domain 2 › Fumarase/aspartase (Central domain) | 0.54 | 45.0 | 3.42e-01 | 89.8% | 99.1% |
| 4opcA00 | 3.50.50.60 | Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain | 0.53 | 44.0 | 2.96e-01 | 94.9% | 71.2% |
| 6i3mE01 | 1.20.120.420 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › translation initiation factor eif-2b, domain 1 | 0.53 | 42.0 | 3.83e-01 | 86.7% | 87.6% |
| 3dkaB01 | 1.20.120.450 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › dinb family like domain | 0.53 | 49.0 | 4.37e-01 | 100.0% | 80.0% |
| 3r4iA02 | 6.10.140.960 | Special › Helix non-globular › Helix Hairpins › | 0.53 | 29.0 | 3.53e-01 | 99.0% | 85.0% |
| 4e21B02 | 1.10.1040.10 | Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 | 0.52 | 44.0 | 4.00e-01 | 100.0% | 67.2% |
| 3efoB01 | 1.20.120.730 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Sec23/Sec24 helical domain | 0.52 | 44.0 | 3.80e-01 | 90.8% | 74.8% |
| 2gf2A02 | 1.10.1040.10 | Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 | 0.52 | 44.0 | 3.97e-01 | 92.9% | 67.2% |
| 1qoyA00 | 1.20.1170.10 | Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; › | 0.52 | 42.0 | 3.06e-01 | 89.8% | 73.6% |
| 7d3uC01 | 1.10.287.3510 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.51 | 38.0 | 3.74e-01 | 99.0% | 71.0% |
| 3ay5A01 | 1.20.1420.10 | Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › Talin, central domain | 0.50 | 43.0 | 3.85e-01 | 90.8% | 75.9% |
ECOD (57)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3600354 | 4016.1.1.0 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase | 0.91 | 78.0 | 6.64e-01 | 100.0% | 58.7% |
| 3652359 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.91 | 84.0 | 6.73e-01 | 100.0% | 55.3% |
| 3708939 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.91 | 78.0 | 6.51e-01 | 100.0% | 56.8% |
| 223696 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.89 | 86.0 | 7.21e-01 | 100.0% | 65.6% |
| 4878008 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.89 | 75.0 | 6.89e-01 | 100.0% | 71.1% |
| 3935542 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.88 | 80.0 | 6.74e-01 | 100.0% | 62.0% |
| 3328306 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.88 | 84.0 | 6.52e-01 | 100.0% | 64.7% |
| 3610015 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.88 | 84.0 | 6.83e-01 | 100.0% | 62.4% |
| 3718739 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.87 | 83.0 | 6.79e-01 | 100.0% | 66.7% |
| 4946918 | 159.1.1.0 ↗ | alpha bundles › all-alpha NTP pyrophosphatases › all-alpha NTP pyrophosphatases › Hypothetical protein AF_0060 | 0.87 | 53.0 | 5.04e-01 | 100.0% | 54.5% |
| 3634044 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.87 | 83.0 | 6.43e-01 | 100.0% | 63.7% |
| 3789604 | 4016.1.1.0 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase | 0.87 | 83.0 | 7.00e-01 | 100.0% | 67.3% |
| 3276180 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.87 | 82.0 | 6.35e-01 | 100.0% | 67.7% |
| 3625174 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.86 | 81.0 | 6.13e-01 | 100.0% | 65.2% |
| 3096549 | 4016.1.1.0 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase | 0.85 | 81.0 | 6.62e-01 | 100.0% | 65.1% |
| 3630114 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.85 | 80.0 | 6.86e-01 | 100.0% | 70.3% |
| 5047538 | 159.1.1.0 ↗ | alpha bundles › all-alpha NTP pyrophosphatases › all-alpha NTP pyrophosphatases › Hypothetical protein AF_0060 | 0.85 | 51.0 | 4.92e-01 | 100.0% | 54.5% |
| 4238706 | 101.1.2.9 ↗ | alpha arrays › HTH › HTH › winged helix domain › DNA_topoisoIV | 0.84 | 79.0 | 5.39e-01 | 100.0% | 40.0% |
| 3220667 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.84 | 79.0 | 6.96e-01 | 100.0% | 72.6% |
| 3508111 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.84 | 79.0 | 6.27e-01 | 100.0% | 71.7% |
| 3768919 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.84 | 79.0 | 5.39e-01 | 100.0% | 41.3% |
| 3267708 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.83 | 77.0 | 6.63e-01 | 100.0% | 66.2% |
| 4830953 | 101.1.2.9 ↗ | alpha arrays › HTH › HTH › winged helix domain › DNA_topoisoIV | 0.83 | 78.0 | 6.31e-01 | 100.0% | 57.8% |
| 2443871 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.83 | 78.0 | 6.41e-01 | 100.0% | 67.5% |
| 3833806 | 4016.1.1.0 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase | 0.83 | 76.0 | 6.51e-01 | 100.0% | 65.5% |
| 4452951 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.81 | 76.0 | 6.14e-01 | 100.0% | 65.7% |
| 5024978 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.81 | 68.0 | 5.92e-01 | 100.0% | 60.7% |
| 3598050 | 192.4.1.0 ↗ | alpha bundles › Long alpha-hairpin › Ribosomal protein L29 (L29p) › Ribosomal protein L29 (L29p) | 0.80 | 51.0 | 5.71e-01 | 100.0% | 80.0% |
| 1297277 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.80 | 68.0 | 5.43e-01 | 100.0% | 48.6% |
| 4373100 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.79 | 67.0 | 5.81e-01 | 100.0% | 60.7% |
| 5083298 | 4016.1.1.0 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase | 0.79 | 67.0 | 5.72e-01 | 100.0% | 58.7% |
| 3642338 | 3567.1.1.0 ↗ | a+b duplicates or obligate multimers › MPER trimer › MPER trimer › MPER trimer | 0.79 | 51.0 | 5.80e-01 | 100.0% | 85.3% |
| 4299749 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.79 | 67.0 | 5.82e-01 | 100.0% | 61.4% |
| 5029847 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.77 | 46.0 | 5.31e-01 | 100.0% | 80.0% |
| 4005523 | 3860.1.1.167 ↗ | alpha bundles › Myosin VI lever arm › Myosin VI lever arm › Myosin VI lever arm › MscS_porin | 0.76 | 49.0 | 4.08e-01 | 100.0% | 40.0% |
| 5062336 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.72 | 67.0 | 5.53e-01 | 100.0% | 78.2% |
| 3454977 | 611.9.1.0 ↗ | alpha bundles › N-cbl like › Resistance protein (Rx) N-terminal domain › Resistance protein (Rx) N-terminal domain | 0.70 | 42.0 | 3.72e-01 | 100.0% | 43.0% |
| 5083711 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.70 | 49.0 | 3.58e-01 | 100.0% | 29.6% |
| 4501744 | 632.22.1.1 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats › EzrA | 0.68 | 45.0 | 4.49e-01 | 100.0% | 66.0% |
| 5059804 | 633.21.1.0 ↗ | alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 | 0.68 | 42.0 | 4.13e-01 | 98.0% | 58.1% |
| 3879813 | 197.1.1.3 ↗ | alpha bundles › Acyl-CoA binding protein-like › Acyl-CoA binding protein-like › Acyl-CoA binding protein-like › ACBP | 0.64 | 43.0 | 4.07e-01 | 100.0% | 56.7% |
| 5065286 | 129.1.1.0 ↗ | alpha arrays › 6-phosphogluconate dehydrogenase C-terminal domain-like › 6-phosphogluconate dehydrogenase C-terminal domain-like › 6-phosphogluconate dehydrogenase C-terminal domain-like | 0.64 | 45.0 | 4.27e-01 | 100.0% | 62.3% |
| 3196934 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.61 | 42.0 | 3.58e-01 | 100.0% | 45.2% |
| 5017954 | 101.1.2.0 ↗ | alpha arrays › HTH › HTH › winged helix domain | 0.60 | 42.0 | 4.86e-01 | 79.6% | 100.0% |
| 3833818 | 3562.1.1.11 ↗ | alpha bundles › Calcium release-activated calcium channel protein 1 › Calcium release-activated calcium channel protein 1 › Calcium release-activated calcium channel protein 1 › PGG | 0.60 | 45.0 | 3.88e-01 | 99.0% | 51.3% |
| 4086752 | 578.1.1.1 ↗ | alpha arrays › YcfC-like › YcfC-like › YcfC-like › DUF489 | 0.60 | 50.0 | 4.00e-01 | 92.9% | 57.6% |
| 4168471 | 4207.1.1.1 ↗ | alpha duplicates or obligate multimers › Mediator hinge subcomplex-like › Mediator hinge subcomplex-like › RNA polymerase II holoenzyme component SRB7 (MED21) › Med21 | 0.59 | 49.0 | 4.15e-01 | 100.0% | 55.5% |
| 3729492 | 601.4.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains | 0.59 | 53.0 | 4.62e-01 | 100.0% | 89.3% |
| 3408531 | 3922.1.1.0 ↗ | alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 | 0.57 | 52.0 | 4.84e-01 | 100.0% | 80.8% |
| 3680901 | 4177.1.1.0 ↗ | alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like | 0.56 | 35.0 | 2.71e-01 | 100.0% | 29.5% |
| 3997603 | 601.2.1.5 ↗ | alpha bundles › Four-helical up-and-down bundle › Cytochromes › Cytochromes › Ctr | 0.56 | 44.0 | 3.80e-01 | 100.0% | 55.9% |
| 3272022 | 609.1.1.1 ↗ | alpha bundles › Domain of poly(ADP-ribose) polymerase › Domain of poly(ADP-ribose) polymerase › Domain of poly(ADP-ribose) polymerase › PARP_reg | 0.55 | 52.0 | 4.42e-01 | 100.0% | 65.3% |
| 3399005 | 3291.1.1.0 ↗ | alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related | 0.55 | 45.0 | 4.74e-01 | 100.0% | 94.4% |
| 3344640 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.55 | 39.0 | 3.20e-01 | 72.4% | 48.8% |
| 5030301 | 129.1.1.3 ↗ | alpha arrays › 6-phosphogluconate dehydrogenase C-terminal domain-like › 6-phosphogluconate dehydrogenase C-terminal domain-like › 6-phosphogluconate dehydrogenase C-terminal domain-like › UDPG_MGDP_dh | 0.53 | 40.0 | 3.86e-01 | 98.0% | 70.0% |
| 3601755 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.52 | 43.0 | 2.74e-01 | 100.0% | 17.0% |
| 3473900 | 364.1.1.1 ↗ | few secondary structure elements › TAZ domain › TAZ domain › TAZ domain › zf-TAZ | 0.52 | 40.0 | 4.20e-01 | 98.0% | 87.8% |
D4
medium
residues 419-558_599-630_672-737
Domain cluster:
rep: DNA_topoisomerase_2__YP_009162467__Salmon_gill_poxvirus__1680908__D385-517_553-621_640-664
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01751.29 best | Toprim | 35.1 | 1.80e-08 | 48.7% | 84.4% |
| PF16898.11 | TOPRIM_C | 77.4 | 1.60e-21 | 44.5% | 67.2% |
D5
medium
residues 868-907_1084-1114
Domain cluster:
rep: DNA_topoisomerase_II__YP_009325819__Only_Syngen_Nebraska_virus_5__1917232__D775-833_920-935
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00521.27 best | DNA_topoisoIV | 50.7 | 1.90e-13 | 66.2% | 10.0% |
D6
medium
residues 908-982_1022-1083
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00521.27 best | DNA_topoisoIV | 39.0 | 6.50e-10 | 100.0% | 28.3% |
CATH (23)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 8gccA02 | 3.30.1360.40 | Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › | 0.94 | 58.0 | 7.48e-01 | 78.1% | 100.0% |
| 3qx3B03 | 3.30.1360.40 | Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › | 0.92 | 65.0 | 7.67e-01 | 87.6% | 100.0% |
| 3l4jA04 | 3.30.1360.40 | Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › | 0.87 | 63.0 | 7.32e-01 | 87.6% | 100.0% |
| 3lpxB02 | 3.30.1360.40 | Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › | 0.83 | 56.0 | 6.69e-01 | 82.5% | 98.9% |
| 2b4vA03 | 3.30.70.1970 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.66 | 36.0 | 4.19e-01 | 70.1% | 72.7% |
| 4d9uA01 | 3.30.200.20 | Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1 | 0.65 | 33.0 | 3.99e-01 | 70.1% | 75.0% |
| 2cdqA03 | 3.30.70.260 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain | 0.63 | 39.0 | 4.75e-01 | 86.1% | 100.0% |
| 3im8A02 | 3.30.70.250 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Malonyl-CoA ACP transacylase, ACP-binding | 0.63 | 30.0 | 3.95e-01 | 70.1% | 83.6% |
| 5w2fA01 | 3.30.780.10 | Alpha Beta › 2-Layer Sandwich › Translation Initiation Factor Eif1 › SUI1-like domain | 0.62 | 36.0 | 4.37e-01 | 73.7% | 90.7% |
| 3vwaA01 | 3.30.200.20 | Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1 | 0.61 | 33.0 | 3.96e-01 | 70.1% | 77.8% |
| 2x7gA01 | 3.30.200.20 | Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1 | 0.60 | 32.0 | 3.93e-01 | 70.8% | 79.5% |
| 2d9oA00 | 3.30.70.330 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain | 0.60 | 34.0 | 3.89e-01 | 70.1% | 75.0% |
| 3u5eU00 | 3.30.1360.210 | Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › | 0.59 | 36.0 | 4.10e-01 | 70.1% | 82.0% |
| 1s9iB01 | 3.30.200.20 | Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1 | 0.58 | 32.0 | 3.74e-01 | 71.5% | 77.4% |
| 1zpwX00 | 3.30.70.240 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.58 | 28.0 | 3.47e-01 | 70.1% | 73.2% |
| 5mmjh01 | 3.30.1370.30 | Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › | 0.58 | 32.0 | 4.22e-01 | 70.8% | 100.0% |
| 3s6eB00 | 3.30.70.330 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain | 0.57 | 35.0 | 3.81e-01 | 70.1% | 73.0% |
| 4g6tA00 | 3.30.1460.10 | Alpha Beta › 2-Layer Sandwich › Yope Regulator; Chain: A, › | 0.54 | 36.0 | 3.72e-01 | 83.9% | 71.1% |
| 2qrrA00 | 3.30.70.260 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain | 0.54 | 31.0 | 3.62e-01 | 70.8% | 79.4% |
| 3kxyJ00 | 3.30.1460.10 | Alpha Beta › 2-Layer Sandwich › Yope Regulator; Chain: A, › | 0.54 | 36.0 | 3.72e-01 | 73.0% | 72.1% |
| 4c57B00 | 1.10.510.10 | Mainly Alpha › Orthogonal Bundle › Transferase(Phosphotransferase); domain 1 › Transferase(Phosphotransferase) domain 1 | 0.53 | 42.0 | 3.20e-01 | 83.9% | 57.5% |
| 2ee3A00 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.52 | 32.0 | 3.52e-01 | 75.9% | 76.9% |
| 2w1zA02 | 3.30.200.20 | Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1 | 0.51 | 36.0 | 3.62e-01 | 72.3% | 92.9% |
ECOD (33)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3719735 | 4014.1.1.1 ↗ | a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV | 0.94 | 78.0 | 7.22e-01 | 100.0% | 70.3% |
| 2390536 | 4014.1.1.1 ↗ | a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV | 0.92 | 68.0 | 6.32e-01 | 89.8% | 63.6% |
| 3594650 | 4014.1.1.0 ↗ | a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase | 0.90 | 73.0 | 6.82e-01 | 100.0% | 71.2% |
| 3614277 | 4014.1.1.1 ↗ | a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV | 0.89 | 72.0 | 6.42e-01 | 100.0% | 63.3% |
| 3277529 | 4014.1.1.1 ↗ | a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV | 0.89 | 73.0 | 6.85e-01 | 100.0% | 72.5% |
| 4887990 | 4014.1.1.1 ↗ | a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV | 0.87 | 71.0 | 6.66e-01 | 100.0% | 71.4% |
| 4878007 | 101.1.2.9 ↗ | alpha arrays › HTH › HTH › winged helix domain › DNA_topoisoIV | 0.84 | 63.0 | 6.22e-01 | 90.5% | 73.9% |
| 3096551 | 4014.1.1.1 ↗ | a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV | 0.80 | 68.0 | 6.10e-01 | 100.0% | 66.5% |
| 4266765 | 4014.1.1.1 ↗ | a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV | 0.79 | 68.0 | 6.33e-01 | 100.0% | 74.5% |
| 4624017 | 4014.1.1.1 ↗ | a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV | 0.77 | 68.0 | 6.13e-01 | 100.0% | 71.1% |
| 3962339 | 4014.1.1.0 ↗ | a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase | 0.75 | 69.0 | 6.18e-01 | 100.0% | 71.9% |
| 3965475 | 4014.1.1.1 ↗ | a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV | 0.72 | 67.0 | 5.79e-01 | 100.0% | 75.1% |
| 3492350 | 304.9.1.1 ↗ | a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 | 0.66 | 35.0 | 4.05e-01 | 70.1% | 69.0% |
| 4938565 | 304.128.1.0 ↗ | a+b two layers › Alpha-beta plaits › ferredoxin-like domain in periplasmic region of MacB › ferredoxin-like domain in periplasmic region of MacB | 0.60 | 35.0 | 4.29e-01 | 70.8% | 88.9% |
| 3720011 | 206.1.1.1 ↗ | a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase | 0.59 | 44.0 | 3.27e-01 | 77.4% | 56.4% |
| 5032152 | 306.6.1.0 ↗ | a+b two layers › Glucose permease domain IIB-like › PH0987 N-terminal domain-like › PH0987 N-terminal domain-like | 0.58 | 43.0 | 4.74e-01 | 84.7% | 98.2% |
| 4119510 | 304.8.1.5 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › NIL | 0.56 | 32.0 | 3.71e-01 | 71.5% | 77.0% |
| 3735406 | 206.1.1.1 ↗ | a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase | 0.56 | 45.0 | 3.48e-01 | 86.1% | 90.5% |
| 4027407 | 206.1.1.1 ↗ | a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase | 0.56 | 41.0 | 2.94e-01 | 78.1% | 73.0% |
| 3308738 | 304.9.1.0 ↗ | a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD | 0.55 | 38.0 | 3.78e-01 | 88.3% | 67.6% |
| 4196383 | 304.8.1.5 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › NIL | 0.54 | 32.0 | 3.63e-01 | 71.5% | 78.0% |
| 3599405 | 206.1.1.0 ↗ | a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase | 0.54 | 44.0 | 3.23e-01 | 87.6% | 66.1% |
| 4052934 | 206.1.1.17 ↗ | a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Kdo | 0.53 | 41.0 | 3.27e-01 | 81.8% | 76.4% |
| 3581710 | 331.3.1.3 ↗ | a+b two layers › TBP-like › Bet v1-like › Bet v1-like › START | 0.53 | 42.0 | 3.58e-01 | 83.9% | 79.1% |
| 3709688 | 206.1.1.0 ↗ | a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase | 0.52 | 42.0 | 3.08e-01 | 86.1% | 67.4% |
| None | — | 0.52 | 42.0 | 3.35e-01 | 86.9% | 77.5% | |
| 3984011 | 206.1.1.33 ↗ | a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › OspG_kinase | 0.52 | 36.0 | 3.38e-01 | 72.3% | 70.9% |
| 3213664 | 206.1.1.1 ↗ | a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase | 0.52 | 42.0 | 3.20e-01 | 86.9% | 54.6% |
| 4304504 | 304.8.1.5 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › NIL | 0.51 | 33.0 | 3.83e-01 | 86.1% | 90.0% |
| 3789126 | 206.1.1.1 ↗ | a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase | 0.51 | 42.0 | 3.04e-01 | 88.3% | 64.8% |
| 3504203 | 206.1.1.1 ↗ | a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase | 0.51 | 43.0 | 3.37e-01 | 91.2% | 72.4% |
| 3181363 | 206.1.1.72 ↗ | a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase, Pkinase_fungal | 0.51 | 41.0 | 3.20e-01 | 86.9% | 57.7% |
| 3412664 | 206.1.1.1 ↗ | a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase | 0.50 | 42.0 | 2.99e-01 | 88.3% | 60.8% |