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DNA_topoisomerase_II

Euk-Vir

Lausannevirus

DNA_topoisomerase_II__YP_004347024__Lausannevirus__999883

Identity

Accession:: YP_004347024 ↗
Protein ID:: DNA_topoisomerase_II
Kingdom:: euk

Quality

86.6 mean pLDDT

Taxonomy

Bamfordvirae› Nucleocytoviricota› Megaviricetes› Pimascovirales› Marseilleviridae› Losannavirus› Lausannevirus

TaxID: 999883

Cluster

View cluster (39 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 58-248

PDB

Domain cluster: rep: IMGVR_UViG_3300039190_000305-3300039190-Ga0399989_003201_3_1937__D82-97_167-336

D2 high residues 253-399

PDB

Domain cluster: rep: topoisomerase_IIA__YP_009001040__Pithovirus_sibericum__1450746__D250-321_335-390

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00204.32 best	DNA_gyraseB	34.8	1.70e-08	96.6%	58.1%

D3 high residues 417-546_585-667

PDB

Domain cluster: rep: DNA_topoisomerase_2__YP_009162467__Salmon_gill_poxvirus__1680908__D385-517_553-621_640-664

Pfam (2)

Accession	Name	Score	E-value	Q cov	HMM cov
PF01751.29 best	Toprim	35.9	9.80e-09	53.0%	89.6%
PF16898.11	TOPRIM_C	41.2	2.50e-10	43.7%	67.2%

D4 high residues 971-1089

PDB

Domain cluster: rep: putative_DNA_topoisomerase__YP_294202__Emiliania_huxleyi_virus_86__181082__D963-1088

D5 medium residues 1-57

PDB

Domain cluster: representative

CATH (6)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1pvgA01	3.30.565.10	Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain	0.89	74.0	4.73e-01	91.2%	20.9%
3ks7A02	2.60.120.230	Mainly Beta › Sandwich › Jelly Rolls ›	0.55	43.0	3.19e-01	94.7%	63.1%
1wq8A00	2.10.90.10	Mainly Beta › Ribbon › Cystine Knot Cytokines, subunit B › Cystine-knot cytokines	0.51	37.0	3.24e-01	80.7%	83.8%
2c7yA00	3.40.47.10	Alpha Beta › 3-Layer(aba) Sandwich › Peroxisomal Thiolase; Chain A, domain 1 › Thiolase/Chalcone synthase	0.51	40.0	2.48e-01	91.2%	87.5%
2xauA03	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.51	34.0	2.42e-01	70.2%	98.9%
5jm6A02	2.30.250.10	Mainly Beta › Roll › Aminopeptidase i, Domain 2 › Aminopeptidase i, Domain 2	0.51	39.0	2.97e-01	84.2%	69.9%

ECOD (7)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3789605	225.1.1.0 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0.84	74.0	4.76e-01	96.5%	23.3%
3594649	225.1.1.0 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0.84	74.0	4.77e-01	100.0%	22.9%
4617838	225.1.1.3 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c	0.84	74.0	4.76e-01	100.0%	22.9%
3317524	225.1.1.0 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0.83	69.0	4.61e-01	96.5%	24.3%
4983372	304.48.1.20 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Thg1	0.54	41.0	2.81e-01	89.5%	79.6%
4321860	304.48.1.17 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › DNA_pol_B_2	0.52	39.0	2.83e-01	84.2%	85.3%
3777032	5054.1.1.11 ↗	alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels › SK_channel	0.51	39.0	2.76e-01	91.2%	35.0%

D6 medium residues 549-583

PDB

Domain cluster: rep: DNA_topoisomerase_II__YP_009238657__Brazilian_marseillevirus__1813599__D550-583

D7 medium residues 674-816

PDB

Domain cluster: rep: DNA_topoisomerase_2__YP_009162467__Salmon_gill_poxvirus__1680908__D669-796

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00521.27 best	DNA_topoisoIV	153.4	1.30e-44	100.0%	32.0%

D8 medium residues 817-959

PDB

Domain cluster: rep: DNA_topoisomerase_2__YP_003986988__Acanthamoeba_polyphaga_mimivirus__212035__D908-982_1022-1083

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00521.27 best	DNA_topoisoIV	60.6	1.90e-16	98.6%	35.3%