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DNA_topoisomerase_II

Euk-Vir

Chrysochromulina_ericina_virus

DNA_topoisomerase_II__YP_009173327__Chrysochromulina_ericina_virus__455364

Identity

Accession:
YP_009173327 ↗
Protein ID:
DNA_topoisomerase_II
Kingdom:
euk

Quality

86.8 mean pLDDT

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 271-400
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00204.32 best DNA_gyraseB 79.4 3.20e-22 97.7% 66.7%
D2 high residues 1003-1131
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00521.27 best DNA_topoisoIV 39.4 4.90e-10 90.7% 26.2%
CATH (50)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
8gccA03 1.10.268.10 Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3 0.92 71.0 7.89e-01 79.1% 100.0%
3qx3A04 1.10.268.10 Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3 0.91 65.0 7.34e-01 72.9% 100.0%
1bgwA03 1.10.268.10 Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3 0.90 66.0 7.13e-01 74.4% 100.0%
1t72A01 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.81 43.0 4.53e-01 87.6% 57.3%
1oahA02 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.80 48.0 4.65e-01 89.1% 54.9%
2gtsA00 1.10.287.850 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain 0.78 38.0 4.88e-01 85.3% 79.2%
3lssA01 1.10.287.40 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain 0.77 48.0 5.13e-01 85.3% 71.4%
4z4qA04 1.10.268.10 Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3 0.77 52.0 6.19e-01 72.9% 100.0%
3hr0B01 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.77 45.0 5.70e-01 87.6% 96.2%
1zvuA03 1.10.268.10 Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3 0.77 68.0 6.66e-01 96.1% 87.1%
4u7iA00 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.76 33.0 3.84e-01 84.5% 55.9%
3m7gA02 1.10.8.1010 Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › 0.76 43.0 5.03e-01 91.5% 76.8%
1owaA02 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.74 40.0 4.37e-01 86.0% 63.2%
4aflA00 6.10.140.1740 Special › Helix non-globular › Helix Hairpins › 0.71 44.0 4.93e-01 85.3% 78.4%
2q0oC00 1.10.287.160 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat 0.71 41.0 4.98e-01 79.8% 86.0%
1wcrA00 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.70 39.0 4.28e-01 85.3% 66.0%
5mawD00 1.20.1330.10 Mainly Alpha › Up-down Bundle › f41 fragment of flagellin, N-terminal domain › f41 fragment of flagellin, N-terminal domain 0.69 57.0 4.42e-01 86.0% 80.4%
2i0mA01 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.69 38.0 4.18e-01 86.8% 65.1%
1vctA01 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.66 41.0 4.43e-01 91.5% 73.4%
3ay5A01 1.20.1420.10 Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › Talin, central domain 0.64 35.0 3.53e-01 89.1% 51.9%
1qu7A00 1.10.287.950 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Methyl-accepting chemotaxis protein 0.63 47.0 3.78e-01 86.8% 43.2%
3pwxA01 1.20.1330.10 Mainly Alpha › Up-down Bundle › f41 fragment of flagellin, N-terminal domain › f41 fragment of flagellin, N-terminal domain 0.63 52.0 4.60e-01 86.8% 84.2%
4dylA02 1.10.287.160 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat 0.63 41.0 4.72e-01 85.3% 90.4%
6xkyA01 1.20.1330.10 Mainly Alpha › Up-down Bundle › f41 fragment of flagellin, N-terminal domain › f41 fragment of flagellin, N-terminal domain 0.63 51.0 4.55e-01 87.6% 90.4%
1jmwA00 1.20.120.30 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Aspartate receptor, ligand-binding domain 0.62 50.0 4.79e-01 85.3% 98.6%
2gl2B00 1.10.287.1700 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.60 40.0 4.35e-01 85.3% 79.8%
4ys0A02 1.10.3060.10 Mainly Alpha › Orthogonal Bundle › Helical scaffold and wing domains of SecA › Helical scaffold and wing domains of SecA 0.59 33.0 2.98e-01 80.6% 41.2%
7b7tA01 1.20.1270.30 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.59 51.0 4.69e-01 91.5% 84.5%
1jqkA03 1.20.1270.30 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.58 49.0 4.38e-01 89.9% 78.3%
3i01A01 1.20.1270.30 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.57 49.0 4.41e-01 91.5% 82.5%
4mh6A00 1.10.287.1700 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.56 48.0 4.39e-01 86.8% 71.1%
1orjD00 1.20.120.340 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Flagellar protein FliS 0.55 45.0 4.61e-01 84.5% 92.0%
3fseB02 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.55 43.0 4.15e-01 81.4% 77.1%
4cgkA01 6.10.250.3150 Special › Helix non-globular › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › 0.55 44.0 3.67e-01 84.5% 51.9%
1rx0A03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.55 49.0 4.63e-01 96.1% 96.1%
8a1gC01 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.55 48.0 4.20e-01 91.5% 79.0%
3qa8A04 1.20.1270.250 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.54 39.0 3.18e-01 85.3% 41.6%
3pltA00 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.54 47.0 3.90e-01 91.5% 68.2%
3iqcA00 1.20.120.340 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Flagellar protein FliS 0.54 40.0 4.16e-01 76.7% 91.6%
6q45G01 1.10.287.80 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ATP synthase, gamma subunit, helix hairpin domain 0.54 45.0 4.28e-01 86.8% 83.6%
6p73A02 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.53 39.0 3.75e-01 74.4% 79.7%
1zkeA00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.53 29.0 3.58e-01 84.5% 85.2%
4nqiD00 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.52 45.0 3.65e-01 91.5% 70.7%
2nsfA01 1.20.120.450 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › dinb family like domain 0.52 38.0 3.60e-01 76.7% 76.1%
2qgaB01 1.10.275.10 Mainly Alpha › Orthogonal Bundle › Fumarase C; Chain B, domain 1 › Fumarase/aspartase (N-terminal domain) 0.52 30.0 3.15e-01 86.8% 62.3%
3mpxA01 1.20.900.10 Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain 0.51 44.0 3.76e-01 93.8% 83.0%
1sziA02 1.20.120.340 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Flagellar protein FliS 0.51 39.0 3.84e-01 79.8% 99.3%
5y06A01 1.10.287.1490 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.51 42.0 3.45e-01 87.6% 69.0%
2m6bA00 1.20.58.390 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Neurotransmitter-gated ion-channel transmembrane domain 0.51 41.0 3.98e-01 88.4% 94.7%
1qsdA00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.50 35.0 3.96e-01 91.5% 92.2%
ECOD (78)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3328306 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.97 95.0 8.06e-01 100.0% 84.2%
3789604 4016.1.1.0 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase 0.97 94.0 8.85e-01 100.0% 92.0%
3708939 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.97 91.0 8.43e-01 100.0% 80.6%
3276180 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.96 94.0 7.89e-01 100.0% 86.2%
3718739 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.96 94.0 8.44e-01 100.0% 89.1%
3610015 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.96 94.0 8.42e-01 100.0% 84.8%
3634044 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.96 93.0 7.93e-01 100.0% 83.2%
3600354 4016.1.1.0 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase 0.96 90.0 8.47e-01 100.0% 83.3%
3652359 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.96 93.0 8.28e-01 100.0% 77.1%
3625174 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.95 92.0 7.54e-01 100.0% 82.9%
3768919 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.94 91.0 6.60e-01 99.2% 53.0%
3508111 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.94 91.0 7.94e-01 100.0% 91.7%
4238706 101.1.2.9 alpha arrays › HTH › HTH › winged helix domain › DNA_topoisoIV 0.94 91.0 6.59e-01 100.0% 51.8%
3630114 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.94 89.0 8.47e-01 97.7% 93.1%
3935542 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.94 89.0 8.33e-01 97.7% 84.7%
4452951 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.93 89.0 7.89e-01 100.0% 86.3%
4830953 101.1.2.9 alpha arrays › HTH › HTH › winged helix domain › DNA_topoisoIV 0.91 87.0 7.70e-01 100.0% 79.2%
3220667 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.91 84.0 8.25e-01 96.1% 96.3%
3267708 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.90 86.0 8.22e-01 100.0% 91.0%
223696 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.89 84.0 7.95e-01 100.0% 90.1%
2443871 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.88 83.0 7.57e-01 100.0% 91.0%
5055566 3922.1.1.0 alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 0.88 46.0 4.92e-01 87.6% 59.1%
3864224 603.1.1.103 alpha bundles › STAT-like › t-snare proteins › t-snare proteins › PF29732 0.87 41.0 3.73e-01 84.5% 37.0%
3096549 4016.1.1.0 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase 0.86 81.0 7.35e-01 100.0% 91.0%
3833806 4016.1.1.0 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase 0.83 67.0 6.39e-01 83.7% 75.9%
5024978 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.82 77.0 7.34e-01 99.2% 87.6%
5083298 4016.1.1.0 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase 0.81 76.0 7.18e-01 99.2% 84.7%
4373100 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.81 74.0 7.13e-01 96.9% 86.9%
4552385 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.81 74.0 6.94e-01 99.2% 81.3%
1780091 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.80 74.0 6.86e-01 99.2% 80.4%
4570966 4016.1.1.0 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase 0.79 73.0 6.94e-01 98.4% 88.0%
2325068 3755.3.1.148 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › CT398_CC 0.78 45.0 3.85e-01 84.5% 39.4%
4883080 101.1.2.9 alpha arrays › HTH › HTH › winged helix domain › DNA_topoisoIV 0.78 72.0 7.10e-01 98.4% 94.8%
4174306 4016.1.1.1 alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.76 70.0 6.68e-01 100.0% 86.0%
3770253 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.71 42.0 3.67e-01 89.9% 40.5%
3987991 5086.1.1.94 alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › HB_LcnD 0.68 49.0 4.11e-01 85.3% 45.7%
4324499 3755.1.1.3 alpha bundles › YscO-like › Putative type III secretion protein YscO-related › Putative type III secretion protein YscO-related › SPAM 0.67 47.0 4.50e-01 87.6% 63.4%
4946656 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.67 43.0 4.51e-01 87.6% 70.0%
3839889 601.51.1.0 alpha bundles › Four-helical up-and-down bundle › alpha-helical domain in phase 1 flagellin › alpha-helical domain in phase 1 flagellin 0.66 55.0 5.25e-01 86.0% 93.1%
4940954 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.66 48.0 3.59e-01 86.8% 34.3%
3639658 1072.1.1.1 alpha bundles › Hsp90 co-chaperone Cdc37 N-terminal domain › Hsp90 co-chaperone Cdc37 N-terminal domain › Hsp90 co-chaperone Cdc37 N-terminal domain › CDC37_N 0.64 51.0 4.70e-01 84.5% 76.4%
5047089 603.1.1.0 alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.63 34.0 3.68e-01 83.7% 60.0%
3853566 604.5.1.0 alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) 0.63 37.0 3.91e-01 89.1% 65.2%
3249720 601.4.1.0 alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains 0.61 50.0 5.03e-01 86.8% 100.0%
4013477 1025.1.1.0 alpha bundles › Stonustoxin helical domain › Stonustoxin helical domain › Stonustoxin helical domain 0.61 39.0 4.19e-01 92.2% 75.5%
3871823 2004.1.1.433 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N, AAA_23 0.58 47.0 3.03e-01 83.7% 22.0%
3741747 632.22.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats 0.58 45.0 3.55e-01 84.5% 58.2%
3699448 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.57 47.0 4.28e-01 85.3% 97.6%
3546316 3922.1.1.186 alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › WWC1 0.57 47.0 4.05e-01 92.2% 59.5%
3213281 4177.1.1.1 alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › FCH 0.56 49.0 3.76e-01 91.5% 78.5%
3818265 3755.4.1.0 alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain 0.56 47.0 4.34e-01 85.3% 85.2%
4001188 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.56 43.0 2.90e-01 87.6% 23.4%
4077196 2004.1.1.442 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N, AAA_21 0.56 46.0 3.02e-01 85.3% 36.9%
4943562 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.56 46.0 3.88e-01 85.3% 59.0%
4178099 632.22.1.176 alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats › PF27734 0.56 43.0 4.00e-01 87.6% 65.8%
3393894 3755.4.1.0 alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain 0.56 47.0 4.25e-01 86.8% 83.6%
1291200 4177.1.1.1 alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › FCH 0.56 49.0 3.65e-01 91.5% 74.8%
4551983 5050.1.1.1 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Sugar_tr 0.55 45.0 3.50e-01 85.3% 81.5%
3706820 3567.1.1.0 a+b duplicates or obligate multimers › MPER trimer › MPER trimer › MPER trimer 0.55 43.0 3.95e-01 86.8% 64.4%
3593528 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.55 45.0 4.34e-01 87.6% 75.3%
3908810 4177.1.1.1 alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › FCH 0.55 48.0 3.61e-01 92.2% 71.5%
4998688 192.2.1.89 alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin › DUF7121 0.55 42.0 3.31e-01 85.3% 41.6%
3605247 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.55 45.0 4.16e-01 84.5% 72.9%
5002102 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.54 42.0 3.78e-01 87.6% 60.6%
3254000 4177.1.1.8 alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › BAR_3 0.54 47.0 3.63e-01 91.5% 65.8%
4540951 3755.3.1.469 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › CC_PcsB 0.54 41.0 3.27e-01 86.0% 41.2%
3519973 4177.1.1.0 alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like 0.54 45.0 3.54e-01 87.6% 47.8%
3605639 1189.1.1.6 alpha bundles › VSG (variant surface glycoprotein) N-terminal domain and haptoglobin-hemoglobin receptor › VSG (variant surface glycoprotein) N-terminal domain and haptoglobin-hemoglobin receptor › VSG (variant surface glycoprotein) N-terminal domain and haptoglobin-hemoglobin receptor › ISG65-75 0.53 46.0 3.46e-01 93.0% 72.8%
3207855 5086.1.1.0 alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins 0.53 42.0 3.95e-01 87.6% 70.7%
4941675 2004.1.1.198 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_23 0.53 43.0 2.82e-01 84.5% 23.1%
3412891 150.1.1.31 alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › Tweety 0.53 47.0 3.62e-01 95.3% 68.0%
4980098 3834.1.1.0 alpha bundles › TcA alpha pore-forming domain › TcA alpha pore-forming domain › TcA alpha pore-forming domain 0.52 43.0 3.36e-01 87.6% 77.0%
5002671 3755.3.1.637 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › DUF7121 0.52 42.0 3.91e-01 86.0% 68.8%
3778005 604.1.1.55 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › RasGAP_C 0.51 37.0 3.69e-01 89.1% 70.4%
3201650 109.3.1.0 alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat 0.51 33.0 3.19e-01 86.8% 55.3%
3213527 4177.1.1.1 alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › FCH 0.51 44.0 3.35e-01 92.2% 73.7%
3415933 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.51 42.0 3.99e-01 86.8% 86.0%
3878898 603.1.1.0 alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.51 44.0 3.62e-01 90.7% 80.5%
D3 medium residues 18-95_237-269
PDB
Domain cluster: representative
CATH (3)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1pvgA01 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.84 80.0 5.90e-01 98.2% 98.8%
1d0xA04 1.20.120.720 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Myosin VI head, motor domain, U50 subdomain 0.60 41.0 3.87e-01 71.2% 87.6%
3pf7B00 1.10.620.20 Mainly Alpha › Orthogonal Bundle › Ribonucleotide Reductase, subunit A › Ribonucleotide Reductase, subunit A 0.54 44.0 2.94e-01 90.1% 71.1%
ECOD (8)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4617838 225.1.1.3 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c 0.84 71.0 5.32e-01 88.3% 95.1%
3594649 225.1.1.0 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 0.84 71.0 5.31e-01 88.3% 95.1%
3317524 225.1.1.0 a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 0.76 53.0 4.09e-01 81.1% 36.2%
3711985 3883.1.1.1 alpha bundles › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-OH_P_transf 0.55 43.0 3.33e-01 83.8% 94.0%
3495008 3382.1.1.1 alpha arrays › Protein Wnt-8 › Protein Wnt-8 › Protein Wnt-8 › wnt 0.55 43.0 3.00e-01 82.0% 76.4%
3996971 859.1.1.3 a+b two layers › The spindle assembly checkpoint protein mad2 › The spindle assembly checkpoint protein mad2 › The spindle assembly checkpoint protein mad2 › ATG101 0.53 41.0 3.25e-01 81.1% 54.9%
3544881 109.4.1.363 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Tcf25 0.51 39.0 2.81e-01 82.0% 83.3%
4965147 5001.1.1.292 alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › HisKA_7TM 0.51 39.0 3.09e-01 82.9% 81.7%
D5 medium residues 408-526_546-553
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF01751.29 best Toprim 27.7 3.50e-06 73.2% 72.9%
CATH (41)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1bgwA02 3.40.50.670 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.76 71.0 6.28e-01 97.6% 81.9%
7wgrA03 3.40.50.11610 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain 0.65 50.0 5.00e-01 92.9% 78.6%
1umdB02 3.40.50.920 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.62 45.0 4.56e-01 92.1% 75.0%
1itzA03 3.40.50.920 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.61 44.0 4.49e-01 93.7% 74.8%
6q2eA01 3.40.50.11840 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Diphthamide synthesis DPH1/DPH2 domain 1 0.61 36.0 4.31e-01 81.1% 86.2%
3od1A02 3.40.50.12590 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.61 30.0 4.13e-01 74.8% 100.0%
4tkzA00 3.40.50.510 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Phosphotransferase system, mannose-type IIA component 0.60 42.0 4.21e-01 82.7% 70.0%
3lzdA01 3.40.50.11840 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Diphthamide synthesis DPH1/DPH2 domain 1 0.59 36.0 4.03e-01 81.1% 78.9%
1jmkC01 3.40.50.1820 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain 0.59 45.0 4.06e-01 94.5% 59.3%
2jfqA02 3.40.50.1860 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.58 44.0 4.64e-01 81.9% 88.6%
3lkbA02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.58 40.0 3.65e-01 82.7% 53.9%
1gzhD02 3.40.50.10190 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › BRCT domain 0.58 34.0 3.57e-01 86.6% 62.2%
3mw8A01 3.40.50.10090 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.57 38.0 3.93e-01 80.3% 71.8%
2jfnA02 3.40.50.1860 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.57 44.0 4.63e-01 81.9% 89.5%
2wjwA02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.57 41.0 3.77e-01 81.1% 57.7%
3n0xA02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.57 41.0 3.77e-01 82.7% 57.9%
2h9aA02 3.40.50.11600 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.56 46.0 4.64e-01 92.9% 86.5%
2vxbA02 3.40.50.10190 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › BRCT domain 0.56 30.0 3.61e-01 87.4% 79.0%
1xktA01 3.40.50.1820 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain 0.56 43.0 3.84e-01 92.9% 56.8%
2dgdA01 3.40.50.1860 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.56 39.0 4.49e-01 85.8% 100.0%
4p53A01 3.40.50.1970 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.56 40.0 3.68e-01 81.1% 56.2%
4n03A02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.56 38.0 3.41e-01 82.7% 50.0%
1d3yB02 3.40.1360.10 Alpha Beta › 3-Layer(aba) Sandwich › Dna Topoisomerase Vi A Subunit; Chain: A, domain 2 › 0.55 48.0 4.02e-01 93.7% 60.8%
2jfzA02 3.40.50.1860 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.55 43.0 4.45e-01 82.7% 88.1%
3hriA02 3.40.50.800 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Anticodon-binding domain 0.55 35.0 4.00e-01 85.0% 92.0%
1httA02 3.40.50.800 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Anticodon-binding domain 0.55 36.0 4.00e-01 86.6% 86.7%
1cvrA01 3.40.50.10390 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Gingipain r; domain 1 0.54 43.0 4.45e-01 83.5% 91.5%
1wu7A03 3.40.50.800 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Anticodon-binding domain 0.54 35.0 3.87e-01 82.7% 85.6%
4qgsA01 3.40.50.1970 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.53 42.0 3.80e-01 82.7% 65.1%
2ynmC02 3.40.50.1980 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Nitrogenase molybdenum iron protein domain 0.53 41.0 4.03e-01 81.9% 76.3%
1jflA02 3.40.50.1860 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.53 39.0 4.20e-01 81.1% 89.9%
4f2gA01 3.40.50.1370 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Aspartate/ornithine carbamoyltransferase 0.53 35.0 3.35e-01 83.5% 57.1%
3grfA01 3.40.50.1370 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Aspartate/ornithine carbamoyltransferase 0.52 31.0 3.11e-01 82.7% 53.6%
4mcjG00 3.40.50.450 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.52 42.0 4.00e-01 94.5% 72.7%
4hwtA02 3.40.50.800 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Anticodon-binding domain 0.52 36.0 3.81e-01 97.6% 81.8%
2o1mA02 3.40.190.10 Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II 0.52 31.0 3.19e-01 81.1% 61.2%
1jfrA00 3.40.50.1820 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain 0.52 44.0 3.53e-01 94.5% 48.1%
1fj2A00 3.40.50.1820 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain 0.51 46.0 3.79e-01 100.0% 73.8%
1ufoA00 3.40.50.1820 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain 0.51 44.0 3.61e-01 95.3% 54.0%
3l41A02 3.40.50.10190 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › BRCT domain 0.51 33.0 3.48e-01 86.6% 73.5%
2bonA01 3.40.50.10330 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Probable inorganic polyphosphate/atp-NAD kinase; domain 1 0.50 38.0 3.81e-01 79.5% 100.0%
ECOD (72)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
1165402 2006.1.3.3 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain › Toprim,TOPRIM_C 0.96 90.0 8.57e-01 96.9% 97.9%
3551383 2006.1.3.3 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain › Toprim,TOPRIM_C 0.95 92.0 6.70e-01 100.0% 50.3%
3213306 2006.1.3.21 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain › TOPRIM_C 0.94 88.0 6.57e-01 96.1% 51.9%
4876995 2006.1.3.0 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain 0.93 81.0 8.08e-01 89.0% 100.0%
3789608 2006.1.3.0 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain 0.92 86.0 6.40e-01 96.1% 50.9%
3594652 2006.1.3.0 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain 0.91 86.0 6.38e-01 96.9% 51.3%
4878011 2006.1.3.21 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain › TOPRIM_C 0.85 77.0 6.27e-01 93.7% 59.2%
3520955 2006.1.3.1 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain › DNA_gyraseB_C,Toprim 0.84 78.0 5.90e-01 96.1% 49.1%
4945733 2006.1.3.0 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain 0.84 76.0 5.86e-01 94.5% 51.2%
None 0.83 77.0 6.04e-01 96.1% 55.2%
3964707 2006.1.3.0 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain 0.83 76.0 6.03e-01 95.3% 55.7%
5059966 2006.1.3.2 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain › Toprim 0.82 66.0 7.14e-01 83.5% 100.0%
3164150 2006.1.3.1 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain › DNA_gyraseB_C,Toprim 0.82 75.0 5.98e-01 95.3% 56.4%
1878568 2006.1.3.1 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain › DNA_gyraseB_C,Toprim 0.82 73.0 7.17e-01 92.9% 92.5%
4100838 2006.1.3.1 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain › DNA_gyraseB_C,Toprim 0.81 73.0 5.88e-01 93.7% 57.6%
None 0.81 78.0 6.73e-01 100.0% 76.5%
2452014 2006.1.3.1 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain › DNA_gyraseB_C,Toprim 0.81 74.0 5.83e-01 96.1% 54.4%
1759361 2006.1.3.2 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain › Toprim 0.76 71.0 6.76e-01 97.6% 97.9%
4324572 2007.1.3.42 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › CheY-like › PF29921 0.67 42.0 4.14e-01 84.3% 58.5%
4375310 2006.1.3.6 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain › Toprim_2 0.67 51.0 5.18e-01 92.9% 80.8%
4953479 7522.1.1.4 a/b three-layered sandwiches › TK C-terminal domain-like › TK C-terminal domain-like › TK C-terminal domain-like › PFOR_II 0.66 46.0 4.98e-01 92.9% 82.7%
4052999 7502.1.1.0 a/b three-layered sandwiches › Anticodon-binding domain of Class II aaRS › Anticodon-binding domain of Class II aaRS › Anticodon-binding domain of Class II aaRS 0.66 30.0 4.37e-01 75.6% 100.0%
3771364 7522.1.1.3 a/b three-layered sandwiches › TK C-terminal domain-like › TK C-terminal domain-like › TK C-terminal domain-like › OxoGdeHyase_C 0.65 50.0 4.96e-01 93.7% 75.6%
3940898 7522.1.1.3 a/b three-layered sandwiches › TK C-terminal domain-like › TK C-terminal domain-like › TK C-terminal domain-like › OxoGdeHyase_C 0.65 50.0 4.81e-01 93.7% 70.8%
5048291 7522.1.1.0 a/b three-layered sandwiches › TK C-terminal domain-like › TK C-terminal domain-like › TK C-terminal domain-like 0.65 45.0 4.79e-01 92.9% 79.1%
4946085 2007.1.7.3 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Rossmann-like domain in dehydroquinate synthase-like enzymes › Fe-ADH_2 0.65 43.0 3.92e-01 81.1% 51.5%
3567975 7522.1.1.3 a/b three-layered sandwiches › TK C-terminal domain-like › TK C-terminal domain-like › TK C-terminal domain-like › OxoGdeHyase_C 0.64 51.0 4.94e-01 93.7% 75.0%
4946545 7522.1.1.0 a/b three-layered sandwiches › TK C-terminal domain-like › TK C-terminal domain-like › TK C-terminal domain-like 0.64 45.0 4.76e-01 93.7% 80.0%
4929208 2007.1.16.1 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Iron-sulphur enzyme Dph2 › Diphthamide_syn 0.62 38.0 4.28e-01 81.1% 80.0%
5021609 7522.1.1.4 a/b three-layered sandwiches › TK C-terminal domain-like › TK C-terminal domain-like › TK C-terminal domain-like › PFOR_II 0.62 44.0 4.66e-01 92.9% 81.6%
4971249 2007.1.10.0 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › PrpR receptor domain-like 0.62 38.0 4.38e-01 86.6% 82.1%
5054900 7522.1.1.0 a/b three-layered sandwiches › TK C-terminal domain-like › TK C-terminal domain-like › TK C-terminal domain-like 0.62 47.0 4.42e-01 93.7% 66.7%
3723137 7522.1.1.3 a/b three-layered sandwiches › TK C-terminal domain-like › TK C-terminal domain-like › TK C-terminal domain-like › OxoGdeHyase_C 0.61 50.0 4.77e-01 92.9% 73.3%
5018445 7522.1.1.0 a/b three-layered sandwiches › TK C-terminal domain-like › TK C-terminal domain-like › TK C-terminal domain-like 0.61 47.0 4.54e-01 92.9% 72.1%
5030600 2007.1.16.1 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Iron-sulphur enzyme Dph2 › Diphthamide_syn 0.61 36.0 4.14e-01 81.1% 78.9%
3823490 2007.1.2.4 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › ANF_receptor 0.61 42.0 3.70e-01 81.1% 48.6%
4031610 2007.1.2.6 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › Glyco_tran_WecG 0.61 41.0 3.44e-01 85.8% 40.2%
3947905 2010.1.1.3 a/b three-layered sandwiches › EDD domain › EDD domain › EDD domain › EIIA-man 0.61 42.0 4.23e-01 81.1% 71.2%
4246539 2007.1.7.2 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Rossmann-like domain in dehydroquinate synthase-like enzymes › DHQ_synthase 0.60 42.0 3.79e-01 81.1% 52.6%
3587277 2010.1.1.3 a/b three-layered sandwiches › EDD domain › EDD domain › EDD domain › EIIA-man 0.59 41.0 4.15e-01 82.7% 70.8%
3697509 7568.1.1.14 a/b three-layered sandwiches › BRCT domain › BRCT domain › BRCT domain › NIBRIN_BRCT_II 0.59 45.0 4.54e-01 86.6% 81.6%
4932292 7595.1.1.2 a/b three-layered sandwiches › B12 binding domain in carbon monoxide dehydrogenase corrinoid/iron-sulfur protein gamma subunit › B12 binding domain in carbon monoxide dehydrogenase corrinoid/iron-sulfur protein gamma subunit › B12 binding domain in carbon monoxide dehydrogenase corrinoid/iron-sulfur protein gamma subunit › DUF6513 0.58 36.0 3.90e-01 82.7% 71.8%
5083260 2007.1.16.1 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Iron-sulphur enzyme Dph2 › Diphthamide_syn 0.58 36.0 3.99e-01 81.9% 76.2%
4886405 4002.1.1.2 alpha bundles › alpha-helical domain in dehydroquinate synthase-like enzymes › alpha-helical domain in dehydroquinate synthase-like enzymes › alpha-helical domain in dehydroquinate synthase-like enzymes › DHQ_synthase 0.58 41.0 3.75e-01 81.9% 55.3%
4209227 2007.1.4.3 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Phosphofructokinase N-terminal domain › NAD_kinase 0.58 32.0 3.57e-01 80.3% 68.0%
2050056 2007.1.5.0 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › ATC-like 0.57 41.0 4.43e-01 87.4% 88.7%
4944763 2007.3.1.3 a/b three-layered sandwiches › Flavodoxin-like › Succinyl-CoA synthetase domains › Succinyl-CoA synthetase domains › Succ_CoA_lig 0.57 43.0 3.99e-01 96.9% 63.1%
5046178 2007.1.2.0 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I 0.57 41.0 4.09e-01 82.7% 73.1%
3658466 7522.1.1.0 a/b three-layered sandwiches › TK C-terminal domain-like › TK C-terminal domain-like › TK C-terminal domain-like 0.56 44.0 4.65e-01 92.1% 91.3%
None 0.56 40.0 3.63e-01 81.9% 54.3%
3178717 7579.1.1.32 a/b three-layered sandwiches › alpha/beta-Hydrolases › alpha/beta-Hydrolases › alpha/beta-Hydrolases › FrsA-like 0.56 48.0 3.35e-01 94.5% 34.4%
4951984 2007.3.1.3 a/b three-layered sandwiches › Flavodoxin-like › Succinyl-CoA synthetase domains › Succinyl-CoA synthetase domains › Succ_CoA_lig 0.55 44.0 4.03e-01 100.0% 63.5%
5044161 2007.3.1.3 a/b three-layered sandwiches › Flavodoxin-like › Succinyl-CoA synthetase domains › Succinyl-CoA synthetase domains › Succ_CoA_lig 0.55 42.0 3.83e-01 96.9% 58.9%
4477176 7502.1.1.0 a/b three-layered sandwiches › Anticodon-binding domain of Class II aaRS › Anticodon-binding domain of Class II aaRS › Anticodon-binding domain of Class II aaRS 0.55 34.0 3.92e-01 82.7% 89.4%
1312813 2006.1.3.0 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain 0.55 47.0 3.89e-01 92.9% 58.0%
3993695 2007.5.1.23 a/b three-layered sandwiches › Flavodoxin-like › SGNH hydrolase › SGNH hydrolase › SGNH 0.54 45.0 3.90e-01 96.1% 57.0%
4024370 7577.1.1.5 a/b three-layered sandwiches › PLP-dependent transferases › PLP-dependent transferases › PLP-dependent transferases › SHMT 0.54 39.0 2.94e-01 82.7% 31.9%
5010696 7502.1.1.1 a/b three-layered sandwiches › Anticodon-binding domain of Class II aaRS › Anticodon-binding domain of Class II aaRS › Anticodon-binding domain of Class II aaRS › HGTP_anticodon 0.54 36.0 3.83e-01 97.6% 76.3%
4671615 7502.1.1.1 a/b three-layered sandwiches › Anticodon-binding domain of Class II aaRS › Anticodon-binding domain of Class II aaRS › Anticodon-binding domain of Class II aaRS › HGTP_anticodon 0.53 36.0 3.94e-01 97.6% 84.8%
1397999 7576.1.1.1 a/b three-layered sandwiches › Gingipain R extra N-terminal alpha/beta domain › Gingipain R extra N-terminal alpha/beta domain › Gingipain R extra N-terminal alpha/beta domain › Peptidase_C25 0.53 42.0 4.04e-01 83.5% 77.6%
2032264 2007.1.7.2 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Rossmann-like domain in dehydroquinate synthase-like enzymes › DHQ_synthase 0.53 41.0 3.64e-01 82.7% 71.9%
3826893 7579.1.1.0 a/b three-layered sandwiches › alpha/beta-Hydrolases › alpha/beta-Hydrolases › alpha/beta-Hydrolases 0.52 45.0 3.73e-01 93.7% 68.4%
3485118 7579.1.1.6 a/b three-layered sandwiches › alpha/beta-Hydrolases › alpha/beta-Hydrolases › alpha/beta-Hydrolases › Abhydrolase_1 0.52 45.0 4.19e-01 94.5% 86.3%
4021824 7579.1.1.0 a/b three-layered sandwiches › alpha/beta-Hydrolases › alpha/beta-Hydrolases › alpha/beta-Hydrolases 0.52 45.0 3.23e-01 96.1% 33.7%
4209926 7502.1.1.1 a/b three-layered sandwiches › Anticodon-binding domain of Class II aaRS › Anticodon-binding domain of Class II aaRS › Anticodon-binding domain of Class II aaRS › HGTP_anticodon 0.52 34.0 3.77e-01 83.5% 87.4%
5064251 2003.1.14.2 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › Aspartate/ornithine carbamoyltransferase › OTCace_N 0.51 37.0 3.40e-01 83.5% 57.6%
5000969 2007.3.1.3 a/b three-layered sandwiches › Flavodoxin-like › Succinyl-CoA synthetase domains › Succinyl-CoA synthetase domains › Succ_CoA_lig 0.51 43.0 3.79e-01 96.9% 62.7%
4983543 2007.3.1.3 a/b three-layered sandwiches › Flavodoxin-like › Succinyl-CoA synthetase domains › Succinyl-CoA synthetase domains › Succ_CoA_lig 0.51 43.0 3.81e-01 96.9% 62.7%
3961881 7579.1.1.17 a/b three-layered sandwiches › alpha/beta-Hydrolases › alpha/beta-Hydrolases › alpha/beta-Hydrolases › Peptidase_S15 0.51 44.0 3.22e-01 96.1% 35.8%
5076169 2003.1.14.2 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › Aspartate/ornithine carbamoyltransferase › OTCace_N 0.50 36.0 3.43e-01 83.5% 61.3%
3231032 2007.5.1.23 a/b three-layered sandwiches › Flavodoxin-like › SGNH hydrolase › SGNH hydrolase › SGNH 0.50 43.0 4.10e-01 94.5% 91.3%
4930288 2007.1.5.2 a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › ATC-like › CCG 0.50 37.0 3.96e-01 82.7% 90.0%
D6 medium residues 604-666
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF16898.11 best TOPRIM_C 49.0 9.90e-13 100.0% 50.8%
ECOD (7)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3551383 2006.1.3.3 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain › Toprim,TOPRIM_C 0.91 85.0 5.30e-01 100.0% 26.6%
3789608 2006.1.3.0 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain 0.90 84.0 5.30e-01 100.0% 24.7%
3213306 2006.1.3.21 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain › TOPRIM_C 0.89 82.0 5.25e-01 100.0% 28.5%
3594652 2006.1.3.0 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain 0.87 81.0 5.13e-01 100.0% 24.4%
3817446 2006.1.3.21 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain › TOPRIM_C 0.82 73.0 5.22e-01 100.0% 35.0%
None 0.56 38.0 3.05e-01 73.0% 91.4%
4997019 2006.1.4.2 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like › PIN 0.50 34.0 2.75e-01 71.4% 77.0%
D7 medium residues 681-809
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00521.27 best DNA_topoisoIV 155.8 2.40e-45 100.0% 29.7%
D8 medium residues 878-969
PDB
Domain cluster: representative
CATH (71)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
8gccA02 3.30.1360.40 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › 0.94 73.0 7.61e-01 100.0% 86.0%
3qx3B03 3.30.1360.40 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › 0.91 71.0 6.91e-01 100.0% 75.0%
3l4jA04 3.30.1360.40 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › 0.85 67.0 6.50e-01 100.0% 75.5%
6bq9A02 3.30.1360.40 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › 0.80 60.0 6.02e-01 100.0% 77.7%
3lpxB02 3.30.1360.40 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › 0.77 62.0 6.17e-01 100.0% 83.0%
3eeeA00 3.90.1520.10 Alpha Beta › Alpha-Beta Complex › H-NOX domain › H-NOX domain 0.70 49.0 3.82e-01 72.8% 35.1%
3hxiA01 3.30.760.10 Alpha Beta › 2-Layer Sandwich › RNA Cap, Translation Initiation Factor Eif4e › RNA Cap, Translation Initiation Factor Eif4e 0.68 52.0 4.23e-01 94.6% 43.9%
5abxA00 3.30.760.10 Alpha Beta › 2-Layer Sandwich › RNA Cap, Translation Initiation Factor Eif4e › RNA Cap, Translation Initiation Factor Eif4e 0.67 50.0 4.08e-01 94.6% 42.2%
2e5gA01 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.65 46.0 5.06e-01 94.6% 93.1%
4q5eA01 3.30.200.20 Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1 0.65 42.0 4.60e-01 71.7% 81.3%
2av5A00 3.30.70.3250 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Ribonuclease P, Pop5 subunit 0.64 48.0 4.62e-01 94.6% 68.9%
1s9iB01 3.30.200.20 Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1 0.64 45.0 4.54e-01 72.8% 74.2%
1sjrA00 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.64 45.0 4.27e-01 94.6% 62.0%
2gqqA02 3.30.70.920 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Lrp/AsnC effector binding domain/regulation of amino acid metabolism (RAM) domain 0.64 44.0 4.60e-01 94.6% 77.6%
1s79A00 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.64 48.0 4.62e-01 95.7% 70.9%
4wsqB00 1.10.510.10 Mainly Alpha › Orthogonal Bundle › Transferase(Phosphotransferase); domain 1 › Transferase(Phosphotransferase) domain 1 0.63 56.0 3.92e-01 100.0% 44.8%
2ghpA03 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.63 45.0 4.71e-01 95.7% 82.9%
2onlC01 3.30.200.20 Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1 0.63 44.0 4.51e-01 77.2% 76.7%
3h7hB00 3.30.70.940 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › NusG, N-terminal domain 0.63 44.0 4.37e-01 92.4% 70.5%
2wmcA00 3.30.760.10 Alpha Beta › 2-Layer Sandwich › RNA Cap, Translation Initiation Factor Eif4e › RNA Cap, Translation Initiation Factor Eif4e 0.63 49.0 4.01e-01 95.7% 44.8%
2b4vA03 3.30.70.1970 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.63 45.0 4.42e-01 95.7% 69.7%
3ofgB00 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.63 47.0 4.82e-01 94.6% 85.1%
3g8qA02 3.30.70.1940 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.62 44.0 4.62e-01 94.6% 83.7%
2g4bA01 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.62 47.0 4.71e-01 95.7% 79.6%
4uy9A01 3.30.200.20 Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1 0.61 43.0 4.36e-01 72.8% 76.7%
3nynA01 3.30.200.20 Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1 0.61 43.0 3.69e-01 72.8% 47.6%
2m9kA00 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.61 46.0 4.61e-01 94.6% 78.5%
3hheA02 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.61 45.0 4.83e-01 93.5% 92.3%
1wwhA01 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.61 43.0 4.69e-01 95.7% 91.9%
5mmiU01 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.61 47.0 4.89e-01 94.6% 92.7%
2kjwA00 3.30.70.60 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Ribosomal protein S6/Translation elongation factor EF1B 0.60 41.0 4.14e-01 94.6% 68.8%
1y0hB00 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.60 45.0 4.47e-01 94.6% 75.5%
2bopA00 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.60 43.0 4.47e-01 94.6% 82.4%
1tuwA00 3.30.70.1090 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Dimeric alpha+beta barrel. 0.60 45.0 4.35e-01 94.6% 70.8%
5ajiB03 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.60 45.0 4.51e-01 93.5% 78.9%
3znuA00 3.30.70.1060 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Dimeric alpha+beta barrel 0.60 44.0 4.38e-01 93.5% 75.5%
3nynB01 3.30.200.20 Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1 0.59 41.0 3.00e-01 71.7% 26.3%
1b24A01 3.10.28.10 Alpha Beta › Roll › Endonuclease I-creI › Homing endonucleases 0.59 47.0 4.69e-01 90.2% 85.3%
2x7fC01 3.30.200.20 Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1 0.59 41.0 4.08e-01 71.7% 75.5%
3g2fA01 3.30.200.20 Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1 0.59 41.0 4.25e-01 77.2% 78.2%
2joeA01 3.30.1830.10 Alpha Beta › 2-Layer Sandwich › YehR-like fold › YehR-like 0.58 50.0 4.45e-01 92.4% 85.2%
6fdyU01 3.30.200.20 Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1 0.58 40.0 4.30e-01 71.7% 85.0%
5qinA01 3.30.200.20 Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1 0.58 41.0 4.26e-01 77.2% 80.0%
5mmjh01 3.30.1370.30 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › 0.58 42.0 4.62e-01 93.5% 92.0%
4bwpB01 1.10.510.10 Mainly Alpha › Orthogonal Bundle › Transferase(Phosphotransferase); domain 1 › Transferase(Phosphotransferase) domain 1 0.58 52.0 3.82e-01 100.0% 55.6%
4mt1A07 3.30.70.1440 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Multidrug efflux transporter AcrB pore domain 0.58 44.0 4.32e-01 95.7% 74.5%
3p96A02 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.58 40.0 4.18e-01 95.7% 79.8%
6n3dA01 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.58 44.0 4.54e-01 93.5% 87.2%
3e3pA01 3.30.200.20 Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1 0.58 41.0 4.39e-01 75.0% 91.0%
4hl9A00 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.58 44.0 4.41e-01 94.6% 79.8%
3s6eB00 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.57 44.0 4.17e-01 96.7% 69.4%
4c8yA01 3.30.70.1890 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.56 45.0 4.36e-01 94.6% 77.1%
2bbeA00 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.56 42.0 4.14e-01 94.6% 72.8%
3e8oB00 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.56 42.0 4.11e-01 93.5% 74.0%
2ffsA00 3.30.530.20 Alpha Beta › 2-Layer Sandwich › Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4 › START domain 0.56 47.0 4.10e-01 94.6% 94.5%
4qu6A01 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.55 42.0 4.24e-01 94.6% 83.3%
4o4bB00 3.30.470.160 Alpha Beta › 2-Layer Sandwich › D-amino Acid Aminotransferase; Chain A, domain 1 › Inositol polyphosphate kinase 0.55 48.0 3.57e-01 100.0% 82.4%
4dpoB00 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.55 42.0 4.10e-01 94.6% 75.2%
1iujA00 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.55 42.0 4.15e-01 94.6% 77.5%
1r89A03 3.30.70.590 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Poly(A) polymerase predicted RNA binding domain 0.54 44.0 3.93e-01 95.7% 61.9%
3w9iA06 3.30.70.1430 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Multidrug efflux transporter AcrB pore domain 0.54 45.0 4.44e-01 94.6% 85.3%
4xr7E01 1.10.510.10 Mainly Alpha › Orthogonal Bundle › Transferase(Phosphotransferase); domain 1 › Transferase(Phosphotransferase) domain 1 0.54 46.0 3.31e-01 100.0% 45.8%
3bdeB00 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.52 41.0 4.10e-01 94.6% 82.8%
1tr0A00 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.52 43.0 4.15e-01 94.6% 80.2%
1wh0A01 2.60.40.790 Mainly Beta › Sandwich › Immunoglobulin-like › 0.52 46.0 4.34e-01 96.7% 88.3%
3hx9B00 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.52 41.0 4.08e-01 94.6% 82.7%
2mobA00 3.90.56.10 Alpha Beta › Alpha-Beta Complex › Phenol Hydroxylase P2 Protein › Monooxygenase component MmoB/DmpM 0.52 42.0 4.24e-01 89.1% 94.7%
1xkpC00 3.30.1460.10 Alpha Beta › 2-Layer Sandwich › Yope Regulator; Chain: A, › 0.51 45.0 4.11e-01 100.0% 73.0%
4mt1A06 3.30.70.1430 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Multidrug efflux transporter AcrB pore domain 0.51 42.0 4.13e-01 94.6% 88.1%
5k9fA00 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.51 42.0 4.04e-01 94.6% 80.6%
3fpwA01 3.30.450.150 Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › Haem-degrading domain 0.50 37.0 3.42e-01 79.3% 83.2%
ECOD (91)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3614277 4014.1.1.1 a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV 0.90 67.0 5.20e-01 100.0% 39.4%
3188905 4014.1.1.1 a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV 0.87 72.0 5.59e-01 100.0% 43.9%
3096551 4014.1.1.1 a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV 0.81 69.0 5.34e-01 100.0% 44.9%
3932148 304.9.1.1 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.71 47.0 4.90e-01 95.7% 74.1%
3617026 206.1.1.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase 0.68 55.0 3.85e-01 88.0% 67.7%
3739160 304.9.1.1 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.67 47.0 4.59e-01 96.7% 67.0%
4104254 304.17.1.2 a+b two layers › Alpha-beta plaits › N-utilization substance G protein NusG, N-terminal domain › N-utilization substance G protein NusG, N-terminal domain › Spt5-NGN 0.66 46.0 4.47e-01 94.6% 63.8%
3486351 304.17.1.0 a+b two layers › Alpha-beta plaits › N-utilization substance G protein NusG, N-terminal domain › N-utilization substance G protein NusG, N-terminal domain 0.66 46.0 4.39e-01 94.6% 60.9%
3373813 219.1.1.0 a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases 0.66 55.0 3.42e-01 89.1% 40.8%
3863832 304.9.1.1 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.66 45.0 4.33e-01 94.6% 61.9%
4024263 4014.1.1.1 a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV 0.65 59.0 4.49e-01 100.0% 50.7%
3222428 206.1.1.20 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › PK_Tyr_Ser-Thr 0.65 54.0 3.83e-01 90.2% 69.6%
3924393 304.17.1.2 a+b two layers › Alpha-beta plaits › N-utilization substance G protein NusG, N-terminal domain › N-utilization substance G protein NusG, N-terminal domain › Spt5-NGN 0.65 46.0 4.54e-01 94.6% 68.0%
4999312 306.2.1.0 a+b two layers › Glucose permease domain IIB-like › arginine repressor C terminal domain-related › C-terminal domain of arginine repressor 0.65 51.0 5.09e-01 96.7% 81.1%
3700463 206.1.1.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase 0.65 54.0 3.78e-01 90.2% 70.7%
3699404 304.9.1.1 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.65 43.0 4.61e-01 94.6% 78.8%
3940307 304.17.1.2 a+b two layers › Alpha-beta plaits › N-utilization substance G protein NusG, N-terminal domain › N-utilization substance G protein NusG, N-terminal domain › Spt5-NGN 0.65 47.0 4.60e-01 95.7% 70.0%
3926163 206.1.1.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase 0.64 58.0 4.01e-01 100.0% 46.2%
3483586 206.1.1.0 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase 0.62 51.0 3.46e-01 90.2% 63.6%
3284662 304.4.1.4 a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel › ABM 0.62 47.0 4.75e-01 93.5% 81.1%
1178470 304.9.1.1 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.62 46.0 4.84e-01 93.5% 87.8%
3362205 206.1.1.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase 0.61 55.0 3.92e-01 100.0% 46.4%
3734198 304.9.1.0 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD 0.61 45.0 4.30e-01 94.6% 65.5%
3645166 206.1.1.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase 0.61 54.0 3.89e-01 98.9% 48.0%
4272563 305.1.1.1 a+b two layers › DCoH-like › RBP11-like subunits of RNA polymerase › RBP11-like subunits of RNA polymerase › RNA_pol_L 0.61 51.0 5.04e-01 100.0% 85.0%
3488012 206.1.1.0 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase 0.61 55.0 3.86e-01 100.0% 48.1%
5072410 306.6.1.6 a+b two layers › Glucose permease domain IIB-like › PH0987 N-terminal domain-like › PH0987 N-terminal domain-like › GH3_C 0.61 48.0 4.91e-01 98.9% 87.8%
3665483 206.1.1.20 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › PK_Tyr_Ser-Thr 0.61 53.0 3.61e-01 100.0% 43.1%
3707666 206.1.1.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase 0.61 55.0 3.75e-01 100.0% 42.4%
3607364 304.9.1.1 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.61 43.0 4.06e-01 94.6% 59.1%
3885537 327.16.1.0 a+b two layers › Alpha-lytic protease prodomain-like › Ring-building motif II in type III secretion system › Ring-building motif II in type III secretion system 0.61 44.0 4.83e-01 93.5% 93.3%
3363115 206.1.1.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase 0.61 54.0 3.85e-01 100.0% 47.0%
3264347 206.1.1.70 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase, ABC1 0.61 54.0 3.90e-01 100.0% 51.3%
3715910 206.1.1.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase 0.60 54.0 3.65e-01 100.0% 37.7%
3469996 206.1.1.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase 0.60 54.0 3.76e-01 100.0% 41.9%
4376910 305.1.1.0 a+b two layers › DCoH-like › RBP11-like subunits of RNA polymerase › RBP11-like subunits of RNA polymerase 0.60 53.0 5.27e-01 100.0% 93.7%
3177508 206.1.1.74 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase, PK_Tyr_Ser-Thr 0.60 53.0 3.64e-01 100.0% 50.6%
3994783 304.9.1.1 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.60 45.0 4.05e-01 94.6% 56.9%
None 0.60 52.0 3.61e-01 100.0% 43.3%
None 0.60 52.0 3.14e-01 100.0% 20.7%
3371886 206.1.1.0 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase 0.59 52.0 3.11e-01 100.0% 19.9%
3453348 206.1.1.0 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase 0.59 52.0 2.95e-01 100.0% 12.8%
None 0.59 52.0 2.97e-01 100.0% 14.5%
5072239 3501.1.1.0 a+b two layers › protein PCC1 › protein PCC1 › protein PCC1 0.59 42.0 4.30e-01 93.5% 76.7%
3435863 206.1.1.20 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › PK_Tyr_Ser-Thr 0.59 52.0 4.01e-01 100.0% 67.9%
3596486 206.1.1.71 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase, Kdo 0.59 52.0 3.64e-01 100.0% 41.3%
3669764 206.1.1.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase 0.59 52.0 3.53e-01 100.0% 43.4%
3614882 206.1.1.0 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase 0.59 53.0 3.72e-01 100.0% 48.5%
3462640 206.1.1.0 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase 0.59 51.0 2.87e-01 100.0% 11.0%
3631350 304.9.1.0 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD 0.59 45.0 4.43e-01 100.0% 76.0%
4004212 206.1.1.20 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › PK_Tyr_Ser-Thr 0.59 52.0 3.76e-01 100.0% 50.0%
3317877 206.1.1.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase 0.59 50.0 4.00e-01 96.7% 48.2%
3553717 206.1.1.76 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase, ABC1, Pkinase_fungal 0.59 52.0 3.63e-01 100.0% 44.8%
3272342 206.1.1.20 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › PK_Tyr_Ser-Thr 0.59 52.0 3.67e-01 100.0% 44.4%
3630348 206.1.1.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase 0.58 52.0 2.98e-01 100.0% 13.8%
3614305 206.1.1.71 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase, Kdo 0.58 51.0 3.40e-01 100.0% 34.7%
4139990 304.11.1.2 a+b two layers › Alpha-beta plaits › Probable ACP-binding domain of malonyl-CoA ACP transacylase › Probable ACP-binding domain of malonyl-CoA ACP transacylase › SAT 0.58 43.0 4.47e-01 97.8% 83.5%
4234725 304.28.1.4 a+b two layers › Alpha-beta plaits › Ferredoxin domains in multidrug efflux transporter › Multidrug efflux transporter AcrB pore domain › SecD_1st 0.58 44.0 4.44e-01 94.6% 80.0%
4854269 304.4.1.7 a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel › Cyclase_polyket 0.58 44.0 4.32e-01 95.7% 73.1%
4934427 304.109.1.4 a+b two layers › Alpha-beta plaits › Ribosomal proteins S24e, L23 and L15e › Ribosomal proteins S24e, L23 and L15e › Ribosomal_S24e 0.58 40.0 3.89e-01 70.7% 70.0%
4934933 304.102.1.2 a+b two layers › Alpha-beta plaits › Pseudouridine synthase › Pseudouridine synthase › TruD 0.58 51.0 3.88e-01 100.0% 85.3%
3658490 206.1.1.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase 0.58 50.0 3.92e-01 100.0% 66.0%
3688261 327.11.2.0 a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Eukaryotic type KH-domain (KH-domain type I) 0.58 43.0 4.22e-01 94.6% 74.0%
3180087 206.1.1.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase 0.58 51.0 3.52e-01 100.0% 40.3%
3619557 304.9.1.0 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD 0.58 44.0 4.14e-01 81.5% 90.0%
4928084 304.4.1.4 a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel › ABM 0.57 44.0 4.39e-01 93.5% 81.1%
3276016 206.1.1.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase 0.57 51.0 3.43e-01 100.0% 45.8%
3693170 304.8.1.0 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.56 37.0 4.04e-01 93.5% 82.7%
3647322 206.1.1.1 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase 0.56 47.0 3.98e-01 94.6% 84.4%
3738021 304.8.1.105 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › PF30953 0.56 42.0 3.85e-01 94.6% 60.8%
3595977 304.9.1.0 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD 0.56 42.0 4.30e-01 94.6% 84.4%
3424312 206.1.1.74 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase, PK_Tyr_Ser-Thr 0.56 49.0 3.52e-01 100.0% 38.4%
4591683 305.1.1.0 a+b two layers › DCoH-like › RBP11-like subunits of RNA polymerase › RBP11-like subunits of RNA polymerase 0.56 47.0 4.71e-01 95.7% 90.5%
3669930 304.8.1.0 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.56 43.0 4.46e-01 100.0% 91.8%
3932922 206.1.1.0 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase 0.56 49.0 3.44e-01 98.9% 51.8%
3647228 206.1.1.20 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › PK_Tyr_Ser-Thr 0.56 46.0 4.04e-01 95.7% 90.7%
4026995 304.9.1.1 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.55 45.0 4.33e-01 96.7% 78.1%
3990670 304.9.1.1 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.54 46.0 4.35e-01 96.7% 80.0%
3887323 304.9.1.0 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD 0.54 42.0 3.89e-01 96.7% 63.2%
3187311 304.9.1.0 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD 0.54 43.0 4.26e-01 96.7% 82.0%
5055367 304.12.1.0 a+b two layers › Alpha-beta plaits › Ribosomal protein S6 › Ribosomal protein S6 0.53 39.0 3.94e-01 78.3% 80.0%
3460420 304.51.1.0 a+b two layers › Alpha-beta plaits › CRISPR transcript (pre-crRNA) processing endoribonuclease-related › CRISPR transcript (pre-crRNA) processing endoribonuclease-related 0.53 44.0 4.22e-01 94.6% 80.0%
4026822 304.9.1.13 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › GUCT 0.53 44.0 4.27e-01 93.5% 83.8%
3937461 304.151.1.0 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain of receptor-type protein tyrosine phosphatase › Ferredoxin-like domain of receptor-type protein tyrosine phosphatase 0.53 44.0 4.20e-01 94.6% 83.6%
3405420 304.9.1.1 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.53 43.0 3.73e-01 97.8% 56.0%
3500837 206.1.1.20 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › PK_Tyr_Ser-Thr 0.52 46.0 4.12e-01 100.0% 83.0%
4019320 304.9.1.0 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD 0.52 44.0 4.36e-01 95.7% 91.0%
4024337 304.9.1.0 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD 0.52 43.0 4.11e-01 96.7% 78.2%
3279592 304.4.1.14 a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel › Dabb 0.52 42.0 3.79e-01 90.2% 94.6%
3434217 3887.2.1.1 a+b two layers › Yeast killer toxin-like › Antifungal protein ginkbilobin-2 › Antifungal protein ginkbilobin-2 › Stress-antifung 0.51 31.0 3.23e-01 100.0% 64.7%
3284008 304.4.1.57 a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel › MFS_3 0.50 39.0 3.80e-01 94.6% 75.2%