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DNA_topoisomerase_II
Euk-VirBrazilian_marseillevirus
DNA_topoisomerase_II__YP_009238657__Brazilian_marseillevirus__1813599
Identity
- Accession:
- YP_009238657 ↗
- Protein ID:
- DNA_topoisomerase_II
- Kingdom:
- euk
Quality
86.8
mean pLDDT
Taxonomy
Bamfordvirae›
Nucleocytoviricota›
Megaviricetes›
Pimascovirales›
Marseilleviridae›
Marseillevirus›
Brazilian_marseillevirus
TaxID: 1813599
Cluster
View cluster (39 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 79-218
D2
high
residues 253-399
Domain cluster:
rep: topoisomerase_IIA__YP_009001040__Pithovirus_sibericum__1450746__D250-321_335-390
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00204.32 best | DNA_gyraseB | 34.5 | 2.00e-08 | 98.0% | 55.8% |
D3
high
residues 417-546_585-608
Domain cluster:
rep: DNA_topoisomerase_2__YP_009162467__Salmon_gill_poxvirus__1680908__D385-517_553-621_640-664
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01751.29 best | Toprim | 35.6 | 1.20e-08 | 73.4% | 88.5% |
D4
high
residues 673-802
Domain cluster:
rep: DNA_topoisomerase_2__YP_009162467__Salmon_gill_poxvirus__1680908__D669-796
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00521.27 best | DNA_topoisoIV | 128.3 | 5.50e-37 | 100.0% | 28.8% |
D5
high
residues 968-1087
Domain cluster:
rep: putative_DNA_topoisomerase__YP_294202__Emiliania_huxleyi_virus_86__181082__D963-1088
CATH (63)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 8gccA03 | 1.10.268.10 | Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3 | 0.95 | 75.0 | 8.11e-01 | 80.8% | 100.0% |
| 1bgwA03 | 1.10.268.10 | Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3 | 0.93 | 69.0 | 7.25e-01 | 75.8% | 100.0% |
| 3qx3A04 | 1.10.268.10 | Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3 | 0.93 | 67.0 | 7.37e-01 | 74.2% | 100.0% |
| 2q0oC00 | 1.10.287.160 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat | 0.82 | 46.0 | 5.42e-01 | 85.8% | 77.9% |
| 1fioA00 | 1.20.58.70 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.82 | 51.0 | 4.21e-01 | 86.7% | 39.5% |
| 2oduA02 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.81 | 49.0 | 5.27e-01 | 85.8% | 70.5% |
| 2dq0A01 | 1.10.287.40 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain | 0.80 | 50.0 | 5.34e-01 | 86.7% | 71.0% |
| 2ot4A03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.80 | 48.0 | 5.06e-01 | 90.8% | 67.3% |
| 1qdbA02 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.78 | 47.0 | 4.42e-01 | 90.8% | 51.0% |
| 3lssA01 | 1.10.287.40 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain | 0.77 | 50.0 | 5.16e-01 | 85.8% | 69.6% |
| 6p73A02 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.77 | 46.0 | 4.37e-01 | 90.8% | 50.3% |
| 1zvuA03 | 1.10.268.10 | Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3 | 0.76 | 69.0 | 6.56e-01 | 97.5% | 85.7% |
| 2qywA00 | 1.20.58.400 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › t-snare proteins | 0.74 | 42.0 | 4.72e-01 | 86.7% | 70.5% |
| 1wncB00 | 1.20.5.300 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › | 0.74 | 41.0 | 4.94e-01 | 88.3% | 80.2% |
| 1oahA02 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.71 | 45.0 | 4.29e-01 | 88.3% | 54.2% |
| 1qu7A00 | 1.10.287.950 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Methyl-accepting chemotaxis protein | 0.71 | 48.0 | 3.83e-01 | 88.3% | 36.6% |
| 8a1gC01 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.70 | 44.0 | 3.79e-01 | 89.2% | 41.4% |
| 1jalA03 | 1.10.150.300 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Obg-related GTPase Ych/YyaF, coiled-coil domain | 0.69 | 35.0 | 4.12e-01 | 83.3% | 70.4% |
| 1quuA01 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.69 | 44.0 | 4.33e-01 | 89.2% | 60.3% |
| 6gy8A01 | 1.20.1170.10 | Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; › | 0.68 | 55.0 | 3.97e-01 | 86.7% | 84.3% |
| 3u0cA00 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.67 | 51.0 | 4.63e-01 | 87.5% | 61.6% |
| 6xkyA01 | 1.20.1330.10 | Mainly Alpha › Up-down Bundle › f41 fragment of flagellin, N-terminal domain › f41 fragment of flagellin, N-terminal domain | 0.67 | 55.0 | 4.69e-01 | 86.7% | 100.0% |
| 3lbxB01 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.65 | 39.0 | 4.11e-01 | 89.2% | 65.4% |
| 4u7iA00 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.65 | 37.0 | 4.13e-01 | 88.3% | 71.0% |
| 8b70A01 | 1.20.1740.10 | Mainly Alpha › Up-down Bundle › Amino acid/polyamine transporter I › Amino acid/polyamine transporter I | 0.65 | 51.0 | 3.54e-01 | 84.2% | 68.2% |
| 4issA02 | 1.20.58.1700 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.65 | 39.0 | 4.74e-01 | 78.3% | 94.7% |
| 6vq6H01 | 1.10.287.3240 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.63 | 53.0 | 4.28e-01 | 86.7% | 81.4% |
| 4cgkA01 | 6.10.250.3150 | Special › Helix non-globular › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › | 0.62 | 48.0 | 3.85e-01 | 86.7% | 44.4% |
| 1sziA02 | 1.20.120.340 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Flagellar protein FliS | 0.62 | 49.0 | 4.69e-01 | 83.3% | 97.1% |
| 3pe0A02 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.62 | 39.0 | 4.17e-01 | 84.2% | 72.6% |
| 3i01A01 | 1.20.1270.30 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.61 | 53.0 | 4.61e-01 | 92.5% | 78.5% |
| 2q12A00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.60 | 52.0 | 4.01e-01 | 90.8% | 67.8% |
| 4wpcA00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.60 | 53.0 | 3.88e-01 | 92.5% | 68.6% |
| 5wp3B00 | 1.10.132.20 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor | 0.59 | 37.0 | 3.96e-01 | 89.2% | 72.5% |
| 8ex5A02 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.59 | 48.0 | 3.88e-01 | 85.8% | 93.7% |
| 4mh6A00 | 1.10.287.1700 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.59 | 50.0 | 4.46e-01 | 87.5% | 78.6% |
| 2efkA01 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.59 | 52.0 | 3.92e-01 | 92.5% | 77.9% |
| 3g67A00 | 1.10.287.950 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Methyl-accepting chemotaxis protein | 0.58 | 49.0 | 3.99e-01 | 88.3% | 65.3% |
| 3ofnY00 | 1.10.287.80 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ATP synthase, gamma subunit, helix hairpin domain | 0.58 | 44.0 | 4.51e-01 | 88.3% | 83.5% |
| 4nqiD00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.57 | 49.0 | 3.90e-01 | 92.5% | 70.7% |
| 2oexA01 | 1.20.120.560 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › alix/aip1 in complex with the ypdl late domain | 0.57 | 42.0 | 3.95e-01 | 85.0% | 64.3% |
| 1kz7A01 | 1.20.900.10 | Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain | 0.56 | 47.0 | 3.95e-01 | 87.5% | 85.5% |
| 6xj1A01 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.56 | 50.0 | 3.85e-01 | 93.3% | 78.8% |
| 1pw4A01 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.56 | 48.0 | 3.99e-01 | 92.5% | 93.8% |
| 4e40A00 | 1.20.1260.80 | Mainly Alpha › Up-down Bundle › Ferritin › | 0.56 | 48.0 | 3.77e-01 | 92.5% | 73.1% |
| 8ek4A01 | 1.20.120.20 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein | 0.56 | 39.0 | 3.78e-01 | 92.5% | 64.7% |
| 2ch7A00 | 1.10.287.950 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Methyl-accepting chemotaxis protein | 0.55 | 47.0 | 3.41e-01 | 89.2% | 44.7% |
| 2b5uA02 | 1.10.287.620 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix Hairpins | 0.55 | 46.0 | 4.10e-01 | 86.7% | 80.7% |
| 3pltA00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.55 | 48.0 | 3.91e-01 | 92.5% | 68.2% |
| 4cbeA00 | 1.20.120.1640 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › | 0.55 | 45.0 | 3.82e-01 | 90.8% | 98.1% |
| 4im0A04 | 1.20.1270.420 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.55 | 48.0 | 3.78e-01 | 94.2% | 71.0% |
| 2hsbA00 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.54 | 34.0 | 3.43e-01 | 81.7% | 60.3% |
| 3cazB00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.54 | 47.0 | 3.84e-01 | 91.7% | 76.7% |
| 1mabG00 | 1.10.287.80 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ATP synthase, gamma subunit, helix hairpin domain | 0.54 | 42.0 | 4.22e-01 | 81.7% | 85.5% |
| 3zsuA00 | 1.20.120.290 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Oxygen-evolving enhancer protein 3 (PsbQ), four-helix up-down bundle | 0.54 | 43.0 | 4.34e-01 | 84.2% | 97.5% |
| 3ajwA00 | 1.10.287.1700 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.53 | 42.0 | 4.07e-01 | 87.5% | 75.4% |
| 2yyiA03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.52 | 40.0 | 3.38e-01 | 82.5% | 81.0% |
| 2oexA02 | 1.20.140.50 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › alix/aip1 like domains | 0.52 | 44.0 | 3.71e-01 | 90.8% | 73.6% |
| 1wpaA01 | 6.10.140.340 | Special › Helix non-globular › Helix Hairpins › | 0.52 | 40.0 | 4.36e-01 | 85.0% | 98.0% |
| 1h7cA00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.51 | 39.0 | 4.22e-01 | 90.0% | 92.2% |
| 5y06A01 | 1.10.287.1490 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.51 | 42.0 | 3.35e-01 | 86.7% | 46.3% |
| 2ix5A03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.51 | 46.0 | 4.25e-01 | 100.0% | 96.1% |
| 2au5A00 | 1.20.120.590 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › EF2947-like | 0.50 | 37.0 | 3.69e-01 | 78.3% | 89.1% |
ECOD (75)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3610015 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.97 | 94.0 | 8.21e-01 | 100.0% | 82.4% |
| 3652359 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.97 | 94.0 | 8.11e-01 | 100.0% | 74.7% |
| 3718739 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.96 | 93.0 | 8.14e-01 | 100.0% | 86.7% |
| 3789604 | 4016.1.1.0 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase | 0.96 | 93.0 | 8.44e-01 | 100.0% | 89.3% |
| 3600354 | 4016.1.1.0 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase | 0.96 | 92.0 | 8.42e-01 | 100.0% | 80.7% |
| 3768919 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.95 | 92.0 | 6.55e-01 | 100.0% | 52.0% |
| 3708939 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.95 | 91.0 | 8.22e-01 | 100.0% | 78.1% |
| 4238706 | 101.1.2.9 ↗ | alpha arrays › HTH › HTH › winged helix domain › DNA_topoisoIV | 0.95 | 91.0 | 6.49e-01 | 100.0% | 50.5% |
| 3508111 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.95 | 91.0 | 7.73e-01 | 100.0% | 89.4% |
| 3276180 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.94 | 91.0 | 7.45e-01 | 100.0% | 84.1% |
| 3634044 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.94 | 90.0 | 7.49e-01 | 100.0% | 81.1% |
| 3625174 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.94 | 90.0 | 7.22e-01 | 100.0% | 81.0% |
| 3630114 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.94 | 90.0 | 8.31e-01 | 100.0% | 92.4% |
| 3935542 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.93 | 90.0 | 8.19e-01 | 100.0% | 84.0% |
| 3096549 | 4016.1.1.0 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase | 0.91 | 87.0 | 7.62e-01 | 100.0% | 88.6% |
| 3220667 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.86 | 81.0 | 7.74e-01 | 99.2% | 95.6% |
| 4932829 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.85 | 79.0 | 7.33e-01 | 98.3% | 85.5% |
| 5083298 | 4016.1.1.0 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase | 0.84 | 78.0 | 7.17e-01 | 98.3% | 82.7% |
| 5024978 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.84 | 78.0 | 7.25e-01 | 98.3% | 85.5% |
| 4523639 | 5086.1.1.92 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › HH_AprE | 0.84 | 49.0 | 4.11e-01 | 86.7% | 37.4% |
| 1780091 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.84 | 78.0 | 7.01e-01 | 99.2% | 79.1% |
| 3833806 | 4016.1.1.0 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase | 0.83 | 68.0 | 6.31e-01 | 85.0% | 73.8% |
| 4299749 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.83 | 77.0 | 7.20e-01 | 99.2% | 86.2% |
| 1297277 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.83 | 77.0 | 6.62e-01 | 99.2% | 69.6% |
| 4373100 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.82 | 76.0 | 7.08e-01 | 98.3% | 85.5% |
| 4552385 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.82 | 77.0 | 6.96e-01 | 100.0% | 79.4% |
| 4043618 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.82 | 75.0 | 6.92e-01 | 98.3% | 82.7% |
| 3968781 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.81 | 48.0 | 4.47e-01 | 86.7% | 49.0% |
| 4946213 | 4016.1.1.18 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_gyraseA_C | 0.80 | 75.0 | 6.98e-01 | 100.0% | 84.8% |
| 4259224 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.79 | 50.0 | 4.51e-01 | 86.7% | 49.7% |
| 4218225 | 4016.1.1.1 ↗ | alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV | 0.79 | 73.0 | 6.65e-01 | 100.0% | 81.3% |
| 4883080 | 101.1.2.9 ↗ | alpha arrays › HTH › HTH › winged helix domain › DNA_topoisoIV | 0.78 | 71.0 | 6.88e-01 | 98.3% | 92.5% |
| 1760269 | 3567.1.1.0 ↗ | a+b duplicates or obligate multimers › MPER trimer › MPER trimer › MPER trimer | 0.74 | 43.0 | 4.41e-01 | 85.8% | 59.5% |
| 4024105 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.73 | 48.0 | 3.59e-01 | 86.7% | 28.7% |
| 5078867 | 603.1.1.0 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins | 0.71 | 38.0 | 4.36e-01 | 89.2% | 68.9% |
| 3569017 | 604.1.1.1 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin | 0.70 | 44.0 | 3.95e-01 | 87.5% | 46.3% |
| 3920125 | 3755.3.1.450 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › Uso1_p115_C | 0.69 | 50.0 | 4.16e-01 | 86.7% | 46.2% |
| 3305747 | 192.2.1.18 ↗ | alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin › ING | 0.65 | 50.0 | 4.75e-01 | 86.7% | 67.9% |
| 3763261 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.65 | 50.0 | 3.92e-01 | 85.8% | 42.7% |
| 3397986 | 3755.4.1.1 ↗ | alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › PI3K_P85_iSH2 | 0.64 | 50.0 | 4.29e-01 | 86.7% | 53.9% |
| 3715936 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.64 | 51.0 | 4.39e-01 | 86.7% | 56.6% |
| 3927148 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.62 | 48.0 | 3.81e-01 | 85.8% | 44.2% |
| 3964486 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.62 | 51.0 | 4.52e-01 | 88.3% | 63.1% |
| 3663497 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.61 | 50.0 | 4.52e-01 | 86.7% | 65.2% |
| 3838987 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.61 | 49.0 | 4.01e-01 | 85.0% | 49.5% |
| 3235307 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.60 | 50.0 | 3.44e-01 | 86.7% | 29.6% |
| 3962991 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.60 | 50.0 | 4.14e-01 | 85.8% | 53.8% |
| 3970727 | 192.2.1.0 ↗ | alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin | 0.60 | 50.0 | 4.80e-01 | 87.5% | 77.0% |
| 5056871 | 3755.4.1.0 ↗ | alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain | 0.60 | 50.0 | 3.53e-01 | 85.8% | 35.2% |
| 3598168 | 3755.1.1.0 ↗ | alpha bundles › YscO-like › Putative type III secretion protein YscO-related › Putative type III secretion protein YscO-related | 0.59 | 49.0 | 4.34e-01 | 86.7% | 62.4% |
| 3675423 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.59 | 47.0 | 4.21e-01 | 85.8% | 61.3% |
| 3858356 | 632.22.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats | 0.59 | 47.0 | 4.35e-01 | 85.8% | 67.6% |
| 3768341 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.59 | 55.0 | 4.46e-01 | 96.7% | 62.0% |
| 4629385 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.59 | 51.0 | 4.67e-01 | 89.2% | 76.7% |
| 5047670 | 3755.3.1.637 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › DUF7121 | 0.59 | 49.0 | 3.92e-01 | 85.8% | 65.1% |
| 4006117 | 3755.4.1.0 ↗ | alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain | 0.59 | 49.0 | 3.94e-01 | 85.8% | 65.2% |
| 3921802 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.59 | 50.0 | 4.43e-01 | 89.2% | 64.8% |
| 3920715 | 2004.1.1.674 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_21, AAA_23, SbcC_Walker_B | 0.58 | 49.0 | 3.11e-01 | 86.7% | 39.0% |
| 3702347 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.58 | 49.0 | 4.25e-01 | 87.5% | 83.4% |
| 3936511 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.58 | 48.0 | 3.16e-01 | 86.7% | 78.7% |
| 4001189 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.58 | 48.0 | 3.12e-01 | 85.8% | 23.7% |
| 5060002 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.58 | 49.0 | 4.25e-01 | 88.3% | 67.4% |
| 5033885 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.58 | 48.0 | 3.89e-01 | 85.8% | 51.2% |
| 5072280 | 4177.1.1.0 ↗ | alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like | 0.58 | 49.0 | 3.96e-01 | 89.2% | 71.6% |
| 4988997 | 192.2.1.0 ↗ | alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin | 0.58 | 45.0 | 3.86e-01 | 87.5% | 53.9% |
| 3976707 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.56 | 45.0 | 3.89e-01 | 86.7% | 99.0% |
| 4446434 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.55 | 45.0 | 4.25e-01 | 87.5% | 74.3% |
| 4431851 | 3922.1.1.0 ↗ | alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 | 0.54 | 39.0 | 3.87e-01 | 79.2% | 70.0% |
| 3594185 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.53 | 44.0 | 3.60e-01 | 85.8% | 79.5% |
| 3628940 | 3755.1.1.0 ↗ | alpha bundles › YscO-like › Putative type III secretion protein YscO-related › Putative type III secretion protein YscO-related | 0.53 | 43.0 | 4.51e-01 | 86.7% | 94.5% |
| 4983939 | 5059.1.1.1 ↗ | alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › EamA | 0.52 | 43.0 | 3.96e-01 | 84.2% | 82.1% |
| 3944338 | 3755.4.1.0 ↗ | alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain | 0.51 | 42.0 | 4.20e-01 | 88.3% | 86.7% |
| 3897636 | 3291.1.1.0 ↗ | alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related | 0.51 | 41.0 | 3.69e-01 | 85.0% | 65.6% |
| 3787685 | 3755.3.1.298 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › ING | 0.51 | 42.0 | 3.94e-01 | 88.3% | 84.8% |
| 3532021 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.50 | 40.0 | 3.95e-01 | 85.0% | 80.8% |
D6
medium
residues 16-78
D7
medium
residues 550-583
Domain cluster:
representative
D8
medium
residues 609-672
Domain cluster:
representative
CATH (8)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3kdqA00 | 6.10.320.10 | Special › Helix non-globular › Ferritin › | 0.60 | 42.0 | 3.21e-01 | 75.0% | 53.3% |
| 1oxjA02 | 1.25.40.170 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Smaug, PHAT domain | 0.56 | 44.0 | 3.88e-01 | 93.8% | 97.2% |
| 5lewA03 | 1.10.10.1600 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Bacterial DNA polymerase III alpha subunit, thumb domain | 0.53 | 39.0 | 3.79e-01 | 79.7% | 82.2% |
| 4mk3A02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.52 | 41.0 | 3.44e-01 | 87.5% | 50.4% |
| 3wqlA01 | 3.40.1180.10 | Alpha Beta › 3-Layer(aba) Sandwich › Undecaprenyl pyrophosphate synthetase › Decaprenyl diphosphate synthase-like | 0.52 | 41.0 | 2.94e-01 | 98.4% | 25.4% |
| 2wg7A00 | 1.20.90.10 | Mainly Alpha › Up-down Bundle › Phospholipase A2 › Phospholipase A2 domain | 0.51 | 44.0 | 3.67e-01 | 100.0% | 82.6% |
| 1iyhB02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.51 | 40.0 | 3.50e-01 | 90.6% | 56.5% |
| 4gouA03 | 1.20.900.10 | Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain | 0.51 | 42.0 | 3.05e-01 | 95.3% | 60.4% |
ECOD (20)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3817446 | 2006.1.3.21 ↗ | a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain › TOPRIM_C | 0.85 | 76.0 | 5.36e-01 | 96.9% | 35.0% |
| 4205259 | 109.4.1.2 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Arm | 0.65 | 54.0 | 3.36e-01 | 96.9% | 19.8% |
| 3373080 | 109.4.1.1854 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PF28619, PF28652, PF28655 | 0.63 | 48.0 | 2.94e-01 | 87.5% | 17.7% |
| 3440506 | 109.4.1.541 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › DUF4220 | 0.60 | 49.0 | 3.45e-01 | 98.4% | 90.8% |
| 3266520 | 192.9.1.3 ↗ | alpha bundles › Long alpha-hairpin › Sporulation inhibitor Sda › Sporulation inhibitor Sda › DUF4326 | 0.58 | 44.0 | 4.74e-01 | 89.1% | 100.0% |
| 3710421 | 603.1.1.0 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins | 0.57 | 45.0 | 3.55e-01 | 92.2% | 71.0% |
| 3673142 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.57 | 46.0 | 2.99e-01 | 96.9% | 61.3% |
| 3399345 | 109.4.1.130 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PHAT | 0.56 | 45.0 | 3.91e-01 | 95.3% | 99.1% |
| 5028980 | 3883.1.1.1 ↗ | alpha bundles › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-OH_P_transf | 0.55 | 41.0 | 3.02e-01 | 84.4% | 38.0% |
| 3714993 | 2498.1.1.0 ↗ | mixed a+b and a/b › Zincin-like › "Metalloproteases (""zincins"") catalytic domain" › "Metalloproteases (""zincins"") catalytic domain" | 0.54 | 47.0 | 3.26e-01 | 98.4% | 68.9% |
| 3352878 | 170.2.1.0 ↗ | alpha bundles › Retrovirus capsid protein › Retrovirus capsid protein N-terminal domain › Retrovirus capsid protein N-terminal domain | 0.53 | 36.0 | 3.23e-01 | 71.9% | 99.0% |
| 3926959 | 605.6.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › HP1531-like › HP1531-like | 0.53 | 39.0 | 3.60e-01 | 87.5% | 60.0% |
| 4857956 | 3995.1.1.0 ↗ | alpha bundles › Vesicular stomatitis virus L polymerase connector domain › Vesicular stomatitis virus L polymerase connector domain › Vesicular stomatitis virus L polymerase connector domain | 0.53 | 39.0 | 3.13e-01 | 78.1% | 67.9% |
| 4192 | 4970.1.1.0 ↗ | alpha bundles › fingers domain in bacteriophage RB69-like DNA polymerase I › fingers domain in bacteriophage RB69-like DNA polymerase I › fingers domain in bacteriophage RB69-like DNA polymerase I | 0.53 | 39.0 | 3.36e-01 | 98.4% | 49.1% |
| 3309008 | 375.1.1.246 ↗ | few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related › Rad50_zn_hook | 0.53 | 37.0 | 3.18e-01 | 73.4% | 95.2% |
| 4988993 | 5086.1.1.231 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › Rad50_zn_hook | 0.52 | 41.0 | 3.14e-01 | 85.9% | 90.0% |
| 5029796 | 192.2.1.0 ↗ | alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin | 0.52 | 36.0 | 2.96e-01 | 73.4% | 81.7% |
| 3440540 | 192.15.1.180 ↗ | alpha bundles › Long alpha-hairpin › Endosomal sorting complex assembly domains › Endosomal sorting complex assembly domains › Sec10_HB, Sec10_N | 0.52 | 43.0 | 3.47e-01 | 96.9% | 69.6% |
| 3642338 | 3567.1.1.0 ↗ | a+b duplicates or obligate multimers › MPER trimer › MPER trimer › MPER trimer | 0.51 | 35.0 | 3.35e-01 | 71.9% | 80.0% |
| 3244401 | 192.2.1.0 ↗ | alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin | 0.50 | 35.0 | 2.94e-01 | 73.4% | 77.4% |