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DNA_topoisomerase_II

Euk-Vir

Tunisvirus_fontaine2

DNA_topoisomerase_II__YP_009506801__Tunisvirus_fontaine2__1421067

Identity

Accession:
YP_009506801 ↗
Protein ID:
DNA_topoisomerase_II
Kingdom:
euk

Quality

85.7 mean pLDDT

Taxonomy

Bamfordvirae› Nucleocytoviricota› Megaviricetes› Pimascovirales› Marseilleviridae› Losannavirus› Tunisvirus_fontaine2

TaxID: 1421067

Cluster

View cluster (39 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 37-144_173-263
PDB
Domain cluster: rep: SR-VP_2-4_scaffold_141_2548329_prodigal-single.1__X__X__00037__D32-204
CATH (12)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1pvgA01 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.90 88.0 8.08e-01 100.0% 87.3%
1s14B00 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.89 69.0 7.28e-01 100.0% 88.2%
1aj6A00 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.81 68.0 6.92e-01 100.0% 88.1%
3cwvA01 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.75 64.0 6.48e-01 100.0% 87.9%
2o1uB01 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.74 56.0 6.13e-01 81.9% 93.3%
1h7sA01 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.73 58.0 5.97e-01 99.0% 85.0%
1y4uB01 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.71 58.0 5.96e-01 100.0% 87.6%
1b63A01 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.68 58.0 5.67e-01 100.0% 81.9%
1nijA02 3.30.1220.10 Alpha Beta › 2-Layer Sandwich › Hypothetical Protein Yjia; Chain: A;domain 2 › CobW-like, C-terminal domain 0.62 31.0 3.95e-01 84.9% 80.2%
1aroP05 1.10.150.20 Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › 5' to 3' exonuclease, C-terminal subdomain 0.52 27.0 2.70e-01 93.5% 45.0%
4djbA00 3.30.70.2870 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Mastadenovirus E4 ORF3 0.52 27.0 3.47e-01 75.4% 84.7%
4k15A00 2.60.40.3860 Mainly Beta › Sandwich › Immunoglobulin-like › 0.50 25.0 2.98e-01 82.9% 68.1%
ECOD (34)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3789605 225.1.1.0 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 0.90 88.0 8.02e-01 100.0% 87.8%
4617838 225.1.1.3 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c 0.89 87.0 7.97e-01 100.0% 88.2%
3594649 225.1.1.0 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 0.89 87.0 7.97e-01 100.0% 88.2%
3998214 225.1.1.3 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c 0.89 87.0 7.83e-01 100.0% 83.5%
4875911 225.1.1.3 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c 0.87 85.0 7.57e-01 100.0% 86.6%
3461648 225.1.1.0 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 0.87 85.0 7.87e-01 100.0% 89.6%
3317524 225.1.1.0 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 0.84 68.0 6.61e-01 83.4% 93.6%
4945731 225.1.1.38 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › DNA_gyraseB 0.78 70.0 6.61e-01 100.0% 79.6%
3198261 225.1.1.0 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 0.75 61.0 6.26e-01 82.4% 94.7%
3542858 225.1.1.13 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HSP90 0.72 59.0 5.61e-01 100.0% 73.8%
3530518 225.1.1.7 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.70 61.0 6.12e-01 100.0% 89.0%
4943430 225.1.1.39 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › DNA_mis_repair 0.70 58.0 6.06e-01 98.5% 91.9%
4453541 225.1.1.7 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.69 60.0 5.87e-01 100.0% 83.8%
4273009 225.1.1.7 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.69 57.0 5.87e-01 98.0% 88.9%
3974412 225.1.1.7 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.69 60.0 5.97e-01 100.0% 87.8%
3377134 225.1.1.0 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 0.69 50.0 5.73e-01 95.0% 98.7%
4030281 225.1.1.7 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.69 59.0 5.44e-01 100.0% 72.2%
4233929 225.1.1.7 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.69 59.0 5.64e-01 100.0% 78.7%
4404190 225.1.1.7 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.68 58.0 5.58e-01 100.0% 78.7%
3595333 225.1.1.0 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 0.67 61.0 5.93e-01 100.0% 87.8%
4076203 225.1.1.7 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.65 60.0 5.49e-01 100.0% 76.8%
3716539 225.1.1.7 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.65 61.0 5.70e-01 100.0% 82.1%
None — 0.65 58.0 5.74e-01 100.0% 89.9%
4029843 212.1.1.0 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like 0.64 58.0 5.49e-01 100.0% 80.8%
3308932 225.1.1.7 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.64 60.0 5.56e-01 100.0% 81.7%
3421099 225.1.1.2 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HSP90,HATPase_c_3 0.64 60.0 5.35e-01 100.0% 74.0%
3902919 225.1.1.2 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HSP90,HATPase_c_3 0.64 59.0 5.43e-01 100.0% 78.8%
3169949 225.1.1.7 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.64 57.0 5.49e-01 98.5% 84.1%
None — 0.62 58.0 5.63e-01 100.0% 90.9%
3461740 884.1.1.1 ↗ a+b two layers › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › CobW_C 0.61 30.0 4.15e-01 77.4% 92.9%
3313688 884.1.1.1 ↗ a+b two layers › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › CobW_C 0.61 30.0 4.12e-01 78.9% 92.0%
3621921 327.11.2.0 ↗ a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Eukaryotic type KH-domain (KH-domain type I) 0.55 22.0 3.37e-01 77.4% 93.2%
5055086 10.1.2.0 ↗ beta sandwiches › jelly-roll › Concanavalin A-like › GOLD domain-like (DEPRECATED) 0.51 24.0 3.32e-01 70.9% 88.4%
5083968 10.1.2.0 ↗ beta sandwiches › jelly-roll › Concanavalin A-like › GOLD domain-like (DEPRECATED) 0.51 30.0 3.64e-01 72.4% 90.4%
D2 high residues 273-419
PDB
Domain cluster: rep: topoisomerase_IIA__YP_009001040__Pithovirus_sibericum__1450746__D250-321_335-390
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00204.32 best DNA_gyraseB 34.7 1.70e-08 94.6% 54.6%
D3 high residues 437-564_622-687
PDB
Domain cluster: rep: DNA_topoisomerase_2__YP_009162467__Salmon_gill_poxvirus__1680908__D385-517_553-621_640-664
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF01751.29 best Toprim 32.9 8.20e-08 58.8% 88.5%
PF16898.11 TOPRIM_C 30.0 7.60e-07 37.6% 54.7%
D4 high residues 698-867
PDB
Domain cluster: rep: DNA_topoisomerase_2__YP_009162467__Salmon_gill_poxvirus__1680908__D669-796
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00521.27 best DNA_topoisoIV 179.9 1.10e-52 100.0% 37.6%
D5 high residues 876-961
PDB
Domain cluster: rep: IMGVR_UViG_3300007985_000017-3300007985-Ga0100381_100027569__D212-299
CATH (90)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3qx3B03 3.30.1360.40 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › 0.94 90.0 8.47e-01 100.0% 95.0%
3l4jA04 3.30.1360.40 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › 0.94 90.0 8.41e-01 100.0% 95.1%
8gccA02 3.30.1360.40 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › 0.94 83.0 8.34e-01 91.9% 100.0%
3lpxB02 3.30.1360.40 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › 0.82 72.0 7.00e-01 94.2% 96.8%
6bq9A02 3.30.1360.40 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › 0.78 67.0 6.54e-01 94.2% 96.8%
7qh2C03 3.30.70.2740 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.74 53.0 5.57e-01 75.6% 96.2%
2yweA03 3.30.70.870 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Elongation Factor G (Translational Gtpase), domain 3 0.71 52.0 5.29e-01 75.6% 86.6%
2pa8D01 3.30.1360.10 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › RNA polymerase, RBP11-like subunit 0.71 53.0 5.33e-01 80.2% 78.4%
1xppD00 3.30.1360.10 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › RNA polymerase, RBP11-like subunit 0.70 54.0 5.17e-01 82.6% 72.3%
1y0hB00 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.69 50.0 4.85e-01 76.7% 80.6%
4aybL00 3.30.1360.10 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › RNA polymerase, RBP11-like subunit 0.69 52.0 5.17e-01 81.4% 80.2%
2phcB01 3.30.1360.40 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › 0.69 54.0 5.57e-01 83.7% 97.6%
6ruiK00 3.30.1360.10 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › RNA polymerase, RBP11-like subunit 0.69 55.0 5.25e-01 88.4% 79.6%
3onqA02 3.30.70.2730 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.68 50.0 5.16e-01 77.9% 85.2%
1i6uA01 3.30.1370.30 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › 0.68 51.0 5.74e-01 82.6% 100.0%
3znuA00 3.30.70.1060 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Dimeric alpha+beta barrel 0.68 48.0 4.73e-01 74.4% 79.8%
2kwaA00 3.30.1360.40 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › 0.67 54.0 5.18e-01 88.4% 94.1%
5w2fA01 3.30.780.10 Alpha Beta › 2-Layer Sandwich › Translation Initiation Factor Eif1 › SUI1-like domain 0.67 52.0 5.29e-01 83.7% 89.5%
6lpnA04 3.30.70.2740 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.67 50.0 4.88e-01 79.1% 80.0%
4pcqA02 3.30.70.920 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Lrp/AsnC effector binding domain/regulation of amino acid metabolism (RAM) domain 0.67 47.0 4.80e-01 73.3% 79.8%
1cc8A00 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.67 46.0 4.98e-01 74.4% 84.7%
5xogK00 3.30.1360.10 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › RNA polymerase, RBP11-like subunit 0.67 57.0 5.20e-01 93.0% 70.8%
6gmhK00 3.30.1360.10 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › RNA polymerase, RBP11-like subunit 0.66 55.0 5.02e-01 91.9% 69.6%
1dcoA00 3.30.1360.20 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › Transcriptional coactivator/pterin dehydratase 0.66 51.0 4.88e-01 83.7% 82.8%
2ebbA00 3.30.1360.20 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › Transcriptional coactivator/pterin dehydratase 0.66 51.0 4.97e-01 84.9% 84.4%
2efpA02 3.30.70.920 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Lrp/AsnC effector binding domain/regulation of amino acid metabolism (RAM) domain 0.66 46.0 4.43e-01 73.3% 69.4%
2b4vA03 3.30.70.1970 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.65 48.0 4.61e-01 77.9% 71.7%
1zpvA00 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.65 47.0 4.79e-01 76.7% 84.7%
2kjwA00 3.30.70.60 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Ribosomal protein S6/Translation elongation factor EF1B 0.65 47.0 4.60e-01 76.7% 74.0%
1usmA00 3.30.1360.20 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › Transcriptional coactivator/pterin dehydratase 0.65 49.0 5.17e-01 81.4% 100.0%
4h5bA00 3.30.1460.70 Alpha Beta › 2-Layer Sandwich › Yope Regulator; Chain: A, › 0.65 51.0 4.23e-01 84.9% 65.8%
2cg4A02 3.30.70.920 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Lrp/AsnC effector binding domain/regulation of amino acid metabolism (RAM) domain 0.65 46.0 4.70e-01 74.4% 81.0%
4d9uA01 3.30.200.20 Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1 0.65 47.0 4.70e-01 79.1% 75.0%
2p92A00 3.30.70.1490 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Cysteine protease Prp 0.64 52.0 5.04e-01 88.4% 90.5%
1ygyA04 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.64 45.0 4.76e-01 74.4% 84.2%
4o1pD02 1.10.510.10 Mainly Alpha › Orthogonal Bundle › Transferase(Phosphotransferase); domain 1 › Transferase(Phosphotransferase) domain 1 0.64 49.0 3.55e-01 83.7% 53.6%
1m1hA01 3.30.70.940 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › NusG, N-terminal domain 0.63 44.0 4.26e-01 73.3% 69.0%
4qmfB01 3.30.1370.10 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › K Homology domain, type 1 0.63 45.0 4.62e-01 75.6% 86.6%
2bujB01 3.30.200.20 Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1 0.63 44.0 4.35e-01 73.3% 73.4%
2dbbA02 3.30.70.920 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Lrp/AsnC effector binding domain/regulation of amino acid metabolism (RAM) domain 0.63 45.0 4.41e-01 74.4% 71.0%
3p96A02 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.63 45.0 4.56e-01 75.6% 83.3%
3tviA02 3.30.2130.10 Alpha Beta › 2-Layer Sandwich › VC0802-like › VC0802-like 0.63 49.0 4.04e-01 84.9% 95.0%
1dq3A04 3.10.28.10 Alpha Beta › Roll › Endonuclease I-creI › Homing endonucleases 0.63 46.0 4.26e-01 79.1% 63.2%
4v1al00 3.30.780.10 Alpha Beta › 2-Layer Sandwich › Translation Initiation Factor Eif1 › SUI1-like domain 0.63 54.0 4.72e-01 96.5% 81.2%
4g6tA00 3.30.1460.10 Alpha Beta › 2-Layer Sandwich › Yope Regulator; Chain: A, › 0.62 47.0 4.15e-01 81.4% 69.5%
1qupA01 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.62 44.0 4.75e-01 74.4% 90.0%
3v2uC02 3.30.70.3170 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.62 45.0 4.44e-01 77.9% 82.1%
2m9kA00 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.62 46.0 4.48e-01 77.9% 73.1%
2x7gA01 3.30.200.20 Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1 0.62 44.0 4.40e-01 74.4% 77.3%
3zxoA00 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.61 46.0 4.12e-01 81.4% 91.2%
6n3dA01 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.61 45.0 4.50e-01 76.7% 89.5%
3s6eB00 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.61 46.0 4.26e-01 80.2% 71.2%
2j0wA03 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.61 47.0 4.83e-01 83.7% 93.8%
5mmiU01 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.61 43.0 4.47e-01 75.6% 93.9%
2cdqA03 3.30.70.260 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain 0.61 51.0 5.20e-01 94.2% 97.6%
3c1mA02 3.30.2130.10 Alpha Beta › 2-Layer Sandwich › VC0802-like › VC0802-like 0.60 47.0 3.89e-01 86.0% 96.3%
3i4pA02 3.30.70.920 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Lrp/AsnC effector binding domain/regulation of amino acid metabolism (RAM) domain 0.60 43.0 4.35e-01 74.4% 79.8%
4lowA00 3.30.1360.20 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › Transcriptional coactivator/pterin dehydratase 0.60 51.0 5.22e-01 95.3% 98.8%
1a9nD00 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.60 44.0 4.36e-01 79.1% 81.7%
2hfsA02 3.30.70.890 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › GHMP kinase, C-terminal domain 0.60 43.0 3.62e-01 74.4% 89.7%
5i2cB01 3.30.2130.10 Alpha Beta › 2-Layer Sandwich › VC0802-like › VC0802-like 0.60 46.0 3.91e-01 82.6% 92.5%
4js8A01 3.30.200.20 Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1 0.60 48.0 4.76e-01 86.0% 83.1%
5mmjh01 3.30.1370.30 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › 0.60 48.0 5.11e-01 84.9% 100.0%
2qmaA02 3.90.1150.10 Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 0.60 46.0 4.15e-01 84.9% 64.8%
1i94H01 3.30.1370.30 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › 0.60 47.0 4.98e-01 83.7% 100.0%
2f9jA01 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.59 44.0 4.58e-01 79.1% 86.3%
1vqyB01 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.59 43.0 4.20e-01 76.7% 89.5%
5ixuA00 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.59 42.0 4.03e-01 75.6% 82.4%
5k9fA00 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.59 42.0 4.02e-01 75.6% 82.5%
4c57B00 1.10.510.10 Mainly Alpha › Orthogonal Bundle › Transferase(Phosphotransferase); domain 1 › Transferase(Phosphotransferase) domain 1 0.59 51.0 3.55e-01 98.8% 56.2%
5ylyA01 2.40.30.10 Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › Translation factors 0.59 45.0 4.16e-01 82.6% 83.9%
1q9uA00 3.30.310.70 Alpha Beta › 2-Layer Sandwich › TATA-Binding Protein › TT1751-like domain 0.58 42.0 3.69e-01 75.6% 100.0%
4e1oA03 3.90.1150.10 Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 0.58 45.0 4.39e-01 86.0% 82.7%
4g1vA02 2.40.30.10 Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › Translation factors 0.58 46.0 4.13e-01 84.9% 83.9%
1kzlA02 2.40.30.20 Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › 0.58 45.0 4.27e-01 82.6% 79.2%
1cqxA02 2.40.30.10 Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › Translation factors 0.57 45.0 4.17e-01 84.9% 82.9%
2eixA01 2.40.30.10 Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › Translation factors 0.57 45.0 4.19e-01 83.7% 82.1%
7ylrA01 2.40.30.10 Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › Translation factors 0.57 45.0 4.25e-01 84.9% 90.5%
6k2lA01 2.40.30.10 Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › Translation factors 0.57 43.0 3.99e-01 81.4% 89.2%
2m8hA00 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.55 45.0 4.34e-01 95.3% 78.2%
2plgA01 3.30.1460.10 Alpha Beta › 2-Layer Sandwich › Yope Regulator; Chain: A, › 0.55 41.0 3.66e-01 82.6% 72.0%
6hhnA01 3.30.70.100 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.55 39.0 3.90e-01 76.7% 91.3%
1wjwA01 3.30.310.50 Alpha Beta › 2-Layer Sandwich › TATA-Binding Protein › Alpha-D-phosphohexomutase, C-terminal domain 0.55 38.0 3.87e-01 74.4% 96.5%
2zqeA00 3.30.1370.110 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › 0.54 41.0 4.29e-01 81.4% 95.0%
2ab5B01 3.10.28.10 Alpha Beta › Roll › Endonuclease I-creI › Homing endonucleases 0.54 38.0 3.44e-01 76.7% 63.3%
3kmuA01 3.30.200.20 Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1 0.53 40.0 4.04e-01 84.9% 81.6%
1x19A02 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.53 40.0 3.26e-01 80.2% 85.6%
3hbxA03 3.90.1150.160 Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › 0.53 45.0 4.49e-01 98.8% 97.7%
3pieA02 3.30.1370.250 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › 0.52 40.0 3.84e-01 84.9% 98.0%
2awnC03 2.40.50.140 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins 0.51 27.0 3.09e-01 82.6% 70.7%
ECOD (94)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3719735 4014.1.1.1 ↗ a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV 0.95 91.0 7.04e-01 100.0% 57.0%
2390536 4014.1.1.1 ↗ a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV 0.94 85.0 6.62e-01 94.2% 55.6%
3998667 4014.1.1.1 ↗ a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV 0.93 89.0 6.56e-01 100.0% 52.8%
3789606 4014.1.1.0 ↗ a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase 0.92 88.0 6.78e-01 100.0% 58.2%
3594650 4014.1.1.0 ↗ a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase 0.92 87.0 6.89e-01 100.0% 56.9%
3277529 4014.1.1.1 ↗ a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV 0.92 88.0 6.88e-01 100.0% 58.7%
3614277 4014.1.1.1 ↗ a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV 0.90 85.0 6.48e-01 100.0% 50.6%
4878007 101.1.2.9 ↗ alpha arrays › HTH › HTH › winged helix domain › DNA_topoisoIV 0.90 82.0 6.73e-01 95.3% 64.8%
4887990 4014.1.1.1 ↗ a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV 0.90 85.0 6.71e-01 100.0% 58.4%
3220665 4014.1.1.1 ↗ a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV 0.87 82.0 6.32e-01 100.0% 58.9%
4266765 4014.1.1.1 ↗ a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV 0.83 77.0 6.09e-01 100.0% 59.4%
4624017 4014.1.1.1 ↗ a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV 0.83 77.0 5.91e-01 100.0% 58.3%
5052421 305.1.1.2 ↗ a+b two layers › DCoH-like › RBP11-like subunits of RNA polymerase › RBP11-like subunits of RNA polymerase › RNA_pol_L_2 0.75 59.0 5.75e-01 84.9% 83.2%
3602746 304.8.1.0 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.73 53.0 5.53e-01 76.7% 86.3%
5066723 305.1.1.0 ↗ a+b two layers › DCoH-like › RBP11-like subunits of RNA polymerase › RBP11-like subunits of RNA polymerase 0.72 55.0 5.33e-01 81.4% 75.8%
3833178 304.8.1.0 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.72 57.0 5.91e-01 84.9% 97.5%
5046913 3016.1.1.0 ↗ a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases 0.72 58.0 5.47e-01 87.2% 79.6%
4954138 305.1.1.2 ↗ a+b two layers › DCoH-like › RBP11-like subunits of RNA polymerase › RBP11-like subunits of RNA polymerase › RNA_pol_L_2 0.71 54.0 5.46e-01 81.4% 85.9%
3253387 305.1.1.2 ↗ a+b two layers › DCoH-like › RBP11-like subunits of RNA polymerase › RBP11-like subunits of RNA polymerase › RNA_pol_L_2 0.71 56.0 5.48e-01 86.0% 85.3%
3290652 306.2.1.0 ↗ a+b two layers › Glucose permease domain IIB-like › arginine repressor C terminal domain-related › C-terminal domain of arginine repressor 0.71 57.0 5.66e-01 86.0% 86.7%
3807910 304.8.1.45 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant 0.71 55.0 5.73e-01 83.7% 97.5%
4386736 305.1.1.2 ↗ a+b two layers › DCoH-like › RBP11-like subunits of RNA polymerase › RBP11-like subunits of RNA polymerase › RNA_pol_L_2 0.71 54.0 5.27e-01 81.4% 78.5%
3452017 304.8.1.0 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.71 56.0 5.85e-01 86.0% 97.5%
4951755 305.1.1.2 ↗ a+b two layers › DCoH-like › RBP11-like subunits of RNA polymerase › RBP11-like subunits of RNA polymerase › RNA_pol_L_2 0.70 53.0 5.41e-01 81.4% 84.7%
4618856 305.1.1.2 ↗ a+b two layers › DCoH-like › RBP11-like subunits of RNA polymerase › RBP11-like subunits of RNA polymerase › RNA_pol_L_2 0.70 54.0 5.16e-01 82.6% 73.0%
3818197 304.8.1.0 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.70 54.0 5.72e-01 81.4% 100.0%
5040160 305.1.1.2 ↗ a+b two layers › DCoH-like › RBP11-like subunits of RNA polymerase › RBP11-like subunits of RNA polymerase › RNA_pol_L_2 0.70 55.0 5.26e-01 84.9% 76.0%
5054002 305.1.1.2 ↗ a+b two layers › DCoH-like › RBP11-like subunits of RNA polymerase › RBP11-like subunits of RNA polymerase › RNA_pol_L_2 0.69 52.0 5.33e-01 81.4% 85.0%
3660837 304.8.1.0 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.69 54.0 5.43e-01 83.7% 96.5%
4932521 305.1.1.0 ↗ a+b two layers › DCoH-like › RBP11-like subunits of RNA polymerase › RBP11-like subunits of RNA polymerase 0.68 51.0 5.10e-01 79.1% 78.4%
4936622 305.1.1.1 ↗ a+b two layers › DCoH-like › RBP11-like subunits of RNA polymerase › RBP11-like subunits of RNA polymerase › RNA_pol_L 0.68 52.0 5.12e-01 82.6% 78.9%
5035806 305.1.1.2 ↗ a+b two layers › DCoH-like › RBP11-like subunits of RNA polymerase › RBP11-like subunits of RNA polymerase › RNA_pol_L_2 0.68 53.0 5.30e-01 84.9% 83.3%
5046930 305.1.1.2 ↗ a+b two layers › DCoH-like › RBP11-like subunits of RNA polymerase › RBP11-like subunits of RNA polymerase › RNA_pol_L_2 0.68 52.0 5.03e-01 81.4% 75.8%
4273759 305.1.1.2 ↗ a+b two layers › DCoH-like › RBP11-like subunits of RNA polymerase › RBP11-like subunits of RNA polymerase › RNA_pol_L_2 0.68 54.0 5.18e-01 91.9% 74.7%
3345132 304.8.1.45 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant 0.68 60.0 5.43e-01 97.7% 93.9%
3285929 304.8.1.0 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.68 56.0 5.57e-01 90.7% 97.8%
4358940 304.8.1.21 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › ACT_9 0.68 50.0 5.03e-01 77.9% 85.9%
4138832 304.8.1.2 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › ACT 0.68 53.0 5.25e-01 83.7% 93.3%
4458219 304.102.1.2 ↗ a+b two layers › Alpha-beta plaits › Pseudouridine synthase › Pseudouridine synthase › TruD 0.67 53.0 4.09e-01 86.0% 90.8%
3438815 304.8.1.45 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant 0.67 54.0 5.43e-01 87.2% 95.3%
3445077 304.8.1.0 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.67 52.0 5.34e-01 84.9% 97.6%
4945349 304.4.1.0 ↗ a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel 0.67 48.0 4.69e-01 75.6% 82.1%
3367362 304.8.1.45 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant 0.67 51.0 5.32e-01 82.6% 100.0%
3713330 305.2.1.1 ↗ a+b two layers › DCoH-like › Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH) › Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH) › Pterin_4a 0.67 52.0 4.70e-01 84.9% 74.2%
3298082 304.8.1.45 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant 0.67 53.0 5.24e-01 87.2% 88.2%
3252217 305.1.1.2 ↗ a+b two layers › DCoH-like › RBP11-like subunits of RNA polymerase › RBP11-like subunits of RNA polymerase › RNA_pol_L_2 0.67 57.0 5.15e-01 93.0% 69.6%
3998431 306.3.1.1 ↗ a+b two layers › Glucose permease domain IIB-like › eIF1-like › eIF1-like › SUI1 0.66 53.0 4.94e-01 87.2% 72.7%
3318862 304.8.1.45 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant 0.66 52.0 5.26e-01 86.0% 91.8%
3675774 304.8.1.45 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant 0.66 52.0 5.28e-01 86.0% 96.5%
3171307 306.3.1.1 ↗ a+b two layers › Glucose permease domain IIB-like › eIF1-like › eIF1-like › SUI1 0.66 55.0 4.98e-01 90.7% 72.2%
3551826 305.1.1.2 ↗ a+b two layers › DCoH-like › RBP11-like subunits of RNA polymerase › RBP11-like subunits of RNA polymerase › RNA_pol_L_2 0.66 55.0 5.01e-01 93.0% 68.7%
3719440 305.1.1.2 ↗ a+b two layers › DCoH-like › RBP11-like subunits of RNA polymerase › RBP11-like subunits of RNA polymerase › RNA_pol_L_2 0.66 55.0 4.83e-01 91.9% 62.4%
3364258 304.8.1.45 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant 0.66 51.0 5.11e-01 84.9% 97.7%
136198 305.1.1.2 ↗ a+b two layers › DCoH-like › RBP11-like subunits of RNA polymerase › RBP11-like subunits of RNA polymerase › RNA_pol_L_2 0.65 55.0 4.94e-01 91.9% 66.4%
3165990 310.3.1.22 ↗ a+b two layers › RRF/tRNA synthetase additional domain-like › General secretion pathway protein M (EpsM) periplasmic domain-related › General secretion pathway protein M (EpsM) periplasmic domain-related › PF27480, PF30181 0.65 48.0 4.39e-01 77.9% 99.1%
3831627 304.8.1.45 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant 0.65 52.0 5.38e-01 87.2% 98.8%
3802901 304.8.1.0 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.65 48.0 5.11e-01 80.2% 98.7%
4205520 304.8.1.0 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.65 52.0 5.16e-01 87.2% 91.1%
3645785 304.8.1.57 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › ACT_ACR_D1 0.65 52.0 4.91e-01 87.2% 77.1%
3688090 306.6.1.1 ↗ a+b two layers › Glucose permease domain IIB-like › PH0987 N-terminal domain-like › PH0987 N-terminal domain-like › CT_C_D 0.65 58.0 5.71e-01 96.5% 94.4%
3617948 304.9.1.1 ↗ a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.65 51.0 4.71e-01 83.7% 80.9%
3739949 306.6.1.0 ↗ a+b two layers › Glucose permease domain IIB-like › PH0987 N-terminal domain-like › PH0987 N-terminal domain-like 0.65 49.0 4.97e-01 81.4% 97.6%
3315331 304.8.1.45 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant 0.65 51.0 5.26e-01 84.9% 100.0%
3671608 304.8.1.0 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.65 52.0 4.88e-01 89.5% 78.2%
3653904 304.8.1.0 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.65 51.0 5.27e-01 84.9% 100.0%
3815383 304.8.1.0 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.64 56.0 5.69e-01 97.7% 100.0%
3661475 304.8.1.0 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.64 56.0 4.57e-01 97.7% 58.3%
3377982 304.8.1.57 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › ACT_ACR_D1 0.64 49.0 4.91e-01 83.7% 94.4%
3223352 306.3.1.2 ↗ a+b two layers › Glucose permease domain IIB-like › eIF1-like › eIF1-like › Img2 0.64 56.0 4.67e-01 96.5% 80.0%
3325750 304.8.1.45 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant 0.64 53.0 5.49e-01 98.8% 98.8%
3198542 206.1.1.1 ↗ a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase 0.63 51.0 3.65e-01 88.4% 43.1%
3641694 306.3.1.1 ↗ a+b two layers › Glucose permease domain IIB-like › eIF1-like › eIF1-like › SUI1 0.63 53.0 5.00e-01 93.0% 81.9%
4297454 306.3.1.2 ↗ a+b two layers › Glucose permease domain IIB-like › eIF1-like › eIF1-like › Img2 0.63 54.0 4.66e-01 96.5% 77.5%
5010169 304.3.1.1 ↗ a+b two layers › Alpha-beta plaits › HMA-related › HMA, heavy metal-associated domain › HMA 0.63 45.0 4.64e-01 76.7% 84.3%
3456962 304.8.1.45 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant 0.62 54.0 5.45e-01 96.5% 97.6%
4055815 304.8.1.21 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › ACT_9 0.62 45.0 4.74e-01 77.9% 94.7%
3367441 304.8.1.0 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.62 55.0 5.28e-01 100.0% 88.9%
3486967 5104.1.1.0 ↗ a+b three layers › C-terminal domain in DHH phosphoesterases › C-terminal domain in DHH phosphoesterases › C-terminal domain in DHH phosphoesterases 0.62 53.0 4.45e-01 96.5% 65.3%
3477161 5104.1.1.3 ↗ a+b three layers › C-terminal domain in DHH phosphoesterases › C-terminal domain in DHH phosphoesterases › C-terminal domain in DHH phosphoesterases › DHHA2 0.62 53.0 4.45e-01 96.5% 65.3%
3824912 304.8.1.45 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant 0.61 51.0 5.30e-01 97.7% 100.0%
3285931 304.8.1.0 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.61 54.0 4.90e-01 97.7% 73.0%
3612286 304.9.1.1 ↗ a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1 0.61 44.0 4.21e-01 77.9% 73.3%
4292806 304.8.1.0 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.61 53.0 4.98e-01 97.7% 88.6%
3172743 304.9.1.0 ↗ a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD 0.61 44.0 4.27e-01 77.9% 79.0%
3959682 304.8.1.0 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.60 45.0 4.75e-01 82.6% 89.3%
5022986 304.113.1.0 ↗ a+b two layers › Alpha-beta plaits › Alpha subunit of glutamate synthase, insertion domain › Alpha subunit of glutamate synthase, insertion domain 0.60 44.0 4.50e-01 77.9% 96.2%
3540753 206.1.1.71 ↗ a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase, Kdo 0.59 52.0 3.65e-01 100.0% 48.6%
5026235 304.165.1.5 ↗ a+b two layers › Alpha-beta plaits › Uncharacterized protein Ta1207 › Uncharacterized protein Ta1207 › HVO_A0563_N 0.59 51.0 4.30e-01 95.3% 70.3%
5013605 304.165.1.0 ↗ a+b two layers › Alpha-beta plaits › Uncharacterized protein Ta1207 › Uncharacterized protein Ta1207 0.59 51.0 4.30e-01 95.3% 71.0%
3706698 871.1.1.1 ↗ a+b two layers › SSo0622-like (Pfam 02676) › SSo0622-like (Pfam 02676) › SSo0622-like (Pfam 02676) › TYW3 0.59 50.0 3.67e-01 95.3% 97.5%
3329478 304.8.1.2 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › ACT 0.59 52.0 4.70e-01 100.0% 80.8%
3382396 304.8.1.0 ↗ a+b two layers › Alpha-beta plaits › ACT-like › ACT-like 0.58 50.0 5.10e-01 96.5% 98.8%
3207339 206.1.1.11 ↗ a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › APH 0.57 50.0 3.60e-01 100.0% 95.1%
3242704 206.1.2.3 ↗ a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › SAICAR synthase › IPK 0.53 41.0 2.91e-01 84.9% 77.6%
D6 high residues 990-1109
PDB
Domain cluster: rep: putative_DNA_topoisomerase__YP_294202__Emiliania_huxleyi_virus_86__181082__D963-1088
D7 medium residues 565-621
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF16898.11 best TOPRIM_C 51.1 2.10e-13 100.0% 43.8%
CATH (16)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3nuhB02 3.30.300.370 Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › 0.87 66.0 5.07e-01 80.7% 100.0%
3m4iA02 3.30.1490.440 Alpha Beta › 2-Layer Sandwich › Dna Ligase; domain 1 › 0.77 67.0 6.37e-01 100.0% 95.6%
1wh2A01 3.30.1490.40 Alpha Beta › 2-Layer Sandwich › Dna Ligase; domain 1 › GYF domain 0.71 48.0 4.75e-01 78.9% 67.2%
3l2pA02 3.30.1490.70 Alpha Beta › 2-Layer Sandwich › Dna Ligase; domain 1 › 0.69 48.0 4.53e-01 78.9% 59.2%
3tiiA03 3.30.1490.20 Alpha Beta › 2-Layer Sandwich › Dna Ligase; domain 1 › ATP-grasp fold, A domain 0.66 43.0 4.21e-01 87.7% 60.0%
4d05A01 3.30.1490.70 Alpha Beta › 2-Layer Sandwich › Dna Ligase; domain 1 › 0.64 46.0 4.24e-01 82.5% 57.9%
3nyiB01 3.40.50.10170 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.61 45.0 3.32e-01 80.7% 49.0%
5d8dD03 3.30.1490.20 Alpha Beta › 2-Layer Sandwich › Dna Ligase; domain 1 › ATP-grasp fold, A domain 0.60 43.0 4.20e-01 78.9% 68.2%
1s4dE02 3.30.950.10 Alpha Beta › 2-Layer Sandwich › Methyltransferase, Cobalt-precorrin-4 Transmethylase; Domain 2 › Tetrapyrrole methylase, C-terminal domain 0.60 48.0 3.73e-01 93.0% 46.8%
1x4xA00 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.58 42.0 3.54e-01 80.7% 47.2%
3fysA01 3.40.50.10170 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.58 45.0 3.36e-01 96.5% 32.7%
3glkA03 3.30.1490.20 Alpha Beta › 2-Layer Sandwich › Dna Ligase; domain 1 › ATP-grasp fold, A domain 0.58 40.0 4.05e-01 78.9% 72.9%
3ce8A00 3.30.70.120 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.56 47.0 4.14e-01 98.2% 96.6%
2incA00 1.10.620.20 Mainly Alpha › Orthogonal Bundle › Ribonucleotide Reductase, subunit A › Ribonucleotide Reductase, subunit A 0.56 43.0 2.60e-01 87.7% 32.0%
3egrA00 3.10.20.520 Alpha Beta › Roll › Ubiquitin-like (UB roll) › Phenylacetic acid degradation B 0.56 43.0 4.25e-01 91.2% 93.7%
1x9nA02 3.30.1490.70 Alpha Beta › 2-Layer Sandwich › Dna Ligase; domain 1 › 0.53 39.0 3.53e-01 82.5% 56.0%
ECOD (39)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3213306 2006.1.3.21 ↗ a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain › TOPRIM_C 0.93 85.0 5.30e-01 100.0% 20.7%
3789608 2006.1.3.0 ↗ a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain 0.93 85.0 5.27e-01 100.0% 20.4%
3551383 2006.1.3.3 ↗ a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain › Toprim,TOPRIM_C 0.90 82.0 5.05e-01 100.0% 19.3%
3096550 4012.1.1.1 ↗ a+b two layers › SSHS domain › SSHS domain in type II DNA topoisomerase › SSHS domain in type II DNA topoisomerase › TOPRIM_C 0.84 65.0 7.00e-01 82.5% 100.0%
4406660 2006.1.3.1 ↗ a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain › DNA_gyraseB_C,Toprim 0.82 73.0 4.76e-01 100.0% 24.6%
5062217 4012.1.1.0 ↗ a+b two layers › SSHS domain › SSHS domain in type II DNA topoisomerase › SSHS domain in type II DNA topoisomerase 0.80 57.0 5.85e-01 80.7% 78.2%
3084511 4012.1.1.1 ↗ a+b two layers › SSHS domain › SSHS domain in type II DNA topoisomerase › SSHS domain in type II DNA topoisomerase › TOPRIM_C 0.79 55.0 6.12e-01 82.5% 100.0%
None — 0.76 65.0 4.35e-01 100.0% 27.7%
4507341 3675.1.1.0 ↗ a+b complex topology › DNA gyrase subunit B insertion domain › DNA gyrase subunit B insertion domain › DNA gyrase subunit B insertion domain 0.73 51.0 3.70e-01 73.7% 30.3%
3700912 822.1.1.2 ↗ a+b two layers › GYF/BRK domain-like › GYF domain › GYF domain › GYF_2 0.73 50.0 4.83e-01 78.9% 63.1%
3845539 386.1.1.0 ↗ few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers 0.73 49.0 4.22e-01 77.2% 44.4%
3595258 304.9.1.0 ↗ a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD 0.73 50.0 4.23e-01 78.9% 43.2%
3574017 822.1.1.2 ↗ a+b two layers › GYF/BRK domain-like › GYF domain › GYF domain › GYF_2 0.73 50.0 4.65e-01 71.9% 58.6%
3333626 822.1.1.0 ↗ a+b two layers › GYF/BRK domain-like › GYF domain › GYF domain 0.72 51.0 5.06e-01 82.5% 71.7%
4958377 822.1.1.2 ↗ a+b two layers › GYF/BRK domain-like › GYF domain › GYF domain › GYF_2 0.72 48.0 5.12e-01 70.2% 81.2%
3308182 822.1.1.2 ↗ a+b two layers › GYF/BRK domain-like › GYF domain › GYF domain › GYF_2 0.71 50.0 4.30e-01 77.2% 46.7%
3885453 386.1.1.257 ↗ few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › zf-C2H2_Z280C_D 0.71 45.0 5.08e-01 73.7% 92.5%
3787008 822.1.1.1 ↗ a+b two layers › GYF/BRK domain-like › GYF domain › GYF domain › GYF 0.70 49.0 4.79e-01 77.2% 65.6%
3924848 822.1.1.1 ↗ a+b two layers › GYF/BRK domain-like › GYF domain › GYF domain › GYF 0.70 49.0 4.48e-01 77.2% 56.0%
3229566 386.1.1.0 ↗ few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers 0.70 50.0 4.40e-01 77.2% 51.8%
3855045 822.1.1.2 ↗ a+b two layers › GYF/BRK domain-like › GYF domain › GYF domain › GYF_2 0.70 50.0 4.93e-01 78.9% 71.7%
3323677 822.1.1.2 ↗ a+b two layers › GYF/BRK domain-like › GYF domain › GYF domain › GYF_2 0.70 49.0 4.91e-01 78.9% 71.7%
3561065 822.1.1.0 ↗ a+b two layers › GYF/BRK domain-like › GYF domain › GYF domain 0.70 51.0 2.72e-01 77.2% 21.6%
379802 822.1.1.1 ↗ a+b two layers › GYF/BRK domain-like › GYF domain › GYF domain › GYF 0.69 50.0 4.37e-01 77.2% 58.1%
3930342 822.1.1.2 ↗ a+b two layers › GYF/BRK domain-like › GYF domain › GYF domain › GYF_2 0.69 47.0 4.83e-01 71.9% 74.5%
3458276 822.1.1.1 ↗ a+b two layers › GYF/BRK domain-like › GYF domain › GYF domain › GYF 0.67 48.0 4.65e-01 78.9% 66.2%
3998943 101.1.15.1 ↗ alpha arrays › HTH › HTH › HAT1, C-terminal domain › MOZ_SAS 0.67 48.0 4.02e-01 80.7% 42.9%
3517152 386.1.1.0 ↗ few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers 0.67 44.0 4.13e-01 77.2% 53.3%
3214218 386.1.1.0 ↗ few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers 0.67 47.0 4.11e-01 80.7% 47.8%
5022386 304.1.1.1 ↗ a+b two layers › Alpha-beta plaits › GHMP Kinase, C-terminal domain › GHMP Kinase, C-terminal domain › GHMP_kinases_C 0.66 48.0 3.89e-01 80.7% 99.2%
3690933 304.9.1.0 ↗ a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD 0.65 46.0 3.81e-01 75.4% 74.3%
2573463 302.3.1.0 ↗ a+b two layers › Reverse ferredoxin › a+b domain in low-molecular-weight S-layer protein › a+b domain in low-molecular-weight S-layer protein 0.64 46.0 4.05e-01 78.9% 50.6%
3388590 379.1.1.0 ↗ few secondary structure elements › Kazal-type serine protease inhibitors-like › Kazal-type serine protease inhibitors › Kazal-type serine protease inhibitors 0.63 46.0 4.54e-01 87.7% 75.0%
3467232 4076.1.1.0 ↗ a+b two layers › L9 N-domain-like › L9 N-domain-like › L9 N-domain-like 0.62 50.0 4.76e-01 93.0% 92.9%
1937230 2010.1.1.1 ↗ a/b three-layered sandwiches › EDD domain › EDD domain › EDD domain › DegV 0.61 45.0 3.30e-01 80.7% 48.1%
3534502 109.4.1.1310 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_TRIP12_N 0.59 42.0 2.35e-01 89.5% 5.7%
3669087 304.7.1.11 ↗ a+b two layers › Alpha-beta plaits › Protease propeptides/inhibitors › Protease propeptides/inhibitors › MORF_dom 0.58 40.0 4.20e-01 75.4% 88.0%
3609261 101.1.2.0 ↗ alpha arrays › HTH › HTH › winged helix domain 0.54 38.0 3.24e-01 77.2% 47.6%
3238738 207.1.1.52 ↗ beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Leucine-rich repeats › Leucine-rich repeats › FBA_2 0.54 40.0 2.68e-01 84.2% 44.3%