←Back to structures

DNA_topoisomerase_II

Euk-Vir

Shrimp_hemocyte_iridescent_virus

DNA_topoisomerase_II__YP_010084829__Shrimp_hemocyte_iridescent_virus__2039780

Identity

Accession:: YP_010084829 ↗
Protein ID:: DNA_topoisomerase_II
Kingdom:: euk

Quality

87.1 mean pLDDT

Taxonomy

Bamfordvirae› Nucleocytoviricota› Megaviricetes› Pimascovirales› Iridoviridae› Decapodiridovirus› Shrimp_hemocyte_iridescent_virus

TaxID: 2039780

Cluster

View cluster (39 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 65-242

PDB

Domain cluster: rep: IMGVR_UViG_3300039190_000305-3300039190-Ga0399989_003201_3_1937__D82-97_167-336

CATH (14)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1pvgA01	3.30.565.10	Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain	0.96	94.0	8.23e-01	100.0%	73.4%
1s14B00	3.30.565.10	Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain	0.87	74.0	7.41e-01	100.0%	87.1%
1aj6A00	3.30.565.10	Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain	0.83	74.0	7.21e-01	100.0%	85.1%
3cwvA01	3.30.565.10	Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain	0.79	72.0	6.90e-01	100.0%	85.4%
1b63A01	3.30.565.10	Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain	0.79	75.0	6.98e-01	100.0%	82.9%
1h7sA01	3.30.565.10	Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain	0.74	67.0	6.52e-01	100.0%	87.6%
2o1uB01	3.30.565.10	Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain	0.72	62.0	6.45e-01	100.0%	97.6%
1y4uB01	3.30.565.10	Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain	0.68	62.0	6.07e-01	100.0%	89.7%
1nijA02	3.30.1220.10	Alpha Beta › 2-Layer Sandwich › Hypothetical Protein Yjia; Chain: A;domain 2 › CobW-like, C-terminal domain	0.65	36.0	4.41e-01	77.0%	83.6%
2g0iA00	3.30.70.1490	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Cysteine protease Prp	0.57	35.0	4.40e-01	89.3%	99.1%
1v43A03	2.40.50.140	Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins	0.53	18.0	2.95e-01	92.7%	82.8%
3obwA02	3.30.420.60	Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › eRF1 domain 2	0.51	28.0	3.31e-01	90.4%	77.1%
3wnoA03	2.60.120.260	Mainly Beta › Sandwich › Jelly Rolls › Galactose-binding domain-like	0.51	30.0	3.44e-01	80.3%	78.5%
2z4hA01	2.40.128.300	Mainly Beta › Beta Barrel › Lipocalin › NlpE, N-terminal domain	0.50	22.0	3.20e-01	87.6%	89.9%

ECOD (78)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3789605	225.1.1.0 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0.96	94.0	8.23e-01	100.0%	73.5%
3998214	225.1.1.3 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c	0.95	93.0	8.01e-01	100.0%	69.8%
3594649	225.1.1.0 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0.94	92.0	8.06e-01	100.0%	74.3%
4617838	225.1.1.3 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c	0.94	92.0	8.05e-01	100.0%	74.3%
4875911	225.1.1.3 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c	0.93	91.0	7.76e-01	100.0%	72.4%
3317524	225.1.1.0 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0.90	70.0	6.42e-01	79.2%	77.1%
3461648	225.1.1.0 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0.90	87.0	7.69e-01	100.0%	75.8%
1223480	225.1.1.3 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c	0.89	80.0	7.61e-01	98.9%	81.4%
4027049	225.1.1.3 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c	0.87	84.0	7.24e-01	100.0%	76.4%
4038381	225.1.1.3 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c	0.87	84.0	7.63e-01	100.0%	81.8%
4945731	225.1.1.38 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › DNA_gyraseB	0.86	83.0	7.44e-01	100.0%	78.7%
3959843	225.1.1.0 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0.85	82.0	7.27e-01	100.0%	78.3%
4421199	225.1.1.3 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c	0.85	82.0	7.18e-01	100.0%	84.5%
1223478	225.1.1.3 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c	0.85	82.0	6.97e-01	100.0%	71.5%
3198261	225.1.1.0 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0.84	82.0	8.03e-01	100.0%	95.3%
3321967	225.1.1.7 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3	0.82	79.0	7.25e-01	100.0%	83.6%
4453541	225.1.1.7 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3	0.82	77.0	7.18e-01	100.0%	82.4%
3530518	225.1.1.7 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3	0.81	78.0	7.42e-01	100.0%	91.0%
4030281	225.1.1.7 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3	0.80	76.0	6.69e-01	100.0%	71.4%
3716539	225.1.1.7 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3	0.80	77.0	6.81e-01	100.0%	85.4%
4107504	225.1.1.3 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c	0.80	76.0	7.06e-01	100.0%	81.9%
4513602	225.1.1.7 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3	0.80	76.0	7.37e-01	100.0%	90.8%
4943430	225.1.1.39 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › DNA_mis_repair	0.79	76.0	7.56e-01	100.0%	96.2%
3789513	225.1.1.7 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3	0.79	76.0	6.84e-01	100.0%	82.6%
4233929	225.1.1.7 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3	0.79	76.0	6.92e-01	100.0%	79.6%
4404190	225.1.1.7 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3	0.78	75.0	6.84e-01	100.0%	79.6%
4273009	225.1.1.7 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3	0.78	75.0	7.30e-01	100.0%	93.2%
3595333	225.1.1.0 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0.78	75.0	6.95e-01	100.0%	91.5%
3549359	225.1.1.7 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3	0.78	75.0	6.68e-01	100.0%	78.7%
3841889	225.1.1.7 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3	0.78	75.0	7.00e-01	100.0%	86.7%
5036092	225.1.1.0 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0.77	74.0	6.75e-01	100.0%	81.2%
3923679	225.1.1.7 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3	0.77	73.0	6.82e-01	100.0%	86.0%
3974412	225.1.1.7 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3	0.77	71.0	6.74e-01	100.0%	84.4%
4013379	225.1.1.0 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0.76	72.0	6.62e-01	100.0%	82.2%
3825487	225.1.1.7 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3	0.76	72.0	6.46e-01	100.0%	88.7%
4969896	225.1.1.7 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3	0.76	72.0	6.76e-01	100.0%	84.8%
3839737	884.1.1.1 ↗	a+b two layers › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › CobW_C	0.75	35.0	4.88e-01	72.5%	88.9%
3308932	225.1.1.7 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3	0.75	70.0	6.30e-01	100.0%	81.2%
3255595	225.1.1.7 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3	0.74	70.0	6.65e-01	100.0%	88.9%
3367679	225.1.1.13 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HSP90	0.74	66.0	6.76e-01	99.4%	98.2%
3421099	225.1.1.2 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HSP90,HATPase_c_3	0.74	70.0	6.02e-01	100.0%	85.7%
4940507	225.1.1.7 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3	0.74	53.0	6.09e-01	78.1%	97.0%
None	—		0.74	70.0	6.34e-01	100.0%	86.5%
5027973	225.1.1.7 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3	0.74	68.0	6.48e-01	100.0%	84.4%
3902919	225.1.1.2 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HSP90,HATPase_c_3	0.74	70.0	6.18e-01	100.0%	77.6%
None	—		0.73	68.0	6.31e-01	98.3%	86.4%
3656144	225.1.1.3 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c	0.73	69.0	6.17e-01	100.0%	82.6%
4029843	212.1.1.0 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like	0.73	69.0	6.25e-01	100.0%	86.3%
4241931	225.1.1.7 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3	0.73	69.0	6.34e-01	99.4%	85.0%
None	—		0.72	68.0	6.41e-01	99.4%	86.2%
4221311	225.1.1.7 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3	0.72	66.0	6.13e-01	100.0%	78.2%
None	—		0.72	68.0	6.40e-01	99.4%	86.2%
4930695	225.1.1.0 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0.72	68.0	5.79e-01	100.0%	89.5%
4927750	225.1.1.0 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0.72	68.0	6.31e-01	100.0%	85.1%
3735728	225.1.1.19 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › SACS	0.71	63.0	5.69e-01	100.0%	71.1%
5002020	884.1.1.0 ↗	a+b two layers › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain	0.70	39.0	4.87e-01	74.7%	85.2%
5057421	225.1.1.7 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3	0.70	64.0	6.07e-01	100.0%	82.4%
3369389	884.1.1.1 ↗	a+b two layers › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › CobW_C	0.70	35.0	4.69e-01	74.7%	89.5%
4926914	225.1.1.7 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3	0.70	65.0	6.08e-01	100.0%	82.9%
4464688	884.1.1.1 ↗	a+b two layers › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › CobW_C	0.70	36.0	4.81e-01	75.3%	93.6%
4058338	225.1.1.2 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HSP90,HATPase_c_3	0.69	65.0	5.80e-01	100.0%	87.1%
4504528	225.1.1.7 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3	0.68	64.0	5.77e-01	100.0%	86.3%
4076203	225.1.1.7 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3	0.68	64.0	5.66e-01	100.0%	86.8%
3461740	884.1.1.1 ↗	a+b two layers › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › CobW_C	0.68	35.0	4.56e-01	74.7%	87.9%
4589763	225.1.1.7 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3	0.68	64.0	6.01e-01	100.0%	86.2%
5004468	225.1.1.19 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › SACS	0.67	59.0	5.70e-01	100.0%	83.0%
3377134	225.1.1.0 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0.67	52.0	5.63e-01	94.9%	95.3%
3286344	225.1.1.0 ↗	a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0.66	62.0	5.67e-01	99.4%	83.1%
None	—		0.66	62.0	5.77e-01	100.0%	91.8%
3313688	884.1.1.1 ↗	a+b two layers › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › CobW_C	0.65	34.0	4.50e-01	77.0%	91.0%
4188674	4263.2.1.1 ↗	a+b two layers › TTHA1528-like › FtsH Periplasmic Domain › FtsH Periplasmic Domain › FtsH_ext	0.65	33.0	4.42e-01	98.9%	94.4%
4217487	4263.2.1.1 ↗	a+b two layers › TTHA1528-like › FtsH Periplasmic Domain › FtsH Periplasmic Domain › FtsH_ext	0.63	32.0	4.25e-01	98.3%	89.5%
3987928	4263.2.1.1 ↗	a+b two layers › TTHA1528-like › FtsH Periplasmic Domain › FtsH Periplasmic Domain › FtsH_ext	0.63	33.0	4.27e-01	98.3%	90.5%
3522105	884.1.1.1 ↗	a+b two layers › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › CobW_C	0.62	34.0	4.42e-01	75.8%	91.4%
5084091	10.1.2.183 ↗	beta sandwiches › jelly-roll › Concanavalin A-like › GOLD domain-like (DEPRECATED) › PPC	0.57	28.0	3.77e-01	78.1%	88.4%
4976436	884.1.1.0 ↗	a+b two layers › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain	0.54	36.0	4.33e-01	82.0%	100.0%
5055086	10.1.2.0 ↗	beta sandwiches › jelly-roll › Concanavalin A-like › GOLD domain-like (DEPRECATED)	0.53	27.0	3.58e-01	84.8%	89.5%
5083968	10.1.2.0 ↗	beta sandwiches › jelly-roll › Concanavalin A-like › GOLD domain-like (DEPRECATED)	0.52	33.0	3.89e-01	88.2%	90.4%

D2 high residues 258-386

PDB

Domain cluster: rep: topoisomerase_IIA__YP_009001040__Pithovirus_sibericum__1450746__D250-321_335-390

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00204.32 best	DNA_gyraseB	57.4	1.90e-15	92.2%	55.2%

CATH (18)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1qzrA02	3.30.230.10	Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 ›	0.88	81.0	8.31e-01	96.9%	100.0%
3lnuA02	3.30.230.10	Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 ›	0.82	78.0	7.15e-01	100.0%	91.9%
4hy1A02	3.30.230.10	Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 ›	0.81	77.0	7.09e-01	100.0%	91.1%
3zkbI02	3.30.230.10	Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 ›	0.81	76.0	7.01e-01	100.0%	88.7%
3cwvA02	3.30.230.10	Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 ›	0.79	73.0	6.87e-01	97.7%	90.1%
1z5bB03	3.30.230.10	Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 ›	0.65	56.0	5.36e-01	93.0%	87.2%
2f1dA01	3.30.230.40	Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › Imidazole glycerol phosphate dehydratase; domain 1	0.58	39.0	4.64e-01	95.3%	100.0%
4p52A01	3.30.230.10	Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 ›	0.56	46.0	4.13e-01	88.4%	65.6%
3nzkA02	3.30.1700.10	Alpha Beta › 2-Layer Sandwich › lpxc deacetylase, domain 1 › lpxc deacetylase, domain 2	0.54	48.0	4.35e-01	95.3%	91.2%
6n10A01	3.30.230.10	Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 ›	0.53	42.0	3.62e-01	85.3%	69.4%
1nz0D00	3.30.230.10	Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 ›	0.53	39.0	4.18e-01	87.6%	89.2%
1h72C01	3.30.230.10	Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 ›	0.52	42.0	3.91e-01	87.6%	68.3%
1pieA01	3.30.230.10	Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 ›	0.52	43.0	3.69e-01	89.9%	62.1%
1y8cA02	2.20.25.110	Mainly Beta › Single Sheet › N-terminal domain of TfIIb › S-adenosyl-L-methionine-dependent methyltransferases	0.52	21.0	3.13e-01	95.3%	83.3%
3p3cA02	3.30.1700.10	Alpha Beta › 2-Layer Sandwich › lpxc deacetylase, domain 1 › lpxc deacetylase, domain 2	0.51	46.0	4.40e-01	96.9%	97.4%
5dnlA02	3.30.230.40	Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › Imidazole glycerol phosphate dehydratase; domain 1	0.51	38.0	4.18e-01	92.2%	100.0%
2nn6F00	3.30.230.70	Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › GHMP Kinase, N-terminal domain	0.51	40.0	3.43e-01	95.3%	50.2%
1oypA01	3.30.230.70	Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › GHMP Kinase, N-terminal domain	0.51	41.0	3.50e-01	91.5%	52.8%

ECOD (53)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4641709	212.1.1.2 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB	0.88	84.0	7.39e-01	100.0%	77.2%
3220683	212.1.1.2 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB	0.88	84.0	7.63e-01	100.0%	88.5%
3275256	212.1.1.2 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB	0.85	81.0	7.27e-01	100.0%	80.6%
4234522	212.1.1.2 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB	0.85	81.0	7.24e-01	100.0%	88.2%
3513708	212.1.1.2 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB	0.85	80.0	7.38e-01	100.0%	85.0%
3799215	212.1.1.0 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like	0.84	80.0	7.25e-01	100.0%	88.5%
3585145	212.1.1.2 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB	0.84	79.0	7.31e-01	100.0%	91.3%
4000834	212.1.1.2 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB	0.84	79.0	7.21e-01	100.0%	83.0%
3807571	212.1.1.2 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB	0.84	79.0	7.02e-01	100.0%	85.1%
4380841	212.1.1.2 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB	0.84	79.0	7.01e-01	100.0%	85.1%
3433616	212.1.1.2 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB	0.83	79.0	7.23e-01	99.2%	84.4%
3967155	212.1.1.2 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB	0.83	79.0	7.00e-01	100.0%	85.1%
4945732	212.1.1.2 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB	0.83	78.0	6.98e-01	100.0%	83.4%
4261801	212.1.1.2 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB	0.83	79.0	6.78e-01	100.0%	79.5%
3964340	212.1.1.2 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB	0.83	78.0	6.82e-01	100.0%	84.3%
3594648	212.1.1.0 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like	0.83	78.0	7.20e-01	100.0%	83.7%
4288775	212.1.1.2 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB	0.83	78.0	6.86e-01	100.0%	85.0%
4027043	212.1.1.2 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB	0.83	78.0	6.96e-01	100.0%	86.9%
4207771	212.1.1.2 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB	0.83	78.0	6.95e-01	100.0%	85.7%
4339883	212.1.1.2 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB	0.82	78.0	6.79e-01	100.0%	85.4%
3970715	212.1.1.0 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like	0.82	77.0	6.86e-01	100.0%	85.7%
4040519	212.1.1.2 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB	0.82	77.0	7.03e-01	100.0%	83.0%
4298571	212.1.1.2 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB	0.82	76.0	6.69e-01	100.0%	84.3%
1388837	212.1.1.2 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB	0.79	73.0	6.98e-01	96.9%	90.4%
341211	212.1.1.2 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB	0.78	73.0	6.89e-01	100.0%	90.7%
4966371	11.1.1.0 ↗	beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like	0.69	58.0	4.38e-01	90.7%	44.3%
4928705	212.1.1.22 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Topo-VIb_trans	0.68	59.0	4.96e-01	92.2%	68.1%
4584919	212.1.1.22 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Topo-VIb_trans	0.68	58.0	4.98e-01	90.7%	67.5%
5037280	212.1.1.22 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Topo-VIb_trans	0.67	58.0	4.94e-01	93.0%	69.8%
3321965	212.1.1.0 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like	0.66	53.0	5.25e-01	84.5%	99.3%
5023191	212.1.1.22 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Topo-VIb_trans	0.66	56.0	5.10e-01	90.7%	72.4%
4028943	212.1.1.0 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like	0.66	59.0	4.96e-01	98.4%	67.3%
4957148	212.1.1.22 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Topo-VIb_trans	0.65	55.0	4.72e-01	90.7%	67.0%
4207880	212.1.1.0 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like	0.64	38.0	4.22e-01	85.3%	74.0%
4560753	212.1.1.0 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like	0.63	39.0	4.15e-01	89.1%	68.7%
5081565	212.1.1.3 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › GHMP_kinases_N	0.61	50.0	4.33e-01	86.0%	73.7%
4126343	212.1.1.0 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like	0.60	38.0	3.95e-01	89.1%	68.3%
4004154	212.1.1.6 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal_S9	0.59	44.0	3.44e-01	92.2%	37.4%
4977874	212.1.1.3 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › GHMP_kinases_N	0.58	46.0	4.13e-01	82.9%	70.3%
4862453	212.1.1.7 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › IGPD	0.57	39.0	4.55e-01	96.1%	100.0%
4573108	212.1.1.8 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribonuclease_P	0.57	41.0	4.41e-01	88.4%	87.3%
3784150	212.1.1.0 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like	0.56	46.0	4.85e-01	86.0%	100.0%
4369780	212.1.1.3 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › GHMP_kinases_N	0.55	46.0	4.17e-01	89.1%	70.9%
4234903	212.1.1.8 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribonuclease_P	0.55	38.0	4.10e-01	92.2%	84.5%
3663516	212.1.1.24 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Morc6_S5	0.54	41.0	4.43e-01	88.4%	96.2%
4272791	212.1.1.8 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribonuclease_P	0.54	39.0	4.08e-01	89.9%	84.3%
4860816	212.1.1.10 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › RNase_PH	0.53	46.0	4.54e-01	95.3%	92.6%
4989029	212.1.1.0 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like	0.52	47.0	3.86e-01	98.4%	87.7%
3589041	213.1.1.0 ↗	a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat)	0.52	31.0	3.15e-01	73.6%	58.5%
4367647	212.1.1.8 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribonuclease_P	0.52	38.0	4.04e-01	87.6%	89.1%
5024267	212.1.1.0 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like	0.50	40.0	4.14e-01	84.5%	100.0%
3223584	212.1.1.3 ↗	a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › GHMP_kinases_N	0.50	40.0	3.43e-01	86.8%	67.7%
None	—		0.50	41.0	3.70e-01	86.8%	70.3%

D3 high residues 403-664

PDB

Domain cluster: rep: DNA_topoisomerase_2__YP_009162467__Salmon_gill_poxvirus__1680908__D385-517_553-621_640-664

Pfam (2)

Accession	Name	Score	E-value	Q cov	HMM cov
PF16898.11 best	TOPRIM_C	46.5	5.80e-12	47.3%	75.0%
PF01751.29	Toprim	31.2	2.90e-07	45.4%	83.3%

D4 high residues 971-1079

PDB

Domain cluster: rep: KM209246.1__AIM51491.1__HQ82_0234__00002__D56-167

CATH (64)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
8gccA03	1.10.268.10	Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3	0.89	73.0	7.50e-01	86.2%	97.1%
1bgwA03	1.10.268.10	Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3	0.86	68.0	6.84e-01	83.5%	100.0%
3qx3A04	1.10.268.10	Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3	0.86	67.0	6.98e-01	81.7%	100.0%
1fioA00	1.20.58.70	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.82	52.0	4.21e-01	91.7%	37.4%
2oduA02	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.82	52.0	5.36e-01	90.8%	67.6%
2dnxA00	1.20.58.70	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.81	51.0	4.74e-01	90.8%	53.1%
3h3mA00	1.20.58.380	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Flagellar protein flit.	0.81	36.0	4.01e-01	90.8%	52.8%
4id0A02	1.20.1050.10	Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 ›	0.80	46.0	4.57e-01	89.0%	55.4%
2qywA00	1.20.58.400	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › t-snare proteins	0.80	50.0	5.37e-01	89.9%	72.6%
1zvuA03	1.10.268.10	Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3	0.80	75.0	6.82e-01	100.0%	82.1%
1nfvA00	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.79	49.0	4.12e-01	87.2%	40.8%
3lpxA03	1.10.268.10	Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3	0.79	61.0	6.35e-01	81.7%	100.0%
3fppA03	6.10.140.1990	Special › Helix non-globular › Helix Hairpins ›	0.78	49.0	5.42e-01	91.7%	78.4%
1oahA02	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.78	51.0	4.64e-01	96.3%	51.4%
2rd0B00	1.10.287.1490	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.76	48.0	4.43e-01	94.5%	50.4%
2q0oC00	1.10.287.160	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat	0.74	41.0	4.58e-01	90.8%	68.6%
1e1dA02	1.20.1270.20	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 ›	0.73	36.0	4.13e-01	89.9%	61.9%
4hr1A00	1.20.1270.410	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 ›	0.71	45.0	4.38e-01	89.0%	58.5%
3g67A00	1.10.287.950	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Methyl-accepting chemotaxis protein	0.71	50.0	3.92e-01	94.5%	37.1%
3rx6A00	1.20.58.1090	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phage polarity suppression protein monomer	0.71	51.0	4.14e-01	93.6%	42.8%
3a7mA01	1.20.58.380	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Flagellar protein flit.	0.70	36.0	3.68e-01	90.8%	48.2%
3axjB02	1.20.58.200	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 2	0.70	41.0	4.59e-01	92.7%	74.1%
6p73A02	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.69	43.0	3.94e-01	91.7%	49.0%
1owaA02	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.67	39.0	3.95e-01	92.7%	56.6%
7s0rB01	1.20.81.20	Mainly Alpha › Up-down Bundle › Receptor-associated Protein ›	0.66	34.0	3.99e-01	89.9%	71.1%
2p5tA00	1.10.8.130	Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 ›	0.65	38.0	4.07e-01	92.7%	67.4%
4dllB02	1.10.1040.10	Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2	0.63	50.0	4.69e-01	85.3%	70.0%
6xkyA01	1.20.1330.10	Mainly Alpha › Up-down Bundle › f41 fragment of flagellin, N-terminal domain › f41 fragment of flagellin, N-terminal domain	0.63	55.0	4.54e-01	93.6%	77.0%
4l8iB00	1.10.132.20	Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor	0.62	40.0	3.98e-01	97.2%	62.5%
1qu7A00	1.10.287.950	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Methyl-accepting chemotaxis protein	0.62	50.0	3.85e-01	93.6%	41.0%
2cvzA02	1.10.1040.10	Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2	0.61	47.0	4.44e-01	86.2%	67.4%
7b7tA01	1.20.1270.30	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 ›	0.61	56.0	4.83e-01	98.2%	82.0%
3q18A02	1.20.1050.10	Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 ›	0.61	36.0	3.58e-01	87.2%	54.3%
3w6zA02	1.10.1040.10	Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2	0.61	47.0	4.54e-01	84.4%	73.6%
4mh6A00	1.10.287.1700	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.61	50.0	4.34e-01	93.6%	59.1%
2vxxA00	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.60	50.0	4.26e-01	88.1%	70.9%
4aflA00	6.10.140.1740	Special › Helix non-globular › Helix Hairpins ›	0.59	43.0	4.46e-01	91.7%	80.4%
4nx9A01	1.20.1330.10	Mainly Alpha › Up-down Bundle › f41 fragment of flagellin, N-terminal domain › f41 fragment of flagellin, N-terminal domain	0.59	51.0	4.53e-01	94.5%	92.3%
3o7qA02	1.20.1250.20	Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains	0.59	49.0	4.09e-01	90.8%	94.3%
2xubA05	6.10.140.1450	Special › Helix non-globular › Helix Hairpins ›	0.58	48.0	5.17e-01	89.9%	97.9%
1aueB00	1.20.120.150	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › FKBP12-rapamycin binding domain	0.58	34.0	3.59e-01	94.5%	64.9%
1cnt200	1.20.1250.10	Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; ›	0.58	51.0	4.77e-01	92.7%	97.7%
3lk5A00	1.10.600.10	Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase	0.57	46.0	3.25e-01	86.2%	35.7%
2ks9A00	1.20.1070.10	Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins	0.56	44.0	3.07e-01	83.5%	70.0%
1ux5A03	1.20.58.2220	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Formin, FH2 domain	0.56	47.0	3.62e-01	97.2%	41.0%
2f07B00	1.10.357.10	Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2	0.56	36.0	3.02e-01	74.3%	36.2%
8ek4A01	1.20.120.20	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein	0.55	43.0	4.02e-01	97.2%	66.9%
2gf2A02	1.10.1040.10	Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2	0.55	44.0	4.16e-01	89.0%	70.9%
2oerA00	1.10.357.10	Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2	0.55	39.0	3.33e-01	89.9%	45.3%
4e40A00	1.20.1260.80	Mainly Alpha › Up-down Bundle › Ferritin ›	0.54	50.0	3.78e-01	99.1%	72.2%
1pw4A01	1.20.1250.20	Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains	0.54	48.0	3.90e-01	98.2%	91.9%
3vkgA12	1.10.287.2610	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.54	44.0	3.51e-01	92.7%	44.7%
2rfqC03	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.54	50.0	4.19e-01	100.0%	93.1%
4iu9B02	1.20.1250.20	Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains	0.53	42.0	3.46e-01	85.3%	66.0%
7e84A03	1.10.287.70	Mainly Alpha › Orthogonal Bundle › Helix Hairpins ›	0.53	44.0	4.28e-01	91.7%	78.9%
4etrB00	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.53	43.0	4.12e-01	87.2%	76.2%
3t6gB00	1.20.120.230	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like	0.52	44.0	4.15e-01	92.7%	100.0%
3m9vA03	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.52	47.0	4.17e-01	100.0%	96.2%
2clbA01	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.52	48.0	4.17e-01	99.1%	76.7%
1puoB00	1.20.920.50	Mainly Alpha › Up-down Bundle › Histone Acetyltransferase; Chain A ›	0.51	39.0	3.64e-01	81.7%	100.0%
1dn1B00	1.20.58.70	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.51	44.0	3.44e-01	91.7%	45.0%
3cazB00	1.20.1270.60	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain	0.51	46.0	3.66e-01	97.2%	73.3%
1gt0D00	1.10.30.10	Mainly Alpha › Orthogonal Bundle › DNA Binding (I), subunit A › High mobility group box domain	0.50	32.0	3.65e-01	85.3%	87.3%
3kmiA00	1.20.120.940	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Putative aromatic acid exporter, C-terminal domain	0.50	40.0	3.44e-01	85.3%	100.0%

ECOD (78)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3267708	4016.1.1.1 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV	0.95	92.0	8.13e-01	100.0%	80.7%
3328306	4016.1.1.1 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV	0.93	89.0	7.15e-01	100.0%	76.8%
3276180	4016.1.1.1 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV	0.92	88.0	7.02e-01	100.0%	79.5%
3610015	4016.1.1.1 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV	0.92	87.0	7.41e-01	100.0%	76.4%
3789604	4016.1.1.0 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase	0.91	87.0	7.66e-01	100.0%	82.7%
3718739	4016.1.1.1 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV	0.91	87.0	7.36e-01	100.0%	80.6%
3652359	4016.1.1.1 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV	0.91	87.0	7.28e-01	100.0%	68.8%
3600354	4016.1.1.0 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase	0.91	87.0	7.64e-01	100.0%	73.3%
3708939	4016.1.1.1 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV	0.91	87.0	7.54e-01	100.0%	71.0%
3508111	4016.1.1.1 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV	0.91	87.0	7.11e-01	100.0%	83.3%
3630114	4016.1.1.1 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV	0.91	86.0	7.71e-01	100.0%	84.8%
3625174	4016.1.1.1 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV	0.90	86.0	6.70e-01	100.0%	76.2%
3768919	4016.1.1.1 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV	0.90	86.0	6.01e-01	100.0%	48.3%
2443871	4016.1.1.1 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV	0.90	85.0	7.21e-01	100.0%	81.3%
3634044	4016.1.1.1 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV	0.90	85.0	6.87e-01	100.0%	75.8%
4887991	4016.1.1.0 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase	0.89	83.0	8.40e-01	98.2%	99.1%
4878008	4016.1.1.1 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV	0.89	84.0	8.06e-01	100.0%	89.3%
4238706	101.1.2.9 ↗	alpha arrays › HTH › HTH › winged helix domain › DNA_topoisoIV	0.89	84.0	5.89e-01	100.0%	46.9%
4452951	4016.1.1.1 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV	0.89	84.0	7.02e-01	100.0%	77.7%
3935542	4016.1.1.1 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV	0.88	83.0	7.36e-01	100.0%	77.3%
3220667	4016.1.1.1 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV	0.86	81.0	7.44e-01	100.0%	88.9%
5024978	4016.1.1.1 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV	0.85	80.0	7.17e-01	100.0%	79.3%
4932829	4016.1.1.1 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV	0.85	80.0	7.14e-01	100.0%	79.3%
4552385	4016.1.1.1 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV	0.84	79.0	6.92e-01	100.0%	72.3%
4299749	4016.1.1.1 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV	0.84	79.0	7.09e-01	100.0%	79.3%
4946213	4016.1.1.18 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_gyraseA_C	0.84	79.0	7.07e-01	100.0%	79.3%
4373100	4016.1.1.1 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV	0.84	79.0	7.06e-01	100.0%	79.3%
4174306	4016.1.1.1 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV	0.84	78.0	6.94e-01	100.0%	74.7%
1297277	4016.1.1.1 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV	0.83	78.0	6.43e-01	100.0%	64.1%
1780091	4016.1.1.1 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV	0.83	77.0	6.69e-01	100.0%	72.2%
4218225	4016.1.1.1 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV	0.82	76.0	6.72e-01	100.0%	74.8%
3345589	4016.1.1.1 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV	0.82	77.0	6.26e-01	100.0%	61.1%
5083298	4016.1.1.0 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase	0.82	77.0	6.80e-01	100.0%	76.0%
4855518	101.1.2.9 ↗	alpha arrays › HTH › HTH › winged helix domain › DNA_topoisoIV	0.82	76.0	6.37e-01	100.0%	82.6%
3833806	4016.1.1.0 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase	0.82	69.0	6.25e-01	89.9%	71.0%
4043618	4016.1.1.1 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV	0.82	76.0	6.75e-01	100.0%	76.7%
3678791	5086.1.1.0 ↗	alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins	0.81	53.0	4.10e-01	91.7%	34.3%
5062336	4016.1.1.1 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV	0.81	73.0	6.29e-01	97.2%	90.9%
3964486	5086.1.1.0 ↗	alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins	0.80	49.0	4.21e-01	91.7%	41.9%
4883080	101.1.2.9 ↗	alpha arrays › HTH › HTH › winged helix domain › DNA_topoisoIV	0.80	74.0	6.85e-01	100.0%	85.8%
1302406	4016.1.1.1 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV	0.79	72.0	6.50e-01	100.0%	78.2%
3959880	101.1.2.0 ↗	alpha arrays › HTH › HTH › winged helix domain	0.78	59.0	6.43e-01	78.9%	96.7%
5010044	632.22.1.0 ↗	alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats	0.75	48.0	5.12e-01	96.3%	73.7%
4175767	632.22.1.1 ↗	alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats › EzrA	0.73	46.0	4.73e-01	91.7%	65.7%
3372974	3684.1.1.2 ↗	alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › BPS1	0.72	61.0	4.50e-01	89.0%	78.8%
3810014	3291.1.1.0 ↗	alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related	0.71	61.0	5.72e-01	90.8%	75.2%
3529270	632.1.1.3 ↗	alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain › Alpha-mann_mid	0.67	42.0	4.45e-01	94.5%	70.5%
4259224	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.65	51.0	4.48e-01	94.5%	57.4%
3987991	5086.1.1.94 ↗	alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › HB_LcnD	0.65	55.0	4.33e-01	90.8%	46.2%
4034080	5065.1.1.2 ↗	alpha bundles › Type II ABC importer transmembrane domain fold › Type II ABC importer transmembrane domain fold › Type II ABC importer transmembrane domain fold › FecCD	0.64	47.0	3.30e-01	76.1%	73.5%
3169381	874.1.1.0 ↗	a+b duplicates or obligate multimers › Smc hinge domain › Smc hinge domain › Smc hinge domain	0.63	52.0	4.11e-01	90.8%	45.9%
3782183	219.1.1.0 ↗	a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases	0.62	50.0	3.16e-01	94.5%	19.4%
4153184	5086.1.1.0 ↗	alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins	0.62	54.0	4.45e-01	90.8%	56.1%
4535441	192.2.1.0 ↗	alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin	0.62	53.0	4.43e-01	90.8%	56.1%
3999487	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.61	41.0	3.93e-01	91.7%	60.0%
3927712	3922.1.1.0 ↗	alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3	0.60	48.0	4.30e-01	96.3%	60.0%
3976707	5050.1.1.9 ↗	alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1	0.60	50.0	4.16e-01	91.7%	98.5%
3625860	601.20.1.0 ↗	alpha bundles › Four-helical up-and-down bundle › Apolipophorin-III › Apolipophorin-III	0.60	49.0	4.13e-01	88.1%	71.1%
4652027	3291.1.1.0 ↗	alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related	0.60	53.0	4.70e-01	91.7%	87.6%
5079313	5050.1.1.9 ↗	alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1	0.59	51.0	4.15e-01	91.7%	95.4%
3594019	192.8.1.0 ↗	alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain	0.59	53.0	3.81e-01	91.7%	38.5%
1108268	3770.1.1.1 ↗	alpha arrays › Flax-rust effector AvrM › Flax-rust effector AvrM › Flax-rust effector AvrM › AvrM-A	0.59	52.0	4.69e-01	90.8%	72.1%
3497316	3755.4.1.0 ↗	alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain	0.59	51.0	4.41e-01	90.8%	93.8%
5072280	4177.1.1.0 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like	0.59	54.0	4.21e-01	97.2%	75.3%
4024105	5086.1.1.0 ↗	alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins	0.58	49.0	3.54e-01	91.7%	34.9%
3920125	3755.3.1.450 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › Uso1_p115_C	0.58	51.0	4.09e-01	91.7%	51.3%
3276023	2004.1.1.0 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases	0.58	51.0	4.22e-01	91.7%	87.4%
3432720	604.1.1.118 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › GOSR1_N	0.58	47.0	4.20e-01	84.4%	64.1%
3605285	603.1.1.0 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins	0.58	44.0	4.01e-01	80.7%	100.0%
3782069	633.21.1.0 ↗	alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107	0.56	53.0	4.87e-01	99.1%	99.3%
4970947	606.1.1.0 ↗	alpha complex topology › Nop N-terminal domain › Nop N-terminal domain › Nop N-terminal domain	0.56	47.0	4.29e-01	89.9%	87.6%
5076836	2004.1.1.87 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N	0.55	47.0	3.03e-01	91.7%	28.2%
3279891	5050.1.1.9 ↗	alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1	0.55	45.0	3.74e-01	89.0%	90.8%
None	—		0.55	37.0	2.74e-01	100.0%	27.8%
3532021	3755.3.1.0 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin	0.54	46.0	4.34e-01	89.0%	90.8%
3849769	3755.3.1.295 ↗	alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › WWC1	0.53	46.0	4.25e-01	92.7%	100.0%
4030141	103.4.1.0 ↗	alpha arrays › RuvA-C › Elongation factor TFIIS domain 2/ Kix domain of creb binding protein › Elongation factor TFIIS domain 2/ Kix domain of creb binding protein	0.52	38.0	3.80e-01	78.9%	74.5%
3858356	632.22.1.0 ↗	alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats	0.50	44.0	3.98e-01	94.5%	71.7%

D5 medium residues 685-795

PDB

Domain cluster: rep: DNA_topoisomerase_2__YP_009162467__Salmon_gill_poxvirus__1680908__D669-796

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00521.27 best	DNA_topoisoIV	100.1	1.90e-28	100.0%	23.4%

CATH (13)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1bjtA05	3.90.199.10	Alpha Beta › Alpha-Beta Complex › Topoisomerase II; domain 5 › Topoisomerase II, domain 5	0.96	92.0	6.72e-01	100.0%	43.8%
2xcqA02	3.90.199.10	Alpha Beta › Alpha-Beta Complex › Topoisomerase II; domain 5 › Topoisomerase II, domain 5	0.87	80.0	5.85e-01	100.0%	39.9%
1p6rA00	1.10.10.10	Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	0.72	42.0	4.79e-01	80.2%	78.0%
2fe3B01	1.10.10.10	Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	0.72	40.0	4.47e-01	73.0%	70.6%
3ejbH02	1.10.630.10	Mainly Alpha › Orthogonal Bundle › Cytochrome p450 › Cytochrome P450	0.63	42.0	3.22e-01	100.0%	29.0%
1i27A00	1.10.10.10	Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	0.60	34.0	3.98e-01	73.9%	80.8%
2k2aA00	1.10.238.10	Mainly Alpha › Orthogonal Bundle › Recoverin; domain 1 › EF-hand	0.57	34.0	4.10e-01	100.0%	92.9%
1cmjA00	1.10.630.10	Mainly Alpha › Orthogonal Bundle › Cytochrome p450 › Cytochrome P450	0.57	40.0	2.75e-01	71.2%	71.9%
4yzrA00	1.10.630.10	Mainly Alpha › Orthogonal Bundle › Cytochrome p450 › Cytochrome P450	0.55	39.0	2.73e-01	73.0%	72.7%
2b3tA01	1.10.8.10	Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Ubiquitin-associated (UBA) domain	0.53	34.0	3.81e-01	90.1%	84.5%
2o5hA00	1.10.3510.10	Mainly Alpha › Orthogonal Bundle › NMB0513-like › NMB0513-like	0.53	39.0	3.74e-01	77.5%	78.9%
2xqoA00	1.10.530.60	Mainly Alpha › Orthogonal Bundle › Lysozyme ›	0.52	43.0	3.61e-01	92.8%	82.4%
3ja8204	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.52	36.0	2.60e-01	71.2%	88.3%

ECOD (20)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4238706	101.1.2.9 ↗	alpha arrays › HTH › HTH › winged helix domain › DNA_topoisoIV	0.99	94.0	6.51e-01	100.0%	35.7%
3768919	4016.1.1.1 ↗	alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV	0.98	94.0	6.51e-01	100.0%	36.3%
1165372	101.1.2.9 ↗	alpha arrays › HTH › HTH › winged helix domain › DNA_topoisoIV	0.98	80.0	7.30e-01	85.6%	67.4%
3594651	101.1.2.0 ↗	alpha arrays › HTH › HTH › winged helix domain	0.97	93.0	8.68e-01	100.0%	83.8%
3096548	101.1.2.9 ↗	alpha arrays › HTH › HTH › winged helix domain › DNA_topoisoIV	0.95	92.0	8.55e-01	100.0%	85.0%
4096086	101.1.2.9 ↗	alpha arrays › HTH › HTH › winged helix domain › DNA_topoisoIV	0.91	67.0	6.96e-01	79.3%	80.0%
4969077	101.1.2.0 ↗	alpha arrays › HTH › HTH › winged helix domain	0.88	82.0	7.27e-01	100.0%	72.0%
2754385	101.1.2.9 ↗	alpha arrays › HTH › HTH › winged helix domain › DNA_topoisoIV	0.87	81.0	7.04e-01	100.0%	68.1%
4865162	101.1.2.9 ↗	alpha arrays › HTH › HTH › winged helix domain › DNA_topoisoIV	0.87	75.0	7.01e-01	94.6%	76.3%
4946211	101.1.2.9 ↗	alpha arrays › HTH › HTH › winged helix domain › DNA_topoisoIV	0.87	76.0	6.77e-01	100.0%	68.0%
4370976	101.1.2.9 ↗	alpha arrays › HTH › HTH › winged helix domain › DNA_topoisoIV	0.86	79.0	6.92e-01	100.0%	69.0%
5055033	101.1.2.913 ↗	alpha arrays › HTH › HTH › winged helix domain › WH_Lhr	0.70	47.0	5.08e-01	86.5%	84.4%
4013474	101.1.2.0 ↗	alpha arrays › HTH › HTH › winged helix domain	0.65	48.0	4.89e-01	77.5%	90.9%
3291502	101.1.9.0 ↗	alpha arrays › HTH › HTH › Putative DNA-binding domain	0.60	33.0	4.28e-01	90.1%	100.0%
4964643	101.1.2.913 ↗	alpha arrays › HTH › HTH › winged helix domain › WH_Lhr	0.56	48.0	4.33e-01	100.0%	67.1%
4008765	101.1.2.0 ↗	alpha arrays › HTH › HTH › winged helix domain	0.56	43.0	4.40e-01	100.0%	84.4%
4944051	101.1.2.0 ↗	alpha arrays › HTH › HTH › winged helix domain	0.55	49.0	4.25e-01	99.1%	77.6%
3266449	108.1.1.98 ↗	alpha arrays › EF-hand › EF-hand-related › EF-hand › EF-hand_1, EF-hand_5, EF-hand_7	0.53	37.0	3.02e-01	95.5%	38.6%
1284299	101.1.2.25 ↗	alpha arrays › HTH › HTH › winged helix domain › FUR	0.52	41.0	3.66e-01	82.9%	66.5%
3933074	108.1.1.107 ↗	alpha arrays › EF-hand › EF-hand-related › EF-hand › EF-hand_1, EF-hand_7, EF-hand_8	0.52	38.0	3.33e-01	85.6%	49.1%

D6 medium residues 855-939

PDB

Domain cluster: rep: IMGVR_UViG_3300007985_000017-3300007985-Ga0100381_100027569__D212-299

CATH (65)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3qx3B03	3.30.1360.40	Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 ›	0.90	86.0	8.02e-01	100.0%	98.0%
8gccA02	3.30.1360.40	Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 ›	0.89	75.0	7.47e-01	87.1%	100.0%
3l4jA04	3.30.1360.40	Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 ›	0.89	84.0	7.86e-01	100.0%	98.0%
6bq9A02	3.30.1360.40	Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 ›	0.78	64.0	6.24e-01	89.4%	96.8%
3u97A00	3.10.450.530	Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › Ribonuclease toxin, BrnT, of type II toxin-antitoxin system	0.73	29.0	3.04e-01	100.0%	39.0%
2cveA02	3.30.70.240	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.70	48.0	5.32e-01	71.8%	90.9%
1jqgA01	3.30.70.340	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Metallocarboxypeptidase-like	0.69	46.0	4.56e-01	72.9%	64.8%
2l48A00	3.30.70.2030	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.69	48.0	4.86e-01	72.9%	72.9%
7qh2C03	3.30.70.2740	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.68	48.0	4.96e-01	72.9%	96.2%
1zhvA00	3.30.2130.10	Alpha Beta › 2-Layer Sandwich › VC0802-like › VC0802-like	0.67	50.0	4.32e-01	80.0%	91.0%
3vtiA01	3.30.70.100	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.67	47.0	4.51e-01	72.9%	67.7%
3hyiA01	3.10.28.10	Alpha Beta › Roll › Endonuclease I-creI › Homing endonucleases	0.66	55.0	4.28e-01	91.8%	75.9%
2kjwA00	3.30.70.60	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Ribosomal protein S6/Translation elongation factor EF1B	0.65	45.0	4.39e-01	71.8%	72.9%
8dy9I01	3.10.28.10	Alpha Beta › Roll › Endonuclease I-creI › Homing endonucleases	0.65	52.0	3.95e-01	88.2%	82.0%
4efjA01	3.10.28.10	Alpha Beta › Roll › Endonuclease I-creI › Homing endonucleases	0.64	46.0	3.90e-01	75.3%	55.7%
2f5gA00	3.30.70.1290	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Transposase IS200-like	0.64	45.0	3.93e-01	74.1%	67.7%
3p9vA00	3.30.530.20	Alpha Beta › 2-Layer Sandwich › Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4 › START domain	0.64	44.0	3.60e-01	71.8%	93.7%
2af5A01	2.40.128.160	Mainly Beta › Beta Barrel › Lipocalin › C1 set domains (antibody constant domain-like)	0.63	27.0	3.26e-01	98.8%	57.4%
1xxaC00	3.30.1360.40	Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 ›	0.63	47.0	5.08e-01	80.0%	97.3%
1dq3A03	3.10.28.10	Alpha Beta › Roll › Endonuclease I-creI › Homing endonucleases	0.63	45.0	4.47e-01	74.1%	85.1%
3c0wA02	3.10.28.10	Alpha Beta › Roll › Endonuclease I-creI › Homing endonucleases	0.62	44.0	4.19e-01	74.1%	74.8%
1b4bA00	3.30.1360.40	Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 ›	0.62	46.0	4.97e-01	80.0%	97.2%
4i68A00	3.30.70.1800	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.62	42.0	4.18e-01	70.6%	74.4%
2psoB02	3.30.530.20	Alpha Beta › 2-Layer Sandwich › Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4 › START domain	0.61	45.0	3.62e-01	80.0%	95.5%
7qssA01	3.10.28.10	Alpha Beta › Roll › Endonuclease I-creI › Homing endonucleases	0.61	48.0	3.71e-01	84.7%	84.6%
3im8A02	3.30.70.250	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Malonyl-CoA ACP transacylase, ACP-binding	0.61	42.0	4.43e-01	72.9%	83.6%
1lfwA03	3.30.70.360	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.60	53.0	5.30e-01	98.8%	98.9%
3getA02	3.90.1150.10	Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1	0.60	45.0	4.39e-01	81.2%	74.5%
2cpjA00	3.30.70.330	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain	0.60	42.0	4.06e-01	74.1%	66.7%
4nogA01	3.90.1150.10	Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1	0.60	50.0	4.00e-01	92.9%	46.2%
2jx2A00	3.30.70.330	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain	0.59	40.0	4.07e-01	71.8%	74.7%
2cqhA00	3.30.70.330	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain	0.59	41.0	4.04e-01	72.9%	71.0%
2qb7B02	3.10.310.20	Alpha Beta › Roll › Diaminopimelate Epimerase; Chain A, domain 1 › DHHA2 domain	0.59	50.0	4.29e-01	95.3%	91.4%
2dt9A01	3.30.70.260	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain	0.59	46.0	4.82e-01	97.6%	98.6%
2dgrA01	3.30.1370.10	Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › K Homology domain, type 1	0.59	40.0	4.33e-01	71.8%	100.0%
3islA01	3.90.1150.10	Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1	0.59	44.0	3.93e-01	82.4%	67.2%
1vi7A01	3.30.230.30	Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › Impact, N-terminal domain	0.58	44.0	3.76e-01	80.0%	73.3%
3tqeA02	3.30.70.250	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Malonyl-CoA ACP transacylase, ACP-binding	0.58	40.0	4.22e-01	72.9%	84.9%
3mc6A02	3.90.1150.10	Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1	0.57	46.0	4.08e-01	94.1%	58.8%
2if1A00	3.30.780.10	Alpha Beta › 2-Layer Sandwich › Translation Initiation Factor Eif1 › SUI1-like domain	0.57	48.0	4.24e-01	95.3%	63.5%
3madA02	3.90.1150.10	Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1	0.56	46.0	4.06e-01	94.1%	59.5%
2zvfA02	3.10.310.40	Alpha Beta › Roll › Diaminopimelate Epimerase; Chain A, domain 1 ›	0.56	46.0	4.35e-01	94.1%	96.2%
1gupB01	3.30.428.10	Alpha Beta › 2-Layer Sandwich › HIT family, subunit A › HIT-like	0.56	45.0	3.73e-01	92.9%	82.9%
4ritA01	3.90.1150.170	Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 ›	0.56	47.0	3.53e-01	96.5%	39.6%
4eq3A02	2.60.40.10	Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins	0.55	41.0	3.82e-01	78.8%	91.7%
2eo4A00	3.30.428.10	Alpha Beta › 2-Layer Sandwich › HIT family, subunit A › HIT-like	0.55	46.0	3.89e-01	94.1%	88.6%
3mnmA00	2.60.40.1230	Mainly Beta › Sandwich › Immunoglobulin-like › Gamma-adaptin ear (GAE) domain	0.55	45.0	4.17e-01	90.6%	99.1%
7pjjA03	2.60.40.10	Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins	0.55	40.0	3.56e-01	78.8%	77.7%
1z1dB00	3.40.1310.20	Alpha Beta › 3-Layer(aba) Sandwich › Replication Protein E1; Chain: A, ›	0.55	47.0	4.16e-01	98.8%	64.9%
2kx2A00	3.30.780.30	Alpha Beta › 2-Layer Sandwich › Translation Initiation Factor Eif1 ›	0.55	42.0	4.08e-01	84.7%	96.9%
2a1vA00	3.90.1150.30	Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 ›	0.54	46.0	3.98e-01	96.5%	84.8%
2qmaA02	3.90.1150.10	Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1	0.54	45.0	4.07e-01	95.3%	68.0%
4eiuA02	2.60.40.2060	Mainly Beta › Sandwich › Immunoglobulin-like ›	0.54	39.0	3.45e-01	78.8%	93.4%
4m1xD00	3.30.1360.240	Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 ›	0.53	38.0	4.07e-01	77.6%	88.9%
2q1zB02	2.60.120.10	Mainly Beta › Sandwich › Jelly Rolls › Jelly Rolls	0.53	38.0	3.78e-01	76.5%	98.9%
3ffrA01	3.90.1150.10	Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1	0.53	42.0	3.93e-01	95.3%	68.4%
6iq1A00	3.30.428.10	Alpha Beta › 2-Layer Sandwich › HIT family, subunit A › HIT-like	0.52	38.0	3.26e-01	78.8%	74.8%
4k59A00	2.60.40.4380	Mainly Beta › Sandwich › Immunoglobulin-like › Translational regulator CsrA	0.51	35.0	3.85e-01	70.6%	98.5%
1ub9A00	1.10.10.10	Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	0.51	35.0	3.34e-01	70.6%	72.0%
2ln3A00	3.30.110.140	Alpha Beta › 2-Layer Sandwich › Translation Initiation Factor IF3 ›	0.51	38.0	3.87e-01	80.0%	83.1%
7n0eB02	3.30.565.10	Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain	0.51	37.0	3.35e-01	78.8%	91.8%
3l7wA00	1.10.10.10	Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	0.50	37.0	3.51e-01	78.8%	82.9%
3p0tA00	3.30.428.10	Alpha Beta › 2-Layer Sandwich › HIT family, subunit A › HIT-like	0.50	41.0	3.60e-01	92.9%	90.4%
1r62A00	3.30.565.10	Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain	0.50	38.0	3.28e-01	80.0%	88.2%
3l7xA00	3.30.428.10	Alpha Beta › 2-Layer Sandwich › HIT family, subunit A › HIT-like	0.50	36.0	3.06e-01	77.6%	64.3%

ECOD (74)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3614277	4014.1.1.1 ↗	a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV	0.88	84.0	6.32e-01	100.0%	52.2%
3277529	4014.1.1.1 ↗	a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV	0.87	83.0	6.50e-01	100.0%	60.6%
3096551	4014.1.1.1 ↗	a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV	0.84	79.0	5.95e-01	100.0%	56.8%
4624017	4014.1.1.1 ↗	a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV	0.83	76.0	5.86e-01	100.0%	60.0%
2140592	4014.1.1.1 ↗	a+b two layers › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › a+b domain in type II DNA topoisomerase › DNA_topoisoIV	0.80	72.0	5.59e-01	100.0%	60.4%
5008116	304.24.1.39 ↗	a+b two layers › Alpha-beta plaits › EF-G C-terminal domain-like › EF-G C-terminal domain-like › DUF790	0.69	49.0	4.72e-01	74.1%	71.6%
144952	304.5.1.10 ↗	a+b two layers › Alpha-beta plaits › GlnB-like › GlnB-like › CBD_PlyG	0.69	48.0	4.86e-01	72.9%	72.9%
5010365	304.126.1.0 ↗	a+b two layers › Alpha-beta plaits › ferredoxin-like domain in vacuolar ATP synthase subunit C › ferredoxin-like domain in vacuolar ATP synthase subunit C	0.68	48.0	5.22e-01	72.9%	88.6%
3671608	304.8.1.0 ↗	a+b two layers › Alpha-beta plaits › ACT-like › ACT-like	0.67	53.0	4.89e-01	85.9%	78.2%
5022296	242.1.1.7 ↗	a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases › LAGLIDADG_3	0.67	48.0	4.61e-01	74.1%	68.4%
4122798	242.1.1.6 ↗	a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases › LAGLIDADG_WhiA	0.67	49.0	4.54e-01	76.5%	67.6%
4979525	242.1.1.0 ↗	a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases	0.66	55.0	4.16e-01	89.4%	84.6%
4979632	242.1.1.0 ↗	a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases	0.66	48.0	3.72e-01	76.5%	45.6%
3215622	304.7.1.4 ↗	a+b two layers › Alpha-beta plaits › Protease propeptides/inhibitors › Protease propeptides/inhibitors › S8_pro-domain	0.66	45.0	4.61e-01	70.6%	86.3%
3532818	327.11.2.1 ↗	a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Eukaryotic type KH-domain (KH-domain type I) › KH_1	0.65	46.0	4.73e-01	74.1%	93.8%
5056954	305.1.1.0 ↗	a+b two layers › DCoH-like › RBP11-like subunits of RNA polymerase › RBP11-like subunits of RNA polymerase	0.65	48.0	5.06e-01	92.9%	89.3%
4997133	306.3.1.1 ↗	a+b two layers › Glucose permease domain IIB-like › eIF1-like › eIF1-like › SUI1	0.65	50.0	4.84e-01	83.5%	81.1%
3603087	242.1.1.7 ↗	a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases › LAGLIDADG_3	0.64	46.0	4.62e-01	74.1%	78.8%
5028300	242.1.1.0 ↗	a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases	0.64	47.0	4.71e-01	77.6%	75.3%
4937181	305.1.1.2 ↗	a+b two layers › DCoH-like › RBP11-like subunits of RNA polymerase › RBP11-like subunits of RNA polymerase › RNA_pol_L_2	0.64	46.0	4.80e-01	76.5%	82.5%
4993482	242.1.1.0 ↗	a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases	0.64	46.0	4.85e-01	75.3%	90.7%
4619996	306.2.1.1 ↗	a+b two layers › Glucose permease domain IIB-like › arginine repressor C terminal domain-related › C-terminal domain of arginine repressor › Arg_repressor_C	0.64	48.0	4.93e-01	80.0%	87.5%
5041345	304.8.1.0 ↗	a+b two layers › Alpha-beta plaits › ACT-like › ACT-like	0.64	47.0	4.83e-01	78.8%	86.3%
5027689	242.1.1.0 ↗	a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases	0.63	45.0	4.67e-01	75.3%	83.7%
4115001	242.1.1.1 ↗	a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases › LAGLIDADG_1	0.63	45.0	3.93e-01	75.3%	60.8%
3795358	304.8.1.0 ↗	a+b two layers › Alpha-beta plaits › ACT-like › ACT-like	0.63	45.0	4.70e-01	74.1%	90.7%
4943232	242.1.1.0 ↗	a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases	0.63	45.0	4.39e-01	75.3%	71.6%
4972219	242.1.1.0 ↗	a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases	0.63	45.0	4.76e-01	75.3%	90.7%
5052337	304.165.1.0 ↗	a+b two layers › Alpha-beta plaits › Uncharacterized protein Ta1207 › Uncharacterized protein Ta1207	0.63	47.0	4.01e-01	80.0%	62.9%
4464664	304.7.1.4 ↗	a+b two layers › Alpha-beta plaits › Protease propeptides/inhibitors › Protease propeptides/inhibitors › S8_pro-domain	0.63	43.0	4.31e-01	70.6%	80.0%
5028313	242.1.1.0 ↗	a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases	0.63	45.0	4.64e-01	75.3%	83.7%
4964356	304.8.1.125 ↗	a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › DUF7523	0.63	48.0	4.43e-01	82.4%	91.7%
4225320	306.3.1.4 ↗	a+b two layers › Glucose permease domain IIB-like › eIF1-like › eIF1-like › PFF1_C	0.62	48.0	4.47e-01	82.4%	88.6%
4930926	242.1.1.0 ↗	a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases	0.62	45.0	4.37e-01	76.5%	70.5%
5029541	242.1.1.0 ↗	a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases	0.62	44.0	4.40e-01	75.3%	75.6%
4937885	305.1.1.1 ↗	a+b two layers › DCoH-like › RBP11-like subunits of RNA polymerase › RBP11-like subunits of RNA polymerase › RNA_pol_L	0.62	49.0	5.02e-01	96.5%	90.0%
4821455	242.1.1.0 ↗	a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases	0.62	45.0	4.27e-01	76.5%	65.0%
4933740	3016.1.1.0 ↗	a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases	0.62	46.0	4.21e-01	80.0%	72.2%
4139769	306.2.1.1 ↗	a+b two layers › Glucose permease domain IIB-like › arginine repressor C terminal domain-related › C-terminal domain of arginine repressor › Arg_repressor_C	0.62	46.0	4.84e-01	80.0%	92.0%
2834531	242.1.1.7 ↗	a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases › LAGLIDADG_3	0.62	44.0	4.21e-01	75.3%	65.3%
3407270	327.11.2.0 ↗	a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Eukaryotic type KH-domain (KH-domain type I)	0.62	43.0	4.57e-01	74.1%	98.7%
4992013	304.4.1.80 ↗	a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel › DUF790	0.62	51.0	4.31e-01	89.4%	83.6%
5007485	304.165.1.4 ↗	a+b two layers › Alpha-beta plaits › Uncharacterized protein Ta1207 › Uncharacterized protein Ta1207 › HVO_2525_N	0.61	47.0	3.97e-01	82.4%	57.9%
4993815	242.1.1.0 ↗	a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases	0.61	46.0	4.62e-01	78.8%	85.9%
4206032	3016.1.1.1 ↗	a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › Aminotran_1_2	0.61	46.0	4.97e-01	90.6%	100.0%
4611198	3016.1.1.0 ↗	a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases	0.61	46.0	4.45e-01	81.2%	83.2%
3612079	304.9.1.1 ↗	a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1	0.60	43.0	3.99e-01	75.3%	62.7%
3272247	242.1.1.1 ↗	a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases › LAGLIDADG_1	0.60	43.0	3.65e-01	75.3%	51.0%
3586974	306.2.1.1 ↗	a+b two layers › Glucose permease domain IIB-like › arginine repressor C terminal domain-related › C-terminal domain of arginine repressor › Arg_repressor_C	0.60	45.0	4.62e-01	82.4%	87.3%
3600700	304.9.1.0 ↗	a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD	0.60	43.0	4.38e-01	76.5%	85.0%
4963893	3016.1.1.0 ↗	a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases	0.60	44.0	4.33e-01	81.2%	89.5%
3529971	327.11.2.18 ↗	a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Eukaryotic type KH-domain (KH-domain type I) › DTX3L_KH-like	0.59	42.0	4.33e-01	75.3%	95.0%
4961281	304.165.1.2 ↗	a+b two layers › Alpha-beta plaits › Uncharacterized protein Ta1207 › Uncharacterized protein Ta1207 › BAT	0.58	48.0	3.98e-01	89.4%	68.7%
4195110	206.1.1.11 ↗	a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › APH	0.58	45.0	3.33e-01	84.7%	88.5%
4177884	3016.1.1.0 ↗	a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases	0.57	47.0	4.68e-01	91.8%	93.2%
1954203	5104.1.1.1 ↗	a+b three layers › C-terminal domain in DHH phosphoesterases › C-terminal domain in DHH phosphoesterases › C-terminal domain in DHH phosphoesterases › DHHA1	0.57	47.0	4.31e-01	96.5%	88.5%
5031485	242.1.1.7 ↗	a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases › LAGLIDADG_3	0.57	46.0	3.75e-01	87.1%	51.6%
3262615	206.1.1.49 ↗	a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › DUF5898	0.56	45.0	3.68e-01	87.1%	71.2%
4932736	4955.1.1.0 ↗	a+b two layers › permuted ferredoxin-like domain in yeast RNA-polymerase beta-prime subunit › permuted ferredoxin-like domain in yeast RNA-polymerase beta-prime subunit › permuted ferredoxin-like domain in yeast RNA-polymerase beta-prime subunit	0.56	43.0	4.52e-01	92.9%	97.3%
4975750	328.5.1.1 ↗	a+b two layers › IF3-like › SirA-like › SirA-like › TusA	0.56	41.0	4.26e-01	77.6%	83.7%
3487390	304.9.1.0 ↗	a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD	0.56	46.0	4.07e-01	94.1%	61.5%
4946688	12.6.1.13 ↗	beta sandwiches › Glycosyl hydrolase domain-like › Glycoside hydrolase family 127 middle domain-related › Glycoside hydrolase family 127 middle domain-related › Glyco_hydro127C	0.55	40.0	3.60e-01	75.3%	86.1%
224981	11.1.1.129 ↗	beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › Interfer-bind	0.55	41.0	3.81e-01	78.8%	92.5%
4609020	101.1.2.642 ↗	alpha arrays › HTH › HTH › winged helix domain › DUF3631	0.55	38.0	3.77e-01	71.8%	88.9%
143130	306.3.1.3 ↗	a+b two layers › Glucose permease domain IIB-like › eIF1-like › eIF1-like › DUF5750	0.55	42.0	4.08e-01	84.7%	96.9%
4536899	242.1.1.1 ↗	a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases › LAGLIDADG_1	0.54	39.0	3.35e-01	76.5%	61.4%
3205139	3016.1.1.0 ↗	a+b two layers › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases › C-terminal domain in some PLP-dependent transferases	0.54	45.0	4.17e-01	95.3%	79.6%
4479016	3012.1.1.0 ↗	a+b two layers › Cof C2 cap domain › Cof C2 cap domain › Cof C2 cap domain	0.53	39.0	3.56e-01	76.5%	80.0%
5012777	205.1.1.16 ↗	a+b two layers › 4Fe-4S ferredoxin › 4Fe-4S ferredoxin › 4Fe-4S ferredoxin › Fer4_7	0.53	40.0	4.09e-01	95.3%	84.7%
3163957	881.1.1.38 ↗	a+b three layers › Mog1p/PsbP-like › Mog1p/PsbP-like › Mog1p/PsbP-like › PF27161	0.53	40.0	3.27e-01	82.4%	60.6%
3291654	206.1.1.11 ↗	a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › APH	0.53	44.0	3.29e-01	95.3%	89.6%
3314292	206.1.1.20 ↗	a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › PK_Tyr_Ser-Thr	0.52	44.0	3.03e-01	97.6%	45.8%
3239062	312.1.1.2 ↗	a+b three layers › HIT-like › HIT-related › HIT-related › HIT	0.51	38.0	3.37e-01	80.0%	80.0%
1320675	304.157.1.1 ↗	a+b two layers › Alpha-beta plaits › uncharacterized protein 201phi2-1p060 › uncharacterized protein 201phi2-1p060 › DUF6837	0.51	36.0	3.86e-01	77.6%	89.0%