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Dihydrofolate_reductase

Euk-Vir

Kaumoebavirus_Viruses.

Dihydrofolate_reductase__YP_009352717__Kaumoebavirus_Viruses.__X

Identity

Accession:
YP_009352717 ↗
Protein ID:
Dihydrofolate_reductase
Kingdom:
euk

Quality

94.9 mean pLDDT

Cluster

View cluster (29 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 43-142
PDB
Domain cluster: rep: IMGVR_UViG_3300017956_004020-3300017956-Ga0181580_100249958__D38-113
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00186.25 best DHFR_1 57.6 1.70e-15 99.0% 49.7%
CATH (80)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1j3jB00 3.40.430.10 Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A 0.91 82.0 6.17e-01 100.0% 43.5%
1bozA00 3.40.430.10 Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A 0.90 84.0 6.61e-01 100.0% 52.2%
3vcoA00 3.40.430.10 Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A 0.90 84.0 6.61e-01 100.0% 53.0%
3nzbX00 3.40.430.10 Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A 0.89 86.0 6.51e-01 100.0% 48.5%
1ao8A00 3.40.430.10 Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A 0.89 74.0 6.16e-01 99.0% 53.7%
3ix9A00 3.40.430.10 Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A 0.89 72.0 5.96e-01 98.0% 51.2%
6pf8A01 3.40.430.10 Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A 0.88 78.0 6.30e-01 100.0% 52.8%
1aoeA00 3.40.430.10 Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A 0.87 78.0 6.07e-01 100.0% 49.0%
2h2qB01 3.40.430.10 Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A 0.86 81.0 6.18e-01 100.0% 68.4%
3k2hA01 3.40.430.10 Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A 0.85 81.0 6.38e-01 100.0% 65.2%
4eckA01 3.40.430.10 Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A 0.85 81.0 6.40e-01 99.0% 55.3%
3ky8A01 3.40.430.10 Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A 0.78 69.0 5.70e-01 99.0% 55.2%
5yw4A00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.69 62.0 4.30e-01 99.0% 91.8%
3vc7A00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.68 60.0 4.58e-01 99.0% 97.5%
4bucA03 3.90.190.20 Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Mur ligase, C-terminal domain 0.68 56.0 5.15e-01 89.0% 75.8%
3l8hA00 3.40.50.1000 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HAD superfamily/HAD-like 0.67 57.0 4.79e-01 95.0% 92.7%
4uejA02 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.67 57.0 5.17e-01 94.0% 91.3%
1id1A00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.67 58.0 5.07e-01 97.0% 98.0%
5kiaA02 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.67 57.0 5.21e-01 95.0% 91.8%
2j8zA02 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.66 58.0 5.10e-01 96.0% 86.8%
1jvbA02 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.66 58.0 5.14e-01 96.0% 89.4%
3pi7A02 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.65 58.0 5.12e-01 99.0% 89.8%
1pjcA02 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.65 59.0 4.87e-01 100.0% 78.4%
6vloD01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.65 57.0 4.51e-01 99.0% 94.8%
4g65A03 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.64 56.0 5.11e-01 98.0% 94.0%
1lssA00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.64 56.0 5.14e-01 98.0% 96.2%
1ff9A01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.64 56.0 4.75e-01 98.0% 89.9%
2vdwG00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.64 54.0 4.07e-01 98.0% 65.6%
1f8fA02 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.64 54.0 4.89e-01 95.0% 90.5%
3g7uA01 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.64 56.0 4.62e-01 99.0% 78.1%
4g65A01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.63 54.0 4.96e-01 97.0% 96.4%
4bucA01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.63 54.0 5.59e-01 94.0% 100.0%
5o1pA01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.63 55.0 4.59e-01 96.0% 90.8%
4gvlA01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.63 53.0 4.88e-01 95.0% 86.0%
3tkaA01 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.63 54.0 4.55e-01 99.0% 79.9%
3wicA02 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.63 55.0 4.53e-01 97.0% 68.3%
4ilkA02 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.63 54.0 4.92e-01 96.0% 91.0%
1i24A01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.62 54.0 4.20e-01 99.0% 100.0%
3ggdA00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.62 55.0 4.19e-01 99.0% 74.5%
2nxcA03 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.62 55.0 4.82e-01 99.0% 82.4%
7cluA02 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.62 53.0 4.11e-01 95.0% 69.7%
4rv9A02 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.62 54.0 4.36e-01 99.0% 75.1%
3eoeD01 3.40.1380.20 Alpha Beta › 3-Layer(aba) Sandwich › Pyruvate Kinase; Chain: A, domain 1 › Pyruvate kinase, C-terminal domain 0.61 48.0 4.31e-01 89.0% 60.6%
1nv8A02 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.61 53.0 4.36e-01 99.0% 76.1%
6yu8A01 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.61 52.0 3.96e-01 98.0% 79.5%
3bkwB00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.61 53.0 4.18e-01 98.0% 78.2%
3pt9A02 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.61 53.0 3.85e-01 100.0% 72.0%
2r7kA01 3.40.50.20 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.60 50.0 4.85e-01 91.0% 86.5%
2pd2A00 3.40.1260.10 Alpha Beta › 3-Layer(aba) Sandwich › Hypothetical Protein Ychn; Chain: A, › DsrEFH-like 0.60 42.0 4.18e-01 73.0% 100.0%
3busB00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.60 53.0 4.06e-01 100.0% 65.3%
7oo1A02 3.40.1380.20 Alpha Beta › 3-Layer(aba) Sandwich › Pyruvate Kinase; Chain: A, domain 1 › Pyruvate kinase, C-terminal domain 0.60 49.0 4.68e-01 89.0% 85.6%
2gm3A00 3.40.50.620 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HUPs 0.60 53.0 4.61e-01 98.0% 94.1%
2o57A02 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.60 51.0 4.42e-01 97.0% 83.0%
3e7pA00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.60 52.0 3.97e-01 100.0% 60.9%
5bxyA00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.60 53.0 4.59e-01 99.0% 75.3%
3l8dA00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.59 51.0 4.18e-01 99.0% 83.7%
4qttB00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.59 52.0 4.38e-01 100.0% 77.7%
1l1sA00 3.40.1260.10 Alpha Beta › 3-Layer(aba) Sandwich › Hypothetical Protein Ychn; Chain: A, › DsrEFH-like 0.59 42.0 4.11e-01 74.0% 100.0%
4kavA00 3.40.720.10 Alpha Beta › 3-Layer(aba) Sandwich › Alkaline Phosphatase, subunit A › Alkaline Phosphatase, subunit A 0.59 50.0 3.59e-01 99.0% 82.9%
2p6rA01 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.58 47.0 3.89e-01 90.0% 78.9%
1cozA00 3.40.50.620 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HUPs 0.58 49.0 4.60e-01 95.0% 88.9%
2pbzA01 3.40.50.20 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.58 44.0 4.80e-01 87.0% 100.0%
3dfzB01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.58 52.0 4.83e-01 99.0% 93.6%
8tbxA01 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.57 46.0 3.67e-01 90.0% 76.9%
4k28A02 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.57 50.0 4.44e-01 98.0% 87.1%
6gitA02 3.60.21.10 Alpha Beta › 4-Layer Sandwich › Purple Acid Phosphatase; chain A, domain 2 › Metallo-dependent phosphatases 0.57 48.0 3.41e-01 97.0% 86.7%
4inoA01 3.40.50.1980 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Nitrogenase molybdenum iron protein domain 0.56 47.0 4.30e-01 93.0% 78.7%
4e4tB01 3.40.50.20 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.56 50.0 4.85e-01 100.0% 97.3%
5lomA02 3.40.190.10 Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II 0.56 40.0 4.13e-01 99.0% 81.3%
5niiB01 3.50.50.60 Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain 0.56 47.0 3.92e-01 96.0% 73.8%
2yzhA00 3.40.30.10 Alpha Beta › 3-Layer(aba) Sandwich › Glutaredoxin › Glutaredoxin 0.55 41.0 3.49e-01 79.0% 64.1%
3qtgA03 3.40.1380.20 Alpha Beta › 3-Layer(aba) Sandwich › Pyruvate Kinase; Chain: A, domain 1 › Pyruvate kinase, C-terminal domain 0.55 43.0 4.15e-01 90.0% 74.8%
4ntcA01 3.50.50.60 Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain 0.55 46.0 3.78e-01 97.0% 75.6%
3op1A01 3.40.50.620 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HUPs 0.52 46.0 3.82e-01 100.0% 76.8%
6x50A03 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.51 43.0 3.51e-01 97.0% 90.5%
1s3zA00 3.40.630.30 Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) 0.51 41.0 3.66e-01 89.0% 85.0%
3lteD00 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.51 44.0 4.17e-01 97.0% 85.4%
1dekA01 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.51 37.0 3.58e-01 98.0% 66.1%
2oktA02 3.20.20.120 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Enolase-like C-terminal domain 0.51 43.0 3.46e-01 96.0% 90.8%
5da9A01 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.50 44.0 3.08e-01 99.0% 97.7%
ECOD (91)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4667474 7501.1.1.1 ↗ a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.97 91.0 7.18e-01 100.0% 53.9%
2831687 7501.1.1.1 ↗ a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.93 75.0 6.00e-01 99.0% 48.0%
3631503 7501.1.1.1 ↗ a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.91 87.0 5.91e-01 100.0% 55.2%
3738384 7501.1.1.1 ↗ a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.91 87.0 6.30e-01 100.0% 45.0%
4021830 7501.1.1.0 ↗ a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases 0.91 87.0 6.42e-01 100.0% 53.6%
3697700 7501.1.1.1 ↗ a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.90 86.0 5.89e-01 100.0% 58.5%
3360231 7501.1.1.1 ↗ a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.90 86.0 6.38e-01 100.0% 45.0%
3913441 7501.1.1.1 ↗ a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.90 84.0 6.56e-01 100.0% 51.1%
4228699 7501.1.1.1 ↗ a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.90 79.0 6.06e-01 100.0% 45.5%
10268 7501.1.1.1 ↗ a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.90 87.0 6.56e-01 100.0% 48.5%
3232633 7501.1.1.1 ↗ a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.89 84.0 6.56e-01 100.0% 52.4%
4392834 7501.1.1.1 ↗ a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.89 85.0 6.26e-01 100.0% 46.1%
2503171 7501.1.1.1 ↗ a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.88 78.0 6.23e-01 100.0% 52.0%
3593841 7501.1.1.0 ↗ a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases 0.88 83.0 6.22e-01 100.0% 51.8%
3611921 7501.1.1.1 ↗ a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.88 83.0 6.13e-01 100.0% 50.0%
3900511 7501.1.1.1 ↗ a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.87 81.0 6.39e-01 100.0% 52.4%
4115051 7501.1.1.1 ↗ a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.87 83.0 6.05e-01 100.0% 42.1%
3187913 7501.1.1.1 ↗ a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.86 83.0 6.18e-01 100.0% 51.8%
185430 7501.1.1.1 ↗ a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.85 81.0 6.40e-01 100.0% 65.6%
3056343 7501.1.1.1 ↗ a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.85 81.0 6.13e-01 100.0% 68.9%
136031 7501.1.1.1 ↗ a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.84 80.0 6.02e-01 100.0% 48.4%
3740375 7501.1.1.0 ↗ a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases 0.79 71.0 5.60e-01 100.0% 50.0%
3581890 7501.1.1.1 ↗ a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 0.77 73.0 5.71e-01 100.0% 55.9%
4629136 7570.1.1.1 ↗ a/b three-layered sandwiches › MurD-like peptide ligases, peptide-binding domain › MurD-like peptide ligases, peptide-binding domain › MurD-like peptide ligases, peptide-binding domain › Mur_ligase_C 0.68 56.0 5.07e-01 90.0% 70.5%
1066760 7570.1.1.1 ↗ a/b three-layered sandwiches › MurD-like peptide ligases, peptide-binding domain › MurD-like peptide ligases, peptide-binding domain › MurD-like peptide ligases, peptide-binding domain › Mur_ligase_C 0.68 56.0 5.07e-01 89.0% 72.4%
3757398 2003.1.5.97 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_32 0.66 58.0 3.92e-01 99.0% 64.8%
3849065 2003.1.5.97 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_32 0.65 58.0 4.01e-01 99.0% 62.3%
None — 0.65 59.0 4.37e-01 100.0% 72.0%
3959189 2003.1.1.19 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › AlaDh_PNT_C 0.65 47.0 4.56e-01 78.0% 68.2%
3268798 2003.1.1.39 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Sacchrp_dh_NADP 0.65 57.0 4.35e-01 97.0% 90.0%
3314937 2003.1.1.46 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › F420_oxidored 0.64 58.0 4.63e-01 100.0% 86.5%
5001253 2003.1.1.386 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Sacchrp_dh_C 0.64 56.0 3.80e-01 96.0% 94.0%
3562150 2003.1.1.39 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Sacchrp_dh_NADP 0.64 57.0 4.68e-01 99.0% 87.6%
4494002 2003.1.1.20 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Epimerase 0.64 56.0 5.26e-01 95.0% 95.8%
3573654 2003.1.9.1 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › Activating enzymes of the ubiquitin-like proteins › ThiF 0.64 57.0 4.08e-01 99.0% 86.8%
5037981 2003.1.1.28 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › TrkA_N 0.64 57.0 4.88e-01 99.0% 90.0%
None — 0.63 56.0 4.68e-01 99.0% 78.9%
4382403 2003.1.1.31 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › CbiJ 0.63 55.0 4.83e-01 97.0% 73.3%
None — 0.63 56.0 4.51e-01 99.0% 88.2%
5068315 298.1.1.15 ↗ a+b two layers › FwdE/GAPDH domain-like › Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain › Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain › Sacchrp_dh_C 0.63 54.0 3.59e-01 98.0% 79.6%
4992932 2003.1.5.79 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_23 0.63 55.0 4.18e-01 98.0% 79.2%
4528181 2003.1.10.10 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › PreATP-grasp domain › DUF1246 0.62 53.0 5.17e-01 94.0% 88.2%
4024861 2003.1.5.82 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_31 0.62 54.0 4.02e-01 99.0% 75.3%
4930425 7512.1.1.30 ↗ a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › Glyco_transf_4 0.62 54.0 4.59e-01 98.0% 94.1%
4999329 2003.1.5.66 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 0.62 54.0 4.34e-01 98.0% 72.7%
4888011 2003.1.5.182 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › RrnaAD, Methyltransf_11 0.62 53.0 4.52e-01 97.0% 73.8%
5082502 2003.1.1.28 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › TrkA_N 0.62 55.0 4.93e-01 99.0% 90.0%
3988514 2003.1.1.71 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › CoA_binding_3 0.62 54.0 5.10e-01 98.0% 90.8%
5012063 2003.1.5.65 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › DOT1 0.62 54.0 4.72e-01 97.0% 75.3%
4997232 2003.1.1.20 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Epimerase 0.62 54.0 3.61e-01 100.0% 73.3%
5025715 2003.1.1.24 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Shikimate_DH 0.61 54.0 4.08e-01 99.0% 46.5%
4944121 7518.1.1.0 ↗ a/b three-layered sandwiches › PK C-terminal domain-like › PK C-terminal domain-like › PK C-terminal domain-like 0.61 50.0 4.55e-01 89.0% 80.5%
4872424 7545.1.1.0 ↗ a/b three-layered sandwiches › YchN-like › YchN-like › YchN-like 0.61 42.0 4.19e-01 73.0% 100.0%
165764 7545.1.1.1 ↗ a/b three-layered sandwiches › YchN-like › YchN-like › YchN-like › DsrE 0.60 42.0 4.18e-01 73.0% 100.0%
5042835 2003.1.10.21 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › PreATP-grasp domain › PylC-like_N 0.60 50.0 4.99e-01 93.0% 100.0%
3017364 2003.1.5.151 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_23, Methyltransf_25 0.60 53.0 3.96e-01 100.0% 74.8%
2495218 2003.1.5.152 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › CMAS, Methyltransf_25 0.60 53.0 3.88e-01 98.0% 55.6%
4997441 2005.1.1.3 ↗ a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › Usp 0.60 51.0 4.44e-01 96.0% 87.7%
5025625 2003.1.10.4 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › PreATP-grasp domain › GARS_N 0.60 51.0 5.00e-01 95.0% 86.4%
3965543 2003.1.1.20 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Epimerase 0.60 52.0 4.01e-01 99.0% 87.9%
3183984 2003.1.5.81 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_25 0.60 51.0 3.98e-01 98.0% 69.4%
5020238 2003.1.10.21 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › PreATP-grasp domain › PylC-like_N 0.60 52.0 4.92e-01 100.0% 89.6%
5015712 2003.1.5.54 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_10 0.60 51.0 3.87e-01 98.0% 64.0%
4972422 2003.1.5.0 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases 0.60 52.0 3.88e-01 98.0% 61.5%
4963544 7518.1.1.1 ↗ a/b three-layered sandwiches › PK C-terminal domain-like › PK C-terminal domain-like › PK C-terminal domain-like › PK_C 0.60 49.0 4.50e-01 89.0% 79.2%
5043369 2003.1.5.66 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 0.60 51.0 3.97e-01 99.0% 65.0%
2602554 7510.1.1.0 ↗ a/b three-layered sandwiches › Isocitrate/Isopropylmalate dehydrogenase-like › Isocitrate/Isopropylmalate dehydrogenase-like › Isocitrate/Isopropylmalate dehydrogenase-like 0.59 50.0 4.82e-01 95.0% 92.2%
3266441 2003.1.4.0 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › DHS-like NAD/FAD-binding domain 0.59 51.0 4.21e-01 97.0% 64.9%
4974466 2007.1.14.1 ↗ a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Chelatase-like › Oxidored_nitro 0.59 50.0 4.67e-01 95.0% 78.4%
3278512 2003.1.5.81 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_25 0.59 51.0 4.10e-01 99.0% 84.3%
4995351 2003.1.5.81 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_25 0.59 42.0 4.07e-01 77.0% 67.3%
5010693 7512.1.1.12 ↗ a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › Glyco_tran_28_C 0.59 51.0 4.51e-01 96.0% 80.0%
4967361 2003.1.1.65 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › NAD_binding_7 0.59 51.0 4.47e-01 100.0% 77.5%
5047638 2003.1.5.66 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 0.59 51.0 3.98e-01 100.0% 77.4%
4932817 2003.1.5.81 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_25 0.58 49.0 4.01e-01 97.0% 80.5%
4512900 2003.1.5.0 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases 0.58 50.0 4.55e-01 96.0% 74.1%
4408656 2003.1.5.53 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › tRNA_U5-meth_tr 0.58 50.0 3.59e-01 98.0% 40.0%
5033275 2003.1.5.81 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_25 0.58 51.0 3.72e-01 100.0% 54.3%
4992446 7518.1.1.1 ↗ a/b three-layered sandwiches › PK C-terminal domain-like › PK C-terminal domain-like › PK C-terminal domain-like › PK_C 0.58 48.0 4.52e-01 89.0% 85.0%
3588376 7545.1.1.1 ↗ a/b three-layered sandwiches › YchN-like › YchN-like › YchN-like › DsrE 0.58 42.0 4.18e-01 93.0% 73.1%
3283157 2003.1.5.46 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › MTS 0.58 41.0 3.94e-01 77.0% 63.6%
3673942 2003.1.5.115 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_29 0.58 45.0 4.69e-01 90.0% 95.6%
3296184 7558.1.1.1 ↗ a/b three-layered sandwiches › Glycerol-3-phosphate (1)-acyltransferase › Glycerol-3-phosphate (1)-acyltransferase › Glycerol-3-phosphate (1)-acyltransferase › Acyltransferase 0.56 47.0 3.58e-01 98.0% 66.7%
3437975 7558.1.1.1 ↗ a/b three-layered sandwiches › Glycerol-3-phosphate (1)-acyltransferase › Glycerol-3-phosphate (1)-acyltransferase › Glycerol-3-phosphate (1)-acyltransferase › Acyltransferase 0.55 48.0 3.63e-01 100.0% 66.8%
4945625 2004.1.1.1203 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › RMMBL 0.55 46.0 4.22e-01 97.0% 76.4%
4977521 213.1.1.0 ↗ a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) 0.53 42.0 3.81e-01 85.0% 79.3%
5032479 2004.1.1.0 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.53 44.0 4.05e-01 96.0% 80.7%
4153562 2004.1.1.23 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SNF2-rel_dom 0.53 46.0 3.52e-01 100.0% 65.2%
3594769 2007.1.4.0 ↗ a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Phosphofructokinase N-terminal domain 0.53 45.0 4.13e-01 97.0% 88.1%
4180794 7550.1.1.1 ↗ a/b three-layered sandwiches › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › Tetrapyrrole methylase N-terminal domain › TP_methylase 0.52 42.0 4.15e-01 92.0% 88.2%
140826 2005.1.1.28 ↗ a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › FAD_syn 0.52 46.0 3.81e-01 100.0% 75.9%