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Dihydrofolate_reductase_incomplete_domain

Euk-Vir

Pandoravirus_salinus

Dihydrofolate_reductase_incomplete_domain__YP_008438723__Pandoravirus_salinus__1349410

Identity

Accession:
YP_008438723 ↗
Protein ID:
Dihydrofolate_reductase_incomplete_domain
Kingdom:
euk

Quality

60.1 mean pLDDT

Taxonomy

Pandoravirus› Pandoravirus_salinus

TaxID: 1349410

Cluster

View cluster (5 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 23-192
PDB
Domain cluster: rep: dihydrofolate_reductase__YP_009119754__Pandoravirus_inopinatum__1605721__D21-210
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00186.25 best DHFR_1 40.5 3.30e-10 75.3% 72.3%
D2 high residues 829-893
PDB
D3 medium residues 402-603
PDB
Domain cluster: rep: hypothetical_protein_pqer_cds_630__YP_009483321__Pandoravirus_quercus__2107709__D155-338
D4 medium residues 604-623_641-754
PDB
Domain cluster: representative
CATH (35)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
4crwA00 1.25.40.180 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.70 62.0 5.16e-01 100.0% 56.2%
6tblB01 1.25.10.10 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant 0.70 55.0 5.94e-01 97.0% 100.0%
1sz9C00 1.25.40.90 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.69 55.0 5.44e-01 99.3% 80.7%
4jxtA00 1.25.40.90 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.68 54.0 5.53e-01 100.0% 86.9%
3sl9B00 1.25.10.10 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant 0.68 54.0 5.07e-01 100.0% 69.1%
4xriA00 1.25.10.10 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant 0.68 63.0 3.76e-01 100.0% 15.5%
3vldA01 1.25.10.50 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › 0.67 58.0 4.46e-01 100.0% 41.4%
3l9tA02 1.25.40.290 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › ARM repeat domains 0.67 49.0 5.18e-01 100.0% 87.3%
5ewpA00 1.25.10.10 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant 0.66 56.0 4.64e-01 98.5% 51.0%
2w3cA01 1.25.10.10 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant 0.66 59.0 4.68e-01 99.3% 49.4%
4c0eA01 1.25.40.790 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.65 59.0 4.65e-01 100.0% 54.8%
3on4D00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.65 50.0 4.48e-01 80.6% 79.5%
4k6jB00 1.25.10.10 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant 0.64 58.0 3.99e-01 100.0% 45.2%
2jqqA00 1.20.58.1240 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.64 54.0 5.17e-01 91.8% 83.8%
1bk6A00 1.25.10.10 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant 0.64 57.0 4.01e-01 98.5% 31.3%
1xqrA00 1.25.10.10 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant 0.63 58.0 4.60e-01 100.0% 50.2%
4flbA00 1.25.40.90 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.63 51.0 5.23e-01 98.5% 89.3%
4hz4A02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.63 49.0 5.34e-01 85.1% 99.1%
2fd5A02 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.62 43.0 4.38e-01 70.9% 80.3%
7ru9C01 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.61 50.0 4.02e-01 100.0% 44.6%
5vjcA00 1.25.10.10 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant 0.61 55.0 4.42e-01 100.0% 59.9%
4kwaB00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.61 45.0 4.05e-01 78.4% 76.6%
3ihvA01 1.25.40.890 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.60 45.0 4.26e-01 88.1% 64.6%
3gw4A00 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.59 41.0 3.71e-01 92.5% 50.5%
5cmyA00 1.25.40.90 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.58 49.0 4.81e-01 91.0% 90.8%
6hwjA01 3.90.1200.10 Alpha Beta › Alpha-Beta Complex › Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2 › Aminoglycoside phosphotransferase (APH), C-terminal lobe 0.58 47.0 3.93e-01 88.8% 100.0%
3tt9A00 1.25.10.10 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant 0.57 51.0 4.29e-01 100.0% 73.0%
4qhpA05 1.25.50.10 Mainly Alpha › Alpha Horseshoe › Zincin-like fold › Peptidase M1, alanyl aminopeptidase, C-terminal domain 0.56 50.0 3.82e-01 99.3% 72.2%
3ro3A00 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.54 41.0 3.90e-01 95.5% 66.7%
2qibB00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.54 41.0 3.58e-01 79.9% 65.4%
8hk0C01 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.53 34.0 3.36e-01 94.0% 57.3%
3qwwA03 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.53 40.0 3.58e-01 87.3% 55.5%
3we9A00 1.10.600.10 Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase 0.51 43.0 3.57e-01 91.8% 62.3%
7powA01 1.20.120.1760 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › CDP-alcohol phosphotransferase transmembrane (TM) domain 0.50 45.0 3.98e-01 99.3% 92.9%
3gi8C00 1.20.1740.10 Mainly Alpha › Up-down Bundle › Amino acid/polyamine transporter I › Amino acid/polyamine transporter I 0.50 43.0 3.09e-01 96.3% 92.6%
ECOD (27)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3185438 603.1.1.97 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins › Syntaxin, SNARE 0.72 53.0 4.65e-01 76.9% 95.0%
3592170 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.71 65.0 4.88e-01 100.0% 44.1%
4015211 109.4.1.1594 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPP2R1A-like_HEAT, VPS15-like_hel 0.70 56.0 3.61e-01 100.0% 19.0%
3787559 109.4.1.1255 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Adaptin_N, Cnd1 0.69 56.0 3.55e-01 100.0% 18.2%
4019940 603.1.1.1 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins › Syntaxin 0.69 52.0 4.44e-01 79.1% 85.0%
4014763 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.68 62.0 4.87e-01 100.0% 72.9%
5051080 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.66 56.0 4.85e-01 91.8% 61.2%
3613191 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.66 59.0 4.62e-01 99.3% 46.0%
3625716 109.4.1.266 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › XMAP215_CLASP_TOG 0.66 60.0 3.55e-01 100.0% 13.8%
3501789 109.3.1.289 ↗ alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat › E3_UBR4_N 0.66 59.0 5.06e-01 99.3% 76.8%
3600028 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.66 57.0 4.21e-01 94.0% 63.2%
3355930 109.4.1.1495 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PF26522 0.65 52.0 5.51e-01 93.3% 98.3%
3717033 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.65 56.0 4.11e-01 93.3% 37.2%
3711872 109.4.1.1255 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Adaptin_N, Cnd1 0.64 57.0 3.53e-01 100.0% 17.0%
3597481 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.64 58.0 4.25e-01 97.8% 47.4%
3795795 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.64 59.0 4.82e-01 100.0% 62.1%
3271522 109.4.1.413 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › FANCI_S2,FANCI_HD2 0.64 58.0 3.82e-01 100.0% 32.0%
4025667 109.4.1.70 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › CID 0.63 55.0 5.56e-01 97.8% 95.6%
3587885 1075.5.1.4 ↗ alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › Polysacc_synt 0.63 46.0 3.71e-01 75.4% 66.5%
3234252 109.4.1.266 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › XMAP215_CLASP_TOG 0.63 58.0 4.52e-01 100.0% 53.9%
4998419 109.4.1.257 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PDS5 0.62 57.0 4.62e-01 100.0% 59.6%
3990257 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.61 50.0 5.28e-01 95.5% 96.7%
5075298 1075.5.1.8 ↗ alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › Polysacc_synt_3 0.61 44.0 3.48e-01 74.6% 72.6%
3416312 3352.1.1.0 ↗ alpha bundles › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain 0.57 45.0 3.36e-01 83.6% 69.3%
3287499 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.54 41.0 4.19e-01 100.0% 83.1%
5010685 5050.1.1.0 ↗ alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.53 40.0 3.85e-01 77.6% 78.0%
3226518 109.5.1.1 ↗ alpha superhelices › Repetitive alpha hairpins › adenylylcyclase associated protein, CAP-N › adenylylcyclase associated protein, CAP-N › CAP_N 0.52 40.0 3.70e-01 82.1% 74.3%
D5 medium residues 899-1023
PDB
D6 medium residues 1024-1108
PDB
D7 medium residues 1109-1135_1149-1215
PDB