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Dihydrofolate_reductase_incomplete_domain
Euk-VirPandoravirus_salinus
Dihydrofolate_reductase_incomplete_domain__YP_009430065__Pandoravirus_salinus__1349410
Identity
- Accession:
- YP_009430065 ↗
- Protein ID:
- Dihydrofolate_reductase_incomplete_domain
- Kingdom:
- euk
Quality
48.5
mean pLDDT
Cluster
View cluster (2 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 42-68_133-223
Domain cluster:
representative
CATH (23)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 6pf8A01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.81 | 64.0 | 5.49e-01 | 82.2% | 87.5% |
| 1j3jB00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.80 | 65.0 | 5.16e-01 | 83.9% | 79.2% |
| 3ix9A00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.80 | 64.0 | 5.63e-01 | 83.1% | 87.3% |
| 1ao8A00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.80 | 64.0 | 5.66e-01 | 83.1% | 88.9% |
| 2w9hA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.80 | 63.0 | 5.67e-01 | 82.2% | 87.9% |
| 1dhiA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.80 | 63.0 | 5.63e-01 | 82.2% | 88.1% |
| 5eccA00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.80 | 63.0 | 5.66e-01 | 82.2% | 87.3% |
| 3k2hA01 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.79 | 63.0 | 5.31e-01 | 83.1% | 85.6% |
| 2hxvA02 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.74 | 59.0 | 4.83e-01 | 82.2% | 88.9% |
| 1cz3B00 | 3.40.430.10 | Alpha Beta › 3-Layer(aba) Sandwich › Dihydrofolate Reductase, subunit A › Dihydrofolate Reductase, subunit A | 0.74 | 58.0 | 5.13e-01 | 82.2% | 86.3% |
| 5f2kB02 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.60 | 46.0 | 3.79e-01 | 82.2% | 100.0% |
| 3tmaA02 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.59 | 46.0 | 4.02e-01 | 82.2% | 95.5% |
| 3n9vB00 | 3.60.10.10 | Alpha Beta › 4-Layer Sandwich › Deoxyribonuclease I; Chain A › Endonuclease/exonuclease/phosphatase | 0.58 | 46.0 | 3.51e-01 | 85.6% | 96.2% |
| 1b4uB00 | 3.40.830.10 | Alpha Beta › 3-Layer(aba) Sandwich › Protocatechuate 4,5-dioxygenase; Chain B › LigB-like | 0.58 | 45.0 | 3.37e-01 | 82.2% | 91.6% |
| 4m3sA00 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.57 | 45.0 | 4.11e-01 | 85.6% | 87.4% |
| 3wraA01 | 3.40.830.10 | Alpha Beta › 3-Layer(aba) Sandwich › Protocatechuate 4,5-dioxygenase; Chain B › LigB-like | 0.56 | 49.0 | 3.73e-01 | 99.2% | 95.7% |
| 1jsxA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.55 | 42.0 | 3.57e-01 | 81.4% | 81.3% |
| 4lfhD02 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.53 | 29.0 | 3.35e-01 | 83.9% | 71.8% |
| 1k8wA01 | 3.30.2350.10 | Alpha Beta › 2-Layer Sandwich › Pseudouridine synthase › Pseudouridine synthase | 0.53 | 39.0 | 3.09e-01 | 75.4% | 96.3% |
| 4e2aA00 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.52 | 40.0 | 3.63e-01 | 83.1% | 84.7% |
| 1mhmA00 | 3.60.90.10 | Alpha Beta › 4-Layer Sandwich › S-adenosylmethionine decarboxylase › S-adenosylmethionine decarboxylase | 0.52 | 41.0 | 3.15e-01 | 82.2% | 97.2% |
| 5hh1A00 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.51 | 40.0 | 3.40e-01 | 83.1% | 78.5% |
| 4qjvB00 | 3.30.1360.10 | Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › RNA polymerase, RBP11-like subunit | 0.51 | 29.0 | 3.22e-01 | 83.9% | 69.1% |
ECOD (23)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2831687 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.81 | 64.0 | 5.55e-01 | 82.2% | 80.9% |
| 4115051 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.81 | 65.0 | 4.97e-01 | 83.1% | 82.1% |
| 2503171 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.80 | 64.0 | 5.46e-01 | 83.1% | 86.6% |
| 185430 | 7501.1.1.1 ↗ | a/b three-layered sandwiches › Dihydrofolate reductases › Dihydrofolate reductases › Dihydrofolate reductases › DHFR_1 | 0.79 | 63.0 | 5.32e-01 | 83.1% | 86.0% |
| 5042970 | 2003.1.5.5 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › UPF0020 | 0.61 | 48.0 | 4.09e-01 | 82.2% | 92.4% |
| 3817212 | 304.8.1.0 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like | 0.60 | 30.0 | 3.83e-01 | 72.0% | 81.4% |
| 3457406 | 2003.1.5.5 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › UPF0020 | 0.60 | 47.0 | 3.58e-01 | 83.1% | 83.0% |
| 4304538 | 2003.1.5.5 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › UPF0020 | 0.59 | 47.0 | 3.45e-01 | 83.1% | 73.8% |
| 3615134 | 2003.1.5.5 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › UPF0020 | 0.59 | 46.0 | 3.45e-01 | 82.2% | 75.0% |
| 5059031 | 2003.1.5.5 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › UPF0020 | 0.59 | 46.0 | 3.96e-01 | 83.1% | 90.0% |
| 3184468 | 2003.1.5.5 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › UPF0020 | 0.59 | 46.0 | 3.48e-01 | 83.9% | 79.0% |
| 3365317 | 304.8.1.0 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like | 0.57 | 31.0 | 3.74e-01 | 83.9% | 78.8% |
| 3456962 | 304.8.1.45 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant | 0.56 | 31.0 | 3.68e-01 | 84.7% | 77.4% |
| 3408311 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.55 | 32.0 | 3.47e-01 | 85.6% | 67.0% |
| 3302370 | 304.8.1.0 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like | 0.55 | 31.0 | 3.64e-01 | 85.6% | 79.5% |
| 3646028 | 246.3.1.4 ↗ | a+b four layers › Carbon-nitrogen hydrolase-like › DNase I-like › DNase I-like › Exo_endo_phos2 | 0.53 | 47.0 | 3.41e-01 | 99.2% | 91.3% |
| 3333863 | 304.8.1.47 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › ACT_ACR9_3rd | 0.53 | 28.0 | 2.92e-01 | 74.6% | 55.5% |
| 3468691 | 304.8.1.0 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like | 0.52 | 32.0 | 3.64e-01 | 85.6% | 80.9% |
| 3305434 | 304.8.1.0 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like | 0.52 | 32.0 | 3.58e-01 | 85.6% | 78.9% |
| 3965660 | 223.1.1.110 ↗ | a+b three layers › Profilin-like › sensor domains › sensor domains › PF30364 | 0.51 | 32.0 | 3.06e-01 | 82.2% | 52.1% |
| 4419286 | 304.8.1.0 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like | 0.51 | 33.0 | 3.65e-01 | 88.1% | 81.7% |
| 3317802 | 304.8.1.45 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant | 0.50 | 31.0 | 3.35e-01 | 86.4% | 73.7% |
| 3384789 | 304.8.1.45 ↗ | a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › bHLH-TF_ACT-like_plant | 0.50 | 31.0 | 3.22e-01 | 86.4% | 64.5% |
D2
medium
residues 69-132
Domain cluster:
representative
CATH (3)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2xzlA05 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.56 | 45.0 | 3.25e-01 | 92.2% | 81.6% |
| 4mybA00 | 3.90.550.10 | Alpha Beta › Alpha-Beta Complex › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A | 0.55 | 47.0 | 3.33e-01 | 100.0% | 30.0% |
| 4l2iA01 | 3.40.50.620 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HUPs | 0.52 | 43.0 | 3.17e-01 | 100.0% | 66.8% |
ECOD (4)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3402804 | 7512.1.1.6 ↗ | a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › Glyco_transf_20 | 0.65 | 51.0 | 3.38e-01 | 87.5% | 66.1% |
| 3781102 | 7527.1.1.1 ↗ | a/b three-layered sandwiches › SurE-like/CoA-transferase family III (CaiB/BaiF) › SurE-like/CoA-transferase family III (CaiB/BaiF) › SurE-like/CoA-transferase family III (CaiB/BaiF) › SurE | 0.57 | 46.0 | 3.08e-01 | 93.8% | 62.4% |
| 4953504 | 7516.1.1.11 ↗ | a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › CTP_transf_3 | 0.56 | 48.0 | 3.34e-01 | 100.0% | 33.3% |
| 5074580 | 2007.1.3.0 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › CheY-like | 0.53 | 42.0 | 2.93e-01 | 93.8% | 23.5% |
D3
medium
residues 539-565_597-655
D4
medium
residues 656-886
D5
medium
residues 947-989_1035-1064
D6
medium
residues 1096-1139_1187-1223
D7
medium
residues 1224-1331