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E2_protein
Euk-VirSemliki_Forest_virus
E2_protein__NP_819006__Semliki_Forest_virus__11033
Identity
- Accession:
- NP_819006 ↗
- Protein ID:
- E2_protein
- Kingdom:
- euk
Quality
82.5
mean pLDDT
Taxonomy
Orthornavirae›
Kitrinoviricota›
Alsuviricetes›
Martellivirales›
Togaviridae›
Alphavirus›
Semliki_Forest_virus
TaxID: 11033
Cluster
View cluster (15 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 2-168
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00943.26 best | Alpha_E2_glycop | 289.6 | 4.80e-86 | 92.8% | 38.5% |
CATH (22)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 7ffnN01 | 2.60.40.3200 | Mainly Beta › Sandwich › Immunoglobulin-like › Alphavirus E2 glycoprotein, A domain | 0.94 | 90.0 | 8.72e-01 | 99.4% | 90.6% |
| 3n40P02 | 2.60.40.3200 | Mainly Beta › Sandwich › Immunoglobulin-like › Alphavirus E2 glycoprotein, A domain | 0.94 | 91.0 | 8.11e-01 | 98.8% | 76.0% |
| 3muuB01 | 2.60.40.3200 | Mainly Beta › Sandwich › Immunoglobulin-like › Alphavirus E2 glycoprotein, A domain | 0.92 | 84.0 | 8.44e-01 | 96.4% | 93.5% |
| 2ee3A00 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.65 | 40.0 | 4.89e-01 | 77.2% | 94.4% |
| 3q48A02 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.64 | 33.0 | 4.49e-01 | 70.1% | 100.0% |
| 2ox5B00 | 2.60.40.2470 | Mainly Beta › Sandwich › Immunoglobulin-like › SoxY domain | 0.63 | 37.0 | 4.42e-01 | 71.9% | 85.5% |
| 2hczX02 | 2.60.40.760 | Mainly Beta › Sandwich › Immunoglobulin-like › Expansin, cellulose-binding-like domain | 0.63 | 36.0 | 4.36e-01 | 70.1% | 87.5% |
| 3d30A02 | 2.60.40.760 | Mainly Beta › Sandwich › Immunoglobulin-like › Expansin, cellulose-binding-like domain | 0.63 | 35.0 | 4.45e-01 | 91.6% | 94.7% |
| 2xg5A02 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.60 | 33.0 | 4.28e-01 | 70.7% | 96.7% |
| 3cmgA04 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.59 | 32.0 | 4.27e-01 | 82.6% | 100.0% |
| 2oxgC00 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.59 | 36.0 | 4.50e-01 | 70.1% | 99.0% |
| 4o65A00 | 2.60.120.570 | Mainly Beta › Sandwich › Jelly Rolls › Particulate methane monooxygenase, b subunit. Chain: A, domain 1 | 0.59 | 44.0 | 4.57e-01 | 75.4% | 94.8% |
| 3q0hB00 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.57 | 36.0 | 4.34e-01 | 71.3% | 97.2% |
| 5iroD00 | 2.60.40.3530 | Mainly Beta › Sandwich › Immunoglobulin-like › | 0.56 | 35.0 | 4.26e-01 | 78.4% | 99.0% |
| 4jdzA02 | 2.60.40.1290 | Mainly Beta › Sandwich › Immunoglobulin-like › | 0.56 | 39.0 | 3.93e-01 | 70.7% | 100.0% |
| 4ei0A01 | 2.60.40.3550 | Mainly Beta › Sandwich › Immunoglobulin-like › Domain of unknown function DUF4466 | 0.55 | 40.0 | 4.28e-01 | 73.7% | 100.0% |
| 2qsqB01 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.55 | 35.0 | 4.30e-01 | 70.7% | 100.0% |
| 1ix2A00 | 2.60.40.1220 | Mainly Beta › Sandwich › Immunoglobulin-like › | 0.54 | 33.0 | 4.13e-01 | 70.1% | 100.0% |
| 2fauA02 | 2.60.40.640 | Mainly Beta › Sandwich › Immunoglobulin-like › | 0.54 | 38.0 | 4.18e-01 | 73.1% | 93.4% |
| 2pndA00 | 2.60.40.10 | Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins | 0.53 | 37.0 | 4.25e-01 | 71.9% | 100.0% |
| 5umsA02 | 2.30.29.30 | Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) | 0.51 | 26.0 | 3.26e-01 | 72.5% | 79.4% |
| 1b9mA03 | 2.40.50.100 | Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain | 0.50 | 21.0 | 2.96e-01 | 82.6% | 83.1% |
ECOD (30)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1759174 | 11.1.1.19 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › Alpha_E2_glycop | 0.93 | 83.0 | 8.74e-01 | 91.0% | 100.0% |
| 4826054 | 11.1.1.19 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › Alpha_E2_glycop | 0.93 | 77.0 | 8.33e-01 | 84.4% | 99.3% |
| 4822748 | 11.1.1.19 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › Alpha_E2_glycop | 0.93 | 76.0 | 8.32e-01 | 85.0% | 100.0% |
| 3394602 | 11.1.1.462 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › REJ | 0.71 | 39.0 | 5.13e-01 | 74.9% | 98.9% |
| 3415795 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.68 | 39.0 | 5.05e-01 | 78.4% | 98.9% |
| 3534418 | 11.1.1.2 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › fn3 | 0.65 | 39.0 | 4.54e-01 | 74.9% | 82.5% |
| 5039363 | 11.1.4.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Prealbumin-like | 0.64 | 33.0 | 4.24e-01 | 70.1% | 87.8% |
| 2324090 | 11.1.1.326 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › GldM_3rd | 0.64 | 33.0 | 4.48e-01 | 71.9% | 98.8% |
| 3251297 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.63 | 40.0 | 4.84e-01 | 70.1% | 97.3% |
| 4402022 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.61 | 31.0 | 4.27e-01 | 71.3% | 100.0% |
| 2387783 | 11.1.1.38 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › Big_2 | 0.61 | 36.0 | 4.46e-01 | 80.2% | 97.9% |
| 3631298 | 4.1.1.1 ↗ | beta barrels › SH3 › SH3 › SH3 › SH3_1 | 0.59 | 20.0 | 2.86e-01 | 71.3% | 62.7% |
| 5017141 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.58 | 39.0 | 4.55e-01 | 74.9% | 94.2% |
| 3252859 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.57 | 34.0 | 4.25e-01 | 82.6% | 97.0% |
| 3935228 | 11.1.1.590 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › NUP210_Ig15 | 0.57 | 36.0 | 4.30e-01 | 71.3% | 98.1% |
| 4633854 | 11.1.1.39 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › Big_1 | 0.56 | 33.0 | 4.10e-01 | 71.3% | 96.0% |
| 5027795 | 11.1.4.23 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Prealbumin-like › CarboxypepD_reg | 0.56 | 29.0 | 3.74e-01 | 75.4% | 88.9% |
| 4881877 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.56 | 35.0 | 4.13e-01 | 75.4% | 91.2% |
| 1824160 | 395.1.1.2 ↗ | few secondary structure elements › Midkine-related › Midkine-related › Midkine-related › PTN_MK_N | 0.56 | 20.0 | 3.12e-01 | 72.5% | 81.2% |
| 3410505 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.56 | 36.0 | 3.65e-01 | 71.3% | 65.5% |
| 3683419 | 11.1.5.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Common fold of diphtheria toxin/transcription factors/cytochrome f | 0.55 | 35.0 | 4.25e-01 | 89.2% | 100.0% |
| 3546263 | 11.1.1.99 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › V-set | 0.54 | 36.0 | 4.21e-01 | 72.5% | 94.2% |
| 3707624 | 11.1.5.29 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Common fold of diphtheria toxin/transcription factors/cytochrome f › Sec23_BS | 0.54 | 38.0 | 3.62e-01 | 71.9% | 91.3% |
| 3601949 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.53 | 37.0 | 4.00e-01 | 71.3% | 100.0% |
| 3849404 | 11.1.1.99 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › V-set | 0.53 | 36.0 | 3.95e-01 | 74.3% | 84.4% |
| 3319546 | 11.1.1.214 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › Pur_ac_phosph_N | 0.53 | 38.0 | 4.01e-01 | 74.3% | 81.9% |
| 3475562 | 11.1.1.9 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › Arrestin_N | 0.53 | 38.0 | 3.99e-01 | 74.3% | 94.8% |
| 3852387 | 11.1.1.99 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › V-set | 0.52 | 37.0 | 4.23e-01 | 82.0% | 97.6% |
| 3229200 | 11.1.1.179 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › Ig_3 | 0.52 | 37.0 | 3.94e-01 | 77.2% | 83.4% |
| 3753272 | 11.1.1.1 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › Cadherin | 0.50 | 35.0 | 3.71e-01 | 74.9% | 80.5% |
D2
high
residues 173-240
Domain cluster:
rep: polyprotein__BAA92847__Sagiyama_virus__59303__D507-561
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00943.26 best | Alpha_E2_glycop | 117.8 | 7.30e-34 | 100.0% | 16.9% |
D3
medium
residues 268-337
Domain cluster:
rep: E2_protein__NP_740659__Sleeping_disease_virus__78540__D289-352
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00943.26 best | Alpha_E2_glycop | 124.7 | 5.80e-36 | 100.0% | 17.4% |
D4
medium
residues 351-414
Domain cluster:
rep: uncovered_polypeptide_truncated_polyprotein__YP_006491235_0-756__Venezuelan_equine_encephalitis_virus__11036__D698-750
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00943.26 best | Alpha_E2_glycop | 99.6 | 2.50e-28 | 100.0% | 15.9% |