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E47
Euk-VirMurid_betaherpesvirus_8
E47__YP_007016453__Murid_betaherpesvirus_8__1261657
Identity
- Accession:
- YP_007016453 ↗
- Protein ID:
- E47
- Kingdom:
- euk
Quality
76.7
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Muromegalovirus›
Murid_betaherpesvirus_8
TaxID: 1261657
Cluster
View cluster (39 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 1-112
Domain cluster:
rep: tegument_protein_UL37__YP_004940219__Saimiriine_betaherpesvirus_4__1535247__D1-106
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF04523.19 best | Herpes_U30 | 49.6 | 2.40e-13 | 81.2% | 7.7% |
D2
medium
residues 113-216
Domain cluster:
representative
CATH (30)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 7oq4Z01 | 1.20.120.950 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Uncharacterised protein DUF5062 | 0.69 | 40.0 | 4.10e-01 | 77.9% | 59.2% |
| 1wpaA01 | 6.10.140.340 | Special › Helix non-globular › Helix Hairpins › | 0.67 | 47.0 | 4.83e-01 | 72.1% | 87.9% |
| 2v6yA00 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.66 | 46.0 | 5.22e-01 | 85.6% | 100.0% |
| 3kkbA00 | 1.20.120.880 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Histidine kinase (KinB), sensor domain | 0.65 | 53.0 | 4.97e-01 | 98.1% | 70.6% |
| 4hwdD00 | 1.20.58.120 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain | 0.65 | 52.0 | 5.58e-01 | 92.3% | 100.0% |
| 4dloB02 | 1.25.40.610 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.64 | 47.0 | 4.56e-01 | 84.6% | 68.4% |
| 1hs7A00 | 1.20.58.70 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.64 | 53.0 | 5.46e-01 | 89.4% | 97.9% |
| 4wnfA00 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.62 | 44.0 | 3.28e-01 | 89.4% | 29.4% |
| 2igpA00 | 1.10.418.30 | Mainly Alpha › Orthogonal Bundle › Actin-binding Protein, T-fimbrin; domain 1 › Ncd80 complex, Ncd80 subunit | 0.62 | 30.0 | 2.94e-01 | 76.0% | 42.1% |
| 2crbA00 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.60 | 44.0 | 4.58e-01 | 87.5% | 82.5% |
| 2lqgA00 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.60 | 48.0 | 4.39e-01 | 86.5% | 78.3% |
| 2ntxA01 | 1.20.58.2010 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › PRONE domain, subdomain 1 | 0.60 | 53.0 | 4.25e-01 | 100.0% | 63.8% |
| 7e4mA01 | 1.10.600.10 | Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase | 0.59 | 44.0 | 3.25e-01 | 77.9% | 31.2% |
| 6ldkA01 | 1.10.730.10 | Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1 | 0.58 | 44.0 | 3.75e-01 | 80.8% | 51.7% |
| 1ya0A01 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.58 | 46.0 | 3.68e-01 | 92.3% | 43.2% |
| 4ijjB00 | 1.20.120.910 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › DksA, coiled-coil domain | 0.58 | 41.0 | 3.77e-01 | 73.1% | 67.7% |
| 2dw4A03 | 1.10.287.80 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ATP synthase, gamma subunit, helix hairpin domain | 0.57 | 39.0 | 4.00e-01 | 73.1% | 73.3% |
| 2nwlC00 | 1.10.3860.10 | Mainly Alpha › Orthogonal Bundle › Proton glutamate symport protein › Sodium:dicarboxylate symporter | 0.57 | 47.0 | 3.13e-01 | 89.4% | 63.3% |
| 2yykA01 | 1.10.3140.10 | Mainly Alpha › Orthogonal Bundle › 4-hydroxybutyryl-coa dehydratase, domain 1 › 4-hydroxybutyryl-coa dehydratase, domain 1 | 0.57 | 39.0 | 3.59e-01 | 83.7% | 54.0% |
| 2a9uA01 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.56 | 42.0 | 3.98e-01 | 84.6% | 65.9% |
| 2q0oC00 | 1.10.287.160 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat | 0.56 | 39.0 | 4.26e-01 | 71.2% | 89.5% |
| 3hr0B01 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.56 | 35.0 | 3.96e-01 | 73.1% | 83.5% |
| 3fppA03 | 6.10.140.1990 | Special › Helix non-globular › Helix Hairpins › | 0.55 | 38.0 | 4.11e-01 | 73.1% | 83.0% |
| 7zxkC01 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.54 | 37.0 | 3.28e-01 | 70.2% | 73.3% |
| 1i6zA00 | 1.20.58.120 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain | 0.53 | 47.0 | 4.34e-01 | 100.0% | 87.4% |
| 1lqsL01 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.53 | 37.0 | 3.84e-01 | 72.1% | 93.0% |
| 4hr1A00 | 1.20.1270.410 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.53 | 42.0 | 4.04e-01 | 84.6% | 75.4% |
| 2wdqD00 | 1.20.1300.10 | Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Fumarate reductase/succinate dehydrogenase, transmembrane subunit | 0.52 | 37.0 | 3.76e-01 | 75.0% | 89.5% |
| 3cuxA02 | 1.20.1220.12 | Mainly Alpha › Up-down Bundle › Malate Synthase G; Chain: A; Domain 4 › Malate synthase, domain III | 0.52 | 36.0 | 3.49e-01 | 73.1% | 86.0% |
| 2xgjA04 | 1.20.1500.20 | Mainly Alpha › Up-down Bundle › YheA-like fold › | 0.51 | 35.0 | 3.25e-01 | 70.2% | 91.7% |
ECOD (14)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3519300 | 1147.1.1.1 ↗ | alpha bundles › RNA polymerase II elongation factor ELL2 C-terminal domain › RNA polymerase II elongation factor ELL2 C-terminal domain › RNA polymerase II elongation factor ELL2 C-terminal domain › Occludin_ELL | 0.58 | 40.0 | 3.84e-01 | 70.2% | 76.7% |
| 3539186 | 3187.1.1.0 ↗ | alpha bundles › Microtubule-Binding Domain of Flagellar Dynein › Microtubule-Binding Domain of Flagellar Dynein › Microtubule-Binding Domain of Flagellar Dynein | 0.57 | 50.0 | 3.62e-01 | 98.1% | 54.8% |
| 3245526 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.57 | 45.0 | 4.52e-01 | 86.5% | 96.2% |
| 3292519 | 5054.1.1.2 ↗ | alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels › Ion_trans | 0.56 | 49.0 | 3.77e-01 | 98.1% | 86.1% |
| 3207999 | 3660.1.1.4 ↗ | alpha bundles › Protein-export membrane protein secG › Protein-export membrane protein secG › Protein-export membrane protein secG › DUF7785 | 0.56 | 39.0 | 4.10e-01 | 72.1% | 92.6% |
| 3582116 | 1147.1.1.1 ↗ | alpha bundles › RNA polymerase II elongation factor ELL2 C-terminal domain › RNA polymerase II elongation factor ELL2 C-terminal domain › RNA polymerase II elongation factor ELL2 C-terminal domain › Occludin_ELL | 0.56 | 39.0 | 3.76e-01 | 72.1% | 66.7% |
| 3611442 | 3324.1.1.2 ↗ | extended segments › Helical arch in Ski2-like helicases › Helical arch in Ski2-like helicases › Helical arch in Ski2-like helicases | 0.56 | 40.0 | 3.70e-01 | 75.0% | 58.5% |
| 3413723 | 603.1.1.0 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins | 0.56 | 43.0 | 4.37e-01 | 83.7% | 93.3% |
| 3197615 | 3755.3.1.355 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › Uds1 | 0.55 | 39.0 | 3.66e-01 | 73.1% | 61.6% |
| 3178900 | 192.2.1.30 ↗ | alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin › Uds1 | 0.55 | 39.0 | 3.46e-01 | 73.1% | 53.1% |
| 3972174 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.54 | 37.0 | 3.16e-01 | 71.2% | 86.9% |
| 3853953 | 601.1.2.53 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › DGKD_4H | 0.52 | 41.0 | 3.89e-01 | 86.5% | 74.4% |
| 4937093 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.52 | 36.0 | 3.43e-01 | 71.2% | 88.3% |
| 3920125 | 3755.3.1.450 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › Uso1_p115_C | 0.50 | 35.0 | 2.88e-01 | 73.1% | 38.5% |
D3
medium
residues 217-314
Domain cluster:
rep: tegument_protein_UL37__YP_004940219__Saimiriine_betaherpesvirus_4__1535247__D207-302
D4
medium
residues 315-477
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF04523.19 best | Herpes_U30 | 63.5 | 1.60e-17 | 95.7% | 16.0% |
CATH (11)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4qs8A01 | 3.40.367.20 | Alpha Beta › 3-Layer(aba) Sandwich › Hexokinase; domain 1 › | 0.61 | 50.0 | 4.19e-01 | 87.1% | 96.1% |
| 3f6tA02 | 1.10.20.110 | Mainly Alpha › Orthogonal Bundle › Histone, subunit A › | 0.59 | 30.0 | 3.18e-01 | 99.4% | 53.1% |
| 2r5uC00 | 1.10.860.10 | Mainly Alpha › Orthogonal Bundle › DNAb Helicase; Chain A › DNAb Helicase; Chain A | 0.59 | 34.0 | 3.70e-01 | 82.2% | 65.9% |
| 2c9kA01 | 1.20.190.10 | Mainly Alpha › Up-down Bundle › Delta-Endotoxin; domain 1 › Pesticidal crystal protein, N-terminal domain | 0.59 | 47.0 | 4.13e-01 | 84.0% | 100.0% |
| 1s35A02 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.55 | 35.0 | 4.24e-01 | 87.7% | 94.5% |
| 3k3uA00 | 1.10.490.10 | Mainly Alpha › Orthogonal Bundle › Globin-like › Globins | 0.55 | 34.0 | 3.71e-01 | 96.3% | 72.3% |
| 1v9mA01 | 1.10.132.50 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › ATP synthase (C/AC39) subunit, domain 3 | 0.54 | 38.0 | 4.41e-01 | 79.1% | 100.0% |
| 5j1gA00 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.53 | 44.0 | 3.97e-01 | 88.3% | 86.0% |
| 4eadA01 | 1.20.970.10 | Mainly Alpha › Up-down Bundle › Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 › Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C | 0.52 | 34.0 | 4.05e-01 | 97.5% | 99.1% |
| 2c0kB00 | 1.10.490.10 | Mainly Alpha › Orthogonal Bundle › Globin-like › Globins | 0.52 | 36.0 | 3.75e-01 | 70.6% | 90.6% |
| 1b0bA00 | 1.10.490.10 | Mainly Alpha › Orthogonal Bundle › Globin-like › Globins | 0.52 | 36.0 | 3.89e-01 | 71.8% | 92.9% |
ECOD (24)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4253878 | 5069.1.1.73 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes › Tmemb_161AB | 0.60 | 45.0 | 3.63e-01 | 76.7% | 97.1% |
| 160372 | 5000.4.1.1 ↗ | alpha arrays › Toxins' membrane translocation domains › delta-Endotoxin (insectocide), N-terminal domain › delta-Endotoxin (insectocide), N-terminal domain › Endotoxin_N | 0.59 | 47.0 | 4.13e-01 | 84.0% | 99.6% |
| 3207708 | 109.4.1.1982 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PF26523 | 0.58 | 53.0 | 5.02e-01 | 99.4% | 87.8% |
| 3271711 | 109.6.1.3 ↗ | alpha superhelices › Repetitive alpha hairpins › Ras GEF › Ras GEF › RasGEF_N | 0.56 | 41.0 | 4.40e-01 | 99.4% | 87.9% |
| 3522864 | 604.1.1.1 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin | 0.56 | 36.0 | 4.28e-01 | 87.7% | 94.5% |
| 3792010 | 604.1.1.105 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin_Anc-1_2 | 0.55 | 33.0 | 3.93e-01 | 87.1% | 90.5% |
| 4223117 | 604.12.1.4 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › ATG1-like_MIT1 | 0.54 | 40.0 | 4.24e-01 | 75.5% | 91.4% |
| 3636767 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.54 | 38.0 | 3.45e-01 | 71.2% | 56.7% |
| 3600392 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.53 | 40.0 | 3.51e-01 | 100.0% | 49.4% |
| 3238670 | 5001.1.1.65 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Serpentine_r_xa | 0.53 | 38.0 | 3.07e-01 | 73.0% | 62.5% |
| 3634707 | 5054.1.1.61 ↗ | alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels › ELO | 0.53 | 44.0 | 3.62e-01 | 89.0% | 82.3% |
| 3405149 | 5000.6.1.1 ↗ | alpha arrays › Toxins' membrane translocation domains › Tethering factor for nuclear proteasome cut8 › Tethering factor for nuclear proteasome cut8 › Cut8 | 0.53 | 43.0 | 4.05e-01 | 99.4% | 71.8% |
| 3437249 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.53 | 39.0 | 3.80e-01 | 96.9% | 69.4% |
| 3206225 | 5001.1.1.39 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › RTA1 | 0.52 | 41.0 | 3.45e-01 | 83.4% | 52.6% |
| 4464410 | 109.4.1.356 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Fungal_trans | 0.52 | 42.0 | 3.11e-01 | 88.3% | 76.4% |
| 3958101 | 5001.1.1.0 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like | 0.52 | 41.0 | 3.49e-01 | 89.0% | 50.2% |
| 3595885 | 603.1.1.0 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins | 0.52 | 46.0 | 3.99e-01 | 100.0% | 75.5% |
| 4311809 | 5001.1.1.1 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 | 0.51 | 39.0 | 3.16e-01 | 80.4% | 81.2% |
| 3959108 | 109.4.1.637 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › DUF2339 | 0.51 | 46.0 | 4.33e-01 | 100.0% | 83.9% |
| 3595491 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.51 | 41.0 | 4.32e-01 | 98.8% | 99.3% |
| 3392456 | 1075.1.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › ABCG5/ABCG8 transmembrane domain › ABC2_membrane | 0.51 | 38.0 | 3.29e-01 | 78.5% | 89.8% |
| 5017479 | 1075.3.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC importer transmembrane domain fold › Type I ABC importer transmembrane domain fold › BPD_transp_1 | 0.50 | 44.0 | 3.13e-01 | 96.9% | 78.2% |
| 3373348 | 3684.1.1.2 ↗ | alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › BPS1 | 0.50 | 43.0 | 3.69e-01 | 91.4% | 82.2% |
| 3931313 | 601.1.3.6 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › A middle domain of Talin 1 › Talin_IBS2B | 0.50 | 38.0 | 3.84e-01 | 95.1% | 78.2% |
D5
medium
residues 524-660
Domain cluster:
rep: tegument_protein_UL37__NP_612690__Panine_betaherpesvirus_2__188763__D546-677
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF04523.19 best | Herpes_U30 | 41.1 | 8.80e-11 | 100.0% | 14.7% |
D6
medium
residues 661-741_759-817
Domain cluster:
rep: tegument_protein_UL37__YP_009253934__Macaca_nemestrina_herpesvirus_7__1846169__D646-742_769-794
CATH (28)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1lrzA03 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.83 | 36.0 | 5.58e-01 | 77.1% | 96.8% |
| 1vx7301 | 1.10.287.310 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.77 | 38.0 | 5.19e-01 | 90.0% | 90.5% |
| 4wzxA01 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.76 | 42.0 | 5.52e-01 | 93.6% | 100.0% |
| 3nbxX03 | 1.20.58.1510 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.74 | 49.0 | 5.71e-01 | 93.6% | 92.1% |
| 4hwhE00 | 1.20.58.120 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain | 0.74 | 47.0 | 5.79e-01 | 95.7% | 100.0% |
| 1yo7A00 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.73 | 49.0 | 5.27e-01 | 97.9% | 79.2% |
| 2gscC00 | 1.20.1440.60 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 23S rRNA-intervening sequence | 0.73 | 45.0 | 5.03e-01 | 95.0% | 78.2% |
| 4hwdD00 | 1.20.58.120 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain | 0.73 | 46.0 | 5.68e-01 | 96.4% | 98.9% |
| 1chuA03 | 1.20.58.100 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain | 0.72 | 43.0 | 5.20e-01 | 98.6% | 93.2% |
| 1vctA01 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.69 | 46.0 | 5.11e-01 | 93.6% | 86.2% |
| 3vkgA12 | 1.10.287.2610 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.68 | 52.0 | 4.42e-01 | 78.6% | 98.1% |
| 1f7uA02 | 1.10.730.10 | Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1 | 0.67 | 42.0 | 4.45e-01 | 95.0% | 69.6% |
| 1dmrA03 | 3.90.55.10 | Alpha Beta › Alpha-Beta Complex › Dimethylsulfoxide Reductase; domain 3 › Dimethylsulfoxide Reductase, domain 3 | 0.67 | 23.0 | 2.96e-01 | 84.3% | 50.6% |
| 2bdeA03 | 1.20.58.1160 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.67 | 37.0 | 4.93e-01 | 80.7% | 100.0% |
| 2zueA03 | 1.10.730.10 | Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1 | 0.67 | 41.0 | 4.44e-01 | 94.3% | 72.3% |
| 2rldA00 | 1.20.1440.60 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 23S rRNA-intervening sequence | 0.66 | 38.0 | 4.23e-01 | 92.9% | 71.1% |
| 3u0cA00 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.65 | 50.0 | 4.86e-01 | 78.6% | 72.8% |
| 1j1jA02 | 1.20.58.200 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 2 | 0.65 | 39.0 | 4.71e-01 | 98.6% | 95.3% |
| 4e6nA02 | 6.10.140.1010 | Special › Helix non-globular › Helix Hairpins › | 0.64 | 31.0 | 4.42e-01 | 73.6% | 100.0% |
| 1v9dB00 | 1.20.58.2220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Formin, FH2 domain | 0.63 | 57.0 | 4.35e-01 | 98.6% | 74.8% |
| 2pfdA03 | 1.20.120.680 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Formiminotetrahydrofolate cyclodeaminase monomer, up-and-down helical bundle | 0.62 | 49.0 | 4.32e-01 | 97.1% | 57.6% |
| 3na7A00 | 1.10.287.1490 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.62 | 47.0 | 3.92e-01 | 79.3% | 52.3% |
| 8ek4A01 | 1.20.120.20 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein | 0.62 | 53.0 | 5.41e-01 | 100.0% | 95.5% |
| 3pe0A02 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.61 | 45.0 | 5.07e-01 | 99.3% | 100.0% |
| 5jrcA00 | 1.20.58.2140 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.61 | 39.0 | 3.60e-01 | 100.0% | 48.9% |
| 1k90B03 | 1.20.140.60 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › | 0.60 | 35.0 | 3.79e-01 | 87.1% | 68.7% |
| 1b04A03 | 1.10.287.610 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.59 | 28.0 | 3.96e-01 | 87.9% | 98.4% |
| 2fefA01 | 1.20.1440.70 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › PA2201 N-terminal domain-like | 0.57 | 43.0 | 4.55e-01 | 98.6% | 88.0% |
ECOD (35)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3754034 | 604.12.1.0 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain | 0.82 | 47.0 | 6.02e-01 | 91.4% | 94.1% |
| 3170239 | 604.12.1.0 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain | 0.75 | 48.0 | 5.89e-01 | 97.9% | 100.0% |
| 3339796 | 650.1.1.1 ↗ | alpha bundles › Chaperone J-domain › Chaperone J-domain › Chaperone J-domain › DnaJ | 0.73 | 36.0 | 4.93e-01 | 85.0% | 90.7% |
| 4387552 | 604.12.1.0 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain | 0.73 | 44.0 | 5.57e-01 | 92.1% | 100.0% |
| 3808390 | 192.29.1.27 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › DUF1218 | 0.73 | 48.0 | 5.77e-01 | 90.0% | 98.9% |
| 3259313 | 174.1.1.0 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain | 0.71 | 52.0 | 5.29e-01 | 95.0% | 76.4% |
| 3939260 | 604.12.1.0 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain | 0.70 | 46.0 | 5.37e-01 | 95.7% | 92.0% |
| 3628755 | 109.4.1.1493 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Zw10_middle, ZW10_C, ZW10_C2 | 0.69 | 52.0 | 3.21e-01 | 100.0% | 14.6% |
| 3789118 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.69 | 40.0 | 3.74e-01 | 91.4% | 45.7% |
| 3478235 | 633.23.1.0 ↗ | alpha bundles › Bromodomain-like › Claudin › Claudin | 0.68 | 48.0 | 5.04e-01 | 95.7% | 78.1% |
| 3884349 | 601.7.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain | 0.67 | 45.0 | 4.74e-01 | 94.3% | 76.0% |
| 3400447 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.67 | 43.0 | 3.64e-01 | 98.6% | 40.4% |
| 3481122 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.67 | 46.0 | 5.29e-01 | 93.6% | 98.0% |
| 5041130 | 601.14.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Hemerythrin › Hemerythrin | 0.66 | 48.0 | 5.04e-01 | 97.1% | 84.0% |
| 3240989 | 3911.1.1.0 ↗ | extended segments › Exosome complex protein LRP1 › Exosome complex protein LRP1 › Exosome complex protein LRP1 | 0.65 | 30.0 | 3.61e-01 | 78.6% | 64.4% |
| 3682989 | 5086.1.1.96 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › DUF632 | 0.64 | 47.0 | 4.70e-01 | 81.4% | 73.1% |
| 3718498 | 604.6.1.0 ↗ | alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain | 0.63 | 39.0 | 4.73e-01 | 95.7% | 96.7% |
| 5005708 | 3755.3.1.127 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › NFACT_N | 0.63 | 48.0 | 4.39e-01 | 79.3% | 75.0% |
| 3602790 | 603.1.1.0 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins | 0.62 | 53.0 | 4.71e-01 | 98.6% | 63.9% |
| 5044090 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.62 | 47.0 | 4.54e-01 | 80.0% | 95.0% |
| 5046472 | 604.3.1.0 ↗ | alpha bundles › Spectrin repeat-like › BAG domain › BAG domain | 0.61 | 40.0 | 4.64e-01 | 98.6% | 96.8% |
| 3634180 | 1075.4.1.2 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane_2 | 0.61 | 53.0 | 4.53e-01 | 95.7% | 70.0% |
| 3410814 | 174.1.1.0 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain | 0.60 | 44.0 | 4.62e-01 | 97.1% | 83.2% |
| 3492339 | 174.1.1.45 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › MENTAL | 0.60 | 46.0 | 4.44e-01 | 97.9% | 71.6% |
| 4666571 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.57 | 33.0 | 4.29e-01 | 77.1% | 100.0% |
| 3243154 | 5001.1.1.59 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7TM_GPCR_Sri | 0.56 | 49.0 | 3.71e-01 | 92.1% | 70.0% |
| 3503534 | 5057.1.1.1 ↗ | alpha bundles › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore › Neur_chan_memb | 0.55 | 43.0 | 4.30e-01 | 100.0% | 79.3% |
| 5040665 | 2004.1.1.198 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_23 | 0.55 | 44.0 | 2.86e-01 | 82.9% | 79.1% |
| 3273836 | 5001.1.1.0 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like | 0.54 | 47.0 | 3.50e-01 | 92.9% | 78.0% |
| 3240671 | 5001.1.1.60 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7TM_GPCR_Srx | 0.53 | 46.0 | 3.54e-01 | 91.4% | 74.0% |
| 3509261 | 601.15.1.2 ↗ | alpha bundles › Four-helical up-and-down bundle › Proteasome activator reg(alpha) › Proteasome activator reg(alpha) › PA28_C | 0.53 | 46.0 | 3.95e-01 | 93.6% | 64.7% |
| 4968259 | 3926.1.1.0 ↗ | alpha bundles › V-type proton ATPase subunit D › V-type proton ATPase subunit D › V-type proton ATPase subunit D | 0.52 | 38.0 | 3.78e-01 | 74.3% | 99.3% |
| 3620531 | 5001.1.1.60 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7TM_GPCR_Srx | 0.52 | 43.0 | 3.20e-01 | 87.9% | 39.4% |
| 3219795 | 5001.1.1.41 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7TM_GPCR_Srw | 0.51 | 44.0 | 3.37e-01 | 93.6% | 47.3% |
| 4976626 | 3714.1.1.0 ↗ | a+b two layers › Lon-like protease MtaLonC helical domain › Lon-like protease MtaLonC helical domain › Lon-like protease MtaLonC helical domain | 0.50 | 40.0 | 3.48e-01 | 87.1% | 72.0% |
D7
medium
residues 742-758_818-886
Domain cluster:
representative
CATH (6)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4fjvA02 | 1.20.1300.20 | Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Peptidase C65 Otubain, subdomain 2 | 0.69 | 48.0 | 4.06e-01 | 73.3% | 66.0% |
| 2js5A00 | 1.10.287.660 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.62 | 43.0 | 4.67e-01 | 73.3% | 94.4% |
| 1vcsA00 | 1.20.58.400 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › t-snare proteins | 0.61 | 44.0 | 4.20e-01 | 75.6% | 70.6% |
| 3l8rA00 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.58 | 43.0 | 4.14e-01 | 80.2% | 74.5% |
| 1m4rB00 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.51 | 40.0 | 3.50e-01 | 98.8% | 53.2% |
| 1vw4T01 | 6.10.330.20 | Special › Helix non-globular › Monooxygenase › | 0.51 | 38.0 | 3.52e-01 | 80.2% | 83.9% |
ECOD (5)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4175269 | 225.1.1.0 ↗ | a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0.61 | 47.0 | 2.95e-01 | 82.6% | 61.8% |
| 3698361 | 5069.1.3.0 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Fumarate reductase respiratory complex transmembrane subunits | 0.60 | 42.0 | 4.08e-01 | 72.1% | 73.7% |
| 3510298 | 605.1.1.140 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HIG_1_N | 0.56 | 40.0 | 4.25e-01 | 75.6% | 100.0% |
| 4142148 | 206.1.1.0 ↗ | a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase | 0.55 | 48.0 | 2.90e-01 | 97.7% | 61.7% |
| 3480359 | 109.3.1.2 ↗ | alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat › Ank,Ank_2 | 0.54 | 37.0 | 2.74e-01 | 73.3% | 24.8% |