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E4_ORFE
Euk-VirMurine_adenovirus_3
E4_ORFE__YP_002822225__Murine_adenovirus_3__573199
Identity
- Accession:
- YP_002822225 ↗
- Protein ID:
- E4_ORFE
- Kingdom:
- euk
Quality
64.5
mean pLDDT
Taxonomy
Bamfordvirae›
Preplasmiviricota›
Pharingeaviricetes›
Rowavirales›
Adenoviridae›
Mastadenovirus›
Murine_adenovirus_3
TaxID: 573199
Cluster
Singleton — not in a non-trivial cluster
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 32-132
Domain cluster:
representative
CATH (68)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2qffA00 | 1.20.1270.10 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.86 | 61.0 | 7.01e-01 | 94.1% | 100.0% |
| 3rguB00 | 1.20.5.420 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › Immunoglobulin FC, subunit C | 0.84 | 67.0 | 7.23e-01 | 95.0% | 97.7% |
| 4dylA02 | 1.10.287.160 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat | 0.82 | 57.0 | 5.87e-01 | 71.3% | 79.8% |
| 2fcwA00 | 1.20.81.10 | Mainly Alpha › Up-down Bundle › Receptor-associated Protein › RAP domain | 0.80 | 59.0 | 5.89e-01 | 77.2% | 92.5% |
| 2e9xA01 | 1.20.58.1030 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.79 | 52.0 | 4.82e-01 | 71.3% | 53.1% |
| 2z1qB04 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.79 | 69.0 | 6.20e-01 | 93.1% | 69.1% |
| 3kavA00 | 1.20.1270.360 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.79 | 59.0 | 5.95e-01 | 94.1% | 77.5% |
| 4im0A04 | 1.20.1270.420 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.79 | 70.0 | 5.26e-01 | 97.0% | 80.3% |
| 2uxwA04 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.78 | 67.0 | 6.18e-01 | 93.1% | 77.7% |
| 1siqA03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.78 | 68.0 | 5.83e-01 | 94.1% | 67.1% |
| 5figA00 | 1.20.1270.360 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.78 | 57.0 | 5.81e-01 | 92.1% | 78.0% |
| 4e40A00 | 1.20.1260.80 | Mainly Alpha › Up-down Bundle › Ferritin › | 0.78 | 68.0 | 5.11e-01 | 96.0% | 82.4% |
| 2b5uA02 | 1.10.287.620 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix Hairpins | 0.78 | 54.0 | 4.56e-01 | 71.3% | 48.4% |
| 1avoB00 | 1.20.120.180 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Proteasome activator pa28, C-terminal domain | 0.77 | 68.0 | 6.08e-01 | 95.0% | 88.6% |
| 4hr1A00 | 1.20.1270.410 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.76 | 66.0 | 6.31e-01 | 94.1% | 86.4% |
| 3bvxA02 | 1.20.1270.50 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Glycoside hydrolase family 38, central domain | 0.76 | 64.0 | 6.26e-01 | 97.0% | 82.9% |
| 2ot4A03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.76 | 64.0 | 6.32e-01 | 97.0% | 86.0% |
| 1i4dA00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.76 | 67.0 | 5.44e-01 | 98.0% | 92.0% |
| 4o6yB00 | 1.20.120.1770 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › | 0.75 | 68.0 | 5.33e-01 | 100.0% | 59.2% |
| 3tulB00 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.75 | 63.0 | 5.69e-01 | 90.1% | 92.5% |
| 2rd0B00 | 1.10.287.1490 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.74 | 51.0 | 4.60e-01 | 71.3% | 66.9% |
| 1x04A00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.74 | 64.0 | 5.07e-01 | 94.1% | 84.5% |
| 1wleA01 | 1.10.287.40 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain | 0.74 | 53.0 | 5.15e-01 | 75.2% | 100.0% |
| 4hkrA00 | 1.20.140.140 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Calcium release-activated calcium channel protein Orai | 0.73 | 64.0 | 5.45e-01 | 98.0% | 58.8% |
| 4i1mB01 | 1.20.120.1700 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › | 0.73 | 62.0 | 5.68e-01 | 91.1% | 86.0% |
| 1op1A00 | 1.20.81.10 | Mainly Alpha › Up-down Bundle › Receptor-associated Protein › RAP domain | 0.73 | 51.0 | 5.53e-01 | 80.2% | 87.8% |
| 3r84A00 | 1.10.287.3490 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.73 | 50.0 | 5.51e-01 | 71.3% | 93.8% |
| 4abmD00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.73 | 48.0 | 5.35e-01 | 73.3% | 88.3% |
| 6p73A02 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.73 | 60.0 | 5.39e-01 | 93.1% | 64.3% |
| 3pf0A00 | 1.20.1420.20 | Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › M75 peptidase, HXXE motif | 0.73 | 63.0 | 4.38e-01 | 94.1% | 36.2% |
| 3lmfA00 | 1.20.1270.360 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.73 | 56.0 | 5.50e-01 | 90.1% | 76.1% |
| 1xg2B00 | 1.20.140.40 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Invertase/pectin methylesterase inhibitor family protein | 0.72 | 61.0 | 5.31e-01 | 91.1% | 77.5% |
| 1wpaA01 | 6.10.140.340 | Special › Helix non-globular › Helix Hairpins › | 0.72 | 49.0 | 5.01e-01 | 70.3% | 96.0% |
| 1qdbA02 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.72 | 61.0 | 5.41e-01 | 97.0% | 65.0% |
| 2yfaA02 | 1.20.1440.210 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › | 0.72 | 59.0 | 5.64e-01 | 88.1% | 76.7% |
| 1bgfA00 | 1.10.532.10 | Mainly Alpha › Orthogonal Bundle › Transcription Factor, Stat-4 › STAT transcription factor, N-terminal domain | 0.72 | 46.0 | 4.32e-01 | 85.1% | 53.2% |
| 1dofA01 | 1.20.200.10 | Mainly Alpha › Up-down Bundle › Fumarase C; Chain A, domain 2 › Fumarase/aspartase (Central domain) | 0.71 | 64.0 | 4.83e-01 | 100.0% | 91.4% |
| 4ciuA02 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.71 | 57.0 | 4.64e-01 | 86.1% | 84.4% |
| 6zhiB02 | 1.20.1270.10 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.71 | 55.0 | 6.03e-01 | 97.0% | 100.0% |
| 3qo8A01 | 1.10.287.40 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain | 0.71 | 52.0 | 5.19e-01 | 77.2% | 98.1% |
| 2yfaB01 | 1.20.1440.210 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › | 0.71 | 62.0 | 5.94e-01 | 97.0% | 89.1% |
| 1b68A00 | 1.20.120.20 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein | 0.71 | 63.0 | 5.70e-01 | 98.0% | 88.4% |
| 8a1gC01 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.71 | 62.0 | 5.12e-01 | 97.0% | 91.7% |
| 1oahA02 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.71 | 59.0 | 5.32e-01 | 92.1% | 65.5% |
| 3ddlA00 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.70 | 62.0 | 4.69e-01 | 100.0% | 77.4% |
| 6xj1A01 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.69 | 59.0 | 4.49e-01 | 96.0% | 86.5% |
| 3na7A00 | 1.10.287.1490 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.68 | 47.0 | 3.60e-01 | 71.3% | 56.1% |
| 3fedA03 | 1.20.930.40 | Mainly Alpha › Up-down Bundle › Transcription Elongation Factor S-II; Chain A › Transferrin receptor-like, dimerisation domain | 0.68 | 58.0 | 5.07e-01 | 94.1% | 80.0% |
| 8ek4A01 | 1.20.120.20 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein | 0.68 | 49.0 | 4.45e-01 | 75.2% | 56.4% |
| 3nvoB02 | 1.20.58.340 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Magnesium transport protein CorA, transmembrane region | 0.68 | 46.0 | 4.47e-01 | 70.3% | 64.7% |
| 2f2gA00 | 1.20.910.10 | Mainly Alpha › Up-down Bundle › Heme Oxygenase; Chain A › Heme oxygenase-like | 0.68 | 60.0 | 4.74e-01 | 100.0% | 79.1% |
| 4k5yA01 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.67 | 56.0 | 4.15e-01 | 90.1% | 98.4% |
| 2uuiA00 | 1.20.120.550 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Membrane associated eicosanoid/glutathione metabolism-like domain | 0.67 | 52.0 | 4.59e-01 | 85.1% | 58.1% |
| 2d1lA00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.65 | 55.0 | 4.18e-01 | 94.1% | 79.9% |
| 3lssA01 | 1.10.287.40 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain | 0.65 | 57.0 | 5.52e-01 | 95.0% | 100.0% |
| 1zvzA02 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.65 | 56.0 | 5.26e-01 | 97.0% | 85.5% |
| 1zb1A00 | 1.25.40.280 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › alix/aip1 like domains | 0.64 | 53.0 | 3.60e-01 | 90.1% | 63.5% |
| 4ys0A02 | 1.10.3060.10 | Mainly Alpha › Orthogonal Bundle › Helical scaffold and wing domains of SecA › Helical scaffold and wing domains of SecA | 0.63 | 49.0 | 4.14e-01 | 83.2% | 95.9% |
| 1jalA03 | 1.10.150.300 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Obg-related GTPase Ych/YyaF, coiled-coil domain | 0.63 | 43.0 | 4.77e-01 | 91.1% | 88.9% |
| 1zylA03 | 1.20.1270.170 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.60 | 47.0 | 4.72e-01 | 86.1% | 81.6% |
| 3etvA01 | 1.10.287.3290 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.60 | 46.0 | 5.00e-01 | 82.2% | 100.0% |
| 6lumG01 | 1.20.1300.10 | Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Fumarate reductase/succinate dehydrogenase, transmembrane subunit | 0.59 | 45.0 | 4.40e-01 | 82.2% | 91.1% |
| 2cdqA02 | 1.20.120.1320 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Aspartokinase, catalytic domain | 0.59 | 50.0 | 5.10e-01 | 94.1% | 99.0% |
| 1cnt200 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.58 | 42.0 | 3.87e-01 | 89.1% | 58.5% |
| 6c7lA02 | 1.20.1090.10 | Mainly Alpha › Up-down Bundle › Dehydroquinate synthase-like, alpha domain › Dehydroquinate synthase-like - alpha domain | 0.58 | 49.0 | 3.97e-01 | 93.1% | 88.7% |
| 1tj7A01 | 1.10.275.10 | Mainly Alpha › Orthogonal Bundle › Fumarase C; Chain B, domain 1 › Fumarase/aspartase (N-terminal domain) | 0.57 | 45.0 | 4.47e-01 | 92.1% | 82.9% |
| 2mgxA00 | 1.20.940.10 | Mainly Alpha › Up-down Bundle › RNA Binding Protein, Prp18; Chain A › Functional domain of the splicing factor Prp18 | 0.56 | 48.0 | 4.46e-01 | 94.1% | 82.4% |
| 4aciA00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.52 | 37.0 | 3.13e-01 | 75.2% | 62.5% |
ECOD (69)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3229806 | 6157.1.1.1 ↗ | alpha bundles › GKAP homology domain 1 › GKAP homology domain 1 › GKAP homology domain 1 › GKAP | 0.88 | 77.0 | 7.38e-01 | 93.1% | 92.2% |
| 3222373 | 605.4.1.18 ↗ | alpha duplicates or obligate multimers › ROP-like › ROP protein › ROP protein › PF29357 | 0.88 | 68.0 | 7.40e-01 | 90.1% | 96.5% |
| 4013477 | 1025.1.1.0 ↗ | alpha bundles › Stonustoxin helical domain › Stonustoxin helical domain › Stonustoxin helical domain | 0.84 | 75.0 | 7.28e-01 | 95.0% | 96.4% |
| 3332048 | 3922.1.1.0 ↗ | alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 | 0.84 | 75.0 | 7.30e-01 | 95.0% | 95.5% |
| 5045176 | 601.1.2.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) | 0.82 | 66.0 | 6.64e-01 | 93.1% | 84.5% |
| 3913276 | 3755.3.1.123 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › Tektin | 0.82 | 73.0 | 5.60e-01 | 97.0% | 80.0% |
| 4214525 | 632.22.1.1 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats › EzrA | 0.81 | 72.0 | 7.25e-01 | 95.0% | 100.0% |
| 3804215 | 1025.1.1.0 ↗ | alpha bundles › Stonustoxin helical domain › Stonustoxin helical domain › Stonustoxin helical domain | 0.81 | 72.0 | 7.25e-01 | 98.0% | 96.0% |
| 3840081 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.81 | 68.0 | 6.00e-01 | 90.1% | 75.5% |
| 3551963 | 601.19.1.23 ↗ | alpha bundles › Four-helical up-and-down bundle › Apolipoprotein › Apolipoprotein › Tektin | 0.80 | 72.0 | 5.94e-01 | 97.0% | 88.6% |
| 4998774 | 2004.1.1.198 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_23 | 0.80 | 56.0 | 3.51e-01 | 71.3% | 15.2% |
| 4175767 | 632.22.1.1 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats › EzrA | 0.79 | 72.0 | 7.12e-01 | 98.0% | 100.0% |
| 5076088 | 5039.1.1.0 ↗ | alpha bundles › Cytochrome c oxidase subunit III-like › Cytochrome c oxidase subunit III-like › Cytochrome c oxidase subunit III-like | 0.79 | 71.0 | 6.38e-01 | 97.0% | 90.4% |
| 3250231 | 4177.1.1.0 ↗ | alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like | 0.79 | 70.0 | 5.42e-01 | 96.0% | 75.3% |
| 3495507 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.78 | 54.0 | 4.55e-01 | 71.3% | 68.5% |
| 4374392 | 2004.1.1.429 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N, AAA_15 | 0.78 | 55.0 | 3.57e-01 | 72.3% | 19.1% |
| 5035839 | 632.11.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like | 0.78 | 56.0 | 6.30e-01 | 86.1% | 100.0% |
| 5035838 | 632.22.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats | 0.78 | 57.0 | 5.97e-01 | 85.1% | 85.6% |
| 3837009 | 6157.1.1.7 ↗ | alpha bundles › GKAP homology domain 1 › GKAP homology domain 1 › GKAP homology domain 1 › RPW8 | 0.77 | 67.0 | 6.81e-01 | 94.1% | 95.0% |
| 3929891 | 601.16.1.2 ↗ | alpha bundles › Four-helical up-and-down bundle › FAT domain of focal adhesion kinase › FAT domain of focal adhesion kinase › Focal_AT | 0.77 | 70.0 | 6.38e-01 | 98.0% | 86.2% |
| 3175351 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.77 | 55.0 | 4.75e-01 | 73.3% | 99.3% |
| 3700663 | 632.1.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain | 0.77 | 65.0 | 6.61e-01 | 91.1% | 94.0% |
| 3596574 | 192.8.1.0 ↗ | alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain | 0.77 | 53.0 | 4.48e-01 | 71.3% | 47.3% |
| 4604091 | 192.2.1.0 ↗ | alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin | 0.77 | 52.0 | 5.31e-01 | 71.3% | 71.0% |
| 4352674 | 632.1.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain | 0.77 | 67.0 | 6.69e-01 | 97.0% | 91.4% |
| 4523046 | 3755.4.1.0 ↗ | alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain | 0.76 | 53.0 | 4.78e-01 | 71.3% | 68.1% |
| 3814378 | 611.7.1.8 ↗ | alpha bundles › N-cbl like › Mixed lineage kinase domain-like (MLKL) N-terminal domain › Mixed lineage kinase domain-like (MLKL) N-terminal domain › RPW8 | 0.76 | 59.0 | 5.63e-01 | 81.2% | 71.3% |
| 5002671 | 3755.3.1.637 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › DUF7121 | 0.76 | 54.0 | 4.60e-01 | 73.3% | 91.9% |
| 5040840 | 2004.1.1.87 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N | 0.76 | 53.0 | 3.12e-01 | 71.3% | 18.6% |
| 4994414 | 632.1.1.2 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain › BE_C | 0.76 | 57.0 | 6.00e-01 | 87.1% | 88.9% |
| 4203130 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.76 | 54.0 | 5.16e-01 | 73.3% | 80.9% |
| 3336154 | 3562.1.1.11 ↗ | alpha bundles › Calcium release-activated calcium channel protein 1 › Calcium release-activated calcium channel protein 1 › Calcium release-activated calcium channel protein 1 › PGG | 0.76 | 63.0 | 5.83e-01 | 96.0% | 70.8% |
| 3725890 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.75 | 64.0 | 6.01e-01 | 93.1% | 100.0% |
| 3997912 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.75 | 68.0 | 6.56e-01 | 100.0% | 87.0% |
| 5060432 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.75 | 52.0 | 4.77e-01 | 71.3% | 83.8% |
| 3217635 | 3684.1.1.30 ↗ | alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PF29678 | 0.75 | 68.0 | 5.70e-01 | 100.0% | 68.8% |
| 3704098 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.75 | 52.0 | 4.32e-01 | 71.3% | 62.4% |
| 3561892 | 4106.1.1.0 ↗ | few secondary structure elements › Zinc hairpin stack › Zinc hairpin stack › Zinc hairpin stack | 0.75 | 60.0 | 5.32e-01 | 94.1% | 60.0% |
| 3891652 | 601.11.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain › Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain › Perilipin | 0.74 | 68.0 | 5.06e-01 | 99.0% | 63.4% |
| 4007316 | 3291.1.1.4 ↗ | alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › PspA_IM30 | 0.74 | 52.0 | 4.53e-01 | 73.3% | 47.7% |
| 3908132 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.74 | 53.0 | 3.90e-01 | 74.3% | 31.5% |
| 3465045 | 3755.4.1.0 ↗ | alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain | 0.73 | 62.0 | 5.92e-01 | 96.0% | 78.3% |
| 3864448 | 192.29.1.7 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › TMEM192 | 0.73 | 66.0 | 5.58e-01 | 100.0% | 81.2% |
| 3967683 | 601.4.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains | 0.73 | 67.0 | 5.84e-01 | 100.0% | 78.0% |
| 3379436 | 633.4.1.1 ↗ | alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI | 0.73 | 65.0 | 5.40e-01 | 98.0% | 72.0% |
| 3466449 | 632.1.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain | 0.73 | 62.0 | 6.40e-01 | 97.0% | 98.9% |
| 3377464 | 3755.3.1.285 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › NET2A | 0.73 | 63.0 | 5.29e-01 | 91.1% | 68.1% |
| 3814473 | 633.4.1.1 ↗ | alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI | 0.72 | 62.0 | 5.21e-01 | 92.1% | 78.2% |
| 4177363 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.72 | 50.0 | 4.45e-01 | 73.3% | 50.3% |
| 3446919 | 611.7.1.15 ↗ | alpha bundles › N-cbl like › Mixed lineage kinase domain-like (MLKL) N-terminal domain › Mixed lineage kinase domain-like (MLKL) N-terminal domain › Rx_N | 0.72 | 64.0 | 5.70e-01 | 96.0% | 79.3% |
| 3699457 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.72 | 50.0 | 4.79e-01 | 72.3% | 92.5% |
| 3267622 | 601.1.1.37 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › Frag1 | 0.72 | 65.0 | 5.99e-01 | 100.0% | 82.3% |
| 5058507 | 603.2.1.0 ↗ | alpha bundles › STAT-like › STAT › STAT | 0.72 | 49.0 | 4.59e-01 | 70.3% | 60.8% |
| 3522104 | 601.11.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain › Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain › Perilipin | 0.71 | 62.0 | 4.90e-01 | 95.0% | 65.0% |
| 3690392 | 5069.1.1.0 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes | 0.71 | 63.0 | 5.20e-01 | 100.0% | 61.1% |
| 4018322 | 611.7.1.0 ↗ | alpha bundles › N-cbl like › Mixed lineage kinase domain-like (MLKL) N-terminal domain › Mixed lineage kinase domain-like (MLKL) N-terminal domain | 0.70 | 62.0 | 5.57e-01 | 99.0% | 77.9% |
| 3306059 | 3755.4.1.46 ↗ | alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › NET2A | 0.70 | 61.0 | 4.55e-01 | 93.1% | 71.1% |
| 3684359 | 604.7.1.0 ↗ | alpha bundles › Spectrin repeat-like › Tubulin chaperone cofactor A › Tubulin chaperone cofactor A | 0.68 | 61.0 | 5.36e-01 | 97.0% | 71.0% |
| 4674184 | 2004.1.1.798 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N, AAA_15, AAA_29 | 0.68 | 51.0 | 3.42e-01 | 79.2% | 28.7% |
| 3466990 | 4323.1.1.8 ↗ | alpha bundles › helical bundle domain in vacuolar ATP synthase subunit C › helical bundle domain in vacuolar ATP synthase subunit C › helical bundle domain in vacuolar ATP synthase subunit C › NET2A | 0.68 | 60.0 | 4.68e-01 | 94.1% | 81.0% |
| 4954894 | 3922.1.1.0 ↗ | alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 | 0.67 | 46.0 | 4.23e-01 | 70.3% | 96.9% |
| 3377710 | 4323.1.1.8 ↗ | alpha bundles › helical bundle domain in vacuolar ATP synthase subunit C › helical bundle domain in vacuolar ATP synthase subunit C › helical bundle domain in vacuolar ATP synthase subunit C › NET2A | 0.67 | 58.0 | 5.07e-01 | 94.1% | 77.3% |
| 3419686 | 3755.4.1.46 ↗ | alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › NET2A | 0.66 | 60.0 | 4.85e-01 | 97.0% | 69.4% |
| 3974221 | 601.4.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains | 0.65 | 58.0 | 5.40e-01 | 100.0% | 80.8% |
| 4979116 | 5041.1.1.0 ↗ | extended segments › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C | 0.65 | 53.0 | 5.14e-01 | 90.1% | 84.3% |
| 4978637 | 3543.1.1.1 ↗ | alpha complex topology › Acid-activated urea channel › Acid-activated urea channel › Acid-activated urea channel › Gpr1_Fun34_YaaH | 0.64 | 57.0 | 4.55e-01 | 98.0% | 85.2% |
| 3563670 | 3758.1.1.54 ↗ | alpha bundles › Bacterial hemolysins-like › Bacterial hemolysins › Bacterial hemolysins › ApoL | 0.64 | 46.0 | 4.88e-01 | 80.2% | 84.4% |
| 5032752 | 5069.1.3.0 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Fumarate reductase respiratory complex transmembrane subunits | 0.60 | 46.0 | 4.90e-01 | 88.1% | 97.6% |
| 3485664 | 174.1.1.1 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin | 0.58 | 52.0 | 4.80e-01 | 98.0% | 76.2% |