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E6

Euk-Vir

Human_papillomavirus

E6__YP_009163891__Human_papillomavirus__10566

Identity

Accession:
YP_009163891 ↗
Protein ID:
E6
Kingdom:
euk

Quality

95.0 mean pLDDT

Taxonomy

Shotokuvirae› Cossaviricota› Papovaviricetes› Zurhausenvirales› Papillomaviridae› Human_papillomavirus

TaxID: 10566

Cluster

View cluster (138 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 9-62
PDB
Domain cluster: rep: putative_E6_protein__YP_008574810__Felis_catus_papillomavirus_4__1398507__D7-59
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00518.23 best E6 33.3 8.10e-08 66.7% 31.8%
CATH (14)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2m3lA00 3.30.240.40 Alpha Beta › 2-Layer Sandwich › CRO Repressor › E6 early regulatory protein 0.88 79.0 7.03e-01 100.0% 72.4%
2ljxA00 3.30.240.40 Alpha Beta › 2-Layer Sandwich › CRO Repressor › E6 early regulatory protein 0.87 78.0 6.79e-01 100.0% 65.9%
5hkxA04 3.30.40.10 Alpha Beta › 2-Layer Sandwich › Herpes Virus-1 › Zinc/RING finger domain, C3HC4 (zinc finger) 0.63 34.0 3.76e-01 70.4% 63.6%
4n4fA02 3.30.40.10 Alpha Beta › 2-Layer Sandwich › Herpes Virus-1 › Zinc/RING finger domain, C3HC4 (zinc finger) 0.61 39.0 4.32e-01 77.8% 85.0%
2w0tA00 3.30.60.160 Alpha Beta › 2-Layer Sandwich › Wheat Germ Agglutinin (Isolectin 2); domain 1 › 0.60 36.0 3.95e-01 92.6% 74.4%
4uyiA00 3.30.710.10 Alpha Beta › 2-Layer Sandwich › Potassium Channel Kv1.1; Chain A › Potassium Channel Kv1.1; Chain A 0.58 39.0 3.12e-01 72.2% 45.7%
3hcsA02 3.30.40.10 Alpha Beta › 2-Layer Sandwich › Herpes Virus-1 › Zinc/RING finger domain, C3HC4 (zinc finger) 0.55 35.0 3.55e-01 88.9% 65.4%
1hw1A01 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.53 38.0 3.45e-01 83.3% 54.7%
3vhtB02 3.30.160.60 Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › Classic Zinc Finger 0.53 29.0 3.43e-01 81.5% 79.4%
2nutB02 2.30.30.380 Mainly Beta › Roll › SH3 type barrels. › Zn-finger domain of Sec23/24 0.53 33.0 3.25e-01 75.9% 54.8%
2f1rA00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.51 35.0 2.61e-01 72.2% 98.0%
3r4iA02 6.10.140.960 Special › Helix non-globular › Helix Hairpins › 0.51 35.0 3.43e-01 74.1% 68.3%
2xocA01 3.30.40.140 Alpha Beta › 2-Layer Sandwich › Herpes Virus-1 › 0.51 37.0 3.28e-01 77.8% 59.0%
4ru1A02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.50 35.0 2.68e-01 92.6% 28.4%
ECOD (39)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4802726 4255.1.1.1 ↗ few secondary structure elements › E6 C-terminal domain-like › E6 C-terminal domain-like › E6 C-terminal domain-like › E6 0.94 87.0 8.16e-01 100.0% 84.4%
185477 4255.1.1.1 ↗ few secondary structure elements › E6 C-terminal domain-like › E6 C-terminal domain-like › E6 C-terminal domain-like › E6 0.93 69.0 6.36e-01 100.0% 62.7%
1734555 4255.1.1.1 ↗ few secondary structure elements › E6 C-terminal domain-like › E6 C-terminal domain-like › E6 C-terminal domain-like › E6 0.91 83.0 7.12e-01 100.0% 66.7%
3036062 4255.1.1.1 ↗ few secondary structure elements › E6 C-terminal domain-like › E6 C-terminal domain-like › E6 C-terminal domain-like › E6 0.89 81.0 7.16e-01 100.0% 71.1%
185478 4255.1.1.1 ↗ few secondary structure elements › E6 C-terminal domain-like › E6 C-terminal domain-like › E6 C-terminal domain-like › E6 0.88 80.0 7.47e-01 100.0% 84.6%
4802727 4255.1.1.1 ↗ few secondary structure elements › E6 C-terminal domain-like › E6 C-terminal domain-like › E6 C-terminal domain-like › E6 0.86 78.0 7.11e-01 100.0% 77.1%
2755068 376.1.1.12 ↗ few secondary structure elements › RING/U-box-like › RING/U-box-like › RING/U-box › zf-RING-like 0.66 34.0 3.54e-01 70.4% 52.0%
3486059 386.1.1.20 ↗ few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › zf-met 0.63 40.0 4.29e-01 98.1% 85.0%
3910824 213.1.1.44 ↗ a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › ATE_C 0.61 45.0 3.11e-01 100.0% 21.4%
3882708 386.1.1.48 ↗ few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › zf_C2HC_14 0.61 33.0 3.87e-01 81.5% 80.0%
4055899 386.1.1.0 ↗ few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers 0.59 33.0 3.92e-01 83.3% 93.3%
3616970 386.1.1.68 ↗ few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › NOA36 0.59 34.0 3.83e-01 70.4% 75.0%
3343296 221.1.1.0 ↗ a+b two layers › beta-Grasp › Ubiquitin-related › Ubiquitin-like 0.58 42.0 3.97e-01 90.7% 61.4%
3469416 101.19.1.1 ↗ alpha arrays › HTH › C-terminal subdomain in oxygen-independent coproporphyrinogen III oxidase HemN › C-terminal subdomain in oxygen-independent coproporphyrinogen III oxidase HemN › HemN_C 0.58 46.0 3.74e-01 92.6% 45.7%
3632980 386.1.1.0 ↗ few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers 0.58 33.0 3.81e-01 94.4% 87.9%
3250670 386.1.1.0 ↗ few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers 0.55 32.0 3.73e-01 94.4% 100.0%
3348294 386.1.1.3 ↗ few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › zf-TRAF 0.55 34.0 3.50e-01 88.9% 66.0%
3279133 101.1.2.0 ↗ alpha arrays › HTH › HTH › winged helix domain 0.55 41.0 3.50e-01 83.3% 73.7%
5052386 375.1.1.0 ↗ few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related 0.55 34.0 3.76e-01 75.9% 82.5%
3852918 4290.1.1.8 ↗ alpha duplicates or obligate multimers › HP0242-like › HP0242-like › HP0242-like › Dynactin_p62 0.55 31.0 2.93e-01 83.3% 39.1%
3902130 375.1.1.107 ↗ few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related › Dynactin_p62 0.55 31.0 2.93e-01 83.3% 39.1%
3394822 375.1.1.179 ↗ few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related › TFIIE_alpha 0.55 42.0 2.84e-01 83.3% 26.7%
4352411 386.1.1.0 ↗ few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers 0.55 33.0 3.44e-01 92.6% 64.0%
3777035 11.1.1.504 ↗ beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › Dynactin_p62 0.55 31.0 2.92e-01 83.3% 39.1%
3539459 386.1.1.3 ↗ few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › zf-TRAF 0.54 33.0 3.46e-01 92.6% 64.0%
3922396 386.1.1.3 ↗ few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › zf-TRAF 0.54 33.0 3.52e-01 87.0% 73.3%
3938245 375.1.1.179 ↗ few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related › TFIIE_alpha 0.53 41.0 2.72e-01 83.3% 24.8%
3260450 386.1.1.0 ↗ few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers 0.53 34.0 3.21e-01 88.9% 52.3%
3223233 375.1.1.179 ↗ few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related › TFIIE_alpha 0.53 40.0 2.66e-01 83.3% 22.6%
4966035 376.1.3.98 ↗ few secondary structure elements › RING/U-box-like › RING/U-box-like › FYVE/PHD zinc finger › DUF7562 0.53 37.0 3.58e-01 74.1% 66.7%
864518 386.1.1.39 ↗ few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › zf-WRNIP1_ubi 0.53 29.0 3.43e-01 81.5% 79.4%
3764172 386.1.1.250 ↗ few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › PRP21_like_P 0.52 28.0 3.33e-01 75.9% 80.0%
3245310 376.1.1.20 ↗ few secondary structure elements › RING/U-box-like › RING/U-box-like › RING/U-box › zf-RING_UBOX 0.52 37.0 3.34e-01 77.8% 65.0%
3275237 376.1.3.0 ↗ few secondary structure elements › RING/U-box-like › RING/U-box-like › FYVE/PHD zinc finger 0.52 38.0 3.74e-01 81.5% 75.0%
3947868 2484.1.1.87 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › MreB-like_C 0.52 37.0 2.67e-01 75.9% 25.5%
3845634 574.1.1.4 ↗ alpha bundles › Surp module (SWAP domain) › Surp module (SWAP domain) › Surp module (SWAP domain) › PRP21_like_P 0.51 27.0 3.21e-01 74.1% 82.8%
3796016 376.1.3.0 ↗ few secondary structure elements › RING/U-box-like › RING/U-box-like › FYVE/PHD zinc finger 0.51 36.0 3.63e-01 75.9% 74.5%
3400504 101.1.15.1 ↗ alpha arrays › HTH › HTH › HAT1, C-terminal domain › MOZ_SAS 0.51 39.0 3.34e-01 87.0% 77.9%
4920017 375.1.1.18 ↗ few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related › SIR2 0.51 36.0 3.90e-01 75.9% 95.5%
D2 high residues 69-131
PDB
Domain cluster: rep: E6__YP_009177725__Trichechus_manatus_latirostris_papillomavirus_4__2848317__D98-164
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00518.23 best E6 46.5 6.50e-12 100.0% 56.4%