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E6_protein

Euk-Vir

Bos_taurus_papillomavirus_13

E6_protein__YP_009272572__Bos_taurus_papillomavirus_13__1887213

Identity

Accession:
YP_009272572 ↗
Protein ID:
E6_protein
Kingdom:
euk

Quality

80.5 mean pLDDT

Taxonomy

Shotokuvirae› Cossaviricota› Papovaviricetes› Zurhausenvirales› Papillomaviridae› Deltapapillomavirus› Bos_taurus_papillomavirus_13

TaxID: 1887213

Cluster

View cluster (138 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 95-155
PDB
Domain cluster: rep: putative_E6_protein__YP_008574810__Felis_catus_papillomavirus_4__1398507__D7-59
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00518.23 best E6 43.6 4.80e-11 98.4% 50.9%
CATH (21)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2m3lA00 3.30.240.40 Alpha Beta › 2-Layer Sandwich › CRO Repressor › E6 early regulatory protein 0.92 87.0 7.94e-01 100.0% 80.3%
2ljxA00 3.30.240.40 Alpha Beta › 2-Layer Sandwich › CRO Repressor › E6 early regulatory protein 0.85 76.0 6.85e-01 98.4% 72.0%
1y8fA00 3.30.60.20 Alpha Beta › 2-Layer Sandwich › Wheat Germ Agglutinin (Isolectin 2); domain 1 › 0.65 42.0 4.47e-01 95.1% 78.4%
3majA02 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.60 41.0 4.12e-01 90.2% 71.7%
2gatA00 3.30.50.10 Alpha Beta › 2-Layer Sandwich › Erythroid Transcription Factor GATA-1; Chain A › Erythroid Transcription Factor GATA-1, subunit A 0.60 32.0 3.14e-01 73.8% 47.0%
2gviA03 3.30.60.20 Alpha Beta › 2-Layer Sandwich › Wheat Germ Agglutinin (Isolectin 2); domain 1 › 0.60 33.0 3.96e-01 72.1% 91.2%
1vd4A00 3.30.40.10 Alpha Beta › 2-Layer Sandwich › Herpes Virus-1 › Zinc/RING finger domain, C3HC4 (zinc finger) 0.57 35.0 3.50e-01 78.7% 58.1%
5i41B00 1.10.1660.10 Mainly Alpha › Orthogonal Bundle › Multidrug-efflux Transporter Regulator; Chain: A; Domain 2 › 0.56 41.0 4.01e-01 86.9% 71.6%
3hh0A01 1.10.1660.10 Mainly Alpha › Orthogonal Bundle › Multidrug-efflux Transporter Regulator; Chain: A; Domain 2 › 0.55 40.0 3.86e-01 88.5% 68.1%
2rdpA00 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.54 42.0 3.20e-01 83.6% 41.4%
1s6lA01 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.54 35.0 3.77e-01 80.3% 78.8%
2l4mA00 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.54 39.0 3.83e-01 91.8% 69.6%
3edpA01 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.54 39.0 3.65e-01 77.0% 65.8%
7bqjA01 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.54 40.0 3.68e-01 83.6% 60.5%
3nw0A03 3.30.40.10 Alpha Beta › 2-Layer Sandwich › Herpes Virus-1 › Zinc/RING finger domain, C3HC4 (zinc finger) 0.53 31.0 3.19e-01 70.5% 56.9%
2wxfA02 3.10.20.90 Alpha Beta › Roll › Ubiquitin-like (UB roll) › Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 0.53 39.0 3.23e-01 82.0% 69.7%
5d8cA00 1.10.1660.10 Mainly Alpha › Orthogonal Bundle › Multidrug-efflux Transporter Regulator; Chain: A; Domain 2 › 0.53 38.0 3.11e-01 88.5% 38.9%
5trdA01 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.53 40.0 3.62e-01 83.6% 64.3%
1mkmB01 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.52 37.0 3.53e-01 80.3% 61.8%
3hcsA02 3.30.40.10 Alpha Beta › 2-Layer Sandwich › Herpes Virus-1 › Zinc/RING finger domain, C3HC4 (zinc finger) 0.51 31.0 3.26e-01 80.3% 69.2%
4yy8B01 3.30.710.10 Alpha Beta › 2-Layer Sandwich › Potassium Channel Kv1.1; Chain A › Potassium Channel Kv1.1; Chain A 0.50 33.0 3.20e-01 70.5% 73.1%
ECOD (35)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
1734555 4255.1.1.1 ↗ few secondary structure elements › E6 C-terminal domain-like › E6 C-terminal domain-like › E6 C-terminal domain-like › E6 0.91 85.0 7.61e-01 100.0% 75.3%
4802727 4255.1.1.1 ↗ few secondary structure elements › E6 C-terminal domain-like › E6 C-terminal domain-like › E6 C-terminal domain-like › E6 0.89 83.0 7.88e-01 100.0% 87.1%
3036062 4255.1.1.1 ↗ few secondary structure elements › E6 C-terminal domain-like › E6 C-terminal domain-like › E6 C-terminal domain-like › E6 0.84 77.0 7.12e-01 100.0% 81.6%
4802726 4255.1.1.1 ↗ few secondary structure elements › E6 C-terminal domain-like › E6 C-terminal domain-like › E6 C-terminal domain-like › E6 0.84 74.0 7.28e-01 98.4% 92.2%
185477 4255.1.1.1 ↗ few secondary structure elements › E6 C-terminal domain-like › E6 C-terminal domain-like › E6 C-terminal domain-like › E6 0.72 57.0 5.59e-01 100.0% 77.6%
305245 375.1.1.18 ↗ few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related › SIR2 0.64 36.0 4.19e-01 80.3% 81.0%
5052386 375.1.1.0 ↗ few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related 0.62 35.0 4.11e-01 77.0% 85.0%
3197805 101.1.9.0 ↗ alpha arrays › HTH › HTH › Putative DNA-binding domain 0.62 38.0 3.68e-01 72.1% 52.9%
3777035 11.1.1.504 ↗ beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › Dynactin_p62 0.60 31.0 3.01e-01 80.3% 40.6%
3343296 221.1.1.0 ↗ a+b two layers › beta-Grasp › Ubiquitin-related › Ubiquitin-like 0.57 39.0 3.76e-01 83.6% 62.9%
None — 0.57 43.0 4.05e-01 88.5% 66.2%
4028586 376.1.1.23 ↗ few secondary structure elements › RING/U-box-like › RING/U-box-like › RING/U-box › zf-C3HC4_2 0.56 31.0 2.84e-01 70.5% 37.6%
3616970 386.1.1.68 ↗ few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › NOA36 0.56 27.0 3.19e-01 72.1% 65.0%
3394822 375.1.1.179 ↗ few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related › TFIIE_alpha 0.56 41.0 2.86e-01 78.7% 29.7%
3583940 386.1.1.112 ↗ few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › zf-C2HC_2 0.55 26.0 3.37e-01 70.5% 83.3%
3223233 375.1.1.179 ↗ few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related › TFIIE_alpha 0.55 41.0 2.75e-01 78.7% 24.8%
3632980 386.1.1.0 ↗ few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers 0.55 30.0 3.64e-01 85.2% 97.0%
3550392 101.1.2.0 ↗ alpha arrays › HTH › HTH › winged helix domain 0.55 40.0 2.88e-01 78.7% 31.4%
3708336 386.1.1.0 ↗ few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers 0.55 27.0 3.53e-01 77.0% 86.7%
3509160 226.1.1.1 ↗ a+b two layers › POZ domain › POZ domain › POZ domain › BTB 0.54 37.0 3.11e-01 72.1% 44.3%
3455782 386.1.1.0 ↗ few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers 0.54 25.0 3.14e-01 70.5% 71.4%
4890082 375.1.1.18 ↗ few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related › SIR2 0.54 33.0 3.67e-01 80.3% 85.7%
3938245 375.1.1.179 ↗ few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related › TFIIE_alpha 0.53 41.0 2.80e-01 83.6% 75.2%
4013540 376.1.3.0 ↗ few secondary structure elements › RING/U-box-like › RING/U-box-like › FYVE/PHD zinc finger 0.53 36.0 3.33e-01 72.1% 51.8%
3348294 386.1.1.3 ↗ few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › zf-TRAF 0.53 31.0 3.31e-01 80.3% 68.0%
3539459 386.1.1.3 ↗ few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › zf-TRAF 0.53 31.0 3.32e-01 85.2% 66.0%
3762788 226.1.1.4 ↗ a+b two layers › POZ domain › POZ domain › POZ domain › BTB_2 0.53 36.0 3.12e-01 73.8% 74.5%
3843296 386.1.1.112 ↗ few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › zf-C2HC_2 0.52 26.0 2.72e-01 72.1% 47.3%
3237093 226.1.1.4 ↗ a+b two layers › POZ domain › POZ domain › POZ domain › BTB_2 0.52 36.0 3.54e-01 75.4% 82.9%
3493356 226.1.1.4 ↗ a+b two layers › POZ domain › POZ domain › POZ domain › BTB_2 0.52 36.0 3.05e-01 77.0% 72.5%
3426279 323.1.1.3 ↗ a+b complex topology › CoA-dependent acyltransferases › CoA-dependent acyltransferases › CoA-dependent acyltransferases › AMP-binding 0.51 35.0 2.41e-01 72.1% 91.7%
3363268 386.1.1.143 ↗ few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › Znf_XAF1_N 0.51 25.0 3.18e-01 70.5% 83.3%
3283922 101.1.2.6 ↗ alpha arrays › HTH › HTH › winged helix domain › GntR 0.51 37.0 3.53e-01 77.0% 74.3%
3884110 226.1.1.4 ↗ a+b two layers › POZ domain › POZ domain › POZ domain › BTB_2 0.50 34.0 2.95e-01 70.5% 75.2%
3634792 376.1.3.27 ↗ few secondary structure elements › RING/U-box-like › RING/U-box-like › FYVE/PHD zinc finger › zf-PHD-like 0.50 38.0 3.50e-01 86.9% 85.9%
D2 medium residues 39-94
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00518.23 best E6 40.6 4.30e-10 89.3% 41.8%
CATH (15)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2ljxA00 3.30.240.40 Alpha Beta › 2-Layer Sandwich › CRO Repressor › E6 early regulatory protein 0.82 65.0 5.66e-01 85.7% 72.0%
2m3lA00 3.30.240.40 Alpha Beta › 2-Layer Sandwich › CRO Repressor › E6 early regulatory protein 0.78 63.0 5.68e-01 87.5% 80.3%
2gatA00 3.30.50.10 Alpha Beta › 2-Layer Sandwich › Erythroid Transcription Factor GATA-1; Chain A › Erythroid Transcription Factor GATA-1, subunit A 0.68 46.0 4.34e-01 91.1% 59.1%
3vd6C01 3.30.50.10 Alpha Beta › 2-Layer Sandwich › Erythroid Transcription Factor GATA-1; Chain A › Erythroid Transcription Factor GATA-1, subunit A 0.67 42.0 4.81e-01 85.7% 87.8%
1gkuB06 1.10.460.10 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; domain 2 › Topoisomerase I, domain 2 0.62 42.0 3.09e-01 76.8% 25.6%
1t6sA01 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.62 37.0 3.26e-01 100.0% 39.5%
2r8rA00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.61 31.0 2.12e-01 87.5% 12.9%
2ctdA00 3.30.160.60 Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › Classic Zinc Finger 0.56 34.0 2.90e-01 96.4% 33.3%
5i41B00 1.10.1660.10 Mainly Alpha › Orthogonal Bundle › Multidrug-efflux Transporter Regulator; Chain: A; Domain 2 › 0.56 38.0 3.67e-01 73.2% 71.6%
1go4A00 3.30.900.10 Alpha Beta › 2-Layer Sandwich › Cell Cycle, Spindle Assembly Checkpoint Protein; Chain A › HORMA domain 0.55 39.0 2.65e-01 75.0% 65.8%
5ttjA01 3.50.50.60 Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain 0.53 42.0 2.90e-01 91.1% 95.0%
2fsjA02 3.30.420.40 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain 0.52 34.0 2.59e-01 80.4% 26.8%
2fclA00 3.30.460.40 Alpha Beta › 2-Layer Sandwich › Beta Polymerase; domain 2 › 0.52 41.0 3.19e-01 98.2% 87.2%
3v33B00 3.40.50.11980 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.51 40.0 3.01e-01 91.1% 90.6%
1tbxB00 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.50 35.0 3.11e-01 76.8% 72.2%
ECOD (18)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4802726 4255.1.1.1 ↗ few secondary structure elements › E6 C-terminal domain-like › E6 C-terminal domain-like › E6 C-terminal domain-like › E6 0.91 71.0 6.76e-01 82.1% 90.6%
3036062 4255.1.1.1 ↗ few secondary structure elements › E6 C-terminal domain-like › E6 C-terminal domain-like › E6 C-terminal domain-like › E6 0.86 79.0 7.06e-01 100.0% 86.8%
1734555 4255.1.1.1 ↗ few secondary structure elements › E6 C-terminal domain-like › E6 C-terminal domain-like › E6 C-terminal domain-like › E6 0.86 69.0 5.99e-01 85.7% 72.8%
4802727 4255.1.1.1 ↗ few secondary structure elements › E6 C-terminal domain-like › E6 C-terminal domain-like › E6 C-terminal domain-like › E6 0.85 62.0 5.71e-01 76.8% 74.3%
185478 4255.1.1.1 ↗ few secondary structure elements › E6 C-terminal domain-like › E6 C-terminal domain-like › E6 C-terminal domain-like › E6 0.85 68.0 6.48e-01 85.7% 90.8%
3388480 377.1.1.0 ↗ few secondary structure elements › Glucocorticoid receptor-like › LIM domain-like › LIM domain-like 0.63 52.0 4.73e-01 91.1% 100.0%
4977157 377.1.1.0 ↗ few secondary structure elements › Glucocorticoid receptor-like › LIM domain-like › LIM domain-like 0.62 43.0 4.70e-01 87.5% 91.1%
3396475 377.1.1.0 ↗ few secondary structure elements › Glucocorticoid receptor-like › LIM domain-like › LIM domain-like 0.60 50.0 4.41e-01 91.1% 86.3%
5081465 101.1.2.14 ↗ alpha arrays › HTH › HTH › winged helix domain › HTH_5 0.55 40.0 3.37e-01 80.4% 93.0%
4088754 2003.1.2.19 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › FAD/NAD(P)-binding domain › Thi4 0.54 46.0 2.98e-01 98.2% 86.3%
3533128 101.1.2.506 ↗ alpha arrays › HTH › HTH › winged helix domain › HTH_NWD1 0.52 38.0 3.11e-01 80.4% 71.8%
3688307 108.1.1.98 ↗ alpha arrays › EF-hand › EF-hand-related › EF-hand › EF-hand_1, EF-hand_5, EF-hand_7 0.51 40.0 2.85e-01 87.5% 67.9%
3244217 101.1.2.506 ↗ alpha arrays › HTH › HTH › winged helix domain › HTH_NWD1 0.51 39.0 3.11e-01 85.7% 58.4%
3922802 101.1.2.506 ↗ alpha arrays › HTH › HTH › winged helix domain › HTH_NWD1 0.51 38.0 3.09e-01 85.7% 73.3%
3464584 376.1.1.1 ↗ few secondary structure elements › RING/U-box-like › RING/U-box-like › RING/U-box › zf-C3HC4 0.50 31.0 2.51e-01 82.1% 26.4%
4407103 327.16.1.0 ↗ a+b two layers › Alpha-lytic protease prodomain-like › Ring-building motif II in type III secretion system › Ring-building motif II in type III secretion system 0.50 34.0 3.39e-01 71.4% 81.7%
4890082 375.1.1.18 ↗ few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related › SIR2 0.50 32.0 3.51e-01 83.9% 85.7%
None — 0.50 36.0 3.24e-01 80.4% 74.1%