←Back to structures

E7

Euk-Vir

Human_papillomavirus_127

E7__YP_003858574__Human_papillomavirus_127__746832

Identity

Accession:
YP_003858574 ↗
Protein ID:
E7
Kingdom:
euk

Quality

77.8 mean pLDDT

Taxonomy

Shotokuvirae› Cossaviricota› Papovaviricetes› Zurhausenvirales› Papillomaviridae› Gammapapillomavirus› Human_papillomavirus_127

TaxID: 746832

Cluster

Singleton — not in a non-trivial cluster

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 44-91
PDB
Domain cluster: rep: transforming_protein_E7__NP_041326__Human_papillomavirus_type_16__333760__D50-96
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00527.24 best E7 49.6 5.00e-13 89.6% 46.7%
CATH (42)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2b9dA01 3.30.160.330 Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › 0.97 68.0 7.50e-01 72.9% 89.7%
2ewlA00 3.30.160.330 Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › 0.94 85.0 8.01e-01 97.9% 83.9%
4kyzA00 3.30.70.600 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Ribosomal protein S10 0.71 51.0 3.53e-01 77.1% 40.1%
1j5yA02 3.30.1340.20 Alpha Beta › 2-Layer Sandwich › Histidine-containing Protein; Chain: A; › 3H domain 0.69 51.0 3.99e-01 79.2% 93.5%
1bqgA01 3.30.390.10 Alpha Beta › 2-Layer Sandwich › Enolase-like; domain 1 › Enolase-like, N-terminal domain 0.66 53.0 3.92e-01 93.8% 61.6%
7ejoB01 3.30.2260.10 Alpha Beta › 2-Layer Sandwich › ERH-like fold › Enhancer of rudimentary 0.63 43.0 3.66e-01 75.0% 42.2%
3g2bA00 1.10.10.1150 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Coenzyme PQQ synthesis protein D (PqqD) 0.63 32.0 2.56e-01 70.8% 24.4%
2vd3A03 3.30.70.120 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.62 44.0 3.94e-01 79.2% 79.7%
1nh8A03 3.30.70.120 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.61 43.0 4.00e-01 79.2% 86.6%
1qysA00 3.30.1710.10 Alpha Beta › 2-Layer Sandwich › top7, de novo designed protein › top7, de novo designed protein 0.60 42.0 3.51e-01 77.1% 39.1%
2xauA03 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.60 43.0 2.93e-01 77.1% 77.6%
5yvxA00 3.30.40.100 Alpha Beta › 2-Layer Sandwich › Herpes Virus-1 › 0.60 48.0 4.48e-01 89.6% 71.7%
2uvaG01 1.20.1050.120 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.59 48.0 3.64e-01 100.0% 84.6%
5lznA00 3.10.20.360 Alpha Beta › Roll › Ubiquitin-like (UB roll) › CKK domain 0.58 40.0 3.20e-01 75.0% 91.0%
4llgM00 3.10.20.510 Alpha Beta › Roll › Ubiquitin-like (UB roll) › RNA polymerase inhibitor 0.58 42.0 4.19e-01 79.2% 76.0%
3p2aA01 2.30.30.380 Mainly Beta › Roll › SH3 type barrels. › Zn-finger domain of Sec23/24 0.58 39.0 4.29e-01 91.7% 91.7%
4lmyA02 3.30.1490.190 Alpha Beta › 2-Layer Sandwich › Dna Ligase; domain 1 › Ferric-uptake regulator, C-terminal dimerisarion domain 0.58 47.0 4.60e-01 95.8% 96.3%
2jvfA00 3.30.1710.10 Alpha Beta › 2-Layer Sandwich › top7, de novo designed protein › top7, de novo designed protein 0.58 41.0 3.42e-01 77.1% 40.4%
4cbgD02 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.57 39.0 2.73e-01 72.9% 43.5%
6eudA02 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.55 40.0 2.78e-01 77.1% 74.7%
2jxtA01 3.10.20.10 Alpha Beta › Roll › Ubiquitin-like (UB roll) › 0.55 40.0 3.49e-01 79.2% 55.3%
6zwwC01 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.55 40.0 2.81e-01 81.2% 74.0%
2hj1A00 3.10.20.280 Alpha Beta › Roll › Ubiquitin-like (UB roll) › RnfH-like 0.55 39.0 3.40e-01 81.2% 48.1%
4mtdA02 3.30.1490.190 Alpha Beta › 2-Layer Sandwich › Dna Ligase; domain 1 › Ferric-uptake regulator, C-terminal dimerisarion domain 0.55 45.0 4.24e-01 100.0% 87.3%
4hjwA00 3.20.20.140 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Metal-dependent hydrolases 0.54 40.0 2.38e-01 79.2% 15.5%
1l1lA01 3.20.70.20 Alpha Beta › Alpha-Beta Barrel › Anaerobic Ribonucleotide-triphosphate Reductase Large Chain › 0.54 45.0 2.60e-01 97.9% 68.7%
1rzmA01 3.30.70.1140 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Phospho-2-dehydro-3-deoxyheptonate aldolase; domain 1 0.53 39.0 3.37e-01 81.2% 73.8%
5sviB00 3.30.40.100 Alpha Beta › 2-Layer Sandwich › Herpes Virus-1 › 0.53 42.0 4.12e-01 89.6% 79.2%
4mtnA01 3.30.1480.10 Alpha Beta › 2-Layer Sandwich › N Utilization Substance Protein A; Chain:P; domain 4 › NusA, N-terminal domain 0.53 41.0 3.51e-01 95.8% 100.0%
1wmhA00 3.10.20.90 Alpha Beta › Roll › Ubiquitin-like (UB roll) › Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 0.53 38.0 3.20e-01 77.1% 92.8%
2fe3A02 3.30.1490.190 Alpha Beta › 2-Layer Sandwich › Dna Ligase; domain 1 › Ferric-uptake regulator, C-terminal dimerisarion domain 0.53 43.0 4.17e-01 100.0% 96.5%
1ln0A00 3.40.1440.10 Alpha Beta › 3-Layer(aba) Sandwich › GIY-YIG endonuclease › GIY-YIG endonuclease 0.53 42.0 3.53e-01 93.8% 94.6%
2xigA02 3.30.1490.190 Alpha Beta › 2-Layer Sandwich › Dna Ligase; domain 1 › Ferric-uptake regulator, C-terminal dimerisarion domain 0.53 41.0 4.08e-01 97.9% 96.4%
6uqjA02 3.20.20.80 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Glycosidases 0.52 36.0 2.22e-01 75.0% 18.6%
1yguA02 3.90.190.10 Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily 0.52 36.0 2.34e-01 75.0% 57.2%
2kd0A01 3.10.20.90 Alpha Beta › Roll › Ubiquitin-like (UB roll) › Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 0.52 38.0 3.33e-01 77.1% 52.1%
5ffiE00 3.10.20.30 Alpha Beta › Roll › Ubiquitin-like (UB roll) › Beta-grasp domain 0.52 37.0 3.00e-01 77.1% 99.0%
1gpqB00 3.40.1420.10 Alpha Beta › 3-Layer(aba) Sandwich › Inhibitor of vertebrate lysozyme, Ivy › Inhibitor of vertebrate lysozyme 0.52 36.0 2.71e-01 75.0% 90.6%
1e7uA01 3.10.20.90 Alpha Beta › Roll › Ubiquitin-like (UB roll) › Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 0.52 36.0 2.45e-01 72.9% 21.0%
3zq5A03 3.30.450.270 Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › PHY domain 0.51 38.0 2.69e-01 75.0% 40.5%
1yuzA02 2.20.28.10 Mainly Beta › Single Sheet › Rubrerythrin, domain 2 › 0.51 31.0 3.32e-01 91.7% 73.7%
5r0dB01 2.60.34.20 Mainly Beta › Sandwich › Substrate Binding Domain Of DNAk; Chain A, domain 1 › 0.51 36.0 2.67e-01 77.1% 69.9%
ECOD (34)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
8138 4123.1.1.1 ↗ few secondary structure elements › E7 C-terminal domain-like › E7 C-terminal domain-like › E7 C-terminal domain-like › E7 0.95 87.0 8.45e-01 97.9% 90.4%
8137 4123.1.1.1 ↗ few secondary structure elements › E7 C-terminal domain-like › E7 C-terminal domain-like › E7 C-terminal domain-like › E7 0.94 85.0 8.25e-01 97.9% 90.4%
4072720 375.6.1.1 ↗ few secondary structure elements › Rubredoxin-like › FlhC-like › FlhC-like › FlhC 0.76 49.0 5.43e-01 93.8% 91.4%
4029830 2485.1.1.0 ↗ a+b three layers › Thioredoxin-like › Thioredoxin-like › Thioredoxin-like 0.69 46.0 3.25e-01 70.8% 23.2%
3935205 382.1.1.0 ↗ few secondary structure elements › Snake toxin-like › Snake toxin-like › Snake toxin-like 0.68 51.0 3.83e-01 79.2% 30.8%
4928795 375.1.1.0 ↗ few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related 0.66 47.0 4.83e-01 100.0% 80.0%
5045741 375.1.1.0 ↗ few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related 0.65 47.0 4.24e-01 77.1% 100.0%
3512976 2004.1.1.5 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ABC_tran 0.63 42.0 2.64e-01 70.8% 47.7%
4991835 375.1.1.0 ↗ few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related 0.61 48.0 4.83e-01 93.8% 86.0%
3308207 5.1.3.22 ↗ beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 6-bladed › GSDH 0.61 42.0 2.64e-01 72.9% 87.7%
2793102 375.1.1.0 ↗ few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related 0.60 39.0 4.32e-01 97.9% 94.1%
3744352 7512.1.1.6 ↗ a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › Glyco_transf_20 0.60 40.0 2.52e-01 70.8% 25.0%
3360654 376.1.3.57 ↗ few secondary structure elements › RING/U-box-like › RING/U-box-like › FYVE/PHD zinc finger › zf_ULT1 0.59 46.0 4.54e-01 93.8% 90.9%
5010744 221.1.1.0 ↗ a+b two layers › beta-Grasp › Ubiquitin-related › Ubiquitin-like 0.59 49.0 4.51e-01 97.9% 78.5%
3258276 4081.1.1.2 ↗ beta sandwiches › Baculovirus p35 protein-related › Baculovirus p35 protein-related › Baculovirus p35 protein-related › VIT 0.59 40.0 2.65e-01 79.2% 15.1%
3170335 2485.1.1.0 ↗ a+b three layers › Thioredoxin-like › Thioredoxin-like › Thioredoxin-like 0.58 44.0 2.92e-01 85.4% 96.0%
4016025 2485.1.1.39 ↗ a+b three layers › Thioredoxin-like › Thioredoxin-like › Thioredoxin-like › GST_N_2 0.57 37.0 2.82e-01 72.9% 24.8%
4422146 2004.1.1.30 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C 0.56 40.0 2.71e-01 77.1% 72.2%
4061421 221.1.1.0 ↗ a+b two layers › beta-Grasp › Ubiquitin-related › Ubiquitin-like 0.56 37.0 3.24e-01 81.2% 42.5%
4962927 221.1.1.1 ↗ a+b two layers › beta-Grasp › Ubiquitin-related › Ubiquitin-like › Fer2 0.55 38.0 3.08e-01 100.0% 36.8%
3739576 327.11.2.27 ↗ a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Eukaryotic type KH-domain (KH-domain type I) › KH_Vigilin 0.55 37.0 3.62e-01 72.9% 61.8%
4085524 375.1.1.0 ↗ few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related 0.55 36.0 3.86e-01 95.8% 91.4%
3369564 130.1.1.39 ↗ alpha arrays › LEM/SAP HeH motif-like › LEM/SAP HeH motif › LEM/SAP HeH motif › DUF7086 0.55 46.0 3.42e-01 100.0% 42.9%
4987387 219.1.1.76 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases › DUF553 0.55 38.0 2.66e-01 77.1% 63.2%
3242889 221.1.1.0 ↗ a+b two layers › beta-Grasp › Ubiquitin-related › Ubiquitin-like 0.54 37.0 3.19e-01 81.2% 41.2%
3588171 101.1.2.25 ↗ alpha arrays › HTH › HTH › winged helix domain › FUR 0.53 42.0 3.14e-01 95.8% 37.2%
5032747 101.1.2.25 ↗ alpha arrays › HTH › HTH › winged helix domain › FUR 0.53 40.0 3.19e-01 89.6% 40.0%
3824313 2004.1.1.30 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C 0.52 39.0 2.68e-01 87.5% 84.1%
4930302 386.1.1.0 ↗ few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers 0.52 34.0 3.84e-01 70.8% 94.3%
3918540 386.1.1.281 ↗ few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › PF27082 0.51 37.0 3.83e-01 100.0% 97.5%
3988478 857.1.1.1 ↗ a+b duplicates or obligate multimers › Cell division protein ZapA-like › Cell division protein ZapA-like › Cell division protein ZapA-like › ZapA 0.51 41.0 3.42e-01 100.0% 54.1%
3897370 3346.1.1.5 ↗ a+b two layers › N-terminal domain in ubiquitin-fold modifier 1 specific protease UfSP2 › N-terminal domain in ubiquitin-fold modifier 1 specific protease UfSP2 › N-terminal domain in ubiquitin-fold modifier 1 specific protease UfSP2 › ODR4-like 0.50 42.0 2.88e-01 100.0% 96.6%
3464487 221.1.1.2 ↗ a+b two layers › beta-Grasp › Ubiquitin-related › Ubiquitin-like › ubiquitin 0.50 42.0 3.68e-01 97.9% 98.7%
4135088 101.1.2.25 ↗ alpha arrays › HTH › HTH › winged helix domain › FUR 0.50 39.0 2.83e-01 89.6% 40.0%