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GTP_cyclohydrolase

Euk-Vir

Pandoravirus_macleodensis

GTP_cyclohydrolase__YP_009480731__Pandoravirus_macleodensis__2107707

Identity

Accession:
YP_009480731 ↗
Protein ID:
GTP_cyclohydrolase
Kingdom:
euk

Quality

76.9 mean pLDDT

Taxonomy

Pandoravirus› Pandoravirus_macleodensis

TaxID: 2107707

Cluster

View cluster (5 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 238-283
PDB
Domain cluster: representative
CATH (32)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
4uqfG01 1.10.286.10 Mainly Alpha › Orthogonal Bundle › GTP Cyclohydrolase I; Chain A, domain 1 › GTP cyclohydrolase I, N-terminal domain 0.99 86.0 8.18e-01 97.8% 80.8%
1is8A01 1.10.286.10 Mainly Alpha › Orthogonal Bundle › GTP Cyclohydrolase I; Chain A, domain 1 › GTP cyclohydrolase I, N-terminal domain 0.94 87.0 7.83e-01 100.0% 80.0%
1a8rA01 1.10.286.10 Mainly Alpha › Orthogonal Bundle › GTP Cyclohydrolase I; Chain A, domain 1 › GTP cyclohydrolase I, N-terminal domain 0.92 86.0 6.77e-01 100.0% 58.8%
1a3qA01 2.60.40.340 Mainly Beta › Sandwich › Immunoglobulin-like › Rel homology domain (RHD), DNA-binding domain 0.78 64.0 4.29e-01 95.7% 24.0%
1hwyA01 1.10.287.140 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.74 54.0 5.23e-01 100.0% 70.6%
1tfeA02 1.10.286.20 Mainly Alpha › Orthogonal Bundle › GTP Cyclohydrolase I; Chain A, domain 1 › 0.74 62.0 6.25e-01 97.8% 95.6%
2no4A02 1.10.150.240 Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 0.74 60.0 5.17e-01 100.0% 57.3%
2w43A02 1.10.150.240 Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 0.74 57.0 5.35e-01 93.5% 70.2%
4hr1A00 1.20.1270.410 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.72 52.0 3.85e-01 78.3% 54.2%
3uuwB02 3.30.360.10 Alpha Beta › 2-Layer Sandwich › Dihydrodipicolinate Reductase; domain 2 › Dihydrodipicolinate Reductase; domain 2 0.71 58.0 3.94e-01 97.8% 81.0%
3vm9A02 6.10.140.2110 Special › Helix non-globular › Helix Hairpins › 0.69 54.0 5.06e-01 87.0% 80.7%
2bg1A01 3.90.1310.40 Alpha Beta › Alpha-Beta Complex › Penicillin-binding protein 2a (Domain 2) › 0.68 55.0 4.86e-01 100.0% 68.8%
1sg7A00 1.10.1740.70 Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › ChaB 0.67 56.0 4.84e-01 97.8% 60.0%
2yevA02 1.10.287.70 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.66 47.0 4.00e-01 76.1% 47.3%
2ic6A00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.65 43.0 3.72e-01 71.7% 45.1%
3nvaA01 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.65 56.0 3.42e-01 97.8% 70.5%
2rldA00 1.20.1440.60 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 23S rRNA-intervening sequence 0.65 56.0 4.20e-01 97.8% 83.3%
3t69A02 3.30.420.310 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › 2-keto-3-deoxy-galactonokinase, C-terminal domain 0.63 47.0 2.98e-01 78.3% 41.2%
3tklB01 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.61 50.0 4.51e-01 89.1% 88.7%
2lo0A00 1.10.286.70 Mainly Alpha › Orthogonal Bundle › GTP Cyclohydrolase I; Chain A, domain 1 › Get5 dimerization domain 0.61 46.0 4.66e-01 95.7% 91.1%
3js6A02 3.30.420.40 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain 0.61 49.0 3.64e-01 100.0% 35.3%
3zvkA00 3.40.50.1010 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 5'-nuclease 0.61 45.0 3.34e-01 82.6% 28.4%
1t72A02 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.60 43.0 3.47e-01 78.3% 53.1%
1wpbG01 1.10.287.680 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.60 53.0 5.05e-01 100.0% 94.4%
3bh1A02 1.20.1570.10 Mainly Alpha › Up-down Bundle › dip2346 fold › dip2346 domain like 0.60 47.0 3.67e-01 87.0% 87.1%
3swhA01 1.10.357.50 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › 0.59 53.0 3.62e-01 100.0% 32.7%
3h1nA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.59 43.0 3.23e-01 78.3% 93.3%
3wfwA00 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.57 45.0 3.40e-01 97.8% 34.8%
4nb5B02 1.10.287.160 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat 0.54 46.0 4.11e-01 87.0% 68.8%
2g5gX02 1.10.8.760 Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Haem-binding uptake, Tiki superfamily, ChaN, domain 2 0.54 40.0 3.93e-01 97.8% 76.3%
1tw9F02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.52 41.0 3.11e-01 89.1% 71.1%
1n2aA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.52 42.0 3.24e-01 91.3% 50.0%
ECOD (33)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3207298 230.1.1.2 ↗ a+b two layers › T-fold › Tetrahydrobiopterin biosynthesis enzymes-like › Tetrahydrobiopterin biosynthesis enzymes-like › GTP_cyclohydroI 0.95 90.0 5.57e-01 100.0% 23.3%
3639170 230.1.1.2 ↗ a+b two layers › T-fold › Tetrahydrobiopterin biosynthesis enzymes-like › Tetrahydrobiopterin biosynthesis enzymes-like › GTP_cyclohydroI 0.95 90.0 6.10e-01 100.0% 35.7%
4074298 230.1.1.2 ↗ a+b two layers › T-fold › Tetrahydrobiopterin biosynthesis enzymes-like › Tetrahydrobiopterin biosynthesis enzymes-like › GTP_cyclohydroI 0.94 89.0 5.55e-01 100.0% 24.0%
4108348 230.1.1.2 ↗ a+b two layers › T-fold › Tetrahydrobiopterin biosynthesis enzymes-like › Tetrahydrobiopterin biosynthesis enzymes-like › GTP_cyclohydroI 0.92 83.0 5.23e-01 100.0% 22.6%
3680284 230.1.1.2 ↗ a+b two layers › T-fold › Tetrahydrobiopterin biosynthesis enzymes-like › Tetrahydrobiopterin biosynthesis enzymes-like › GTP_cyclohydroI 0.92 76.0 4.80e-01 89.1% 20.5%
5749 230.1.1.2 ↗ a+b two layers › T-fold › Tetrahydrobiopterin biosynthesis enzymes-like › Tetrahydrobiopterin biosynthesis enzymes-like › GTP_cyclohydroI 0.92 86.0 5.29e-01 100.0% 22.6%
3663526 230.1.1.2 ↗ a+b two layers › T-fold › Tetrahydrobiopterin biosynthesis enzymes-like › Tetrahydrobiopterin biosynthesis enzymes-like › GTP_cyclohydroI 0.89 77.0 4.79e-01 93.5% 20.5%
3972335 589.1.1.0 ↗ alpha arrays › Triger factor/SurA peptide-binding domain-like › Triger factor/SurA peptide-binding domain-like › Porin chaperone SurA, peptide-binding domain 0.79 66.0 4.47e-01 100.0% 26.1%
4378189 230.3.1.1 ↗ a+b two layers › T-fold › Elongation factor Ts (EF-Ts), dimerisation domain › Elongation factor Ts (EF-Ts), dimerisation domain › EF_TS 0.78 68.0 4.50e-01 100.0% 24.9%
3690556 148.1.1.0 ↗ alpha arrays › Histone-like › Histone-related › Histone 0.78 68.0 6.25e-01 100.0% 86.7%
4465267 589.1.1.1 ↗ alpha arrays › Triger factor/SurA peptide-binding domain-like › Triger factor/SurA peptide-binding domain-like › Porin chaperone SurA, peptide-binding domain › SurA_N 0.77 64.0 4.26e-01 100.0% 23.9%
3270778 108.1.1.96 ↗ alpha arrays › EF-hand › EF-hand-related › EF-hand › EF-hand_1, EF-hand_6, EF-hand_7 0.77 66.0 5.11e-01 95.7% 47.0%
4431778 589.1.1.1 ↗ alpha arrays › Triger factor/SurA peptide-binding domain-like › Triger factor/SurA peptide-binding domain-like › Porin chaperone SurA, peptide-binding domain › SurA_N 0.77 64.0 4.22e-01 100.0% 22.7%
None — 0.77 65.0 3.90e-01 97.8% 13.4%
3511771 162.1.1.0 ↗ alpha bundles › PTS-regulatory domain, PRD › PTS-regulatory domain, PRD › PTS-regulatory domain, PRD 0.74 61.0 4.59e-01 93.5% 39.1%
4414222 3712.1.1.13 ↗ a+b complex topology › Mediator of RNA polymerase II transcription subunit 11 › Mediator of RNA polymerase II transcription subunit 11 › Mediator of RNA polymerase II transcription subunit 11 › CemA 0.74 60.0 5.30e-01 100.0% 61.4%
None — 0.74 65.0 4.05e-01 100.0% 19.1%
4669270 6026.1.1.42 ↗ alpha duplicates or obligate multimers › cwf21 domain › cwf21 domain › cwf21 domain › CemA 0.73 61.0 5.03e-01 100.0% 51.8%
3939986 864.1.1.3 ↗ a+b two layers › DLC › DLC › DLC › Ground-like 0.72 58.0 4.75e-01 91.3% 47.8%
4244661 152.1.2.1 ↗ alpha arrays › RPB6/omega subunit-like › RPB6/omega subunit-like › RNA polymerase omega subunit › RNA_pol_Rpb6 0.70 60.0 5.48e-01 95.7% 78.3%
4034097 162.1.1.1 ↗ alpha bundles › PTS-regulatory domain, PRD › PTS-regulatory domain, PRD › PTS-regulatory domain, PRD › PRD 0.70 57.0 4.40e-01 100.0% 40.0%
3963537 3435.1.1.1 ↗ a+b two layers › Recombination-associated protein rdgC › Recombination-associated protein rdgC › Recombination-associated protein rdgC › RdgC 0.70 59.0 3.64e-01 100.0% 15.4%
4936980 633.10.1.0 ↗ alpha bundles › Bromodomain-like › IVS-encoded protein-like › IVS-encoded protein-like 0.69 50.0 3.73e-01 78.3% 48.7%
3934455 216.1.1.17 ↗ a+b two layers › UBC-like › UBC-like › UBC-like › Med15_C 0.69 51.0 3.98e-01 93.5% 34.8%
3288661 106.1.1.3 ↗ alpha arrays › Globin-like › Globin-like › Globin-like › Bac_globin 0.68 57.0 4.19e-01 95.7% 36.1%
3204604 6155.1.1.4 ↗ alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter › MPC 0.66 47.0 4.03e-01 76.1% 48.0%
4982483 2486.1.1.0 ↗ a/b three-layered sandwiches › ClpP/crotonase › ClpP/crotonase › ClpP/crotonase 0.64 54.0 3.05e-01 97.8% 8.0%
3298325 3846.1.1.0 ↗ alpha bundles › IcmR › IcmR › IcmR 0.62 48.0 4.93e-01 87.0% 100.0%
5027571 2486.1.1.3 ↗ a/b three-layered sandwiches › ClpP/crotonase › ClpP/crotonase › ClpP/crotonase › Carboxyl_trans 0.61 51.0 2.92e-01 97.8% 9.4%
4162480 377.5.1.1 ↗ few secondary structure elements › Glucocorticoid receptor-like › YggX-like (Pfam 04362) › YggX-like (Pfam 04362) › Iron_traffic 0.60 45.0 4.12e-01 95.7% 94.7%
3709879 181.1.1.0 ↗ alpha bundles › Domain of the SRP/SRP receptor G proteins-like › Domain of the SRP/SRP receptor G-proteins › Domain of the SRP/SRP receptor G-proteins 0.59 48.0 4.30e-01 100.0% 64.0%
4083064 192.6.1.0 ↗ alpha bundles › Long alpha-hairpin › Epsilon subunit of F1F0-ATP synthase C-terminal domain › Epsilon subunit of F1F0-ATP synthase C-terminal domain 0.59 52.0 4.93e-01 95.7% 94.3%
59127 109.1.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › Glutathione S-transferase (GST)-C › Glutathione S-transferase (GST)-C 0.54 45.0 3.17e-01 89.1% 59.4%
D2 high residues 290-425
PDB
Domain cluster: rep: BML_08182015_6_5m_scaffold_18_prodigal-single.1__X__X__00293__D9-115
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF01227.28 best GTP_cyclohydroI 184.6 1.60e-54 99.3% 71.0%
D3 medium residues 17-85
PDB
Domain cluster: rep: GTP_cyclohydrolase__YP_008436542__Pandoravirus_salinus__1349410__D50-109
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF01725.22 best Ham1p_like 32.1 1.40e-07 95.7% 35.3%
D4 medium residues 86-174_200-221
PDB
Domain cluster: rep: S2_012_000_R2_scaffold_0_prodigal-single.1__X__X__00394__D55-160
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF01725.22 best Ham1p_like 23.5 6.30e-05 96.4% 43.3%