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H2c1_full_idba_ud_scaffold_88_prodigal-single.1__X__X__00252

Bact-Vir

H2c1_full_idba_ud_scaffold_88_prodigal-single.1__X__X__00252

Identity

Kingdom:
phage

Quality

88.8 mean pLDDT

Cluster

Singleton — not in a non-trivial cluster

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 3-60
PDB
CATH (50)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1whzA00 3.30.920.30 Alpha Beta › 2-Layer Sandwich › Metal Transport, Frataxin; Chain A › Hypothetical protein. 0.71 60.0 5.75e-01 98.3% 85.5%
4hs5A00 3.30.920.10 Alpha Beta › 2-Layer Sandwich › Metal Transport, Frataxin; Chain A › Frataxin/CyaY 0.71 61.0 5.12e-01 100.0% 81.0%
3oajA02 3.10.180.10 Alpha Beta › Roll › 2,3-Dihydroxybiphenyl 1,2-Dioxygenase; domain 1 › 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1 0.69 54.0 4.13e-01 87.9% 47.2%
5yrzB00 3.30.920.30 Alpha Beta › 2-Layer Sandwich › Metal Transport, Frataxin; Chain A › Hypothetical protein. 0.69 58.0 5.90e-01 98.3% 100.0%
4py5A01 3.30.310.10 Alpha Beta › 2-Layer Sandwich › TATA-Binding Protein › TATA-Binding Protein 0.65 58.0 5.39e-01 100.0% 81.9%
5umsA02 2.30.29.30 Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) 0.64 44.0 3.71e-01 72.4% 68.6%
1y13A00 3.30.479.10 Alpha Beta › 2-Layer Sandwich › Tetrahydropterin Synthase; Chain A › 6-pyruvoyl tetrahydropterin synthase/QueD 0.62 48.0 3.45e-01 82.8% 57.7%
4i8oA01 3.30.310.240 Alpha Beta › 2-Layer Sandwich › TATA-Binding Protein › Bacterial toxin RNase RnlA/LsoA, N-terminal domain 0.62 52.0 4.63e-01 100.0% 77.5%
3p34A02 3.30.1120.30 Alpha Beta › 2-Layer Sandwich › Arylsulfatase, C-terminal domain › POLO box domain 0.61 43.0 3.62e-01 74.1% 52.6%
4geqB00 3.30.160.430 Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › 0.61 45.0 4.58e-01 82.8% 82.8%
2d9xA01 2.30.29.30 Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) 0.61 42.0 3.39e-01 72.4% 70.9%
2yf0A01 2.30.29.30 Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) 0.61 45.0 3.94e-01 79.3% 77.0%
5mmiG01 3.90.930.12 Alpha Beta › Alpha-Beta Complex › Outer Surface Protein A; domain 3 › Ribosomal protein L6 0.60 50.0 4.60e-01 100.0% 91.7%
3b0xA03 3.30.460.10 Alpha Beta › 2-Layer Sandwich › Beta Polymerase; domain 2 › Beta Polymerase, domain 2 0.60 47.0 3.91e-01 86.2% 47.6%
3dpuB03 3.30.310.200 Alpha Beta › 2-Layer Sandwich › TATA-Binding Protein › 0.60 51.0 4.26e-01 100.0% 63.0%
2vszB02 2.30.29.30 Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) 0.59 35.0 2.85e-01 100.0% 29.1%
4v0bA00 3.30.720.210 Alpha Beta › 2-Layer Sandwich › Signal recognition particle alu RNA binding heterodimer, srp9/1 › 0.59 39.0 3.84e-01 70.7% 63.5%
3fvcA03 2.30.29.100 Mainly Beta › Roll › PH-domain like › 0.58 41.0 3.40e-01 75.9% 90.9%
3zi1A01 3.10.180.10 Alpha Beta › Roll › 2,3-Dihydroxybiphenyl 1,2-Dioxygenase; domain 1 › 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1 0.58 49.0 3.91e-01 100.0% 53.5%
3getA02 3.90.1150.10 Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 0.58 46.0 4.15e-01 100.0% 88.3%
1onfA02 3.50.50.60 Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain 0.58 39.0 3.09e-01 70.7% 75.4%
2codA01 2.30.29.30 Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) 0.57 40.0 3.44e-01 74.1% 67.7%
1smpI00 2.40.128.10 Mainly Beta › Beta Barrel › Lipocalin › 0.57 42.0 3.61e-01 81.0% 83.0%
2kjzA01 3.30.720.120 Alpha Beta › 2-Layer Sandwich › Signal recognition particle alu RNA binding heterodimer, srp9/1 › 0.57 40.0 4.09e-01 75.9% 81.5%
1kutA02 3.30.470.20 Alpha Beta › 2-Layer Sandwich › D-amino Acid Aminotransferase; Chain A, domain 1 › ATP-grasp fold, B domain 0.57 39.0 3.06e-01 94.8% 32.3%
3rheA00 3.10.180.10 Alpha Beta › Roll › 2,3-Dihydroxybiphenyl 1,2-Dioxygenase; domain 1 › 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1 0.56 44.0 3.71e-01 93.1% 48.2%
1ej6B00 3.90.1830.10 Alpha Beta › Alpha-Beta Complex › Inner capsid protein lambda-1 › Inner capsid protein lambda-1 0.56 42.0 2.30e-01 81.0% 79.6%
4jcwA02 2.60.40.760 Mainly Beta › Sandwich › Immunoglobulin-like › Expansin, cellulose-binding-like domain 0.56 43.0 3.78e-01 84.5% 91.1%
3gvpA02 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.56 47.0 3.46e-01 94.8% 81.8%
3hr8A02 3.30.250.10 Alpha Beta › 2-Layer Sandwich › Rec A Protein; domain 2 › RecA protein, C-terminal domain 0.56 45.0 4.25e-01 100.0% 74.7%
1tj6A00 2.30.29.30 Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) 0.55 38.0 3.14e-01 74.1% 78.3%
3a7rA01 3.30.930.10 Alpha Beta › 2-Layer Sandwich › BirA Bifunctional Protein; domain 2 › Bira Bifunctional Protein; Domain 2 0.55 48.0 3.18e-01 100.0% 23.8%
6g6qA01 2.130.10.10 Mainly Beta › 7 Propeller › Methylamine Dehydrogenase; Chain H › YVTN repeat-like/Quinoprotein amine dehydrogenase 0.55 43.0 3.24e-01 84.5% 44.4%
3uoxB01 3.50.50.60 Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain 0.55 38.0 2.53e-01 100.0% 14.6%
3luqB00 3.30.450.20 Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › PAS domain 0.55 38.0 3.13e-01 74.1% 88.6%
2o7iA01 3.40.190.10 Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II 0.55 45.0 3.40e-01 100.0% 87.7%
2pulB01 3.30.200.20 Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › Phosphorylase Kinase; domain 1 0.55 46.0 4.05e-01 100.0% 95.7%
1icwB00 2.40.50.40 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › 0.54 37.0 3.57e-01 74.1% 63.6%
4bjzA01 3.50.50.60 Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain 0.53 45.0 3.32e-01 98.3% 82.1%
4hb9A01 3.50.50.60 Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain 0.53 46.0 2.82e-01 98.3% 90.1%
1lu4A00 3.40.30.10 Alpha Beta › 3-Layer(aba) Sandwich › Glutaredoxin › Glutaredoxin 0.53 45.0 3.53e-01 100.0% 70.1%
6az1E02 2.40.50.740 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Ribosomal protein S4, central domain 0.53 37.0 3.93e-01 74.1% 88.2%
5wb2B00 2.40.50.40 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › 0.52 35.0 3.25e-01 74.1% 54.8%
3rp7A01 3.50.50.60 Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain 0.52 44.0 3.25e-01 100.0% 58.3%
6b4oA02 3.50.50.60 Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain 0.51 39.0 3.06e-01 81.0% 89.0%
2pt7C01 3.30.450.90 Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › 0.51 41.0 3.55e-01 98.3% 53.8%
3dzmB00 2.40.160.70 Mainly Beta › Beta Barrel › Porin › outer membrane protein from Thermus thermophilus HB27. 0.51 39.0 2.82e-01 89.7% 91.7%
1f44A01 1.10.443.10 Mainly Alpha › Orthogonal Bundle › hpI Integrase; Chain A › Intergrase catalytic core 0.51 43.0 3.07e-01 100.0% 83.5%
4jn7A01 3.30.390.10 Alpha Beta › 2-Layer Sandwich › Enolase-like; domain 1 › Enolase-like, N-terminal domain 0.51 35.0 2.78e-01 77.6% 35.3%
3j7yD02 2.30.30.30 Mainly Beta › Roll › SH3 type barrels. › 0.50 39.0 3.58e-01 89.7% 93.8%
ECOD (63)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
5055849 330.7.1.2 a+b two layers › dsRBD-like › PI-Pfui intein middle domain › PI-Pfui intein middle domain › HicA_toxin 0.71 58.0 5.69e-01 98.3% 84.6%
3257938 330.7.1.2 a+b two layers › dsRBD-like › PI-Pfui intein middle domain › PI-Pfui intein middle domain › HicA_toxin 0.70 59.0 5.92e-01 98.3% 98.3%
5002760 330.7.1.2 a+b two layers › dsRBD-like › PI-Pfui intein middle domain › PI-Pfui intein middle domain › HicA_toxin 0.70 60.0 5.68e-01 100.0% 81.4%
4947543 330.7.1.2 a+b two layers › dsRBD-like › PI-Pfui intein middle domain › PI-Pfui intein middle domain › HicA_toxin 0.70 59.0 5.52e-01 98.3% 78.4%
2330317 330.7.1.2 a+b two layers › dsRBD-like › PI-Pfui intein middle domain › PI-Pfui intein middle domain › HicA_toxin 0.69 58.0 5.90e-01 98.3% 100.0%
5002984 330.7.1.2 a+b two layers › dsRBD-like › PI-Pfui intein middle domain › PI-Pfui intein middle domain › HicA_toxin 0.68 56.0 5.39e-01 98.3% 85.7%
5075316 330.7.1.0 a+b two layers › dsRBD-like › PI-Pfui intein middle domain › PI-Pfui intein middle domain 0.67 56.0 5.39e-01 100.0% 87.1%
None 0.65 54.0 3.65e-01 93.1% 37.0%
3516432 604.29.1.1 alpha bundles › Spectrin repeat-like › Trehalose-6-phosphate phosphatase N-terminal helical bundle › Trehalose-6-phosphate phosphatase N-terminal helical bundle › T6PP_N 0.64 37.0 3.04e-01 74.1% 32.4%
4217299 316.1.1.14 a+b three layers › Nucleotidyltransferase-like › Nucleotidyltransferase › Nucleotidyltransferase › LicD 0.64 54.0 3.56e-01 93.1% 33.2%
5064069 2008.2.1.0 a/b three-layered sandwiches › Restriction endonuclease-like › tRNA-intron endonuclease catalytic domain-like › tRNA-intron endonuclease catalytic domain-like 0.64 51.0 4.62e-01 89.7% 92.5%
3774338 292.2.1.6 a+b two layers › RIP/Polo-box domain › Polo-box domain › Polo-box domain › DUF4520 0.63 48.0 3.88e-01 82.8% 67.3%
3270836 220.1.1.8 beta barrels › PH domain-like › PH domain-like › PH domain-like › GRAM 0.62 43.0 3.45e-01 72.4% 65.2%
3373766 7.1.1.7 beta barrels › PDZ domain › PDZ domain › PDZ domain › PDZ_3 0.62 45.0 3.33e-01 77.6% 78.0%
3823929 220.1.1.163 beta barrels › PH domain-like › PH domain-like › PH domain-like › DUF7046 0.62 46.0 3.60e-01 79.3% 55.0%
4939428 56.2.1.1 beta sandwiches › Epsilon subunit of F1F0-ATP synthase-N › CO dehydrogenase accessory protein CooT › CO dehydrogenase accessory protein CooT › CooT 0.62 39.0 3.94e-01 70.7% 63.3%
3407758 220.1.1.8 beta barrels › PH domain-like › PH domain-like › PH domain-like › GRAM 0.61 42.0 3.43e-01 72.4% 60.9%
3291440 227.1.1.0 a+b two layers › DNA clamp › DNA clamp › DNA clamp 0.60 42.0 3.39e-01 72.4% 75.5%
3256843 220.1.1.8 beta barrels › PH domain-like › PH domain-like › PH domain-like › GRAM 0.60 42.0 3.45e-01 72.4% 56.2%
3439990 220.1.1.76 beta barrels › PH domain-like › PH domain-like › PH domain-like › bPH_2 0.60 41.0 3.53e-01 70.7% 66.7%
4266955 4263.2.1.1 a+b two layers › TTHA1528-like › FtsH Periplasmic Domain › FtsH Periplasmic Domain › FtsH_ext 0.60 40.0 3.89e-01 70.7% 61.5%
3839435 330.9.1.0 a+b two layers › dsRBD-like › C-terminal domain in LINE-1 ORF1p › C-terminal domain in LINE-1 ORF1p 0.60 47.0 4.45e-01 96.6% 69.3%
3256547 220.1.1.0 beta barrels › PH domain-like › PH domain-like › PH domain-like 0.60 42.0 3.47e-01 72.4% 67.0%
3645831 7.1.1.7 beta barrels › PDZ domain › PDZ domain › PDZ domain › PDZ_3 0.60 44.0 3.25e-01 77.6% 81.3%
3939128 220.1.1.0 beta barrels › PH domain-like › PH domain-like › PH domain-like 0.60 41.0 3.42e-01 72.4% 70.9%
3226497 145.1.1.1 alpha arrays › F-box domain › F-box domain › F-box domain › F-box 0.59 40.0 3.27e-01 70.7% 55.7%
1870736 7577.1.1.2 a/b three-layered sandwiches › PLP-dependent transferases › PLP-dependent transferases › PLP-dependent transferases › Aminotran_3 0.59 49.0 3.03e-01 100.0% 73.8%
4337890 298.1.1.24 a+b two layers › FwdE/GAPDH domain-like › Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain › Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain › GFO_IDH_MocA_C3 0.59 49.0 3.42e-01 98.3% 44.8%
4987919 56.2.1.1 beta sandwiches › Epsilon subunit of F1F0-ATP synthase-N › CO dehydrogenase accessory protein CooT › CO dehydrogenase accessory protein CooT › CooT 0.59 41.0 4.16e-01 72.4% 94.8%
3219161 220.1.1.50 beta barrels › PH domain-like › PH domain-like › PH domain-like › PH_17 0.59 43.0 3.51e-01 79.3% 64.5%
3483191 211.1.1.0 a+b two layers › Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase › Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase › Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase 0.58 40.0 4.13e-01 84.5% 78.2%
3260669 5.1.4.155 beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › MIOS_WD40 0.58 47.0 2.79e-01 91.4% 23.1%
3737927 220.1.1.294 beta barrels › PH domain-like › PH domain-like › PH domain-like › PF26663 0.57 39.0 3.24e-01 72.4% 63.6%
None 0.57 47.0 2.94e-01 89.7% 67.9%
2872794 4263.2.1.1 a+b two layers › TTHA1528-like › FtsH Periplasmic Domain › FtsH Periplasmic Domain › FtsH_ext 0.57 38.0 3.46e-01 70.7% 49.4%
4496501 5001.1.1.1 alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 0.57 48.0 3.06e-01 100.0% 30.0%
5014724 295.1.1.51 a+b two layers › ssDNA-binding transcriptional regulator domain-like › ssDNA-binding transcriptional regulator domain › ssDNA-binding transcriptional regulator domain › FtsQ_DivIB_C 0.57 44.0 3.67e-01 84.5% 47.0%
4313114 378.1.1.30 few secondary structure elements › His-Me finger endonucleases › His-Me finger endonucleases › His-Me finger endonucleases › PF30178 0.57 43.0 3.42e-01 82.8% 65.0%
3951067 3439.1.1.1 a+b two layers › PafA/Dop C-terminal domain › PafA/Dop C-terminal domain › PafA/Dop C-terminal domain › Pup_ligase 0.56 46.0 4.41e-01 100.0% 97.1%
3367454 304.8.1.2 a+b two layers › Alpha-beta plaits › ACT-like › ACT-like › ACT 0.56 47.0 3.37e-01 100.0% 31.4%
3914311 211.1.1.14 a+b two layers › Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase › Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase › Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase › GLOD4_N 0.56 39.0 4.00e-01 82.8% 80.0%
5048713 3740.1.1.4 alpha arrays › F420-reducing hydrogenase subunit beta › F420-reducing hydrogenase subunit beta › F420-reducing hydrogenase subunit beta › FrhB_FdhB_C 0.56 47.0 3.03e-01 100.0% 71.4%
3940660 3343.1.1.2 alpha complex topology › gamma-tubulin complex protein 4 (GCP4) › gamma-tubulin complex protein 4 (GCP4) › gamma-tubulin complex protein 4 (GCP4) › GCP_C_terminal,GCP_N_terminal 0.56 48.0 2.78e-01 100.0% 20.0%
3790375 192.2.1.0 alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin 0.55 39.0 3.01e-01 74.1% 56.8%
4426878 2003.1.2.49 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › FAD/NAD(P)-binding domain › FAD_binding_2+FAD_binding_3 0.55 46.0 2.89e-01 91.4% 66.8%
3964178 324.1.1.1 a+b two layers › OsmC-like › OsmC-like › OsmC-like › OsmC 0.55 47.0 3.56e-01 94.8% 65.2%
3783976 192.2.1.2 alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin › Prefoldin 0.55 38.0 3.32e-01 74.1% 75.6%
3608400 2485.1.1.19 a+b three layers › Thioredoxin-like › Thioredoxin-like › Thioredoxin-like › L51_S25_CI-B8 0.54 44.0 3.37e-01 100.0% 40.0%
3464286 5.1.5.37 beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 8-bladed › DUF295 0.54 41.0 2.68e-01 96.6% 16.9%
3251263 4291.1.1.1 beta barrels › Oxysterol-binding protein › Oxysterol-binding protein › Oxysterol-binding protein › Oxysterol_BP 0.54 45.0 2.81e-01 98.3% 62.0%
4034336 4.8.1.13 beta barrels › SH3 › Chromo domain-like › Chromo domain-like › ComK 0.54 45.0 3.45e-01 98.3% 44.1%
4025072 192.2.1.0 alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin 0.54 37.0 3.01e-01 74.1% 71.3%
2577475 7577.1.1.2 a/b three-layered sandwiches › PLP-dependent transferases › PLP-dependent transferases › PLP-dependent transferases › Aminotran_3 0.53 35.0 2.42e-01 93.1% 19.1%
3592522 2485.1.1.0 a+b three layers › Thioredoxin-like › Thioredoxin-like › Thioredoxin-like 0.53 43.0 3.56e-01 100.0% 51.2%
3384540 2485.1.1.122 a+b three layers › Thioredoxin-like › Thioredoxin-like › Thioredoxin-like › Thioredoxin, Thioredoxin_6 0.53 43.0 2.96e-01 100.0% 29.0%
4025332 2003.1.2.24 a/b three-layered sandwiches › Rossmann-like › Rossmann-related › FAD/NAD(P)-binding domain › Pyr_redox_2 0.52 45.0 2.78e-01 98.3% 93.9%
5028564 223.2.1.0 a+b three layers › Profilin-like › profilin-like › profilin-like 0.51 40.0 3.33e-01 87.9% 98.2%
3827695 11.2.1.1 beta sandwiches › Immunoglobulin-like beta-sandwich › C2 domain › C2 domain › C2 0.51 41.0 3.08e-01 93.1% 74.4%
3263649 220.1.1.0 beta barrels › PH domain-like › PH domain-like › PH domain-like 0.51 38.0 3.04e-01 84.5% 38.5%
3652692 2485.1.1.86 a+b three layers › Thioredoxin-like › Thioredoxin-like › Thioredoxin-like › Alba 0.50 42.0 3.01e-01 98.3% 32.4%
4595166 5076.2.1.0 alpha complex topology › Mitochondrial ADP/ATP carrier-like › Putative sulfate permease CysZ › Putative sulfate permease CysZ 0.50 44.0 2.96e-01 100.0% 25.3%
4356259 2003.6.1.2 a/b three-layered sandwiches › Rossmann-like › Ribokinase-like › Ribokinase-like › Carb_kinase 0.50 43.0 2.81e-01 100.0% 22.2%
3276600 11.1.1.801 beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › DUF7035 0.50 39.0 3.04e-01 86.2% 87.4%