←Back to structures

HC-Pro

Euk-Vir

Lupinus_mosaic_virus

HC-Pro__YP_004123942__Lupinus_mosaic_virus__573615

Identity

Accession:: YP_004123942 ↗
Protein ID:: HC-Pro
Kingdom:: euk

Quality

87.7 mean pLDDT

Taxonomy

Orthornavirae› Pisuviricota› Stelpaviricetes› Patatavirales› Potyviridae› Potyvirus› Lupinus_mosaic_virus

TaxID: 573615

Cluster

View cluster (80 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 31-107

PDB

Domain cluster: rep: HC-Pro__YP_009252411__Tobacco_mosqueado_virus__1792583__D31-64_66-104

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00851.25 best	Peptidase_C6	40.3	2.80e-10	98.7%	15.4%

CATH (38)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3r2kA00	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.71	66.0	5.15e-01	100.0%	83.1%
4a25B01	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.69	62.0	4.85e-01	98.7%	87.6%
3n71A03	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.69	49.0	3.55e-01	92.2%	26.8%
3ceqA00	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.68	52.0	3.57e-01	96.1%	24.8%
4dyqA01	1.10.10.60	Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Homeodomain-like	0.68	52.0	4.72e-01	81.8%	78.6%
2yjkC00	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.67	59.0	4.74e-01	100.0%	92.4%
1s3qG00	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.66	57.0	4.51e-01	98.7%	81.0%
2v6kA02	1.20.1050.10	Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 ›	0.64	58.0	4.85e-01	100.0%	73.8%
2nn4A00	1.10.287.760	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › YqgQ-like	0.64	42.0	4.60e-01	87.0%	83.9%
2clbA01	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.64	56.0	4.50e-01	100.0%	95.0%
2yfaA02	1.20.1440.210	Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) ›	0.64	57.0	4.99e-01	100.0%	72.4%
1ldjA02	1.20.1310.10	Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › Cullin Repeats	0.64	51.0	4.44e-01	97.4%	55.3%
4pxoA02	1.20.1050.10	Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 ›	0.64	57.0	4.81e-01	100.0%	73.3%
2ikbC00	1.20.141.10	Mainly Alpha › Up-down Bundle › Chitosanase, subunit A; domain 1 › Chitosanase, subunit A, domain 1	0.64	56.0	4.46e-01	100.0%	85.1%
2qqyA00	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.63	56.0	4.63e-01	98.7%	95.7%
3nivC02	1.20.1050.10	Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 ›	0.63	56.0	4.80e-01	100.0%	77.4%
2zttA00	6.10.140.720	Special › Helix non-globular › Helix Hairpins ›	0.63	45.0	4.61e-01	81.8%	78.1%
1ugoA00	1.20.58.120	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain	0.62	56.0	5.17e-01	100.0%	83.8%
1cunA01	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.61	53.0	4.79e-01	94.8%	90.2%
3ismC01	1.25.40.240	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Ku, C-terminal domain	0.61	52.0	4.17e-01	96.1%	48.7%
1dd5A01	1.10.132.20	Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor	0.60	52.0	4.73e-01	100.0%	91.7%
3lomA00	1.10.600.10	Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase	0.60	52.0	3.58e-01	100.0%	79.9%
4u72A01	1.20.58.480	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.59	52.0	3.79e-01	100.0%	56.3%
5wp3B00	1.10.132.20	Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor	0.59	51.0	4.73e-01	100.0%	91.2%
3lbxB01	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.59	51.0	4.59e-01	96.1%	85.0%
4ap2B01	1.20.1310.10	Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › Cullin Repeats	0.59	52.0	4.33e-01	98.7%	90.3%
1he8A03	1.25.40.70	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Phosphatidylinositol 3-kinase, accessory domain (PIK)	0.59	41.0	3.70e-01	74.0%	91.9%
3pe0A02	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.58	51.0	4.61e-01	98.7%	88.7%
5af7B03	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.58	49.0	3.99e-01	94.8%	73.6%
7wmzC01	3.20.20.220	Alpha Beta › Alpha-Beta Barrel › TIM Barrel ›	0.57	50.0	3.48e-01	100.0%	51.9%
8etcb01	1.20.120.1190	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) ›	0.57	43.0	3.55e-01	81.8%	57.5%
2vixA03	1.20.1280.240	Mainly Alpha › Up-down Bundle › Monooxygenase ›	0.57	50.0	4.42e-01	98.7%	89.4%
6vudA01	1.10.132.20	Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor	0.57	45.0	4.08e-01	88.3%	81.7%
4nuuB02	1.20.58.830	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.57	51.0	4.35e-01	100.0%	92.7%
1ivhA03	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.55	48.0	4.01e-01	100.0%	73.0%
4xxiA00	1.10.490.20	Mainly Alpha › Orthogonal Bundle › Globin-like › Phycocyanins	0.55	48.0	3.93e-01	100.0%	75.5%
1q16C01	1.20.950.20	Mainly Alpha › Up-down Bundle › Fumarate Reductase Cytochrome B subunit › Transmembrane di-heme cytochromes, Chain C	0.53	45.0	3.37e-01	98.7%	52.3%
1x4qA01	1.20.1390.10	Mainly Alpha › Up-down Bundle › PWI domain › PWI domain	0.51	31.0	3.19e-01	89.6%	63.4%

ECOD (45)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3726818	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.74	55.0	4.34e-01	92.2%	38.7%
3522050	109.3.1.131 ↗	alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat › INT_SG_DDX_CT_C	0.74	50.0	5.12e-01	97.4%	73.0%
3271103	109.4.1.1355 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › COG6_N, COG6_C	0.74	60.0	3.56e-01	100.0%	11.4%
3355139	109.52.1.1 ↗	alpha superhelices › Repetitive alpha hairpins › FRIGIDA flowering-time regulator › FRIGIDA flowering-time regulator › Frigida	0.73	61.0	4.12e-01	98.7%	25.5%
5071659	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.70	62.0	5.70e-01	98.7%	79.0%
3465231	192.15.1.189 ↗	alpha bundles › Long alpha-hairpin › Endosomal sorting complex assembly domains › Endosomal sorting complex assembly domains › Frigida	0.69	60.0	6.00e-01	96.1%	91.3%
3792672	5001.1.1.0 ↗	alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like	0.68	56.0	4.20e-01	89.6%	61.1%
3240658	109.4.1.409 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Arm,IBB,Arm_3	0.68	47.0	3.27e-01	72.7%	55.0%
3605710	604.12.1.0 ↗	alpha bundles › Spectrin repeat-like › MIT domain › MIT domain	0.67	58.0	5.88e-01	94.8%	94.7%
3427778	604.1.1.144 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › PF26575	0.67	58.0	5.80e-01	93.5%	92.5%
4060154	4974.1.1.0 ↗	alpha bundles › CRISPR-Cas system first helical domain › CRISPR-Cas system first helical domain › CRISPR-Cas system RNase C2c2 first helical domain	0.67	54.0	4.03e-01	100.0%	35.8%
3582455	3843.1.1.0 ↗	alpha complex topology › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K	0.67	54.0	5.46e-01	94.8%	89.3%
4491518	7516.1.1.153 ↗	a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Glycos_transf_2, Glyco_transf_8	0.66	55.0	3.28e-01	92.2%	18.4%
3703063	604.3.1.0 ↗	alpha bundles › Spectrin repeat-like › BAG domain › BAG domain	0.65	57.0	5.36e-01	98.7%	95.8%
3191246	109.1.1.1 ↗	alpha superhelices › Repetitive alpha hairpins › Glutathione S-transferase (GST)-C › Glutathione S-transferase (GST)-C › GST_C	0.65	58.0	4.79e-01	100.0%	72.1%
4013731	601.1.1.12 ↗	alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › AflR	0.63	56.0	4.50e-01	98.7%	54.7%
3497751	605.1.1.0 ↗	alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase	0.63	53.0	5.18e-01	96.1%	82.4%
3255703	310.2.1.0 ↗	a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF	0.63	56.0	5.04e-01	100.0%	89.9%
3581268	604.1.1.104 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › ANC1_spectrin	0.63	54.0	5.09e-01	96.1%	94.7%
3174622	4967.1.1.0 ↗	alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases	0.62	54.0	4.42e-01	98.7%	85.2%
4579290	4156.1.1.6 ↗	alpha arrays › Sec63 N-terminal subdomain-like › Sec63 N-terminal subdomain-like › Sec63 N-terminal subdomain-like › Helicase_dom4_arc	0.62	52.0	4.44e-01	94.8%	90.8%
4360301	7516.1.1.2 ↗	a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Glycos_transf_2	0.62	54.0	3.66e-01	98.7%	48.1%
5034573	4156.1.1.6 ↗	alpha arrays › Sec63 N-terminal subdomain-like › Sec63 N-terminal subdomain-like › Sec63 N-terminal subdomain-like › Helicase_dom4_arc	0.62	53.0	4.38e-01	97.4%	94.5%
3200625	109.4.1.158 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › ERAP1_C	0.62	43.0	2.88e-01	92.2%	17.5%
4030724	4156.1.1.0 ↗	alpha arrays › Sec63 N-terminal subdomain-like › Sec63 N-terminal subdomain-like › Sec63 N-terminal subdomain-like	0.62	53.0	4.05e-01	97.4%	94.0%
3871543	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.61	54.0	4.55e-01	98.7%	73.8%
3368223	192.29.1.0 ↗	alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding)	0.61	54.0	3.93e-01	100.0%	61.9%
3964840	3636.1.1.0 ↗	a+b two layers › XPD arch domain › XPD arch domain › XPD arch domain	0.60	49.0	3.73e-01	89.6%	62.7%
None	—		0.60	52.0	3.86e-01	100.0%	43.5%
4026956	109.4.1.1304 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_8, TPR_10, TPR_12	0.59	53.0	3.66e-01	100.0%	88.2%
3952765	192.29.1.179 ↗	alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › PF26307	0.59	52.0	4.25e-01	98.7%	67.6%
3288433	633.6.1.1 ↗	alpha bundles › Bromodomain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA_dh_1	0.59	49.0	3.84e-01	94.8%	66.3%
3250251	4967.1.1.16 ↗	alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › TERT_C	0.59	52.0	3.77e-01	100.0%	71.4%
5018993	601.30.1.1 ↗	alpha bundles › Four-helical up-and-down bundle › Helical bundle domain in hypothetical protein PH1320 › Helical bundle domain in hypothetical protein PH1320 › NOG1_N	0.59	49.0	4.25e-01	94.8%	63.2%
3185353	601.30.1.1 ↗	alpha bundles › Four-helical up-and-down bundle › Helical bundle domain in hypothetical protein PH1320 › Helical bundle domain in hypothetical protein PH1320 › NOG1_N	0.58	49.0	4.21e-01	96.1%	63.8%
3243599	601.1.2.0 ↗	alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608)	0.58	49.0	4.40e-01	100.0%	77.4%
3755130	604.1.1.1 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin	0.58	51.0	4.61e-01	98.7%	90.5%
5019542	622.4.1.67 ↗	alpha bundles › YvfG-like › Mite allergen Der p 5-related › Mite allergen Der p 5-related › DUF5518	0.56	48.0	4.47e-01	96.1%	87.9%
3197870	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.56	49.0	4.13e-01	98.7%	82.2%
3271444	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.56	49.0	3.40e-01	100.0%	42.2%
4878877	7579.1.1.14 ↗	a/b three-layered sandwiches › alpha/beta-Hydrolases › alpha/beta-Hydrolases › alpha/beta-Hydrolases › Lipase_3	0.56	46.0	3.32e-01	98.7%	88.1%
4485359	103.2.1.0 ↗	alpha arrays › RuvA-C › ATP cone › ATP cone	0.55	39.0	3.72e-01	100.0%	62.1%
3743731	3615.1.1.0 ↗	alpha bundles › Bacterial dynamin-like protein helical domain › Bacterial dynamin-like protein helical domain › Bacterial dynamin-like protein helical domain	0.55	47.0	3.54e-01	100.0%	53.3%
3545942	5.1.11.11 ↗	beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 9-bladed › WD40	0.51	42.0	2.77e-01	96.1%	19.5%
3749171	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.51	43.0	3.09e-01	96.1%	54.5%

D2 high residues 113-179

PDB

Domain cluster: rep: HC-Pro_protein__YP_006405405__Basella_rugose_mosaic_virus__373398__D110-165

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00851.25 best	Peptidase_C6	52.0	8.20e-14	100.0%	14.1%

D3 medium residues 180-270_320-341

PDB

Domain cluster: rep: HC-Pro__YP_001936179__Verbena_virus_Y__515446__D186-209_223-267_313-337

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00851.25 best	Peptidase_C6	65.3	7.30e-18	84.1%	20.2%

D4 medium residues 271-319_342-458

PDB

Domain cluster: rep: HC-Pro_protein__YP_006590094__Chinese_yam_necrotic_mosaic_virus__128818__D95-261

Pfam (2)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00851.25 best	Peptidase_C6	176.4	1.40e-51	71.7%	26.8%
PF00851.25	Peptidase_C6	42.7	5.30e-11	30.1%	10.9%