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HC-Pro

Euk-Vir

Brugmansia_mosaic_virus

HC-Pro__YP_007354889__Brugmansia_mosaic_virus__1239452

Identity

Accession:
YP_007354889 ↗
Protein ID:
HC-Pro
Kingdom:
euk

Quality

85.6 mean pLDDT

Taxonomy

Orthornavirae› Pisuviricota› Stelpaviricetes› Patatavirales› Potyviridae› Potyvirus› Brugmansia_mosaic_virus

TaxID: 1239452

Cluster

View cluster (80 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 21-104
PDB
Domain cluster: rep: HC-Pro__YP_009252411__Tobacco_mosqueado_virus__1792583__D31-64_66-104
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00851.25 best Peptidase_C6 48.1 1.30e-12 100.0% 18.2%
CATH (54)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
4m0mA03 1.20.1270.430 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.77 52.0 5.37e-01 85.7% 73.4%
3oxfA05 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.74 48.0 5.14e-01 82.1% 74.7%
3ceqA00 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.71 49.0 3.45e-01 86.9% 24.0%
6vudA01 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.69 48.0 4.39e-01 75.0% 55.0%
3bt5A00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.68 56.0 4.64e-01 90.5% 94.7%
2pqrA01 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.68 43.0 4.16e-01 82.1% 57.0%
4a25B01 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.68 59.0 4.78e-01 96.4% 87.6%
6fndA01 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.66 49.0 3.72e-01 82.1% 34.9%
2v6kA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.65 55.0 4.75e-01 92.9% 73.1%
4pxoA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.65 55.0 4.72e-01 92.9% 72.5%
2ikbC00 1.20.141.10 Mainly Alpha › Up-down Bundle › Chitosanase, subunit A; domain 1 › Chitosanase, subunit A, domain 1 0.64 56.0 4.62e-01 100.0% 90.1%
3kyiA00 1.20.120.160 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain 0.64 49.0 4.25e-01 89.3% 53.1%
1yxrA01 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.64 46.0 4.85e-01 82.1% 86.5%
4dlqA02 1.25.40.610 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.63 40.0 3.86e-01 71.4% 55.8%
3nivC02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.63 53.0 4.69e-01 92.9% 76.6%
1ldjA02 1.20.1310.10 Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › Cullin Repeats 0.63 48.0 4.32e-01 90.5% 57.7%
2uubT00 1.20.58.110 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Ribosomal protein S20 0.62 48.0 4.60e-01 92.9% 70.7%
1nigA00 1.20.1200.10 Mainly Alpha › Up-down Bundle › Hypothetical Protein Ta1238; Chain: A; › Cobalamin adenosyltransferase-like 0.62 51.0 4.25e-01 89.3% 91.1%
1vdyA00 1.25.40.90 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.62 41.0 3.51e-01 88.1% 40.7%
2yfaA02 1.20.1440.210 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 0.62 52.0 4.75e-01 95.2% 72.4%
3qwwA03 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.62 55.0 4.24e-01 100.0% 45.0%
1dd5A01 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.61 48.0 4.40e-01 83.3% 84.4%
3n71A03 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.61 55.0 4.09e-01 100.0% 47.9%
3ajfA00 1.20.1440.190 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › Tenuivirus movement protein 0.61 46.0 4.48e-01 79.8% 73.9%
5tqbB01 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.59 52.0 3.41e-01 94.0% 70.8%
2xrhA00 1.20.120.1430 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HP0721 helical bundle 0.59 41.0 3.85e-01 71.4% 78.0%
3r2kA00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.59 49.0 4.05e-01 92.9% 81.8%
1cunA01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.59 48.0 4.50e-01 89.3% 92.2%
2cz2A02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.59 48.0 4.24e-01 91.7% 66.7%
3pe0A01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.58 48.0 4.51e-01 89.3% 93.1%
3pe0A02 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.58 48.0 4.45e-01 89.3% 87.7%
1htjF00 1.10.167.10 Mainly Alpha › Orthogonal Bundle › Regulator of G-protein Signalling 4; domain 2 › Regulator of G-protein Signalling 4, domain 2 0.58 45.0 3.50e-01 82.1% 86.3%
3lbxB01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.58 49.0 4.55e-01 92.9% 88.8%
4ap2B01 1.20.1310.10 Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › Cullin Repeats 0.58 49.0 4.21e-01 92.9% 91.8%
2rldA00 1.20.1440.60 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 23S rRNA-intervening sequence 0.57 47.0 4.25e-01 90.5% 81.6%
1sumB02 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.57 48.0 4.33e-01 95.2% 76.3%
3dpjF00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.57 41.0 3.23e-01 77.4% 38.3%
8hk0B03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.57 45.0 3.81e-01 85.7% 65.9%
3o39A00 1.20.120.1490 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.56 42.0 4.04e-01 81.0% 90.6%
4xxiA00 1.10.490.20 Mainly Alpha › Orthogonal Bundle › Globin-like › Phycocyanins 0.55 48.0 4.06e-01 100.0% 99.3%
2hisA00 3.20.20.80 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Glycosidases 0.55 49.0 3.35e-01 100.0% 78.5%
7ccmB01 1.10.437.10 Mainly Alpha › Orthogonal Bundle › Apoptosis Regulator Bcl-x › Blc2-like 0.55 43.0 3.65e-01 83.3% 54.5%
4uurA00 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.55 46.0 4.14e-01 96.4% 97.6%
4hehA01 1.10.1240.10 Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › Methionine synthase domain 0.55 38.0 3.83e-01 73.8% 71.1%
2vixA03 1.20.1280.240 Mainly Alpha › Up-down Bundle › Monooxygenase › 0.54 44.0 4.12e-01 94.0% 91.2%
1ugoA00 1.20.58.120 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain 0.54 48.0 4.56e-01 100.0% 85.9%
4u72A01 1.20.58.480 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.54 44.0 3.30e-01 90.5% 90.1%
3kn6A02 1.10.510.10 Mainly Alpha › Orthogonal Bundle › Transferase(Phosphotransferase); domain 1 › Transferase(Phosphotransferase) domain 1 0.52 43.0 3.30e-01 94.0% 71.0%
3wd6A02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.52 43.0 3.93e-01 92.9% 76.3%
1sr2A00 1.20.120.160 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain 0.52 38.0 3.50e-01 91.7% 56.9%
3kbbA02 1.10.150.240 Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 0.52 35.0 3.83e-01 70.2% 100.0%
3fiwA02 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.52 39.0 3.51e-01 86.9% 57.3%
2ogwA01 3.40.50.1980 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Nitrogenase molybdenum iron protein domain 0.51 42.0 3.52e-01 90.5% 78.4%
4nuuB02 1.20.58.830 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.50 40.0 3.62e-01 90.5% 94.3%
ECOD (44)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3258417 109.4.1.192 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_8 0.73 50.0 4.08e-01 83.3% 39.3%
3189302 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.72 46.0 4.22e-01 82.1% 51.4%
3918871 109.4.1.3569 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_12, Consortin_N 0.71 51.0 3.82e-01 89.3% 31.5%
3423650 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.70 51.0 4.15e-01 89.3% 42.0%
3605710 604.12.1.0 ↗ alpha bundles › Spectrin repeat-like › MIT domain › MIT domain 0.68 53.0 5.64e-01 85.7% 92.0%
3191246 109.1.1.1 ↗ alpha superhelices › Repetitive alpha hairpins › Glutathione S-transferase (GST)-C › Glutathione S-transferase (GST)-C › GST_C 0.68 60.0 5.03e-01 96.4% 75.0%
5034573 4156.1.1.6 ↗ alpha arrays › Sec63 N-terminal subdomain-like › Sec63 N-terminal subdomain-like › Sec63 N-terminal subdomain-like › Helicase_dom4_arc 0.68 54.0 4.48e-01 84.5% 91.7%
4936653 4156.1.1.6 ↗ alpha arrays › Sec63 N-terminal subdomain-like › Sec63 N-terminal subdomain-like › Sec63 N-terminal subdomain-like › Helicase_dom4_arc 0.67 53.0 4.42e-01 85.7% 92.4%
3411668 604.12.1.1 ↗ alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › MIT 0.67 46.0 4.83e-01 81.0% 80.0%
None — 0.66 59.0 4.44e-01 100.0% 72.7%
3936736 150.1.1.0 ↗ alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin 0.66 55.0 4.75e-01 92.9% 71.9%
3345666 109.1.1.7 ↗ alpha superhelices › Repetitive alpha hairpins › Glutathione S-transferase (GST)-C › Glutathione S-transferase (GST)-C › GST_C_3 0.65 57.0 4.91e-01 97.6% 72.6%
4579290 4156.1.1.6 ↗ alpha arrays › Sec63 N-terminal subdomain-like › Sec63 N-terminal subdomain-like › Sec63 N-terminal subdomain-like › Helicase_dom4_arc 0.64 51.0 4.42e-01 86.9% 90.8%
2492249 109.1.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › Glutathione S-transferase (GST)-C › Glutathione S-transferase (GST)-C 0.64 55.0 4.73e-01 95.2% 73.5%
4015729 192.7.1.0 ↗ alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm 0.64 44.0 3.81e-01 71.4% 83.2%
3909893 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.63 51.0 4.25e-01 85.7% 67.1%
3372307 109.4.1.67 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › RINT1_TIP1 0.60 51.0 2.97e-01 95.2% 33.9%
3200625 109.4.1.158 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › ERAP1_C 0.60 39.0 2.66e-01 83.3% 17.5%
3777122 109.46.1.1 ↗ alpha superhelices › Repetitive alpha hairpins › Helical domain in TOPLESS related protein 2 (TPR2) › Helical domain in TOPLESS related protein 2 (TPR2) › CTLH 0.60 43.0 3.59e-01 85.7% 42.7%
4027582 603.1.1.120 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins › DUF846 0.60 48.0 4.28e-01 88.1% 89.2%
3707094 109.4.1.628 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Sec7-like_HUS 0.60 48.0 3.47e-01 89.3% 34.5%
3389546 604.1.1.1 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin 0.59 45.0 4.63e-01 83.3% 86.3%
3570651 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.58 47.0 4.55e-01 90.5% 93.7%
3781021 604.1.1.1 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin 0.57 45.0 2.84e-01 86.9% 18.9%
4883406 622.4.1.1 ↗ alpha bundles › YvfG-like › Mite allergen Der p 5-related › Mite allergen Der p 5-related › Blo-t-5 0.57 48.0 4.33e-01 94.0% 82.8%
5063088 2008.1.1.59 ↗ a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › PDDEXK_1 0.57 48.0 3.38e-01 96.4% 28.6%
3987791 1076.1.1.1 ↗ alpha bundles › Intramembrane protease Rce1-related › Intramembrane protease Rce1-related › Intramembrane protease Rce1-related › Rce1-like 0.57 47.0 3.47e-01 89.3% 96.7%
5044421 592.2.1.0 ↗ alpha arrays › PWI domain-like › YugE-like › YugE-like 0.56 35.0 3.57e-01 84.5% 63.7%
5047570 150.1.1.0 ↗ alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin 0.56 46.0 3.84e-01 90.5% 91.3%
3533991 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.56 49.0 3.29e-01 95.2% 66.5%
3755130 604.1.1.1 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin 0.56 45.0 4.22e-01 88.1% 91.4%
3841673 604.1.1.1 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin 0.56 46.0 4.34e-01 89.3% 97.0%
3326044 192.15.1.1 ↗ alpha bundles › Long alpha-hairpin › Endosomal sorting complex assembly domains › Endosomal sorting complex assembly domains › VPS28 0.55 44.0 4.08e-01 89.3% 78.2%
3296471 109.2.1.7 ↗ alpha superhelices › Repetitive alpha hairpins › alpha/alpha toroid › alpha/alpha toroid › Terpene_synth 0.54 36.0 2.77e-01 77.4% 28.3%
4485359 103.2.1.0 ↗ alpha arrays › RuvA-C › ATP cone › ATP cone 0.54 37.0 3.61e-01 92.9% 63.2%
3784566 604.1.1.191 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › PF29057 0.54 42.0 4.06e-01 86.9% 94.0%
3965294 3558.1.1.0 ↗ alpha arrays › HSDR subunit helical domain › HSDR subunit helical domain › HSDR subunit helical domain 0.54 40.0 3.88e-01 78.6% 75.8%
3317702 109.1.1.16 ↗ alpha superhelices › Repetitive alpha hairpins › Glutathione S-transferase (GST)-C › Glutathione S-transferase (GST)-C › GST_C_6 0.53 45.0 3.71e-01 97.6% 77.0%
4122005 109.3.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat 0.53 42.0 3.26e-01 89.3% 58.0%
3964840 3636.1.1.0 ↗ a+b two layers › XPD arch domain › XPD arch domain › XPD arch domain 0.52 42.0 3.44e-01 95.2% 87.6%
4999825 4995.1.1.1 ↗ alpha arrays › Methionine synthase domain-like › Methionine synthase domain-like › Methionine synthase domain-like › B12-binding_2 0.52 43.0 4.05e-01 89.3% 84.0%
3743731 3615.1.1.0 ↗ alpha bundles › Bacterial dynamin-like protein helical domain › Bacterial dynamin-like protein helical domain › Bacterial dynamin-like protein helical domain 0.51 42.0 3.21e-01 91.7% 51.9%
5024551 4266.2.1.1 ↗ alpha bundles › Hyaluronidase domain-like › TTHA0068-like › TTHA0068-like › DUF309 0.50 40.0 3.36e-01 89.3% 74.7%
3741702 109.4.1.32 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › MIF4G 0.50 41.0 2.75e-01 89.3% 35.3%
D2 medium residues 111-175
PDB
Domain cluster: rep: HC-Pro_protein__YP_006405405__Basella_rugose_mosaic_virus__373398__D110-165
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00851.25 best Peptidase_C6 59.3 4.80e-16 100.0% 14.5%
D3 medium residues 176-272_305-338
PDB
Domain cluster: rep: HC-Pro__YP_001936179__Verbena_virus_Y__515446__D186-209_223-267_313-337
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF00851.25 best Peptidase_C6 77.7 1.20e-21 73.3% 20.0%
PF00851.25 Peptidase_C6 28.4 1.20e-06 32.1% 8.6%
D4 medium residues 273-304_339-456
PDB
Domain cluster: rep: HC-Pro_protein__YP_006590094__Chinese_yam_necrotic_mosaic_virus__128818__D95-261
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF00851.25 best Peptidase_C6 198.6 2.70e-58 80.0% 26.8%
PF00851.25 Peptidase_C6 28.7 9.30e-07 22.0% 7.0%