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HC-Pro
Euk-VirTobacco_mosqueado_virus
HC-Pro__YP_009252411__Tobacco_mosqueado_virus__1792583
Identity
- Accession:
- YP_009252411 ↗
- Protein ID:
- HC-Pro
- Kingdom:
- euk
Quality
84.9
mean pLDDT
Taxonomy
Orthornavirae›
Pisuviricota›
Stelpaviricetes›
Patatavirales›
Potyviridae›
Potyvirus›
Tobacco_mosqueado_virus
TaxID: 1792583
Cluster
View cluster (80 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 31-64_66-104
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00851.25 best | Peptidase_C6 | 46.3 | 4.40e-12 | 100.0% | 16.6% |
CATH (43)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4y6cA00 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.73 | 53.0 | 3.75e-01 | 93.2% | 26.4% |
| 3n71A03 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.72 | 52.0 | 3.70e-01 | 94.5% | 26.3% |
| 4a25B01 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.69 | 61.0 | 4.74e-01 | 100.0% | 86.3% |
| 3bt5A00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.68 | 60.0 | 4.79e-01 | 100.0% | 94.0% |
| 2zopA00 | 1.10.520.30 | Mainly Alpha › Orthogonal Bundle › Peroxidase; domain 1 › AF1862-like domain | 0.65 | 48.0 | 4.17e-01 | 78.1% | 77.7% |
| 2qqyA00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.64 | 58.0 | 4.66e-01 | 98.6% | 91.3% |
| 5tqbB01 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.64 | 55.0 | 3.54e-01 | 94.5% | 31.0% |
| 4dyqA01 | 1.10.10.60 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Homeodomain-like | 0.63 | 48.0 | 4.24e-01 | 80.8% | 76.7% |
| 2uubT00 | 1.20.58.110 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Ribosomal protein S20 | 0.62 | 51.0 | 4.68e-01 | 100.0% | 67.7% |
| 2oduA02 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.62 | 56.0 | 4.96e-01 | 100.0% | 86.7% |
| 3kyiA00 | 1.20.120.160 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain | 0.62 | 53.0 | 4.38e-01 | 98.6% | 53.1% |
| 1nigA00 | 1.20.1200.10 | Mainly Alpha › Up-down Bundle › Hypothetical Protein Ta1238; Chain: A; › Cobalamin adenosyltransferase-like | 0.62 | 55.0 | 4.41e-01 | 100.0% | 93.2% |
| 2v6kA02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.62 | 55.0 | 4.55e-01 | 100.0% | 68.5% |
| 2rldA00 | 1.20.1440.60 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 23S rRNA-intervening sequence | 0.62 | 56.0 | 4.78e-01 | 100.0% | 72.8% |
| 1yxrA01 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.62 | 49.0 | 4.93e-01 | 93.2% | 86.5% |
| 2pusA04 | 6.10.140.300 | Special › Helix non-globular › Helix Hairpins › | 0.61 | 45.0 | 4.05e-01 | 97.3% | 54.6% |
| 1t98A02 | 1.20.58.590 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Chromosome partition protein MukF, middle domain | 0.61 | 54.0 | 4.20e-01 | 100.0% | 67.5% |
| 6vudA01 | 1.10.132.20 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor | 0.60 | 54.0 | 4.71e-01 | 100.0% | 89.9% |
| 3nivC02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.60 | 53.0 | 4.48e-01 | 100.0% | 72.6% |
| 4s2rQ03 | 3.90.230.10 | Alpha Beta › Alpha-Beta Complex › Creatine Amidinohydrolase › Creatinase/methionine aminopeptidase superfamily | 0.60 | 50.0 | 3.36e-01 | 93.2% | 94.6% |
| 2aj4B03 | 1.20.1440.340 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › | 0.59 | 49.0 | 3.91e-01 | 95.9% | 68.5% |
| 4a64A01 | 1.20.1310.10 | Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › Cullin Repeats | 0.59 | 48.0 | 4.00e-01 | 91.8% | 56.8% |
| 2efkA01 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.58 | 44.0 | 2.96e-01 | 79.5% | 37.4% |
| 3c1yA02 | 1.20.1260.110 | Mainly Alpha › Up-down Bundle › Ferritin › DNA integrity scanning linker region | 0.58 | 51.0 | 4.05e-01 | 98.6% | 58.1% |
| 1fioA00 | 1.20.58.70 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.58 | 50.0 | 3.75e-01 | 100.0% | 51.1% |
| 5mj6A04 | 1.25.50.20 | Mainly Alpha › Alpha Horseshoe › Zincin-like fold › | 0.58 | 42.0 | 2.80e-01 | 94.5% | 17.5% |
| 4abnA01 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.58 | 50.0 | 3.41e-01 | 100.0% | 61.6% |
| 1h7cA00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.57 | 48.0 | 4.32e-01 | 94.5% | 98.1% |
| 1cunA01 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.57 | 51.0 | 4.57e-01 | 100.0% | 93.1% |
| 2yayA02 | 1.20.1670.10 | Mainly Alpha › Up-down Bundle › all-alpha NTP pyrophosphatase › Type II deoxyuridine triphosphatase | 0.56 | 47.0 | 3.96e-01 | 97.3% | 95.6% |
| 3p0uA00 | 1.10.565.10 | Mainly Alpha › Orthogonal Bundle › Retinoid X Receptor › Retinoid X Receptor | 0.56 | 44.0 | 3.15e-01 | 91.8% | 27.9% |
| 1fp3A00 | 1.50.10.10 | Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase › | 0.56 | 47.0 | 3.05e-01 | 100.0% | 18.2% |
| 8hdlA01 | 1.10.600.10 | Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase | 0.56 | 49.0 | 3.46e-01 | 100.0% | 36.5% |
| 1kblA04 | 3.20.20.60 | Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Phosphoenolpyruvate-binding domains | 0.55 | 45.0 | 2.97e-01 | 93.2% | 40.9% |
| 4oydB00 | 1.10.132.20 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor | 0.55 | 47.0 | 4.10e-01 | 98.6% | 88.0% |
| 2vixA03 | 1.20.1280.240 | Mainly Alpha › Up-down Bundle › Monooxygenase › | 0.55 | 47.0 | 4.14e-01 | 100.0% | 86.7% |
| 3pe0A02 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.55 | 48.0 | 4.28e-01 | 100.0% | 87.7% |
| 2lqgA00 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.54 | 45.0 | 3.79e-01 | 97.3% | 71.7% |
| 3ebbA00 | 1.25.10.10 | Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant | 0.53 | 46.0 | 3.20e-01 | 100.0% | 37.9% |
| 3m0fB02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.52 | 46.0 | 3.90e-01 | 100.0% | 77.2% |
| 3owaB04 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.52 | 45.0 | 3.53e-01 | 97.3% | 65.0% |
| 1gvnD00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.52 | 47.0 | 3.17e-01 | 100.0% | 69.3% |
| 1bgcA00 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.52 | 45.0 | 3.57e-01 | 100.0% | 50.0% |
ECOD (41)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3727610 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.76 | 60.0 | 4.38e-01 | 100.0% | 32.6% |
| 3506230 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.74 | 54.0 | 3.82e-01 | 93.2% | 26.7% |
| 4013444 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.73 | 53.0 | 4.69e-01 | 94.5% | 53.3% |
| 3230591 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.72 | 51.0 | 3.49e-01 | 75.3% | 36.6% |
| 3188071 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.72 | 51.0 | 4.22e-01 | 93.2% | 43.2% |
| 3189302 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.72 | 51.0 | 4.47e-01 | 93.2% | 51.4% |
| 3821959 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.71 | 56.0 | 4.52e-01 | 100.0% | 44.3% |
| 4019574 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.71 | 53.0 | 4.49e-01 | 94.5% | 49.6% |
| 3423650 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.71 | 56.0 | 4.39e-01 | 100.0% | 41.3% |
| 3593242 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.69 | 60.0 | 3.38e-01 | 98.6% | 8.3% |
| 3616025 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.69 | 53.0 | 3.69e-01 | 100.0% | 26.1% |
| 4321419 | 4156.1.1.6 ↗ | alpha arrays › Sec63 N-terminal subdomain-like › Sec63 N-terminal subdomain-like › Sec63 N-terminal subdomain-like › Helicase_dom4_arc | 0.68 | 60.0 | 4.80e-01 | 97.3% | 93.1% |
| 3941216 | 7015.1.1.0 ↗ | alpha bundles › Palmitoyltransferase DHHC transmembrane domain › Palmitoyltransferase DHHC transmembrane domain › Palmitoyltransferase DHHC transmembrane domain | 0.66 | 58.0 | 4.92e-01 | 94.5% | 83.5% |
| 4936653 | 4156.1.1.6 ↗ | alpha arrays › Sec63 N-terminal subdomain-like › Sec63 N-terminal subdomain-like › Sec63 N-terminal subdomain-like › Helicase_dom4_arc | 0.66 | 57.0 | 4.55e-01 | 95.9% | 91.7% |
| 3277087 | 192.4.1.0 ↗ | alpha bundles › Long alpha-hairpin › Ribosomal protein L29 (L29p) › Ribosomal protein L29 (L29p) | 0.65 | 52.0 | 4.71e-01 | 84.9% | 78.9% |
| 3423702 | 633.4.1.0 ↗ | alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor | 0.64 | 58.0 | 4.42e-01 | 100.0% | 50.0% |
| 3576991 | 109.3.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat | 0.63 | 56.0 | 4.35e-01 | 100.0% | 81.8% |
| 3462043 | 604.12.1.0 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain | 0.63 | 56.0 | 5.23e-01 | 100.0% | 85.6% |
| 3243897 | 3684.1.1.0 ↗ | alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like | 0.62 | 56.0 | 4.51e-01 | 100.0% | 65.7% |
| 4579290 | 4156.1.1.6 ↗ | alpha arrays › Sec63 N-terminal subdomain-like › Sec63 N-terminal subdomain-like › Sec63 N-terminal subdomain-like › Helicase_dom4_arc | 0.62 | 53.0 | 4.43e-01 | 97.3% | 89.2% |
| 3255703 | 310.2.1.0 ↗ | a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF | 0.60 | 50.0 | 4.33e-01 | 89.0% | 80.7% |
| 3696238 | 206.1.1.0 ↗ | a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase | 0.60 | 55.0 | 3.11e-01 | 100.0% | 12.7% |
| 3461370 | 604.3.1.0 ↗ | alpha bundles › Spectrin repeat-like › BAG domain › BAG domain | 0.60 | 54.0 | 5.16e-01 | 100.0% | 92.9% |
| 3866994 | 601.19.1.36 ↗ | alpha bundles › Four-helical up-and-down bundle › Apolipoprotein › Apolipoprotein › DUF4455 | 0.60 | 52.0 | 3.98e-01 | 98.6% | 77.1% |
| 3825534 | 1065.1.1.0 ↗ | alpha bundles › SPX domain › SPX domain › SPX domain | 0.60 | 53.0 | 3.93e-01 | 100.0% | 57.4% |
| 3807085 | 604.3.1.1 ↗ | alpha bundles › Spectrin repeat-like › BAG domain › BAG domain › BAG | 0.60 | 53.0 | 5.09e-01 | 100.0% | 92.9% |
| 3600217 | 5054.1.1.0 ↗ | alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels | 0.59 | 51.0 | 3.44e-01 | 93.2% | 31.6% |
| 3620153 | 3861.1.1.1 ↗ | alpha bundles › Mitochondrial translocator protein (TSPO) › Mitochondrial translocator protein (TSPO) › Mitochondrial translocator protein (TSPO) › TspO_MBR | 0.58 | 51.0 | 3.94e-01 | 100.0% | 49.7% |
| 3964840 | 3636.1.1.0 ↗ | a+b two layers › XPD arch domain › XPD arch domain › XPD arch domain | 0.58 | 48.0 | 3.59e-01 | 91.8% | 62.2% |
| 3242447 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.58 | 50.0 | 4.47e-01 | 98.6% | 89.5% |
| 3579784 | 604.1.1.1 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin | 0.57 | 50.0 | 4.24e-01 | 98.6% | 76.0% |
| 3301695 | 603.2.1.0 ↗ | alpha bundles › STAT-like › STAT › STAT | 0.57 | 49.0 | 3.51e-01 | 100.0% | 46.1% |
| 3497641 | 604.1.1.1 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin | 0.57 | 47.0 | 4.28e-01 | 93.2% | 89.0% |
| 3570651 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.56 | 47.0 | 4.40e-01 | 95.9% | 89.5% |
| 3392594 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.56 | 50.0 | 4.36e-01 | 100.0% | 82.7% |
| 3215426 | 192.29.1.172 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › PF29678 | 0.55 | 47.0 | 3.94e-01 | 97.3% | 65.4% |
| 3995010 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.55 | 48.0 | 3.95e-01 | 100.0% | 79.3% |
| 4969464 | 604.5.1.0 ↗ | alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) | 0.55 | 49.0 | 4.58e-01 | 98.6% | 86.7% |
| 3518846 | 3861.1.1.1 ↗ | alpha bundles › Mitochondrial translocator protein (TSPO) › Mitochondrial translocator protein (TSPO) › Mitochondrial translocator protein (TSPO) › TspO_MBR | 0.54 | 46.0 | 3.66e-01 | 100.0% | 91.5% |
| 4937575 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.54 | 46.0 | 4.30e-01 | 94.5% | 88.9% |
| 3670976 | 603.1.1.5 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins › Syntaxin-6_N | 0.53 | 44.0 | 3.62e-01 | 95.9% | 67.6% |
D2
high
residues 110-146_148-176
Domain cluster:
rep: HC-Pro_protein__YP_006405405__Basella_rugose_mosaic_virus__373398__D110-165
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00851.25 best | Peptidase_C6 | 63.3 | 3.10e-17 | 98.5% | 14.8% |
D3
medium
residues 186-195_197-236_248-268_315-339_351-379
Domain cluster:
rep: HC-Pro__YP_001936179__Verbena_virus_Y__515446__D186-209_223-267_313-337
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00851.25 best | Peptidase_C6 | 43.2 | 3.90e-11 | 56.8% | 8.9% |
| PF00851.25 | Peptidase_C6 | 36.3 | 4.60e-09 | 52.8% | 14.8% |
D4
medium
residues 237-247_269-314_340-350_380-456
Domain cluster:
rep: HC-Pro_protein__YP_006590094__Chinese_yam_necrotic_mosaic_virus__128818__D95-261
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00851.25 best | Peptidase_C6 | 114.1 | 1.20e-32 | 53.8% | 17.5% |
| PF00851.25 | Peptidase_C6 | 53.4 | 3.00e-14 | 35.2% | 10.2% |