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HC-Pro

Euk-Vir

Euphorbia_ringspot_virus

HC-Pro__YP_009310041__Euphorbia_ringspot_virus__291286

Identity

Accession:
YP_009310041 ↗
Protein ID:
HC-Pro
Kingdom:
euk

Quality

85.9 mean pLDDT

Taxonomy

Orthornavirae› Pisuviricota› Stelpaviricetes› Patatavirales› Potyviridae› Potyvirus› Euphorbia_ringspot_virus

TaxID: 291286

Cluster

View cluster (80 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 118-180
PDB
Domain cluster: rep: HC-Pro_protein__YP_006405405__Basella_rugose_mosaic_virus__373398__D110-165
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00851.25 best Peptidase_C6 39.5 4.90e-10 100.0% 13.6%
D2 medium residues 32-117
PDB
Domain cluster: rep: HC-Pro__YP_009252411__Tobacco_mosqueado_virus__1792583__D31-64_66-104
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00851.25 best Peptidase_C6 42.9 4.50e-11 100.0% 17.3%
CATH (47)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3k6tB00 1.20.5.4010 Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › 0.80 42.0 5.55e-01 75.6% 91.8%
3oxfA05 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.70 49.0 5.28e-01 88.4% 84.0%
2pqrA01 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.70 46.0 4.50e-01 86.0% 61.3%
3iq1B00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.70 64.0 5.16e-01 100.0% 96.9%
3hiuD00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.69 61.0 5.01e-01 95.3% 93.4%
2yjkC00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.69 63.0 5.08e-01 100.0% 94.3%
4a25B01 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.68 60.0 4.89e-01 97.7% 91.9%
2vxxA00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.68 61.0 4.87e-01 100.0% 88.4%
3n71A03 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.68 50.0 3.73e-01 77.9% 52.1%
1zs3A00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.67 57.0 4.55e-01 93.0% 89.5%
3r2kA00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.67 62.0 5.00e-01 100.0% 92.9%
2mtqA00 1.20.58.130 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.66 53.0 5.68e-01 90.7% 100.0%
4dyqA01 1.10.10.60 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Homeodomain-like 0.66 48.0 4.57e-01 76.7% 80.6%
2v6kA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.64 53.0 4.61e-01 89.5% 70.8%
4pxoA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.64 53.0 4.59e-01 89.5% 70.2%
3e6sA00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.64 54.0 4.49e-01 95.3% 88.1%
2ikbC00 1.20.141.10 Mainly Alpha › Up-down Bundle › Chitosanase, subunit A; domain 1 › Chitosanase, subunit A, domain 1 0.64 53.0 4.37e-01 93.0% 85.7%
3nivC02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.63 51.0 4.56e-01 89.5% 74.2%
5tqbB01 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.62 53.0 3.53e-01 91.9% 84.3%
1br0A00 1.20.58.70 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.62 55.0 4.95e-01 98.8% 99.2%
1nigA00 1.20.1200.10 Mainly Alpha › Up-down Bundle › Hypothetical Protein Ta1238; Chain: A; › Cobalamin adenosyltransferase-like 0.62 52.0 4.35e-01 91.9% 95.9%
2yfaA02 1.20.1440.210 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 0.61 52.0 4.74e-01 95.3% 69.8%
4u72A01 1.20.58.480 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.60 49.0 3.67e-01 89.5% 56.3%
1s3qG00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.60 51.0 4.29e-01 100.0% 88.3%
3lqhA02 1.20.920.10 Mainly Alpha › Up-down Bundle › Histone Acetyltransferase; Chain A › Bromodomain-like 0.60 47.0 4.40e-01 84.9% 76.4%
4kb2A01 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.59 47.0 4.42e-01 88.4% 91.7%
1s35A02 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.58 51.0 4.71e-01 97.7% 99.1%
4d0nB01 1.20.900.10 Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain 0.58 51.0 3.73e-01 98.8% 86.1%
2juaA00 1.20.1480.30 Mainly Alpha › Up-down Bundle › hypothetical protein mp506/mpn330, domain 1 › Designed four-helix bundle protein 0.58 49.0 4.63e-01 93.0% 79.4%
3k2jA00 1.20.920.10 Mainly Alpha › Up-down Bundle › Histone Acetyltransferase; Chain A › Bromodomain-like 0.57 46.0 4.12e-01 87.2% 70.2%
1vcsA00 1.20.58.400 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › t-snare proteins 0.57 47.0 4.45e-01 89.5% 86.3%
1zeeA01 1.20.58.600 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.57 46.0 4.17e-01 91.9% 64.4%
4nuuB02 1.20.58.830 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.57 46.0 4.16e-01 90.7% 93.5%
4oydB00 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.57 42.0 3.86e-01 80.2% 82.1%
3lomA00 1.10.600.10 Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase 0.56 46.0 3.24e-01 90.7% 79.9%
2vixA03 1.20.1280.240 Mainly Alpha › Up-down Bundle › Monooxygenase › 0.56 48.0 4.41e-01 95.3% 95.6%
3pe0A01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.56 47.0 4.45e-01 91.9% 97.0%
2uubT00 1.20.58.110 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Ribosomal protein S20 0.56 46.0 4.42e-01 95.3% 79.8%
4u7iA00 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.55 47.0 4.63e-01 94.2% 98.9%
2odmA00 1.10.287.750 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › SO2669-like 0.55 44.0 4.59e-01 93.0% 97.5%
1cunA01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.55 48.0 4.56e-01 96.5% 100.0%
1ugoA00 1.20.58.120 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain 0.55 47.0 4.54e-01 96.5% 87.9%
3pe0A02 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.55 45.0 4.22e-01 90.7% 91.5%
3fb2A01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.54 46.0 4.38e-01 95.3% 97.1%
2radA03 1.20.1440.30 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › Biosynthetic Protein domain 0.53 44.0 3.93e-01 94.2% 70.9%
4dlqA02 1.25.40.610 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.52 40.0 3.87e-01 81.4% 75.8%
1np7A02 1.25.40.80 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.50 40.0 3.62e-01 94.2% 63.0%
ECOD (53)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3312166 109.4.1.777 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.73 52.0 3.81e-01 88.4% 28.7%
3615307 604.12.1.0 ↗ alpha bundles › Spectrin repeat-like › MIT domain › MIT domain 0.73 60.0 5.83e-01 91.9% 80.0%
4970859 601.28.1.0 ↗ alpha bundles › Four-helical up-and-down bundle › VPS28 C-terminal domain-like › VPS28 C-terminal domain-like 0.72 52.0 4.96e-01 90.7% 65.0%
3529996 109.4.1.198 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_12 0.68 51.0 3.92e-01 87.2% 35.8%
5071659 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.68 56.0 5.33e-01 89.5% 78.0%
4491518 7516.1.1.153 ↗ a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Glycos_transf_2, Glyco_transf_8 0.67 58.0 3.48e-01 94.2% 24.8%
3325610 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.67 54.0 4.95e-01 89.5% 67.3%
3465231 192.15.1.189 ↗ alpha bundles › Long alpha-hairpin › Endosomal sorting complex assembly domains › Endosomal sorting complex assembly domains › Frigida 0.66 57.0 5.94e-01 93.0% 100.0%
3605710 604.12.1.0 ↗ alpha bundles › Spectrin repeat-like › MIT domain › MIT domain 0.66 54.0 5.79e-01 89.5% 100.0%
5045529 604.12.1.0 ↗ alpha bundles › Spectrin repeat-like › MIT domain › MIT domain 0.64 46.0 5.14e-01 82.6% 100.0%
3985371 5054.1.1.8 ↗ alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels › Ion_trans_2 0.64 56.0 3.98e-01 93.0% 38.7%
3794336 601.1.2.0 ↗ alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) 0.64 59.0 4.71e-01 100.0% 71.9%
3909893 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.64 56.0 4.76e-01 96.5% 77.1%
3620806 604.1.1.1 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin 0.63 48.0 3.81e-01 91.9% 40.6%
3250251 4967.1.1.16 ↗ alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › TERT_C 0.63 55.0 4.06e-01 95.3% 45.5%
3428033 604.5.1.0 ↗ alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) 0.63 57.0 4.58e-01 100.0% 73.9%
3390613 174.1.1.1 ↗ few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin 0.63 49.0 4.24e-01 82.6% 90.0%
4128901 109.4.1.158 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › ERAP1_C 0.63 42.0 2.97e-01 89.5% 21.9%
3277087 192.4.1.0 ↗ alpha bundles › Long alpha-hairpin › Ribosomal protein L29 (L29p) › Ribosomal protein L29 (L29p) 0.62 50.0 4.81e-01 84.9% 89.5%
3200625 109.4.1.158 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › ERAP1_C 0.62 44.0 3.02e-01 75.6% 32.5%
4026662 4207.1.2.0 ↗ alpha duplicates or obligate multimers › Mediator hinge subcomplex-like › Mediator hinge subcomplex-like › MED7 hinge region 0.62 54.0 4.55e-01 95.3% 79.3%
5023303 601.4.1.0 ↗ alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains 0.61 51.0 4.62e-01 89.5% 69.6%
4013731 601.1.1.12 ↗ alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › AflR 0.61 54.0 4.47e-01 96.5% 99.3%
3866994 601.19.1.36 ↗ alpha bundles › Four-helical up-and-down bundle › Apolipoprotein › Apolipoprotein › DUF4455 0.61 50.0 4.03e-01 90.7% 81.1%
1713219 601.4.1.5 ↗ alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains › HBM 0.61 54.0 4.98e-01 98.8% 80.5%
3726818 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.60 51.0 4.22e-01 93.0% 72.3%
1693420 604.31.1.1 ↗ alpha bundles › Spectrin repeat-like › F-actin-bundling protein ABP34 C-terminal domain › F-actin-bundling protein ABP34 C-terminal domain › F_actin_bund_C 0.60 50.0 4.76e-01 93.0% 100.0%
4017858 109.4.1.1391 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Sec10_HB, Sec10_N 0.60 46.0 3.18e-01 82.6% 26.0%
3488482 150.1.1.0 ↗ alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin 0.60 53.0 4.30e-01 100.0% 75.8%
4029831 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.60 40.0 2.77e-01 91.9% 18.8%
3964840 3636.1.1.0 ↗ a+b two layers › XPD arch domain › XPD arch domain › XPD arch domain 0.60 52.0 4.06e-01 96.5% 86.5%
3174622 4967.1.1.0 ↗ alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases 0.60 53.0 4.45e-01 98.8% 93.3%
3677853 109.4.1.1529 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › eIF3_p135, TPR_12 0.60 54.0 3.14e-01 100.0% 53.3%
3273401 603.1.1.0 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.59 48.0 3.69e-01 89.5% 100.0%
3389546 604.1.1.1 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin 0.59 47.0 4.93e-01 87.2% 92.5%
3368223 192.29.1.0 ↗ alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) 0.59 52.0 3.91e-01 98.8% 46.0%
4324037 109.4.1.681 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Fungal_trans_2 0.59 50.0 3.25e-01 94.2% 25.0%
3271444 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.59 52.0 3.64e-01 96.5% 72.8%
1019380 604.5.1.2 ↗ alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PhoU 0.59 49.0 4.61e-01 93.0% 89.8%
3197870 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.59 53.0 4.53e-01 100.0% 89.6%
3773055 174.1.1.1 ↗ few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin 0.58 50.0 4.20e-01 94.2% 57.9%
3904075 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.58 51.0 4.76e-01 100.0% 100.0%
3581268 604.1.1.104 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › ANC1_spectrin 0.57 47.0 4.61e-01 90.7% 98.9%
None — 0.57 46.0 3.53e-01 89.5% 41.6%
4027582 603.1.1.120 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins › DUF846 0.57 49.0 4.42e-01 95.3% 80.0%
4977048 604.12.1.0 ↗ alpha bundles › Spectrin repeat-like › MIT domain › MIT domain 0.57 48.0 4.55e-01 98.8% 79.6%
3497641 604.1.1.1 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin 0.56 48.0 4.57e-01 93.0% 100.0%
3972817 208.1.1.1 ↗ beta duplicates or obligate multimers › Single-stranded left-handed beta-helix › Trimeric LpxA-like enzymes › Trimeric LpxA-like enzymes › Hexapep 0.56 46.0 3.52e-01 91.9% 72.4%
3488077 604.12.1.0 ↗ alpha bundles › Spectrin repeat-like › MIT domain › MIT domain 0.55 45.0 4.39e-01 89.5% 98.9%
4485359 103.2.1.0 ↗ alpha arrays › RuvA-C › ATP cone › ATP cone 0.54 36.0 3.52e-01 89.5% 62.1%
3872563 604.1.1.1 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin 0.53 47.0 4.27e-01 100.0% 92.2%
5056432 607.1.1.0 ↗ alpha arrays › Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain › Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain › Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain 0.53 44.0 3.91e-01 91.9% 89.6%
3755130 604.1.1.1 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin 0.52 45.0 4.25e-01 98.8% 100.0%
D3 medium residues 183-270_307-339
PDB
Domain cluster: rep: HC-Pro__YP_001936179__Verbena_virus_Y__515446__D186-209_223-267_313-337
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00851.25 best Peptidase_C6 60.8 1.70e-16 71.1% 17.3%
D4 medium residues 271-306_340-458
PDB
Domain cluster: rep: HC-Pro_protein__YP_006590094__Chinese_yam_necrotic_mosaic_virus__128818__D95-261
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF00851.25 best Peptidase_C6 174.5 5.40e-51 79.3% 27.7%
PF00851.25 Peptidase_C6 25.7 7.60e-06 23.2% 6.8%