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HC-Pro
Euk-VirCucurbit_vein_banding_virus
HC-Pro__YP_009389251__Cucurbit_vein_banding_virus__2005044
Identity
- Accession:
- YP_009389251 ↗
- Protein ID:
- HC-Pro
- Kingdom:
- euk
Quality
86.3
mean pLDDT
Taxonomy
Orthornavirae›
Pisuviricota›
Stelpaviricetes›
Patatavirales›
Potyviridae›
Potyvirus›
Cucurbit_vein_banding_virus
TaxID: 2005044
Cluster
View cluster (80 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 26-105
Domain cluster:
rep: HC-Pro_segment__YP_008992246__Zucchini_tigre_mosaic_virus__1406816__D31-111
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00851.25 best | Peptidase_C6 | 37.5 | 2.00e-09 | 100.0% | 17.1% |
D2
medium
residues 113-176
Domain cluster:
rep: HC-Pro_protein__YP_006405405__Basella_rugose_mosaic_virus__373398__D110-165
CATH (43)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 6r1nA01 | 1.10.287.40 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain | 0.82 | 60.0 | 5.00e-01 | 76.6% | 53.4% |
| 2mtqA00 | 1.20.58.130 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.80 | 54.0 | 5.18e-01 | 70.3% | 61.6% |
| 3r84A00 | 1.10.287.3490 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.79 | 58.0 | 5.32e-01 | 76.6% | 63.0% |
| 2kw6A00 | 6.10.140.1300 | Special › Helix non-globular › Helix Hairpins › | 0.78 | 64.0 | 6.41e-01 | 87.5% | 95.4% |
| 4nb5B02 | 1.10.287.160 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat | 0.78 | 57.0 | 5.73e-01 | 76.6% | 87.5% |
| 1wp7A00 | 1.10.287.770 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › YojJ-like | 0.78 | 57.0 | 5.73e-01 | 76.6% | 81.2% |
| 2ic6A00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.77 | 56.0 | 5.42e-01 | 76.6% | 73.2% |
| 2hujA00 | 1.20.120.440 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › YppE-like | 0.75 | 65.0 | 5.26e-01 | 98.4% | 67.2% |
| 3fd9A03 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.75 | 54.0 | 5.17e-01 | 76.6% | 69.9% |
| 2ch7A00 | 1.10.287.950 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Methyl-accepting chemotaxis protein | 0.74 | 53.0 | 3.39e-01 | 76.6% | 96.1% |
| 3l9fA02 | 6.10.140.1570 | Special › Helix non-globular › Helix Hairpins › | 0.72 | 50.0 | 4.71e-01 | 75.0% | 63.0% |
| 6p73A02 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.71 | 52.0 | 4.04e-01 | 78.1% | 37.8% |
| 4xaiB02 | 1.10.565.10 | Mainly Alpha › Orthogonal Bundle › Retinoid X Receptor › Retinoid X Receptor | 0.71 | 60.0 | 4.21e-01 | 92.2% | 55.6% |
| 1ku9A02 | 1.10.287.450 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.70 | 51.0 | 5.13e-01 | 78.1% | 78.1% |
| 2lpeA01 | 6.10.140.1120 | Special › Helix non-globular › Helix Hairpins › | 0.69 | 51.0 | 4.84e-01 | 79.7% | 67.9% |
| 1u7lA02 | 1.20.1460.10 | Mainly Alpha › Up-down Bundle › subunit c (vma5p) of the yeast v-atpase, domain 2 › subunit c (vma5p) of the yeast v-atpase, domain 2 | 0.69 | 50.0 | 3.64e-01 | 78.1% | 59.0% |
| 1ykeD00 | 6.10.280.10 | Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Mediator complex, subunit Med21 | 0.69 | 49.0 | 4.14e-01 | 76.6% | 46.9% |
| 2y39A00 | 1.20.120.1490 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › | 0.69 | 49.0 | 4.16e-01 | 76.6% | 50.0% |
| 4abmD00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.67 | 48.0 | 4.57e-01 | 76.6% | 63.6% |
| 8befJ01 | 1.20.120.1200 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ | 0.67 | 50.0 | 3.64e-01 | 79.7% | 76.5% |
| 3c5iA02 | 3.90.1200.10 | Alpha Beta › Alpha-Beta Complex › Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2 › Aminoglycoside phosphotransferase (APH), C-terminal lobe | 0.66 | 56.0 | 3.72e-01 | 95.3% | 95.9% |
| 1urfA00 | 1.10.287.160 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat | 0.66 | 47.0 | 4.43e-01 | 76.6% | 67.9% |
| 3qo8A01 | 1.10.287.40 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain | 0.66 | 47.0 | 4.07e-01 | 76.6% | 48.1% |
| 1vt0k00 | 1.10.3230.20 | Mainly Alpha › Orthogonal Bundle › Hypothetical protein yqbg › P22 tail accessory factor (Gp4) | 0.66 | 57.0 | 4.46e-01 | 100.0% | 62.8% |
| 4gzrC00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.65 | 44.0 | 4.55e-01 | 70.3% | 77.0% |
| 4k0dA00 | 1.20.120.1730 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › | 0.64 | 57.0 | 4.39e-01 | 100.0% | 60.8% |
| 6dcjA02 | 1.25.40.650 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.64 | 48.0 | 4.15e-01 | 81.2% | 53.8% |
| 3nrxA00 | 1.20.58.1520 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.64 | 45.0 | 3.75e-01 | 76.6% | 42.3% |
| 3qxfA00 | 1.50.10.10 | Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase › | 0.64 | 49.0 | 3.12e-01 | 84.4% | 34.7% |
| 3favD00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.64 | 46.0 | 4.30e-01 | 76.6% | 67.9% |
| 2lhrA00 | 1.20.58.1270 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.63 | 43.0 | 4.11e-01 | 75.0% | 59.0% |
| 4c1sA00 | 1.50.10.20 | Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase › | 0.63 | 54.0 | 3.35e-01 | 95.3% | 77.1% |
| 7zm7601 | 1.20.120.1200 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ | 0.61 | 51.0 | 3.86e-01 | 95.3% | 43.1% |
| 3lssA01 | 1.10.287.40 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain | 0.60 | 43.0 | 3.69e-01 | 78.1% | 45.5% |
| 1vibA00 | 1.10.287.120 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Neurotoxin B-IV-like | 0.60 | 39.0 | 4.14e-01 | 73.4% | 76.4% |
| 4kx7A04 | 1.25.50.20 | Mainly Alpha › Alpha Horseshoe › Zincin-like fold › | 0.60 | 45.0 | 2.91e-01 | 81.2% | 26.9% |
| 3tulB00 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.60 | 51.0 | 4.15e-01 | 100.0% | 94.7% |
| 2okuA00 | 1.20.120.470 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Acyl-CoA dehydrogenase, C-terminal domain | 0.60 | 51.0 | 4.16e-01 | 96.9% | 64.8% |
| 6xj1A01 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.59 | 53.0 | 3.55e-01 | 100.0% | 84.5% |
| 3jsbA01 | 1.20.1440.300 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › RNA-directed RNA polymerase L, helical domain | 0.59 | 46.0 | 4.29e-01 | 95.3% | 66.7% |
| 1t5oA01 | 1.20.120.420 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › translation initiation factor eif-2b, domain 1 | 0.59 | 49.0 | 3.96e-01 | 100.0% | 80.9% |
| 4dmvA01 | 1.20.58.1190 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.59 | 45.0 | 4.20e-01 | 87.5% | 70.6% |
| 6cgvM01 | 1.20.120.1500 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Pre-hexon-linking protein IIIa | 0.57 | 37.0 | 3.01e-01 | 98.4% | 32.1% |
ECOD (23)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3204414 | 1.1.17.0 ↗ | beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel 2 | 0.83 | 60.0 | 3.66e-01 | 76.6% | 15.3% |
| 4961961 | 605.1.1.1 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA | 0.82 | 60.0 | 5.69e-01 | 76.6% | 69.3% |
| 4937604 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.81 | 59.0 | 4.77e-01 | 76.6% | 44.3% |
| 3780286 | 244.1.1.6 ↗ | a+b two layers › FAD-linked reductases, C-terminal domain-like › FAD-linked reductases-C › FAD-linked reductases-C › Amino_oxidase | 0.79 | 57.0 | 3.30e-01 | 76.6% | 9.0% |
| 4500653 | 192.2.1.0 ↗ | alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin | 0.79 | 58.0 | 4.29e-01 | 76.6% | 34.0% |
| 3326073 | 3291.1.1.0 ↗ | alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related | 0.79 | 58.0 | 4.77e-01 | 76.6% | 46.4% |
| 4315986 | 192.7.1.2 ↗ | alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › Seryl_tRNA_N | 0.79 | 56.0 | 4.94e-01 | 73.4% | 53.3% |
| 3923633 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.79 | 57.0 | 4.19e-01 | 76.6% | 34.4% |
| 1879027 | 244.1.1.6 ↗ | a+b two layers › FAD-linked reductases, C-terminal domain-like › FAD-linked reductases-C › FAD-linked reductases-C › Amino_oxidase | 0.78 | 57.0 | 3.45e-01 | 76.6% | 13.4% |
| 4206858 | 4992.1.1.23 ↗ | extended segments › RelB-like › RelB-like › RelB-like › Seryl_tRNA_N | 0.77 | 56.0 | 4.55e-01 | 76.6% | 50.4% |
| 4013459 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.76 | 55.0 | 3.33e-01 | 76.6% | 12.7% |
| 3693258 | 604.7.1.1 ↗ | alpha bundles › Spectrin repeat-like › Tubulin chaperone cofactor A › Tubulin chaperone cofactor A › TBCA | 0.76 | 55.0 | 4.58e-01 | 76.6% | 46.4% |
| 3543713 | 4.1.1.0 ↗ | beta barrels › SH3 › SH3 › SH3 | 0.74 | 53.0 | 4.78e-01 | 76.6% | 57.8% |
| 3774121 | 150.1.1.119 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › Clusterin | 0.73 | 52.0 | 3.92e-01 | 76.6% | 65.6% |
| 3927738 | 632.8.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › alpha-2-Macroglobulin receptor associated protein (RAP) domain 1 › alpha-2-Macroglobulin receptor associated protein (RAP) domain 1 | 0.72 | 57.0 | 4.98e-01 | 85.9% | 96.8% |
| 4106620 | 605.1.1.1 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA | 0.68 | 50.0 | 4.77e-01 | 78.1% | 82.7% |
| 4014222 | 3684.1.1.0 ↗ | alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like | 0.68 | 60.0 | 4.35e-01 | 100.0% | 51.7% |
| 3929573 | 192.8.1.395 ↗ | alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain › CHDCT2 | 0.68 | 57.0 | 5.18e-01 | 92.2% | 100.0% |
| 149872 | 3291.1.1.1 ↗ | alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Snf7 | 0.67 | 48.0 | 4.53e-01 | 78.1% | 81.0% |
| 3228072 | 188.1.1.1 ↗ | alpha arrays › Nuclear receptor ligand-binding domain › Nuclear receptor ligand-binding domain › Nuclear receptor ligand-binding domain › Hormone_recep | 0.63 | 53.0 | 3.55e-01 | 95.3% | 43.0% |
| 1503553 | 3796.1.1.1 ↗ | alpha arrays › Iron-regulated surface determinant protein H linker domain › Iron-regulated surface determinant protein H linker domain › Iron-regulated surface determinant protein H linker domain › Isd_H_B_linker | 0.63 | 43.0 | 4.11e-01 | 75.0% | 59.0% |
| 4882899 | 5038.2.1.1 ↗ | alpha superhelices › Cytochrome c oxidase subunit I-like › MAPEG domain-like › MAPEG domain-like › MAPEG | 0.59 | 51.0 | 3.96e-01 | 100.0% | 76.5% |
| 3838012 | 601.1.2.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) | 0.57 | 48.0 | 3.97e-01 | 100.0% | 86.4% |
D3
medium
residues 209-238_255-295_323-341_366-431
Domain cluster:
rep: HC-Pro_protein__YP_006590094__Chinese_yam_necrotic_mosaic_virus__128818__D95-261
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00851.25 best | Peptidase_C6 | 78.9 | 5.40e-22 | 47.4% | 15.0% |