←Back to structures

HC-Pro

Euk-Vir

Thunberg_fritillary_mosaic_virus

HC-Pro__YP_254715__Thunberg_fritillary_mosaic_virus__299200

Identity

Accession:: YP_254715 ↗
Protein ID:: HC-Pro
Kingdom:: euk

Quality

86.0 mean pLDDT

Taxonomy

Orthornavirae› Pisuviricota› Stelpaviricetes› Patatavirales› Potyviridae› Potyvirus› Thunberg_fritillary_mosaic_virus

TaxID: 299200

Cluster

View cluster (80 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 114-180

PDB

Domain cluster: rep: HC-Pro_protein__YP_006405405__Basella_rugose_mosaic_virus__373398__D110-165

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00851.25 best	Peptidase_C6	37.3	2.40e-09	100.0%	13.6%

D2 medium residues 34-113

PDB

Domain cluster: rep: HC-Pro__YP_009252411__Tobacco_mosqueado_virus__1792583__D31-64_66-104

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00851.25 best	Peptidase_C6	26.3	5.10e-06	98.8%	16.4%

CATH (29)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4d8mA01	1.20.190.10	Mainly Alpha › Up-down Bundle › Delta-Endotoxin; domain 1 › Pesticidal crystal protein, N-terminal domain	0.65	57.0	4.21e-01	100.0%	45.8%
2ra1A01	1.20.58.790	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.63	55.0	5.15e-01	97.5%	98.0%
2d2sA01	1.20.58.1210	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Exo84p, N-terminal helical domain	0.63	56.0	4.98e-01	100.0%	87.9%
1dd5A01	1.10.132.20	Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor	0.63	55.0	4.98e-01	97.5%	94.5%
1ugoA00	1.20.58.120	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain	0.63	56.0	5.22e-01	98.8%	84.8%
2v6kA02	1.20.1050.10	Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 ›	0.63	54.0	4.58e-01	95.0%	70.0%
1cunA01	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.62	54.0	4.99e-01	96.2%	97.1%
4kb2A01	1.10.132.20	Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor	0.61	53.0	4.85e-01	97.5%	94.5%
3edvB01	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.61	55.0	4.61e-01	100.0%	75.7%
4nuuB02	1.20.58.830	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.61	53.0	4.61e-01	97.5%	95.9%
3nivC02	1.20.1050.10	Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 ›	0.61	52.0	4.50e-01	95.0%	73.4%
3pe0A01	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.60	53.0	4.95e-01	97.5%	97.0%
3onjA00	1.20.58.400	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › t-snare proteins	0.60	52.0	4.95e-01	97.5%	96.9%
2qywA00	1.20.58.400	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › t-snare proteins	0.60	52.0	4.97e-01	97.5%	95.8%
2gwcA00	3.30.590.20	Alpha Beta › 2-Layer Sandwich › Creatine Kinase; Chain A, domain 2 ›	0.60	50.0	3.21e-01	93.8%	88.6%
1sumB02	1.20.58.220	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2	0.60	54.0	4.73e-01	100.0%	94.9%
7cjsB01	1.20.1080.10	Mainly Alpha › Up-down Bundle › Glycerol uptake facilitator protein › Glycerol uptake facilitator protein.	0.60	51.0	3.79e-01	95.0%	76.5%
6vudA01	1.10.132.20	Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor	0.60	51.0	4.66e-01	96.2%	95.4%
4ap2B01	1.20.1310.10	Mainly Alpha › Up-down Bundle › 5 helical Cullin repeat like › Cullin Repeats	0.60	49.0	4.22e-01	92.5%	60.4%
1hs7A00	1.20.58.70	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.60	53.0	4.98e-01	100.0%	95.9%
2azjA00	1.10.600.10	Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase	0.59	49.0	3.39e-01	91.3%	75.4%
3axjB02	1.20.58.200	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 2	0.59	51.0	5.03e-01	97.5%	90.6%
1tfkB00	1.20.120.650	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Colicin D	0.58	43.0	4.28e-01	91.3%	74.4%
1e8yA03	1.25.40.70	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Phosphatidylinositol 3-kinase, accessory domain (PIK)	0.57	40.0	3.08e-01	72.5%	54.8%
2d2sA02	1.20.58.1220	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Exo84p, C-terminal helical domain	0.56	46.0	4.31e-01	91.3%	86.1%
4xxiA00	1.10.490.20	Mainly Alpha › Orthogonal Bundle › Globin-like › Phycocyanins	0.56	46.0	3.91e-01	96.2%	76.9%
3ll9B00	3.40.1160.10	Alpha Beta › 3-Layer(aba) Sandwich › Carbamate kinase › Acetylglutamate kinase-like	0.55	45.0	3.18e-01	90.0%	55.8%
3tt9A00	1.25.10.10	Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant	0.54	43.0	3.16e-01	95.0%	30.5%
4hehA01	1.10.1240.10	Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › Methionine synthase domain	0.52	41.0	4.13e-01	88.7%	92.8%

ECOD (35)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4542439	109.4.1.198 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_12	0.75	57.0	4.54e-01	93.8%	42.7%
3615307	604.12.1.0 ↗	alpha bundles › Spectrin repeat-like › MIT domain › MIT domain	0.75	65.0	6.15e-01	97.5%	78.9%
3574981	604.12.1.91 ↗	alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › RSLD_CPSF6	0.74	61.0	6.47e-01	96.2%	100.0%
3773905	604.3.1.33 ↗	alpha bundles › Spectrin repeat-like › BAG domain › BAG domain › RSLD_CPSF6	0.74	61.0	6.31e-01	98.8%	94.7%
4023501	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.70	48.0	4.16e-01	88.7%	46.7%
3640330	604.1.1.0 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat	0.68	61.0	5.04e-01	98.8%	69.3%
3924801	109.4.1.1643 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › RSLD_CPSF6	0.68	61.0	5.73e-01	100.0%	82.1%
5019542	622.4.1.67 ↗	alpha bundles › YvfG-like › Mite allergen Der p 5-related › Mite allergen Der p 5-related › DUF5518	0.67	46.0	4.36e-01	72.5%	83.8%
3325610	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.67	56.0	5.02e-01	93.8%	66.4%
3605710	604.12.1.0 ↗	alpha bundles › Spectrin repeat-like › MIT domain › MIT domain	0.66	57.0	5.89e-01	95.0%	100.0%
3529996	109.4.1.198 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_12	0.66	52.0	3.92e-01	93.8%	35.8%
5035499	604.9.1.0 ↗	alpha bundles › Spectrin repeat-like › Ribosomal protein S20 › Ribosomal protein S20	0.66	51.0	5.25e-01	95.0%	89.3%
3641172	101.1.1.295 ↗	alpha arrays › HTH › HTH › Three-helical HTH › HTH_70	0.65	49.0	4.77e-01	81.2%	83.3%
4579290	4156.1.1.6 ↗	alpha arrays › Sec63 N-terminal subdomain-like › Sec63 N-terminal subdomain-like › Sec63 N-terminal subdomain-like › Helicase_dom4_arc	0.64	53.0	4.58e-01	92.5%	90.0%
3596386	109.4.1.1774 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_CFAP46_N	0.64	58.0	4.62e-01	100.0%	71.6%
3227498	5001.1.1.54 ↗	alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7TM_GPCR_Srbc	0.63	48.0	3.38e-01	82.5%	47.5%
4060154	4974.1.1.0 ↗	alpha bundles › CRISPR-Cas system first helical domain › CRISPR-Cas system first helical domain › CRISPR-Cas system RNase C2c2 first helical domain	0.63	53.0	4.01e-01	98.8%	38.9%
3582455	3843.1.1.0 ↗	alpha complex topology › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K	0.62	52.0	5.36e-01	96.2%	98.7%
3286501	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.61	52.0	4.36e-01	97.5%	53.1%
1693420	604.31.1.1 ↗	alpha bundles › Spectrin repeat-like › F-actin-bundling protein ABP34 C-terminal domain › F-actin-bundling protein ABP34 C-terminal domain › F_actin_bund_C	0.61	54.0	4.95e-01	98.8%	100.0%
3271444	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.60	50.0	3.50e-01	93.8%	36.9%
3612220	206.1.1.1 ↗	a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase	0.59	52.0	3.46e-01	97.5%	66.1%
3841673	604.1.1.1 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin	0.59	51.0	4.76e-01	96.2%	96.0%
3727574	109.57.1.1 ↗	alpha superhelices › Repetitive alpha hairpins › Sterol regulatory element-binding protein 1 (Sre1) C-terminal domain › Sterol regulatory element-binding protein 1 (Sre1) C-terminal domain › DUF2014	0.59	48.0	3.52e-01	91.3%	52.4%
4622749	603.1.1.0 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins	0.59	52.0	4.79e-01	100.0%	90.5%
3489767	604.1.1.1 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin	0.58	52.0	4.48e-01	100.0%	96.0%
3484929	604.1.1.1 ↗	alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin	0.57	49.0	4.61e-01	96.2%	95.0%
3189302	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.57	47.0	4.32e-01	90.0%	83.8%
3243599	601.1.2.0 ↗	alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608)	0.57	48.0	4.38e-01	98.8%	81.7%
3784313	103.2.1.2 ↗	alpha arrays › RuvA-C › ATP cone › ATP cone › ATP-cone	0.56	39.0	3.84e-01	93.8%	65.6%
4485359	103.2.1.0 ↗	alpha arrays › RuvA-C › ATP cone › ATP cone	0.56	38.0	3.70e-01	93.8%	61.1%
3657872	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.56	48.0	4.23e-01	93.8%	77.4%
4258388	109.4.1.158 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › ERAP1_C	0.54	46.0	3.04e-01	95.0%	33.5%
3200625	109.4.1.158 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › ERAP1_C	0.53	44.0	3.00e-01	95.0%	30.0%
4025157	3810.1.1.0 ↗	alpha duplicates or obligate multimers › Uncharacterized protein YP_510488.1 › Uncharacterized protein YP_510488.1 › Uncharacterized protein YP_510488.1	0.51	36.0	3.60e-01	87.5%	70.6%

D3 medium residues 194-271_311-341

PDB

Domain cluster: rep: HC-Pro__YP_001936179__Verbena_virus_Y__515446__D186-209_223-267_313-337

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00851.25 best	Peptidase_C6	54.8	1.20e-14	71.6%	16.8%

D4 medium residues 272-310_342-459

PDB

Domain cluster: rep: HC-Pro_protein__YP_006590094__Chinese_yam_necrotic_mosaic_virus__128818__D95-261

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00851.25 best	Peptidase_C6	162.6	2.20e-47	77.1%	27.1%